Alexandre Montpetit

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness
    Joyce Wang
    Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, QC H3A 2B4, Canada
    BMC Genomics 15:415. 2014
  2. pmc Comparison of genome-wide array genomic hybridization platforms for the detection of copy number variants in idiopathic mental retardation
    Tracy Tucker
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    BMC Med Genomics 4:25. 2011
  3. pmc Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation
    Reedik Magi
    Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    BMC Genomics 8:159. 2007
  4. ncbi request reprint [The Haplotype Map of the human genome: a revolution in the genetics of complex diseases]
    Alexandre Montpetit
    Centre d Innovation de Génome Québec et de l Université McGill, 740 Avenue Dr Penfield, Montreal, Quebec, H3A 1A4 Canada
    Med Sci (Paris) 22:1061-7. 2006
  5. pmc Analysis of the conservation of synteny between Fugu and human chromosome 12
    Alexandre Montpetit
    Division of Hematology Oncology, Charles Bruneau Cancer Center, Sainte Justine Hospital, 3175 Cote Ste Catherine, Montreal, QC, H3T 1C5, Canada
    BMC Genomics 4:30. 2003
  6. doi request reprint Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Canada
    Circ Cardiovasc Genet 3:454-61. 2010
  7. doi request reprint Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans
    Yohan Bosse
    Laval Hospital Research Center, Laval University, Pavillon Margeritte d Youville, Chemin Sainte Foy, Quebec, QC, Canada
    Hum Genet 125:305-18. 2009
  8. doi request reprint K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Hum Mutat 29:689-94. 2008
  9. pmc Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
    Adam M Fontebasso
    Division of Experimental Medicine, McGill University and McGill University Health Centre, Montreal, QC, Canada
    Acta Neuropathol 125:659-69. 2013
  10. ncbi request reprint Association of urokinase-type plasminogen activator with asthma and atopy
    Philippe Bégin
    University of Montreal Community Genomic Medicine Centre, Chicoutimi University Hospital, Saguenay, Quebec, Canada
    Am J Respir Crit Care Med 175:1109-16. 2007

Detail Information

Publications52

  1. pmc Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness
    Joyce Wang
    Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, QC H3A 2B4, Canada
    BMC Genomics 15:415. 2014
    ..In this study, high-throughput sequencing of MAP transposon libraries were analyzed to qualitatively and quantitatively determine the contribution of individual genes to bacterial survival during infection...
  2. pmc Comparison of genome-wide array genomic hybridization platforms for the detection of copy number variants in idiopathic mental retardation
    Tracy Tucker
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    BMC Med Genomics 4:25. 2011
    ..A number of whole genome array genomic hybridization platforms are available, but little is known about their comparative performance in a clinical context...
  3. pmc Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation
    Reedik Magi
    Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    BMC Genomics 8:159. 2007
    ..Less information is available about coverage in samples from other populations...
  4. ncbi request reprint [The Haplotype Map of the human genome: a revolution in the genetics of complex diseases]
    Alexandre Montpetit
    Centre d Innovation de Génome Québec et de l Université McGill, 740 Avenue Dr Penfield, Montreal, Quebec, H3A 1A4 Canada
    Med Sci (Paris) 22:1061-7. 2006
    ..This review details the rationale behind the HapMap project, gives a summary of the results and also describes potential applications of the Haplotype Map...
  5. pmc Analysis of the conservation of synteny between Fugu and human chromosome 12
    Alexandre Montpetit
    Division of Hematology Oncology, Charles Bruneau Cancer Center, Sainte Justine Hospital, 3175 Cote Ste Catherine, Montreal, QC, H3T 1C5, Canada
    BMC Genomics 4:30. 2003
    ..The human chromosome 12p12 is frequently deleted in various hematological malignancies and solid tumors, but the actual tumor suppressor gene remains unidentified...
  6. doi request reprint Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Canada
    Circ Cardiovasc Genet 3:454-61. 2010
    ..Because INSIG2 plays an important role in cholesterol biosynthesis, we hypothesized that human INSIG2 variants might play a role in the regulation of plasma lipid and lipoprotein levels...
  7. doi request reprint Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans
    Yohan Bosse
    Laval Hospital Research Center, Laval University, Pavillon Margeritte d Youville, Chemin Sainte Foy, Quebec, QC, Canada
    Hum Genet 125:305-18. 2009
    ..The low cost associated with a pooling-based GWAS clearly justifies its use in screening for genetic determinants of complex diseases...
  8. doi request reprint K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Hum Mutat 29:689-94. 2008
    ..These results suggest that this coding variant in the squalene synthase gene influences plasma cholesterol levels, possibly by affecting the intracellular production of cholesterol...
  9. pmc Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
    Adam M Fontebasso
    Division of Experimental Medicine, McGill University and McGill University Health Centre, Montreal, QC, Canada
    Acta Neuropathol 125:659-69. 2013
    ..Taken together, our results suggest that mutations disrupting the histone code at H3K36, including H3.3 G34R/V, IDH1 and/or SETD2 mutations, are central to the genesis of hemispheric HGGs in older children and young adults...
  10. ncbi request reprint Association of urokinase-type plasminogen activator with asthma and atopy
    Philippe Bégin
    University of Montreal Community Genomic Medicine Centre, Chicoutimi University Hospital, Saguenay, Quebec, Canada
    Am J Respir Crit Care Med 175:1109-16. 2007
    ..This region has demonstrated evidence for linkage in a genome scan for asthma in a sample from northeastern Quebec. Here, we hypothesized that uPA may function as a regulator of asthma susceptibility...
  11. doi request reprint Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues
    Karine Tremblay
    Hopital Laval, Universite Laval, Quebec, Canada
    J Allergy Clin Immunol 122:529-36.e17. 2008
    ..Eight genes in the immune signaling pathway shown to be differentially expressed in asthmatic lung biopsy specimens in a previous microarray experiment were selected as candidate genes for asthma susceptibility...
  12. ncbi request reprint Identification of a chromosome 8p locus for early-onset coronary heart disease in a French Canadian population
    James C Engert
    McGill University Health Centre, Montreal, Quebec, Canada
    Eur J Hum Genet 16:105-14. 2008
    ..In conclusion, a genome-wide scan and additional fine mapping provide evidence for a locus on chromosome 8 that contributes to CHD in a French Canadian population...
  13. doi request reprint A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid
    Reyhan El Kares
    Department of Pediatrics, Montreal Children s Hospital Research Institute, McGill University, and Département de Médecine, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Kidney Int 78:96-102. 2010
    ..As maternal vitamin A deficiency is widespread in developing countries and may compromise availability of retinol for fetal RA synthesis, our study suggests that the ALDH1A2 rs7169289(G) variant might be protective for such individuals...
  14. pmc Genome-wide assessment of imprinted expression in human cells
    Lisanne Morcos
    McGill University and Genome Quebec Innovation Centre, 740 Dr Penfield Avenue, Montreal, Quebec, H3A 1A4, Canada
    Genome Biol 12:R25. 2011
    ....
  15. doi request reprint Variation at the DPP4 locus influences apolipoprotein B levels in South Asians and exhibits heterogeneity in Europeans related to BMI
    Swneke D Bailey
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Diabetologia 57:738-45. 2014
    ..Genetic studies of lipid levels have focused on Europeans; a study in South Asians could identify novel genes...
  16. pmc Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol
    Guillaume Pare
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Am J Hum Genet 80:673-82. 2007
    ..Using an independent validation sample of 806 individuals, we confirm the EDN1 association (P<.005), whereas the LCAT association was nonsignificant (P=.12)...
  17. doi request reprint Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
    Johan Rung
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Nat Genet 41:1110-5. 2009
    ....
  18. pmc Correction of population stratification in large multi-ethnic association studies
    David Serre
    Genome Quebec Innovation Centre, McGill University, Montreal, Quebec, Canada
    PLoS ONE 3:e1382. 2008
    ..Unfortunately such a recruitment strategy is likely to complicate the study design and to generate concerns regarding population stratification...
  19. pmc Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord
    Alexandre Montpetit
    McGill University, Montreal, Quebec, Canada
    PLoS Genet 4:e1000296. 2008
    ..Together, these results confirm AP1S1 as the gene responsible for MEDNIK syndrome and demonstrate a critical role of AP1S1 in development of the skin and spinal cord...
  20. doi request reprint SNP genotyping of a sclerosing rhabdomyosarcoma: reveals highly aneuploid profile and a specific MDM2/HMGA2 amplification
    Dorothée Bouron-Dal Soglio
    Department of Pathology, CHU Sainte Justine, 3175 chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada
    Hum Pathol 40:1347-52. 2009
    ..Further studies are needed to assess if this anomaly is a specific marker of sclerosing rhabdomyosarcoma...
  21. pmc K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
    Dong Anh Khuong-Quang
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Acta Neuropathol 124:439-47. 2012
    ..Based on prognostic and therapeutic implications, our findings argue for H3.3-mutation testing at diagnosis, which should be rapidly integrated into the clinical decision-making algorithm, particularly in atypical DIPG...
  22. ncbi request reprint A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus
    Alexandre Montpetit
    Division of Hematology Oncology, Charles Bruneau Cancer Center, Research Center, Sainte Justine Hospital, 3175 Cote Ste Catherine, Montreal, QC H3T 1C5, Canada
    Eur J Hum Genet 10:62-71. 2002
    ..The gene predictions were all confirmed by expression analysis using RT-PCR and Northern blot. This transcriptional map is a crucial step toward the identification of the tumour suppressor gene at 12p12...
  23. doi request reprint Newborn serum retinoic acid level is associated with variants of genes in the retinol metabolism pathway
    Daniel C Manolescu
    Department of Medicine, University of Montreal, and Department of Pediatrics, Montreal Children s Hospital Research Institute, Montreal, Quebec H3Z 2Z3, Canada
    Pediatr Res 67:598-602. 2010
    ..CRABP2 facilitates RA binding to its cognate receptor complex and transfer to the nucleus. We hypothesize that individual variation in RA pathway genes may account for subtle variations in RA-dependent human embryogenesis...
  24. pmc Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study
    Swneke D Bailey
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes Care 33:2250-3. 2010
    ..Thiazolidinediones are used to treat type 2 diabetes. Their use has been associated with peripheral edema and congestive heart failure-outcomes that may have a genetic etiology...
  25. pmc Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age
    Adam M Fontebasso
    Division of Experimental Medicine, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    Oncotarget 6:31844-56. 2015
    ..Thus, convergence of pathways affecting the cell cycle and genomic stability may favor aneuploidy in PA, possibly representing an additional molecular driver in older patients with this brain tumor. ..
  26. pmc An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population
    Alexandre Montpetit
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
    PLoS Genet 2:e27. 2006
    ..Overall, our study supports the use of HapMap data in other Caucasian populations, but the SNP density and the bias towards high-frequency SNPs have to be taken into account when designing association studies...
  27. pmc Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas
    Hui Qi Qu
    Montreal Children s Hospital, 2300 Tupper, Montreal, Que, Canada, H3H 1P3
    Neuro Oncol 12:153-63. 2010
    ..It further shows that, despite commonalities in a few CNAs, pGBM and aGBMs are two different diseases...
  28. pmc Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells
    Andréanne Morin
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    BMC Med Genomics 9:59. 2016
    ....
  29. doi request reprint Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
    Jeremy Schwartzentruber
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec H3A 1A4, Canada
    Nature 482:226-31. 2012
    ..This is, to our knowledge, the first report to highlight recurrent mutations in a regulatory histone in humans, and our data suggest that defects of the chromatin architecture underlie paediatric and young adult GBM pathogenesis...
  30. ncbi request reprint Genetic control of alternative splicing in the TAP2 gene: possible implication in the genetics of type 1 diabetes
    Hui Qi Qu
    Endocrine Genetics Laboratory, The McGill University Health Center Montreal Children s Hospital, QC, Canada
    Diabetes 56:270-5. 2007
    ....
  31. doi request reprint Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1147-50. 2008
    ..The present study investigated the role of two FTO SNPs (rs17817449 and rs1421085) in adiposity, insulin sensitivity, and body weight regulation, including energy intake and expenditure...
  32. doi request reprint Global patterns of cis variation in human cells revealed by high-density allelic expression analysis
    Bing Ge
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
    Nat Genet 41:1216-22. 2009
    ..The dense collection of associations will facilitate large-scale isolation of cis-regulatory SNPs...
  33. doi request reprint Somatic point mutations occurring early in development: a monozygotic twin study
    Rui Li
    Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    J Med Genet 51:28-34. 2014
    ....
  34. doi request reprint Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR
    Claudia L Kleinman
    1 McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada 2 Department of Human Genetics, McGill University, Montreal, Quebec, Canada 3
    Nat Genet 46:39-44. 2014
    ..Our data suggest a potential oncogenic re-engagement of an early developmental program in ETMR via epigenetic alteration mediated by an embryonic, brain-specific DNMT3B isoform. ..
  35. doi request reprint Chondroid cystic malformation of the lung with trisomy 8 mosaicism: a new cystic lung malformation
    Dorothée Bouron-Dal Soglio
    Department of Pathology, CHU Sainte Justine, Montreal, Quebec, Canada
    Am J Surg Pathol 32:1095-100. 2008
    ..We believe that this lesion differs from congenital pulmonary airway malformations and from adult-type pulmonary hamartomas. We propose for this malformative mass the name "chondroid cystic malformation of the lung."..
  36. pmc Rare copy number variants contribute to congenital left-sided heart disease
    Marc Phillip Hitz
    Cardiovascular Genetics, Department of Pediatrics, Centre hospitalier universitaire Sainte Justine, Universite de Montreal, Montreal, Quebec, Canada
    PLoS Genet 8:e1002903. 2012
    ..Often viewed as an anatomically circumscript disease, a subset of left-sided CHD may in fact reflect more general genetic perturbations of angiogenesis and/or vascular biology...
  37. doi request reprint What can exome sequencing do for you?
    Jacek Majewski
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    J Med Genet 48:580-9. 2011
    ....
  38. doi request reprint Familial ventricular aneurysms and septal defects map to chromosome 10p15
    Nicolas Tremblay
    Cardiovascular Genetics, Department of Pediatrics, Research Center, Centre hospitalier universitaire Sainte Justine, University of Montreal, Montreal, QC, Canada
    Eur Heart J 32:568-73. 2011
    ..The aim of this study was to identify genetic factors and chromosomal regions contributing to VSD...
  39. ncbi request reprint Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy
    Audrey H Poon
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 170:967-73. 2004
    ..These results identify VDR variants as genetic risk factors for asthma/atopy and implicate a non-human leukocyte antigen immunoregulatory molecule in the pathogenesis of asthma and atopy...
  40. ncbi request reprint An atypical form of erythrokeratodermia variabilis maps to chromosome 7q22
    Thomas G Saba
    McGill University and Genome Quebec Innovation Centre, Montreal, QC, H3A 1A4, Canada
    Hum Genet 116:167-71. 2005
    ..Identification of the gene responsible for this disorder will provide insights into the etiology of this multisystemic disorder...
  41. ncbi request reprint Susceptibility to leprosy is associated with PARK2 and PACRG
    Marcelo T Mira
    McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, PQ H3G1A4, Canada
    Nature 427:636-40. 2004
    ..Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy...
  42. ncbi request reprint High-throughput molecular profiling of blood donors for minor red blood cell and platelet antigens
    Alexandre Montpetit
    McGill University and the Genome Quebec Innovation Center, Montreal, Quebec, Canada
    Transfusion 46:841-8. 2006
    ..This can result in alloimmunization of the patient against one to several minor antigens and may complicate future transfusions...
  43. doi request reprint RNA-Seq as a Tool to Study the Tumor Microenvironment
    Pudchalaluck Panichnantakul
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Methods Mol Biol 1458:311-37. 2016
    ..Here, we describe experimental procedures of RNA-Seq and downstream data processing and analysis, with a focus on the identification of abnormally expressed transcripts and genes. ..
  44. doi request reprint Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis
    Jonathon Torchia
    Division of Hematology Oncology, University of Toronto, Toronto, ON, Canada Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada Department of Pediatrics, University of Toronto, Toronto, ON, Canada
    Lancet Oncol 16:569-82. 2015
    ..We integrated genomic and clinicopathological analyses of a cohort of patients with atypical teratoid rhabdoid tumours to find out the molecular basis for clinical heterogeneity in these tumours...
  45. ncbi request reprint Mutation and biochemical analysis of patients belonging to the cblB complementation class of vitamin B12-dependent methylmalonic aciduria
    Jordan P Lerner-Ellis
    Department of Human Genetics, McGill University, Montreal, Que, Canada
    Mol Genet Metab 87:219-25. 2006
    ..556C >T (p.R186W), was particularly common, accounting for 33% of pathogenic alleles. It was seen almost exclusively in patients of European background and was typically associated with presentation in the first year of life...
  46. ncbi request reprint A genome-wide association study identifies novel risk loci for type 2 diabetes
    Robert Sladek
    Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal H3A 1A4, Canada
    Nature 445:881-5. 2007
    ..These associations explain a substantial portion of disease risk and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits...
  47. ncbi request reprint Germ-line DNA copy number variation frequencies in a large North American population
    George Zogopoulos
    Sam Minuk Cancer Genetics and Biomarker Laboratories, Fred Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Canada
    Hum Genet 122:345-53. 2007
    ..This North American population-based map will be a useful resource for future genetic studies...
  48. pmc Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
    Albert Tenesa
    Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    Nat Genet 40:631-7. 2008
    ..008) and rs4939827 (P < 0.009). Carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75-3.89) for CRC. These findings extend our understanding of the role of common genetic variation in CRC etiology...
  49. pmc Genome-wide detection and characterization of positive selection in human populations
    Pardis C Sabeti
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Nature 449:913-8. 2007
    ....
  50. pmc A second generation human haplotype map of over 3.1 million SNPs
    Kelly A Frazer
    The Scripps Research Institute, 10550 North Torrey Pines Road MEM275, La Jolla, California 92037, USA
    Nature 449:851-61. 2007
    ..Finally, we demonstrate increased differentiation at non-synonymous, compared to synonymous, SNPs, resulting from systematic differences in the strength or efficacy of natural selection between populations...
  51. ncbi request reprint Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
    Brent W Zanke
    Cancer Care Ontario, 620 University Avenue, Toronto, Ontario M5G 1L7, Canada
    Nat Genet 39:989-94. 2007
    ..i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer...
  52. pmc PRKCA and multiple sclerosis: association in two independent populations
    Janna Saarela
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    PLoS Genet 2:e42. 2006
    ....