Michael A Brook

Summary

Affiliation: McMaster University
Country: Canada

Publications

  1. doi request reprint Sweet supramolecular elastomers from α,ω-(β-cyclodextrin terminated) PDMS
    Talena Rambarran
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W, Hamilton, ON, Canada L8S 4M1 and Univ Lyon, CNRS UMR 5223, 17 Avenue Jean Capelle, F 69621 Villeurbanne Cedex, France
    Chem Commun (Camb) 52:6681-4. 2016
  2. doi request reprint Printing silicone-based hydrophobic barriers on paper for microfluidic assays using low-cost ink jet printers
    Vinodh Rajendra
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada
    Analyst 139:6361-5. 2014
  3. doi request reprint Sugar complexation to silicone boronic acids
    Michael A Brook
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W, Hamilton ON, Canada L8S 4M1
    Chem Commun (Camb) 49:1392-4. 2013
  4. ncbi request reprint Platinum in silicone breast implants
    Michael A Brook
    Department of Chemistry, McMaster University, 1280 Main Street W, Hamilton, Ont, Canada L8S 4M1
    Biomaterials 27:3274-86. 2006
  5. doi request reprint Elastomeric hydrogels by polymerizing silicone microemulsions
    Michael A Brook
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W, Hamilton, ON, Canada L8S 4M1
    Chem Commun (Camb) 47:8874-6. 2011
  6. doi request reprint Using a drug to structure its release matrix and release profile
    Michael A Brook
    Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada
    Int J Pharm 358:121-7. 2008
  7. ncbi request reprint Comments on total platinum concentration and platinum oxidation states in body fluids, tissue, and explants from women exposed to silicone and saline breast implants by IC-ICPMS
    Michael A Brook
    Department of Chemistry, McMaster University, 1280 Main Street W, Hamilton, ON, Canada
    Anal Chem 78:5609-11. 2006
  8. ncbi request reprint Fluorescence anisotropy in studies of solute interactions with covalently modified colloidal silica nanoparticles
    Dina Tleugabulova
    Department of Chemistry, McMaster University, Hamilton, Ontario L8S 4M1, Canada
    Langmuir 20:848-54. 2004
  9. ncbi request reprint Surface properties of PEO-silicone composites: reducing protein adsorption
    Hong Chen
    Department of Chemical Engineering, McMaster University, 1280 Main St W, Hamilton ON, Canada L8S 4L7
    J Biomater Sci Polym Ed 16:531-48. 2005
  10. doi request reprint Photocrosslinkable hyaluronic acid as an internal wetting agent in model conventional and silicone hydrogel contact lenses
    Andrea Weeks
    School of Biomedical Engineering, McMaster University, 1280 Main St West, Hamilton, Ontario
    J Biomed Mater Res A 100:1972-82. 2012

Collaborators

Detail Information

Publications54

  1. doi request reprint Sweet supramolecular elastomers from α,ω-(β-cyclodextrin terminated) PDMS
    Talena Rambarran
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W, Hamilton, ON, Canada L8S 4M1 and Univ Lyon, CNRS UMR 5223, 17 Avenue Jean Capelle, F 69621 Villeurbanne Cedex, France
    Chem Commun (Camb) 52:6681-4. 2016
    ..The obtained telechelic copolymers spontaneously produced elastomeric gums. Demixing and supramolecular associations are the driving forces for the construction of these strongly associated (but reversible) physical networks. ..
  2. doi request reprint Printing silicone-based hydrophobic barriers on paper for microfluidic assays using low-cost ink jet printers
    Vinodh Rajendra
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada
    Analyst 139:6361-5. 2014
    ..The utility of the barrier was demonstrated using a coliform assay based on detection of β-galactosidase. ..
  3. doi request reprint Sugar complexation to silicone boronic acids
    Michael A Brook
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W, Hamilton ON, Canada L8S 4M1
    Chem Commun (Camb) 49:1392-4. 2013
    ..Stabilization of the four-coordinate boron structure is provided by Tris buffer that also maintains neutral pH to suppress silicone hydrolysis...
  4. ncbi request reprint Platinum in silicone breast implants
    Michael A Brook
    Department of Chemistry, McMaster University, 1280 Main Street W, Hamilton, Ont, Canada L8S 4M1
    Biomaterials 27:3274-86. 2006
    ....
  5. doi request reprint Elastomeric hydrogels by polymerizing silicone microemulsions
    Michael A Brook
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W, Hamilton, ON, Canada L8S 4M1
    Chem Commun (Camb) 47:8874-6. 2011
    ....
  6. doi request reprint Using a drug to structure its release matrix and release profile
    Michael A Brook
    Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada
    Int J Pharm 358:121-7. 2008
    ..The relationship between excipients, silicone morphology, and release profile is examined...
  7. ncbi request reprint Comments on total platinum concentration and platinum oxidation states in body fluids, tissue, and explants from women exposed to silicone and saline breast implants by IC-ICPMS
    Michael A Brook
    Department of Chemistry, McMaster University, 1280 Main Street W, Hamilton, ON, Canada
    Anal Chem 78:5609-11. 2006
    ..However, the conclusions arrived at by the authors are unsupported by the Experimental Section of the paper and the data that are reported there, and contravene the well-established chemistry of platinum...
  8. ncbi request reprint Fluorescence anisotropy in studies of solute interactions with covalently modified colloidal silica nanoparticles
    Dina Tleugabulova
    Department of Chemistry, McMaster University, Hamilton, Ontario L8S 4M1, Canada
    Langmuir 20:848-54. 2004
    ..The data clearly show the power of time-resolved fluorescence anisotropy decay measurements for probing the modification of silica surfaces and should prove useful in characterization of new chromatographic stationary phases...
  9. ncbi request reprint Surface properties of PEO-silicone composites: reducing protein adsorption
    Hong Chen
    Department of Chemical Engineering, McMaster University, 1280 Main St W, Hamilton ON, Canada L8S 4L7
    J Biomater Sci Polym Ed 16:531-48. 2005
    ....
  10. doi request reprint Photocrosslinkable hyaluronic acid as an internal wetting agent in model conventional and silicone hydrogel contact lenses
    Andrea Weeks
    School of Biomedical Engineering, McMaster University, 1280 Main St West, Hamilton, Ontario
    J Biomed Mater Res A 100:1972-82. 2012
    ..All results found suggest that photocrosslinkable HA has significant potential in contact lens applications...
  11. doi request reprint Water-in-silicone oil emulsion stabilizing surfactants formed from native albumin and alpha,omega-triethoxysilylpropyl-polydimethylsiloxane
    Paul M Zelisko
    Department of Chemistry, McMaster University, Hamilton, Ontario, Canada
    Biomacromolecules 9:2153-61. 2008
    ..Rather, the data is consistent with the direct binding of unhydrolyzed Si(OEt) 3 groups to native HSA. The nature of these interactions is discussed...
  12. ncbi request reprint Protein repellant silicone surfaces by covalent immobilization of poly(ethylene oxide)
    Hong Chen
    Department of Chemical Engineering, McMaster University, 1280 Main St, West Hamilton, Ont, Canada L8S 4L7
    Biomaterials 26:2391-9. 2005
    ..Fibrinogen adsorption from buffer to the PEO-modified surfaces was reduced by more than 90% compared with controls...
  13. doi request reprint Paper-based bioassays using gold nanoparticle colorimetric probes
    Weian Zhao
    Department of Chemistry, School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4M1, Canada
    Anal Chem 80:8431-7. 2008
    ..We believe this simple, practical bioassay platform will be of interest for use in areas such as disease diagnostics, pathogen detection, and quality monitoring of food and water...
  14. doi request reprint Facile phenylboronate modification of silica by a silaneboronate
    Robert Pelton
    Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada
    Langmuir 29:594-8. 2013
    ..This is a new, direct approach for introduction of phenylboronic acid groups onto silica surfaces...
  15. doi request reprint Polyvinylpyrrolidone molecular weight controls silica shell thickness on Au nanoparticles with diglycerylsilane as precursor
    Alan Vanderkooy
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4M1
    ACS Appl Mater Interfaces 4:3980-6. 2012
    ..Under these conditions, higher molecular weight PVP leads to thicker silica shells: PVP acts as the locus for silica growth into an interpenetrating organic-inorganic hybrid structure...
  16. doi request reprint Silica shell/gold core nanoparticles: correlating shell thickness with the plasmonic red shift upon aggregation
    Alan Vanderkooy
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4M1
    ACS Appl Mater Interfaces 3:3942-7. 2011
    ..7 to ~4.3 nm, because of increased distance between adjacent gold cores. These studies provide guidance for the development of colorimetric assays using silica-coated AuNP...
  17. doi request reprint DNA aptamer folding on gold nanoparticles: from colloid chemistry to biosensors
    Weian Zhao
    Department of Chemistry, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5
    J Am Chem Soc 130:3610-8. 2008
    ..Moreover, distinct AuNP aggregation and redispersion stages can be readily operated by controlling aptamer folding and unfolding states with the addition of adenosine and adenosine deaminase...
  18. ncbi request reprint Monitoring solute interactions with poly(ethylene oxide)-modified colloidal silica nanoparticles via fluorescence anisotropy decay
    Dina Tleugabulova
    Department of Chemistry, McMaster University, Hamilton, Ontario, L8S 4M1, Canada
    Langmuir 20:101-8. 2004
    ....
  19. doi request reprint Enzymatic cleavage of nucleic acids on gold nanoparticles: a generic platform for facile colorimetric biosensors
    Weian Zhao
    Department of Chemistry, McMaster University, 1280 Main St West, Hamilton, ON L8S 4M1, Canada
    Small 4:810-6. 2008
    ..This biosensing system should be readily adaptable to other enzymes or substrates for detection of analytes such as small molecules, proteases and their inhibitors...
  20. doi request reprint Design of gold nanoparticle-based colorimetric biosensing assays
    Weian Zhao
    Department of Chemistry, McMaster University, Hamilton, ON, Canada
    Chembiochem 9:2363-71. 2008
    ....
  21. doi request reprint Rapid and efficient assembly of functional silicone surfaces protected by PEG: cell adhesion to peptide-modified PDMS
    Andrew S Mikhail
    Department of Chemical Engineering, McMaster University, 1280 Main St W, Hamilton, ON, Canada L8S 4L7
    J Biomater Sci Polym Ed 21:821-42. 2010
    ..Biological activity was demonstrated by a 5-fold increase in cell adhesion on the peptide-modified surfaces when compared to unmodified PDMS control surfaces...
  22. ncbi request reprint Generic bioaffinity silicone surfaces
    Hong Chen
    Department of Chemical Engineering, McMaster University, 1280 Main Street W, Hamilton ON Canada, L8S 4M1
    Bioconjug Chem 17:21-8. 2006
    ....
  23. ncbi request reprint Inhibitor screening using immobilized enzyme reactor chromatography/mass spectrometry
    Richard J Hodgson
    Department of Chemistry, McMaster University, Hamilton, Ontario, Canada
    Anal Chem 77:7512-9. 2005
    ....
  24. ncbi request reprint Ultrasensitive ATP detection using firefly luciferase entrapped in sugar-modified sol-gel-derived silica
    Jorge A Cruz-Aguado
    Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton ON, Canada L8S 4M1
    J Am Chem Soc 126:6878-9. 2004
    ..The enzyme was active and stable in this material and showed catalytic constants close to those in solution. As little as 20 amol ATP could be detected with the entrapped FL, and the entrapped enzyme could be used over several cycles...
  25. ncbi request reprint Highly active, lipase silicone elastomers
    Amro M Ragheb
    Department of Chemistry, McMaster University, 1280 Main St W, Hamilton, Ont, Canada L8S 4M1
    Biomaterials 26:1653-64. 2005
    ..This effect could be moderated by prior exposure of the lipase to silicone oil. Thus, hydrophobic silicones play a protective/activating role for lipase...
  26. doi request reprint Biocompatible, hyaluronic acid modified silicone elastomers
    Johan G Alauzun
    Department of Chemistry, McMaster University, 1280 Main St W, Hamilton ON L8S 4M1, Canada
    Biomaterials 31:3471-8. 2010
    ..The results suggest that HA modification significantly enhances cell interactions while decreasing protein adsorption and may therefore be effective for improving biocompatibility of PDMS and other materials...
  27. doi request reprint Targeted disinfection of E. coli via bioconjugation to photoreactive TiO2
    Lu Ye
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street, West Hamilton, Ontario, Canada, L8S 4M1
    Bioconjug Chem 24:448-55. 2013
    ..The results give support to the proposal that photocatalytic TiO2 most effectively delivers an oxidizing agent when the titania is bound to the bacterial surface...
  28. ncbi request reprint Entrapment of Src protein tyrosine kinase in sugar-modified silica
    Jorge A Cruz-Aguado
    Department of Chemistry, McMaster University, Hamilton, Ontario L8S 4M1, Canada
    Anal Chem 76:4182-8. 2004
    ..The use of such a system for determination of PTK activity and inhibition is demonstrated, setting the stage for the development of chromatographic and microarray based methods for the screening of kinase inhibitors...
  29. ncbi request reprint Simple and rapid colorimetric biosensors based on DNA aptamer and noncrosslinking gold nanoparticle aggregation
    Weian Zhao
    Department of Chemistry, McMaster University, 1280 Main St, W Hamilton, ON, L8S 4M1, Canada
    Chembiochem 8:727-31. 2007
  30. doi request reprint Generic, anthracene-based hydrogel crosslinkers for photo-controllable drug delivery
    Laura A Wells
    Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S4L8, Canada
    Macromol Biosci 11:988-98. 2011
    ....
  31. doi request reprint Amphiphilic silicone architectures via anaerobic thiol-ene chemistry
    Daniel J Keddie
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, Queensland, Australia 4059
    Org Lett 13:6006-9. 2011
    ..The resulting pure products were coupled to thiol-terminated PEG materials using photogenerated radicals under anaerobic conditions...
  32. doi request reprint Periodic assembly of nanospecies on repetitive DNA sequences generated on gold nanoparticles by rolling circle amplification
    Weian Zhao
    Department of Chemistry, McMaster University, Hamilton, Ontario, Canada
    Methods Mol Biol 474:79-90. 2008
    ..Since these long ssDNA molecules contain many repetitive sequence units, complementary DNA-attached nanospecies can be assembled through specific hybridization in a controllable and periodical manner...
  33. doi request reprint Biomimetic synthesis of gold nanocrystals using a reducing amphiphile
    Ferdinand Gonzaga
    Department of Chemistry, McMaster University 1280 Main Street West Hamilton, ON L8S4M1, Canada
    Small 4:1390-8. 2008
    ..The process, both pH and light dependent, occurs through lipid-directed assembly of metal ions, their reduction and subsequent lipid-directed growth to yield ultrathin (approximately 7 nm thick) quasi two-dimensional gold nanocrystals...
  34. doi request reprint Surface-active copolymer formation stabilizes PEG droplets and bubbles in silicone foams
    Helen So
    School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada
    J Colloid Interface Sci 390:121-8. 2013
    ....
  35. doi request reprint Rolling circle amplification: applications in nanotechnology and biodetection with functional nucleic acids
    Weian Zhao
    Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, ON, L8P 4M1, Canada
    Angew Chem Int Ed Engl 47:6330-7. 2008
    ..In this way, RCA is rapidly becoming a highly versatile DNA amplification tool with wide-ranging applications in genomics, proteomics, diagnosis, biosensing, drug discovery, and nanotechnology...
  36. ncbi request reprint Biotinylation of TiO(2) nanoparticles and their conjugation with streptavidin
    Lu Ye
    Department of Chemical Engineering, Center for Pulp and Paper Research, and Department of Chemistry, McMaster University, 1280 Main Street, West Hamilton, Ontario, Canada L8S 4L7
    Langmuir 23:5630-7. 2007
    ..The implications of these observations, with respect to particle accessibility to tethered streptavidin, are discussed...
  37. doi request reprint Immobilization of bacteriophages on modified silica particles
    Rebecca Cademartiri
    Department of Chemistry, McMaster University, 1280 Main St W, Hamilton, ON L8S 4M1, Canada
    Biomaterials 31:1904-10. 2010
    ..Above the maximum charge concentration, the number of active phage drops...
  38. doi request reprint Poly(ethylene glycol)-or silicone-modified hyaluronan for contact lens wetting agent applications
    Stefan M Paterson
    Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada
    J Biomed Mater Res A 103:2602-10. 2015
    ..However, modified HA did lead to a reduction in lysozyme adsorption in some cases. The leaching rate of HA modified with polyethylene glycol from a 78:22 DMA:TRIS(OH) hydrogel was significantly slower than for unmodified HA...
  39. ncbi request reprint Nearly monodisperse silica microparticles form in silicone (pre)elastomer mixtures
    Vinodh Rajendra
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4M1
    Langmuir 28:1470-7. 2012
    ....
  40. ncbi request reprint Screening of inhibitors using enzymes entrapped in sol-gel-derived materials
    Travis R Besanger
    Department of Chemistry, McMaster University, Hamilton, Ontario, L8S 4M1, Canada
    Anal Chem 75:2382-91. 2003
    ..The implications of these findings for high-throughput screening are discussed...
  41. doi request reprint Facile functionalization of PDMS elastomer surfaces using thiol-ene click chemistry
    Jianfeng Zhang
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4M1
    Langmuir 29:12432-42. 2013
    ....
  42. ncbi request reprint Protein-doped monolithic silica columns for capillary liquid chromatography prepared by the sol-gel method: applications to frontal affinity chromatography
    Richard J Hodgson
    Department of Chemistry, McMaster University, Hamilton, Ontario, L8S 4M1, Canada
    Anal Chem 76:2780-90. 2004
    ..The results suggest that such columns may find use in high-throughput screening of compound mixtures...
  43. ncbi request reprint Silicone elastomers for reduced protein adsorption
    Hong Chen
    Department of Chemistry, McMaster University, Hamilton, ON, Canada L8S 4L7
    Biomaterials 25:2273-82. 2004
    ..Covalently linked PEO films of a variety of chain lengths and total surface coverage can be readily accommodated...
  44. doi request reprint Morphology-controlled synthesis of poly(oxyethylene)silicone or alkylsilicone surfactants with explicit, atomically defined, branched, hydrophobic tails
    Ferdinand Gonzaga
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street W, Hamilton, ON L8S4 M1, Canada
    Chemistry 18:1536-41. 2012
    ..Subtle distinctions in surfactant-related properties, which can be attributed to the three-dimensional structures, can be seen for compounds with comparable numbers of hydrocarbons and silicon groups...
  45. doi request reprint Solvent-mediated generation of cobalt-cluster-stabilised propargyl cations and radicals: allyl migration versus peroxide formation
    John H Kaldis
    Department of Chemistry, McMaster University, Hamilton, ON, Canada
    Chemistry 14:10074-84. 2008
    ..Analogously, protonation of [Co(2)(CO)(6){9-[(vinyldimethylsilyl)ethynyl]-9H-fluoren-9-ol}] (6) yields the corresponding peroxide 28. X-ray crystallographic data are reported for, among others, complexes 17, 24, 26, 27 and 28...
  46. ncbi request reprint Delivery of both active enzyme and bleach from water-in-silicone oil (D(4)) emulsions
    Paul M Zelisko
    Department of Chemistry, Brock University, 500 Glenridge Avenue, St Catharines, Ontario, Canada L2S 3A1
    Langmuir 23:3620-5. 2007
    ..The polyether surfactant thus protects the perborate from hydration and the enzyme from denaturing on contact with silicone oil until excess water and high shear are applied to the emulsion; protective mechanisms are discussed...
  47. doi request reprint Versatile, efficient derivatization of polysiloxanes via click technology
    Ferdinand Gonzaga
    Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4M1, Canada
    Chem Commun (Camb) . 2009
    ....
  48. doi request reprint One-step in-mould modification of PDMS surfaces and its application in the fabrication of self-driven microfluidic channels
    Ayodele Fatona
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W, Hamilton, Ontario, L8S 4M1 Canada
    Lab Chip 15:4322-30. 2015
    ..It is anticipated that the in-mould method can be applied to a range of surface modifications for applications in analytical separations, biosensing, cell isolation and small molecule discovery. ..
  49. doi request reprint Silicone boronates reversibly crosslink using Lewis acid-Lewis base amine complexes
    Laura Dodge
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W, Hamilton ON, L8S 4M1 Canada
    Chemistry 20:9349-56. 2014
    ..Materials could be fully disassembled through introduction of n-butylamine and successfully reformed upon removal of the monofunctional amine by evaporation...
  50. ncbi request reprint DNA polymerization on gold nanoparticles through rolling circle amplification: towards novel scaffolds for three-dimensional periodic nanoassemblies
    Weian Zhao
    Department of Chemistry, McMaster University, 1280 Main St, W Hamilton, ON L8N 3Z5, Canada
    Angew Chem Int Ed Engl 45:2409-13. 2006
  51. ncbi request reprint Rapid assembly of explicit, functional silicones
    John B Grande
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W, Hamilton ON, L8S 4M1, Canada
    Dalton Trans 39:9369-78. 2010
    ..Thermal 3+2-cycloadditions and thiol-ene click reactions are used to convert these compounds into surface active materials...
  52. ncbi request reprint Siloxane-Triarylamine Hybrids: Discrete Room Temperature Liquid Triarylamines via the Piers-Rubinsztajn Reaction
    Brett A Kamino
    Department of Chemical Engineering and Applied Chemistry, The University of Toronto, 200 College Street, Toronto, Ontario, Canada, M5S 3E5, Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada, M5S 3H6, and Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street, Hamilton, ON, Canada, L8S 4M1
    Org Lett 13:154-7. 2011
    ..The interaction between the Lewis acidic tris(pentafluorophenyl)borane catalyst and the Lewis basic starting triarylamine substrate was also investigated by steady state UV-vis spectroscopy and (19)F NMR...
  53. doi request reprint Fibrinolytic poly(dimethyl siloxane) surfaces
    Hong Chen
    State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 122 Luoshi Rd 430070, China
    Macromol Biosci 8:863-70. 2008
    ..In vitro experiments demonstrated that lysine-immobilized surfaces with free epsilon-amino groups were able to dissolve fibrin clots, following exposure to plasma and tissue plasminogen activator. [Figure: see text]...
  54. ncbi request reprint Immobilization of heparin on a silicone surface through a heterobifunctional PEG spacer
    Hong Chen
    Department of Chemical Engineering, McMaster University, Hamilton ONT, Canada L8S 4L7
    Biomaterials 26:7418-24. 2005
    ..The results suggest that the heterbifunctional PEG linker results in a high density of active heparin on the surfaces...