Affiliation: McGill University
- Cellular iron metabolismP Ponka
Lady Davis Institute for Medical Research, Jewish General Hospital and Department of Physiology, McGill University, Montreal, Quebec, Canada
Kidney Int Suppl 69:S2-11. 1999..This suggests that there are unique iron/heme metabolism features in some kidney cells, but the specific aspects of iron and heme metabolism in the kidney are yet to be explained...
- Cell biology of hemeP Ponka
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
Am J Med Sci 318:241-56. 1999..Heme oxygenase, which catalyzes heme degradation, seems to be an important enzymatic antioxidant system, probably by providing biliverdin, which is an antioxidant agent...
- The transferrin receptor: role in health and diseaseP Ponka
Lady Davis Institute for Medical Research of the Sir Mortimer B Davis Jewish General Hospital, Montreal, QC, Canada
Int J Biochem Cell Biol 31:1111-37. 1999..Measurements of serum transferrin receptor concentrations are clinically useful since their levels correlate with the total mass of immature erythroid cells...
- The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cellsD R Richardson
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Biochim Biophys Acta 1331:1-40. 1997..On the other hand, the expression of inducible NOS which produces NO, can be stimulated by Fe chelators and decreased by the addition of Fe salts, suggesting that Fe is involved in the control of NOS expression...
- Iron targeting to mitochondria in erythroid cellsP Ponka
Lady Davis Institute, Jewish General Hospital and Department of Physiology, McGill University, 3755 Cote Ste Catherine Road, Montreal, QC, Canada H3T 1E2
Biochem Soc Trans 30:735-8. 2002....
- Activation of macrophage cytostatic effector mechanisms during acute graft-versus-host disease: release of intracellular iron and nitric oxide-mediated cytostasisF P Nestel
Department of Physiology, McGill University, Montreal, Canada
Blood 96:1836-43. 2000..Blood. 2000;96:1836-1843)..
- Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk miceF Canonne-Hergaux
Department of Biochemistry, McGill University, Montreal, QC, Canada
Blood 98:3823-30. 2001..Together, these results provide further evidence that DMT1 plays a central role in iron acquisition via the transferrin cycle in erythroid cells...
- Mobilization of iron from cells by hydroxyquinoline-based chelatorsC Mouralian
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, 3755 Chemin de la Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
Biochem Pharmacol 71:214-22. 2005..Under the same conditions, C2 revealed a release of 50% of the 59Fe. Overall, both ligands merit in vivo study for oral activity. Their effectiveness at low concentrations makes them candidates for therapeutic use...
- Identification of an erythroid active element in the transferrin receptor geneC N Lok
Lady Davis Institute for Medical Research, Jewish General Hospital, and the Departments of Physiology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
J Biol Chem 275:24185-90. 2000..Our data indicate that the TfR gene promoter contains an erythroid active element that stimulates the receptor gene transcription upon induction of hemoglobin synthesis...