Genomes and Genes
Affiliation: McGill University
- Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's diseaseJudes Poirier
Centre for Studies on the Prevention of Alzheimer s disease, Verdun, Quebec, Canada Molecular Neurobiology Unit, Douglas Mental Health University Institute, Research Centre, Verdun, Quebec, Canada Department of Psychiatry, McGill University, Montreal, Quebec, Canada Electronic address
Neurobiol Aging 35:S3-10. 2014....
- Function and comorbidities of apolipoprotein e in Alzheimer's diseaseValerie Leduc
Department of Psychiatry, Douglas Mental Health University Institute, Perry Pavilion, E 3207 1, 6875 LaSalle Boulevard, Verdun, QC, Canada H4H1R3
Int J Alzheimers Dis 2011:974361. 2011....
- Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled studySamuel T Henderson
Accera Inc, Broomfield, CO 80021, USA
BMC Med Genet 12:137. 2011..To examine the effect of genetic variation in APOE, IDE and IL1B on the response to induced ketosis in the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) in subjects with mild to moderate Alzheimer's disease (AD)...
- Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's diseaseJudes Poirier
McGill Centre for Studies in Aging, Douglas Hospital Research Centre, 6825 LaSalle Blvd, Verdun, Quebec, Canada H4H 1R3
Trends Mol Med 9:94-101. 2003....
- Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's diseaseJudes Poirier
McGill Centre for Studies in Aging and Douglas Mental Health University Institute, Montreal, Quebec, Canada
Alzheimers Dement 4:S91-7. 2008
- Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's diseaseJudes Poirier
Centre for Studies in Aging, McGill University, Douglas Hospital, 6825 Lasalle, Verdun, Que, H4H 1R3, Canada
Neurobiol Aging 26:355-61. 2005....
- Double-blind, vehicle-controlled randomized twelve-month neurodevelopmental toxicity study of common aluminum salts in the ratJ Poirier
Douglas Mental Health University Institute, Verdun, QC, H4H 1R3, Canada
Neuroscience 193:338-62. 2011....
- Motor system alterations in retired former athletes: the role of aging and concussion historyLouis De Beaumont
Centre de Recherche en Neuropsychologie et Cognition CERNEC, Universite de Montreal, Montreal, Canada
BMC Neurol 13:109. 2013..The present study investigated the effects of aging on motor system metabolism and function in former university-level athletes who sustained their last concussion several decades prior to testing...
- A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiologyJean Francois Blain
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
Eur J Neurosci 24:1245-51. 2006....
- A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement miceJean Francois Blain
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H4A 2B4
Neurobiol Dis 21:505-14. 2006..ApoE and beta-amyloid (Abeta) 1-40 accumulated at 30 DPL in hE4 mice. These results suggest that the presence of apoE4 delays the astroglial repair process and indirectly compromises synaptic remodeling...
- Involvement of paraoxonase 1 genetic variants in Alzheimer's disease neuropathologyValerie Leduc
Neuroscience Division, Douglas Mental Health University Institute, Perry Pavilion E 3207 1, 6875 LaSalle Blvd, Verdun, Quebec H4H1R3, Canada
Eur J Neurosci 30:1823-30. 2009..001) and choline acetyltransferase activity (P < 0.05) in, respectively, two of two, five of six, and three of six brain areas. These results suggest an involvement of the PON1 gene in AD etiopathology and responses to treatment...
- The apoE receptor apoER2 is involved in the maintenance of efficient synaptic plasticityCaroline Petit-Turcotte
Douglas Hospital Research Center, 6875 LaSalle Blvd, Verdun, Que, Canada H4H 1R3
Neurobiol Aging 26:195-206. 2005..The results suggest a significant role for apoER2 in signalling various proteins in response to massive deafferentation and may participate in maintaining efficient synaptic plasticity and dendritic remodelling...
- Altered declarative memory in introverted middle-aged adults carrying the BDNF val66met alleleLouis De Beaumont
Department of Psychology, University of Quebec at Trois Rivieres, Trois Rivieres, Quebec, Canada
Behav Brain Res 253:152-6. 2013..Here, we examine the potential relationship between the BDNFMet allele, introversion and declarative memory in middle-age adults...
- APOE and cholesterol homeostasis in Alzheimer's diseaseValerie Leduc
Douglas Mental Health University Institute, 6875 Lasalle, Montreal Verdun, Quebec, H4H 1R3, Canada
Trends Mol Med 16:469-77. 2010....
- Pro-inflammatory cytokines modulate glial apolipoprotein E secretionRosanne Aleong
Department of Neurology and Neurosurgery, Montreal, Quebec, Canada
Curr Alzheimer Res 5:33-7. 2008..These results are consistent with the notion that elevated cytokine expression directly modulates immunosuppression and indirectly apoE-mediated neuronal remodeling...
- Increased caveolin-1 expression in Alzheimer's disease brainSophie B Gaudreault
Departments of Psychiatry and Neurology and Neurosurgery, Douglas Hospital Research Centre, McGill University, Montreal, Que, Canada H4A 2B4
Neurobiol Aging 25:753-9. 2004..These results indicate that caveolin over-expression is linked to alterations of cholesterol distribution in the plasma membrane of brain cells and are consistent with the notion of a deterioration of cholesterol homeostasis in AD...
- Sports concussions and aging: a neuroimaging investigationSebastien Tremblay
Centre de Recherche en Neuropsychologie et Cognition, University of Montreal, Montreal, Canada
Cereb Cortex 23:1159-66. 2013..Findings from this study highlight patterns of decline often associated with abnormal aging...
- A role for caveolin-1 in post-injury reactive neuronal plasticitySophie B Gaudreault
Douglas Hospital Research Center, Neurological Sciences Department, McGill University, Montreal, Canada
J Neurochem 92:831-9. 2005..Altogether, these results indicate that caveolin-1 plays an active role in the regulation of injury-induced synaptic and terminal remodeling in the adult CNS...
- Normalization of gene expression using SYBR green qPCR: a case for paraoxonase 1 and 2 in Alzheimer's disease brainsValerie Leduc
Douglas Mental Health University Institute, Verdun, QC H4H1R3, Canada
J Neurosci Methods 200:14-9. 2011..The use of a computational method allowing the inclusion of possible confounding factors is thus recommended for the analysis of data...
- Altered bidirectional plasticity and reduced implicit motor learning in concussed athletesLouis De Beaumont
Centre de Recherche en Neuropsychologie et Cognition CERNEC, Department of Psychology Université de Montréal, Montreal, Quebec, Canada
Cereb Cortex 22:112-21. 2012....
- Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer's Disease PathologyValerie Leduc
Centre for Studies on Prevention of Alzheimer s Disease StoP AD Centre, Douglas Mental Health University Institute, 6875 Lasalle, Verdun, Quebec, H4H 1R3, Canada
J Mol Neurosci 58:109-19. 2016....
- Polymorphisms at the paraoxonase 1 L55M and Q192R loci affect the pathophysiology of Alzheimer's disease: emphasis on the cholinergic system and beta-amyloid levelsValerie Leduc
Douglas Mental Health University Institute, Verdun, Que, Canada
Neurodegener Dis 5:225-7. 2008..Recent studies have shown that polymorphisms at the PON1 L55M and Q192R loci might affect individual susceptibility to experience-derived and environmental events such as the exposure to inhibitors of cholinesterase (ChEIs)...
- Cholesterol homeostasis and the pathophysiology of Alzheimer's diseaseJean Francois Blain
Douglas Hospital Research Centre, 6875 LaSalle Blvd, Verdun, Quebec, H4H 1R3, Canada
Expert Rev Neurother 4:823-9. 2004....
- Polymorphism of the 5-HT(2A) receptor gene: association with stress-related indices in healthy middle-aged adultsAlexandra J Fiocco
Douglas Mental Health University Institute, Center for Studies on Human Stress, Canada
Front Behav Neurosci 1:3. 2007..Together, these results suggest that carriers of the GG genotype are more susceptible to low mood and display a greater potential for an overactive stress system, which may influence cognitive function in later years...
- Impact of BDNF Val66Met polymorphism on olfactory functions of female concussed athletesCamille Larson-Dupuis
Montreal Sacred Heart Hospital Research Centre, Montreal, Quebec, Canada
Brain Inj 29:963-70. 2015..The BDNF Val66Met polymorphism (BDNFMet), which reduces availability of BDNF in the brain, has surprisingly been associated with better recovery following concussion...
- Could lipoprotein lipase play a role in Alzheimer's disease?Jean Francois Blain
Douglas Hospital Research Center, Verdun, Quebec, Canada
ScientificWorldJournal 4:531-5. 2004..This novel role could have implication for Alzheimer's disease treatment...
- Differential regulation of ABCA1 and ABCG1 gene expressions in the remodeling mouse hippocampus after entorhinal cortex lesion and liver-X receptor agonist treatmentStephanie Belanger Jasmin
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H4A 2B4 Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Quebec, Canada H4H 1R3
Brain Res 1562:39-51. 2014..Further, TO901317-induced up-regulation of ABCA1 appears to be more beneficial in a prevention (pre-lesion) than rescue (post-lesion) treatment; both findings support a central role for ABC transporters in brain plasticity. ..
- Acute and long-term associations between ApoE genetic polymorphism, cortisol levels, and declarative memory performance in older adultsAlexandra J Fiocco
Douglas Hospital Research Center, Montreal Verdun, Quebec, Canada H4H 1R3
Psychoneuroendocrinology 33:625-33. 2008..To date, only one study has reported a relationship between APOE status and cortisol levels, however the relationship was only found to be significant in dementia patients, with a trend observed in healthy controls...
- Butyrylcholinesterase K and Apolipoprotein E-ɛ4 Reduce the Age of Onset of Alzheimer's Disease, Accelerate Cognitive Decline, and Modulate Donepezil Response in Mild Cognitively Impaired SubjectsLouis De Beaumont
Douglas Mental Health University Institute, McGill University, Verdun, Montreal, Canada
J Alzheimers Dis 54:913-922. 2016..Together with the apolipoprotein E4 (APOE-ɛ4) gene, butyrylcholinesterase (BCHE) has become recently one of the few Alzheimer's disease (AD) susceptibility genes with distinct pharmacogenomic properties...
- BDNF Val66Met Polymorphism Interacts with Sleep Consolidation to Predict Ability to Create New Declarative MemoriesNadia Gosselin
Center for Advanced Research in Sleep Medicine and Research Center, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, H4J 1C5, Canada, Departments of Psychology
J Neurosci 36:8390-8. 2016..This study provides new evidence regarding the interacting roles of consolidated sleep and BDNF polymorphism in the ability to learn and stresses the importance of considering BDNF polymorphism when studying how sleep affects cognition...
- A role for lipoprotein lipase during synaptic remodeling in the adult mouse brainJean Francois Blain
Department of Anatomy and Physiology, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
Neurobiol Dis 15:510-9. 2004..These results suggest that LPL is involved in the recycling of cholesterol and lipids released from degenerating terminals after a lesion through a syndecan-4-dependent pathway...
- APOE2 Is Associated with Spatial Navigational Strategies and Increased Gray Matter in the HippocampusKyoko Konishi
Department of Psychiatry, Douglas Mental Health University Institute, McGill University Verdun, QC, Canada
Front Hum Neurosci 10:349. 2016..The current article demonstrates the relationship between brain structure, navigation behavior, and APOE genotypes in healthy young adults. ..
- Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's diseaseDorothee Schoemaker
McGill Centre for Studies in Aging, McGill University, Montreal, QC, Canada Douglas Hospital Research Centre, Montreal, QC, Canada
Alzheimers Dement (Amst) 2:132-9. 2016..The apolipoprotein E (APOE) ε4 allele is a major risk factor for AD. Here, we investigated the effect of the APOE ε4 status on familiarity in cognitively normal aging individuals...
- BDNF Val66Met Polymorphism Influences Visuomotor Associative Learning and the Sensitivity to Action ObservationVincent Taschereau-Dumouchel
Ecole de Psychologie, Universite Laval, Quebec, G1V 0A6, Canada
Sci Rep 6:34907. 2016....
- Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemiaValerie Leduc
aCentre for Studies in Alzheimer s disease prevention bDouglas Mental Health University Institute, McGill University cDepartment of Nutrition, Clinical Research Institute of Montreal IRCM, Montreal University, Montreal, Quebec, Canada
Pharmacogenet Genomics 26:1-11. 2016....
- Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseasesJoris W De Schutter
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Québec H3A 0B8, Canada
J Med Chem 57:5764-76. 2014..Optimization of these compounds could lead to human therapeutics that block tau metabolism and arrest the progression of neurodegeneration...
- Non-steroidal anti-inflammatory drugs mediate increased in vitro glial expression of apolipoprotein E proteinRosanne Aleong
Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
Eur J Neurosci 18:1428-38. 2003..Consequently, NSAID-induced increases in apoE protein may enhance apoE-mediated immunosuppression and compensatory synaptic plasticity, potentially resulting in decreased AD risk and delay of disease onset...
- Current and future management of Alzheimer's diseaseSerge Gauthier
McGill Center for Studies in Aging, Douglas Institute for Mental Health, Montreal, Quebec, Canada
Alzheimers Dement 4:S48-50. 2008..There are multiple research opportunities for better understanding and treatment of this condition. Ongoing cohort studies developed under Leon Thal's leadership will facilitate this process...
- The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer diseaseVeronica Hirsch-Reinshagen
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V4Z 5H5, Canada
J Biol Chem 280:43243-56. 2005..These data suggested that ABCA1-mediated effects on apoE levels and lipidation influenced amyloidogenesis in vivo...
- ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivoBraydon L Burgess
Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
J Lipid Res 49:1254-67. 2008....
- Influence of the apolipoprotein E epsilon4 allele on human embryonic developmentHenrik Zetterberg
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, 41345 Gothenburg, Sweden
Neurosci Lett 324:189-92. 2002..005), suggesting that epsilon4 may have protective effects during embryogenesis. These protective effects might counterbalance the deleterious age-related effects of the epsilon4 allele in natural selection...