W G Foster

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. pmc Developmental and lactational exposure to dieldrin alters mammary tumorigenesis in Her2/neu transgenic mice
    Heather L Cameron
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e4303. 2009
  2. pmc Reproductive and developmental effects of phthalate diesters in females
    Vanessa R Kay
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Crit Rev Toxicol 43:200-19. 2013
  3. pmc The brain-uterus connection: brain derived neurotrophic factor (BDNF) and its receptor (Ntrk2) are conserved in the mammalian uterus
    Jocelyn M Wessels
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 9:e94036. 2014
  4. doi request reprint Circulating metals and persistent organic pollutant concentrations in Canadian and non-Canadian born primiparous women from five Canadian centres: results of a pilot biomonitoring study
    Warren G Foster
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Sci Total Environ 435:326-36. 2012
  5. ncbi request reprint Environmental contaminants and dietary factors in endometriosis
    Warren G Foster
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Ann N Y Acad Sci 955:213-29; discussion 230-2, 396-406. 2002
  6. ncbi request reprint Environmental toxicants and human fertility
    W G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University Medical Center, Hamilton, ON, Canada
    Minerva Ginecol 55:451-7. 2003
  7. pmc Dioxin-induced changes in epididymal sperm count and spermatogenesis
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Environ Health Perspect 118:458-64. 2010
  8. doi request reprint Developmental and lactational exposure to environmentally relevant concentrations of dieldrin does not alter pregnancy outcome and mammary gland morphology in BALB/c mice
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, HSC 3N52D, 1200 Main Street West, Hamilton, Ontario, Canada
    Environ Res 108:21-7. 2008
  9. doi request reprint Environmental estrogens and endocrine disruption: importance of comparative endocrinology
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Endocrinology 149:4267-8. 2008
  10. doi request reprint Endocrine toxicants including 2,3,7,8-terachlorodibenzo-p-dioxin (TCDD) and dioxin-like chemicals and endometriosis: is there a link?
    Warren G Foster
    Centre for Reproductive Care, Hamilton Health Sciences, and Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    J Toxicol Environ Health B Crit Rev 11:177-87. 2008

Collaborators

Detail Information

Publications69

  1. pmc Developmental and lactational exposure to dieldrin alters mammary tumorigenesis in Her2/neu transgenic mice
    Heather L Cameron
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 4:e4303. 2009
    ..Dieldrin exposure also altered the expression of BNDF and TrkB, novel modulators of cancer pathogenesis...
  2. pmc Reproductive and developmental effects of phthalate diesters in females
    Vanessa R Kay
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada
    Crit Rev Toxicol 43:200-19. 2013
    ....
  3. pmc The brain-uterus connection: brain derived neurotrophic factor (BDNF) and its receptor (Ntrk2) are conserved in the mammalian uterus
    Jocelyn M Wessels
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 9:e94036. 2014
    ..Our findings suggest that BDNF and Ntrk2 are transcribed, translated, and conserved across mammalian species including human, mouse, rat, pig, horse, and the bat. ..
  4. doi request reprint Circulating metals and persistent organic pollutant concentrations in Canadian and non-Canadian born primiparous women from five Canadian centres: results of a pilot biomonitoring study
    Warren G Foster
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Sci Total Environ 435:326-36. 2012
    ..Taken together, the data suggest that there are potential regional differences in contaminant body burden and place of birth may also contribute to differences in maternal residue concentrations...
  5. ncbi request reprint Environmental contaminants and dietary factors in endometriosis
    Warren G Foster
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Ann N Y Acad Sci 955:213-29; discussion 230-2, 396-406. 2002
    ..The objective of this paper is to review the weight of the evidence from hospital-based case-control studies and animal experiments for an association between exposure to environmental contaminants and endometriosis...
  6. ncbi request reprint Environmental toxicants and human fertility
    W G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University Medical Center, Hamilton, ON, Canada
    Minerva Ginecol 55:451-7. 2003
    ..This review summarizes the evidence linking environmental toxicant exposure and infertility and examines the biological plausibility for this association...
  7. pmc Dioxin-induced changes in epididymal sperm count and spermatogenesis
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Environ Health Perspect 118:458-64. 2010
    ..Moreover, conflicting reports of TCDD effects on daily sperm production suggest that spermatogenesis may not be as sensitive to the adverse effects of TCDD as previously thought...
  8. doi request reprint Developmental and lactational exposure to environmentally relevant concentrations of dieldrin does not alter pregnancy outcome and mammary gland morphology in BALB/c mice
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, HSC 3N52D, 1200 Main Street West, Hamilton, Ontario, Canada
    Environ Res 108:21-7. 2008
    ..Treatments had no effect on fertility parameters in dams or mammary gland morphology at sexual maturity. Developmental exposure to dieldrin has no effect on mammary gland development in aged BALB/c mice...
  9. doi request reprint Environmental estrogens and endocrine disruption: importance of comparative endocrinology
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Endocrinology 149:4267-8. 2008
  10. doi request reprint Endocrine toxicants including 2,3,7,8-terachlorodibenzo-p-dioxin (TCDD) and dioxin-like chemicals and endometriosis: is there a link?
    Warren G Foster
    Centre for Reproductive Care, Hamilton Health Sciences, and Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    J Toxicol Environ Health B Crit Rev 11:177-87. 2008
    ..In this article, the literature linking environmental toxicants with endometriosis was reviewed and the link with endocrine toxicants discussed...
  11. doi request reprint Environmental contaminants and human infertility: hypothesis or cause for concern?
    Warren G Foster
    Centre for Reproductive Care and Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    J Toxicol Environ Health B Crit Rev 11:162-76. 2008
    ..However, it is postulated that evidence of chemical exposure and potential health consequences of these exposures highlight the need for further research in this area...
  12. doi request reprint Toward less confusing terminology in endocrine disruptor research
    Warren G Foster
    Centre for Reproductive Care and Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5
    J Toxicol Environ Health B Crit Rev 11:152-61. 2008
    ....
  13. ncbi request reprint Reporting results of biomonitoring studies
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, L8N 3Z5, Canada
    Anal Bioanal Chem 387:137-40. 2007
  14. ncbi request reprint Mammary gland morphology in Sprague-Dawley rats following treatment with an organochlorine mixture in utero and neonatal genistein
    Warren G Foster
    Department of Obstetrics and Gynecology, McMaster University and Health Sciences Centre, Hamilton, Ontario, Canada
    Toxicol Sci 77:91-100. 2004
    ....
  15. doi request reprint Human maternal and umbilical cord blood concentrations of polybrominated diphenyl ethers
    Warren G Foster
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Chemosphere 84:1301-9. 2011
    ....
  16. ncbi request reprint Dioxin-like activity and maternal thyroid hormone levels in second trimester maternal serum
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada
    Am J Obstet Gynecol 193:1900-7. 2005
    ..Therefore, the objective of this study was to quantify the overall dioxin-like activity in maternal serum and determine the association between dioxin-like activity and thyroid hormone levels...
  17. ncbi request reprint Detection of phytoestrogens in samples of second trimester human amniotic fluid
    Warren G Foster
    Center for Women s Health, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Toxicol Lett 129:199-205. 2002
    ..44 +/- 1.34 and 1.69 +/- 1.48 ng/ml with maximum levels of 5.52 and 6.54 ng/ml, respectively. Second trimester amniotic fluid contains quantifiable levels of dietary phytoestrogens and thus is a marker of mid pregnancy fetal exposure...
  18. ncbi request reprint Dioxin-induced changes in epididymal sperm count and spermatogenesis
    Warren G Foster
    Department of Obstetrics and Gynecology, McMaster University, ON, Canada
    Cien Saude Colet 16:2893-905. 2011
    ..The mechanisms underlying decreased epididymal sperm count are unknown; however, we contest [corrected] that epididymal function is the key target for the adverse effects of TCDD...
  19. ncbi request reprint Sperm chromatin structure is altered in cynomolgus monkeys with environmentally relevant blood lead levels
    W G Foster
    Environmental Health Directorate, Department of Health, Ottawa, Ontario, Canada
    Toxicol Ind Health 12:723-35. 1996
    ..We conclude that chronic lead exposure alters sperm chromatin structure at blood lead levels relevant to the human population and in the absence of effects on endocrine function and traditional measures of semen quality...
  20. ncbi request reprint Reproductive and thyroid hormone levels in rats following 90-day dietary exposure to PCB 28 (2,4,4'-trichlorobiphenyl) or PCB 77 (3,3'4,4'-tetrachlorobiphenyl)
    D Desaulniers
    Reproductive Toxicology Section, Bureau of Chemical Hazards, Environmental Health Directorate Health Protection Branch, Health Canada Ottawa, Ontario, Canada
    Toxicol Ind Health 13:627-38. 1997
    ..These results suggest that thyroid functions may be more susceptible or adapt less readily than the pituitary gland and the testes to endocrine disruption caused by PCB congeners...
  21. ncbi request reprint Rapid effects of pesticides on human granulosa-lutein cells
    Yanjing Wu
    Department of Obstetrics and Gynecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5
    Reproduction 131:299-310. 2006
    ..These results demonstrate that pesticides can have a rapid effect on human granulosa-lutein cells, and a nongenomic mechanism of action is suggested...
  22. ncbi request reprint Effects of acute exposure to PCBs 126 and 153 on anterior pituitary and thyroid hormones and FSH isoforms in adult Sprague Dawley male rats
    D Desaulniers
    Environmental and Occupational Toxicology Division, Department of Health, Ottawa, Ontario, Canada
    Toxicol Sci 47:158-69. 1999
    ..Serum LH and T4 concentrations were the most sensitive and practical endocrine indicators of PCBs 126 and 153 exposure in male rats...
  23. ncbi request reprint The link between environmental toxicant exposure and endometriosis
    Dana L Anger
    McMaster University, Reproductive Biology Division, Department of Obstetrics and Gynecology, Hamilton, Ontario, Canada L8N 3Z5
    Front Biosci 13:1578-93. 2008
    ..Moreover, differential expression of several novel genes that may be important in the disease provides new targets to test the actions of environmental toxicants in the pathobiology of endometriosis...
  24. ncbi request reprint Reproductive toxicology of environmental toxicants: emerging issues and concerns
    E V Younglai
    Department of Obstetrics and Gynecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada, L8N 3Z5
    Curr Pharm Des 13:3005-19. 2007
    ....
  25. doi request reprint Neurotrophins (BDNF and NGF) in follicular fluid of women with different infertility diagnoses
    J C Sadeu
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Reprod Biomed Online 24:174-9. 2012
    ..It is concluded that, apart from unexplained infertility, the underlying cause of infertility did not affect ovarian output of BDNF and NGF in response to ovulation induction...
  26. ncbi request reprint Chronic lead exposure effects in the cynomolgus monkey (Macaca fascicularis) testis
    W G Foster
    Reproductive Toxicology Section, Health Canada, Ottawa, Ontario, Canada
    Ultrastruct Pathol 22:63-71. 1998
    ..Results of this study on the primate, following extrapolation to humans, could influence further refining of the impact of environmental lead contamination concentrations vis-à-vis the health of children, adults, and aged human beings...
  27. ncbi request reprint Canadian semen quality: an analysis of sperm density among eleven academic fertility centers
    E V Younglai
    Department of Obstetrics and Gynecology, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada
    Fertil Steril 70:76-80. 1998
    ..To determine whether sperm quality has declined among Canadian men during the past 13 years and whether there are regional differences in sperm quality...
  28. ncbi request reprint The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on corticotrophin-releasing hormone, arginine vasopressin, and pro-opiomelanocortin mRNA levels in the hypothalamus of the cynomolgus monkey
    S Shridhar
    Department of Physiology, Queen's University, Kingston, Ontario, Canada
    Toxicol Sci 63:181-8. 2001
    ..We conclude that TCDD stimulated the HPA axis by a central effect involving CRH, but had no effect on the HPG axis at the doses tested...
  29. doi request reprint Dieldrin promotes resistance to anoikis in breast cancer cells in vitro
    Heather L Cameron
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8N 3Z5, Canada
    Reprod Toxicol 25:256-62. 2008
    ..Our results demonstrate that dieldrin increases resistance to anoikis and expression of TrkB and show for the first time TrkB protein expression in human breast cancer...
  30. ncbi request reprint Binding of progesterone to cell surfaces of human granulosa-lutein cells
    Edward V Younglai
    Department of Obstetrics and Gynecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, 1200 Main Street West, Hamilton, Ont, Canada L8N 3Z5
    J Steroid Biochem Mol Biol 101:61-7. 2006
    ..These results demonstrate that the plasma membranes of human granulosa cells possess binding components for progesterone which may be involved in its nongenomic mechanism of action...
  31. ncbi request reprint Quantification of benzo[a]pyrene and other PAHs in the serum and follicular fluid of smokers versus non-smokers
    Michael S Neal
    Centre for Reproductive Care, Hamilton Health Sciences Hamilton, Ontario L8S 1A4, Canada
    Reprod Toxicol 25:100-6. 2008
    ....
  32. ncbi request reprint The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells
    Katie M Edmunds
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario
    Reprod Nutr Dev 45:709-20. 2005
    ..Taken together, our data suggest that genistein can increase aromatase activity in ESC likely via increased enzyme expression...
  33. ncbi request reprint Rapid action of pesticides on cytosolic calcium concentrations in cultures of human umbilical vein endothelial cells
    Edward V Younglai
    Department of Obstetrics and Gynecology, Reproductive Biology Division, McMaster University Medical Centre, 1200 Main Street West, Health Sciences Centre, Hamilton, Ont, Canada L8N 3Z5
    Reprod Toxicol 21:271-9. 2006
    ..Estrone, estriol, pregnenolone and cortisol were not effective. These results demonstrate that pesticides can have a rapid effect on HUVE cells probably through a nongenomic mechanism of action...
  34. ncbi request reprint Environmental and occupational factors affecting fertility and IVF success
    Edward V Younglai
    Department of Obstetrics and Gynaecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada
    Hum Reprod Update 11:43-57. 2005
    ..We consider both the male and female partners since it is essentially their combined contributions of gametes which may be affected by chemicals, which lead to successful outcomes...
  35. ncbi request reprint Synergistic effects between FSH and 1,1-dichloro-2,2-bis(P-chlorophenyl)ethylene (P,P'-DDE) on human granulosa cell aromatase activity
    Edward V Younglai
    Department of Obstetrics and Gynaecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada
    Hum Reprod 19:1089-93. 2004
    ..The objective of this study was to investigate the interaction between FSH and ppDDE on aromatase activity in primary cultures of human granulosa cells...
  36. ncbi request reprint Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes
    A C Holloway
    Department of Obstetrics and Gynecology, McMaster University, Rm 3N52 HSC 1200 Main Street W, Hamilton, ON, Canada, L8N 3Z5
    Diabetologia 48:2661-6. 2005
    ..This study examines the effect of fetal and neonatal exposure to nicotine, the major addictive component of cigarettes, on postnatal growth, adiposity and glucose homeostasis...
  37. ncbi request reprint Dichlorodiphenylchloroethylene elevates cytosolic calcium concentrations and oscillations in primary cultures of human granulosa-lutein cells
    E V Younglai
    Department of Obstetrics and Gynecology, Reproductive Biology Division, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada
    Biol Reprod 70:1693-700. 2004
    ..Our data therefore highlight a novel mechanism through which DDE can alter endocrine homeostasis and possibly act as an endocrine toxicant...
  38. doi request reprint Effect of in vitro exposure to benzo[a]pyrene, a component of cigarette smoke, on folliculogenesis, steroidogenesis and oocyte nuclear maturation
    J C Sadeu
    Department of Obstetrics and Gynecology, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Reprod Toxicol 31:402-8. 2011
    ..These data suggest that B[a]P is an important toxic component of cigarette smoke that adversely affects follicular development and survival...
  39. ncbi request reprint The effects of in utero and lactational exposure to chloroform on postnatal growth and glucose tolerance in male Wistar rats
    Gareth E Lim
    Reproductive Biology Division, Department of Obstetrics and Gynecology, RM HSC 3N52, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5
    Endocrine 25:223-8. 2004
    ..Although fetal and neonatal exposure to chloroform did not elicit physiological changes associated with the onset of type 2 diabetes, there were physiological changes resulting in impaired postnatal growth...
  40. ncbi request reprint Follicle growth is inhibited by benzo-[a]-pyrene, at concentrations representative of human exposure, in an isolated rat follicle culture assay
    Michael S Neal
    Centre for Reproductive Care, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Hum Reprod 22:961-7. 2007
    ..Using a novel isolated rat follicle culture assay, we tested the hypothesis that benzo-[a]-pyrene (B[a]P), a constituent of cigarette smoke, can inhibit follicle growth...
  41. ncbi request reprint Environmental dioxins and endometriosis
    Sherry Rier
    Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Toxicol Sci 70:161-70. 2002
    ....
  42. ncbi request reprint DDE-induced changes in aromatase activity in endometrial stromal cells in culture
    Alison C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Endocrine 27:45-50. 2005
    ..Our data demonstrate that p,p'-DDE treatment can increase aromatase activity in ESC in culture...
  43. doi request reprint Assessing and managing risks arising from exposure to endocrine-active chemicals
    Karen P Phillips
    Faculty of Health Sciences, University of Ottawa, Ontario, Canada
    J Toxicol Environ Health B Crit Rev 11:351-72. 2008
    ....
  44. ncbi request reprint Sidestream smoking is equally as damaging as mainstream smoking on IVF outcomes
    Michael S Neal
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Hum Reprod 20:2531-5. 2005
    ..Our objective was to measure the effects of CS on the fertility of mainstream (MS) or sidestream (SS) smoke-exposed women compared to their non-smoking (NS) counterparts...
  45. ncbi request reprint Appendiceal disease in women with endometriosis and right lower quadrant pain
    R S Harris
    Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160W, Los Angeles, CA 90048, USA
    J Am Assoc Gynecol Laparosc 8:536-41. 2001
    ..No complications from laparoscopic appendectomy occurred. CONCLUSION: Disease of the appendix is common in women with endometriosis and RLQ pain. Appendectomy is particularly likely if preoperative GGE is positive...
  46. ncbi request reprint Levels of environmental contaminants in human follicular fluid, serum, and seminal plasma of couples undergoing in vitro fertilization
    E V Younglai
    Department of Obstetrics and Gynecology, Room 3N52, Health Sciences Centre, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada
    Arch Environ Contam Toxicol 43:121-6. 2002
    ..Of the chemical contaminants detected in the serum and follicular fluid of these women, p,p'-DDE was the most frequently detected, had the highest residue levels, and was associated with failed fertilization...
  47. ncbi request reprint Atrazine-induced changes in aromatase activity in estrogen sensitive target tissues
    A C Holloway
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    J Appl Toxicol 28:260-70. 2008
    ..Therefore it is concluded that microm concentrations of ATR can increase aromatase activity of human granulosa cells but not ESC and this effect is not elicited at the enzyme level...
  48. doi request reprint Key developments in endocrine disrupter research and human health
    Karen P Phillips
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    J Toxicol Environ Health B Crit Rev 11:322-44. 2008
    ..Advances in methodologies of hazard identification (toxicogenomics, transcriptomics, proteomics, metabolomics, bioinformatics) are discussed, as well as epigenetics and emerging biological endpoints...
  49. doi request reprint Bisphenol A concentration-dependently increases human granulosa-lutein cell matrix metalloproteinase-9 (MMP-9) enzyme output
    Miguel A Dominguez
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Reprod Toxicol 25:420-5. 2008
    ..Our findings suggest that BPA treatment can modulate ovarian extracellular matrix stability...
  50. doi request reprint Fetal and early postnatal environmental contaminant exposures and reproductive health effects in the female
    Warren G Foster
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Fertil Steril 89:e53-4. 2008
  51. doi request reprint Hydroxychloroquine attenuates cigarette smoke induced autophagic signaling in the mouse ovary
    H C Furlong
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Reprod Toxicol 61:105-13. 2016
    ..0505; p=0.0065) and attenuated the effects of CS on LC3B and BECN1 expression. In summary, this suggests that CQ attenuates CS-induced autophagy in the ovary and that ovarian protection from toxic insult is potentially feasible. ..
  52. ncbi request reprint Benzo-[a]-pyrene increases invasion in MDA-MB-231 breast cancer cells via increased COX-II expression and prostaglandin E2 (PGE2) output
    M E Miller
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Metastasis 22:149-56. 2005
    ..Moreover, these results suggest a potential role for the AhR signalling pathway in breast cancer invasion...
  53. doi request reprint Clinical markers of endometriosis: have we been too quick to judge?
    K Toor
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Med Hypotheses 82:493-501. 2014
    ..6%). We conclude that experimental design criteria are inconsistently applied making comparisons across studies difficult. Thus, the clinical utility of previously described diagnostic markers of endometriosis remains uncertain. ..
  54. ncbi request reprint Spontaneous appearance of uterine tumors in vehicle and 3-methylcholanthrene-treated Wistar rats
    Dana L Anger
    Reproductive Biology Division, Department of Obstetrics and Gynecology, HSC 3N52D, McMaster University, W Hamilton, Ontario, Canada
    Reprod Toxicol 22:760-4. 2006
    ..The tumors are histologically similar to human dysgerminomas. We conclude that these tumors are unrelated to treatment and are of a granular type not previously documented in Wistar rats...
  55. ncbi request reprint Ovarian effects of a high lactose diet in the female rat
    Gentao Liu
    Cedars Sinai Burns and Allen Research Institute, Cedars Sinai Medical Center University of California Los Angeles School of Medicine, CA, USA
    Reprod Nutr Dev 45:185-92. 2005
    ..From a human health perspective, these results are somewhat reassuring, since in general, women eat lactose-containing foods rather than foods that contain large amounts of free galactose...
  56. ncbi request reprint Tyrosine receptor kinase B (TrkB) protein expression in the human endometrium
    Dana L Anger
    Reproductive Biology Division, Department of Obstetrics and Gynecology, HSC 3N52D, McMaster University, 1200 Main Street W, Hamilton, ON, Canada
    Endocrine 31:167-73. 2007
    ..We conclude that TrkB protein is expressed in human endometrium. Our results also suggest that TrkB expression may be greater in women with endometriosis compared to women without endometriosis...
  57. doi request reprint Cigarette smoke causes follicle loss in mice ovaries at concentrations representative of human exposure
    Anne Mulligan Tuttle
    Medical Sciences, McMaster University, Hamilton, ON, Canada
    Hum Reprod 24:1452-9. 2009
    ..Therefore, we tested the hypothesis that mainstream cigarette smoke and a cigarette smoke constituent, benzo[a]pyrene (BaP), induce apoptosis in ovarian follicles...
  58. ncbi request reprint Do environmental contaminants adversely affect human reproductive physiology?
    Warren G Foster
    Division of Reproductive Biology, Department of Obstetrics and Gynaecology, McMaster University Medical Centre, Hamilton, ON, Canada
    J Obstet Gynaecol Can 25:33-44. 2003
    ....
  59. ncbi request reprint Prenatal exposure to nicotine causes postnatal obesity and altered perivascular adipose tissue function
    Yu Jing Gao
    Department of Anaesthesia HSC 2U3, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Obes Res 13:687-92. 2005
    ..The aim of this study was to examine the effect of fetal and neonatal exposure to nicotine, the major addictive component of cigarette smoke, on postnatal adiposity and blood vessel function...
  60. ncbi request reprint Metabolic effects of dietary lactose in adult female rats
    Gentao Liu
    Cedars Sinai Burns and Allen Research Institute, Cedars Sinai Medical Center University of California, Los Angeles School of Medicine, CA, USA
    Reprod Nutr Dev 43:567-76. 2003
    ..However, these changes are seen in the presence of a decreased body mass. A significant effect on thyroid hormone metabolism is also seen, and may be an adaptive mechanism in lactose-fed rats...
  61. doi request reprint Endocrine toxicants with emphasis on human health risks
    Karen P Phillips
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada
    J Toxicol Environ Health B Crit Rev 11:149-51. 2008
  62. doi request reprint Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples
    Rocio Monroy
    Department of Obstetrics and Gynecology, McMaster University, HSC 3N52D, 1200 Main Street West, Hamilton, Ontario, Canada
    Environ Res 108:56-62. 2008
    ..Taken together our data demonstrate that although there is widespread exposure to PFCs during development, these exposures do not affect birth weight...
  63. ncbi request reprint Dietary galactose inhibits GDF-9 mediated follicular development in the rat ovary
    Gentao Liu
    Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, 90048, USA
    Reprod Toxicol 21:26-33. 2006
    ..The present study suggests that a high galactose diet inhibits follicular development, possibly through down-regulation of GDF-9 in the rat ovary, implying that GDF-9 may be involved in galactose-related ovarian toxicity...
  64. ncbi request reprint Effects of genistein or soy milk during late gestation and lactation on adult uterine organization in the rat
    Claude L Hughes
    Department of Medical and Scientific Services, Quintiles, Inc, Research Triangle Park, North Carolina 27709, USA
    Exp Biol Med (Maywood) 229:108-17. 2004
    ....
  65. ncbi request reprint Environmental dioxins and endometriosis
    Sherry Rier
    The International Endometriosis Association, 8585 N 76th Place, Milwaukee, WI 53223, USA
    Semin Reprod Med 21:145-54. 2003
    ....
  66. ncbi request reprint A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells
    Carole L Yauk
    Environmental and Occupational Toxicology Division, Health Canada, Ottawa, Ont, Canada K1A 0L2
    Mutat Res 578:117-23. 2005
    ..The results indicate that transgene mutations in granulosa cells may provide a sensitive pre-screening tool for potential genotoxic germ cell effects of exposed oocytes...
  67. ncbi request reprint Effects of subchronic exposure to a complex mixture of persistent contaminants in male rats: systemic, immune, and reproductive effects
    Michael G Wade
    Growth and Development Section, Environmental and Occupational Toxicology Section, Safe Environments Directorate, Health Canada, Environmental Health Centre, Tunney s Pasture, Ottawa, Ontario, Canada K1A 0L2
    Toxicol Sci 67:131-43. 2002
    ....
  68. ncbi request reprint What motivates women to take part in clinical and basic science endometriosis research?
    Sanjay K Agarwal
    Department of Reproductive Medicine, UCSD School of Medicine, Basic Science Building 5040, 9500 Gilman Drive, La Jolla, California 92093 0633, USA
    Bioethics 21:263-9. 2007
    ..The objective of this study was to identify factors motivating women to take part in endometriosis research and to determine if these factors differ for women participating in clinical versus basic science studies...
  69. doi request reprint Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erbB2
    Vicki L Davis
    Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    Cancer Res 68:8377-83. 2008
    ..As metastatic progression is linked to patient survival, these data stress the importance of investigating how women's therapies influence all stages of mammary tumorigenesis, particularly for assessing their safety...