James G Martin

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells
    Michael J O'Sullivan
    Meakins Christie Laboratories, Department of Medicine, McGill University and McGill University Health Centre Research Institute, Montreal, Canada
    PLoS ONE 9:e95566. 2014
  2. doi request reprint The modulation of large airway smooth muscle phenotype and effects of epidermal growth factor receptor inhibition in the repeatedly allergen-challenged rat
    S Siddiqui
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 304:L853-62. 2013
  3. pmc Marketing data: has the rise of impact factor led to the fall of objective language in the scientific article?
    Véronique J Fraser
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Respir Res 10:35. 2009
  4. ncbi request reprint Genetic differences in airway smooth muscle function
    James G Martin
    M B B Ch, Meakins Christie Laboratories, Department of Medicine, McGill University, 3626 St Urbain Street, Montreal, PQ, H2X 2P2 Canada
    Proc Am Thorac Soc 5:73-9. 2008
  5. ncbi request reprint Immune responses to viral infections: relevance for asthma
    James G Martin
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Paediatr Respir Rev 7:S125-7. 2006
  6. ncbi request reprint Chlorine-induced injury to the airways in mice
    James G Martin
    Meakins Christie Laboratories, 3626 St Urbain, Montreal, Province of Quebec, H2X 2P2 Canada
    Am J Respir Crit Care Med 168:568-74. 2003
  7. ncbi request reprint The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the rat
    James G Martin
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Immunol 169:3963-9. 2002
  8. ncbi request reprint Immunotherapy as a disease modifier
    James G Martin
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Paediatr Respir Rev 7:S106-7. 2006
  9. ncbi request reprint Airway smooth muscle growth from the perspective of animal models
    James G Martin
    Department of Medicine, Meakins Christie Laboratories, McGill University, 3626 Urbain Street, Montreal, QC, Canada H2X 2P2
    Respir Physiol Neurobiol 137:251-61. 2003
  10. ncbi request reprint Rat models of asthma and chronic obstructive lung disease
    James G Martin
    Meakins Christie Laboratories, McGill University, Montreal, Que, Canada
    Pulm Pharmacol Ther 19:377-85. 2006

Detail Information

Publications92

  1. pmc Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells
    Michael J O'Sullivan
    Meakins Christie Laboratories, Department of Medicine, McGill University and McGill University Health Centre Research Institute, Montreal, Canada
    PLoS ONE 9:e95566. 2014
    ..This study reveals S1PR2 and NF-κB as potential therapeutic targets in neutrophilic airway diseases such as severe asthma...
  2. doi request reprint The modulation of large airway smooth muscle phenotype and effects of epidermal growth factor receptor inhibition in the repeatedly allergen-challenged rat
    S Siddiqui
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 304:L853-62. 2013
    ..Furthermore, the latter results in excessive small airway and, to a lesser degree, large airway narrowing to methacholine, and large airway gene expression of contractile protein is conserved...
  3. pmc Marketing data: has the rise of impact factor led to the fall of objective language in the scientific article?
    Véronique J Fraser
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Respir Res 10:35. 2009
    ..It appears that fundamental research journals of high impact factors have experienced a rise in value-laden terms in the past 25 years...
  4. ncbi request reprint Genetic differences in airway smooth muscle function
    James G Martin
    M B B Ch, Meakins Christie Laboratories, Department of Medicine, McGill University, 3626 St Urbain Street, Montreal, PQ, H2X 2P2 Canada
    Proc Am Thorac Soc 5:73-9. 2008
    ..Certain asthma-related genes such as ADAM33, although potentially important for smooth muscle function, have been incompletely explored...
  5. ncbi request reprint Immune responses to viral infections: relevance for asthma
    James G Martin
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Paediatr Respir Rev 7:S125-7. 2006
    ..Difference in Toll-like receptor expression on airway epithelial cells is a potential mechanism for the altered immune responses of asthmatic children...
  6. ncbi request reprint Chlorine-induced injury to the airways in mice
    James G Martin
    Meakins Christie Laboratories, 3626 St Urbain, Montreal, Province of Quebec, H2X 2P2 Canada
    Am J Respir Crit Care Med 168:568-74. 2003
    ..We conclude that chlorine exposure causes functional and pathological changes in the airways associated with oxidative stress. Inducible nitric oxide synthase is involved in the induction of changes in responsiveness to methacholine...
  7. ncbi request reprint The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the rat
    James G Martin
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Immunol 169:3963-9. 2002
    ..We conclude that PGE(2) is a potent anti-inflammatory agent that may act by reducing allergen-induced Th2 cell activation and cysteinyl-leukotriene synthesis in the rat...
  8. ncbi request reprint Immunotherapy as a disease modifier
    James G Martin
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Paediatr Respir Rev 7:S106-7. 2006
    ..Traditional desensitization immunotherapy is being re-examined and anti-IgE therapy is also enjoying a measure of success...
  9. ncbi request reprint Airway smooth muscle growth from the perspective of animal models
    James G Martin
    Department of Medicine, Meakins Christie Laboratories, McGill University, 3626 Urbain Street, Montreal, QC, Canada H2X 2P2
    Respir Physiol Neurobiol 137:251-61. 2003
    ..The links between T cells and the biochemical mediators of growth have not been established...
  10. ncbi request reprint Rat models of asthma and chronic obstructive lung disease
    James G Martin
    Meakins Christie Laboratories, McGill University, Montreal, Que, Canada
    Pulm Pharmacol Ther 19:377-85. 2006
    ..Inflammation and fibrosis of peripheral airways is an important aspect of COPD that is less well modeled. Novel approaches to the treatment of COPD have been reported including treatments aimed at parenchymal regeneration...
  11. ncbi request reprint Cytokine cross-talk
    James G Martin
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Pediatr Pulmonol Suppl 26:45-6. 2004
  12. ncbi request reprint Cytokine therapies
    James G Martin
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Pediatr Pulmonol Suppl 26:49-51. 2004
  13. doi request reprint Small animals models for drug discovery
    James G Martin
    Meakins Christie Laboratories, McGill University, 3626 St Urbain St, Montreal, Quebec, Canada
    Pulm Pharmacol Ther 24:513-24. 2011
    ..New areas for expansion of modeling include virally mediated airway inflammation, oxidant stress, and the interactions of stimuli triggering innate immune and adaptive immune responses...
  14. doi request reprint Corticosteroids and antigen avoidance decrease airway smooth muscle mass in an equine asthma model
    Mathilde Leclere
    Department of Veterinary Clinical Sciences, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Am J Respir Cell Mol Biol 47:589-96. 2012
    ..Inhaled corticosteroids may accelerate the reversal of smooth muscle remodeling, even if airway inflammation is better controlled with antigen avoidance...
  15. doi request reprint EGF receptor activation during allergic sensitization affects IL-6-induced T-cell influx to airways in a rat model of asthma
    Kimitake Tsuchiya
    Meakins Christie Laboratories, McGill University, Montreal, QC, Canada
    Eur J Immunol 40:1590-602. 2010
    ..EGFR activation during sensitization may affect the subsequent influx of CD4(+) T cells to airways, mainly mediated through IL-6...
  16. pmc Interferon-gamma-dependent inhibition of late allergic airway responses and eosinophilia by CD8+ gammadelta T cells
    Susumu Isogai
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Immunology 122:230-8. 2007
    ..These results indicate that CD8(+)gammadelta T cells inhibit late airway responses and airway eosinophilia through the secretion of IFN-gamma. Defective or altered gammadelta T-cell function may account for some forms of allergic asthma...
  17. ncbi request reprint The effects of CD8+gammadelta T cells on late allergic airway responses and airway inflammation in rats
    Susumu Isogai
    Meakins Christie Laboratories, Department of Medicine, McGill University, 3623 St Urbain, Montreal, Quebec, Canada H2X 2P2
    J Allergy Clin Immunol 112:547-55. 2003
    ..Gamma-delta (gammadelta) T cells regulate immune responses to foreign protein at mucosal surfaces. Whether they can modify allergen-induced early (EAR) and late airway responses (LAR) is unknown...
  18. doi request reprint The presence of LPS in OVA inhalations affects airway inflammation and AHR but not remodeling in a rodent model of asthma
    Kimitake Tsuchiya
    Meakins Christie Laboratories, 3626 St Urbain, Montreal, Quebec, Canada, H2X 2P2
    Am J Physiol Lung Cell Mol Physiol 303:L54-63. 2012
    ....
  19. doi request reprint Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epithelial cells
    Nobuaki Hirota
    Meakins Christie Laboratories, Department of Medicine, McGill University, 3626 St Urbain, Montreal, QC, H2X 2P2 Canada
    FASEB J 26:1704-16. 2012
    ..These results suggest that histamine may induce airway remodeling via the epithelial-derived EGFR ligands amphiregulin and HB-EGF...
  20. doi request reprint An airway smooth muscle cell niche under physiological pulsatile flow culture using a tubular dense collagen construct
    Chiara E Ghezzi
    Department of Mining and Materials Engineering, McGill University, Quebec, Canada H3A 2B2
    Biomaterials 34:1954-66. 2013
    ..The TDCCs provide ASMC niche for greater insight into the responses of 3D seeded SMCs to physiologically equivalent in vitro dynamic conditioning...
  21. doi request reprint Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype
    Paul Andre Risse
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Canada
    Am J Physiol Lung Cell Mol Physiol 300:L958-66. 2011
    ..We conclude that IL-13 inhibits proliferation via the IL-13Rα2 receptor and induces hypercontractility of human ASMC without change of the phenotypic markers of contractility...
  22. doi request reprint Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells
    David Préfontaine
    Meakins Christie Laboratories, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    J Immunol 183:5094-103. 2009
    ..ASMC are a source of the IL-33 cytokine. Our data propose IL-33 as a novel inflammatory marker of severe and refractory asthma...
  23. doi request reprint Sites of allergic airway smooth muscle remodeling and hyperresponsiveness are not associated in the rat
    Sana Siddiqui
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Appl Physiol (1985) 109:1170-8. 2010
    ..We conclude that ASM remodeling induced by repeated allergen challenges involves the entire bronchial tree, whereas AHR reflects alterations in the lung periphery. Prevention of ASM remodeling by corticosteroid does not abrogate AHR...
  24. doi request reprint Th17-associated cytokines promote human airway smooth muscle cell proliferation
    Ying Chang
    Meakins Christie Laboratories and Respiratory Division, Department of Medicine McGill University, 3626 rue St Urbain, Montreal, QC, Canada H2X 2P2
    FASEB J 26:5152-60. 2012
    ....
  25. doi request reprint T Cells localize with proliferating smooth muscle alpha-actin+ cell compartments in asthma
    David Ramos-Barbon
    Meakins Christie Laboratories, McGill University, Montreal, PQ, Canada
    Am J Respir Crit Care Med 182:317-24. 2010
    ..Experimental studies showed that T cells adhere to ASM through vascular cell adhesion molecule-1 (VCAM-1) and drive ASM growth through direct contact between the T cells and smooth muscle alpha-actin (alpha-SMA)(+) cells...
  26. ncbi request reprint Resident CD8+ T cells suppress CD4+ T cell-dependent late allergic airway responses
    Susumu Isogai
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 115:521-6. 2005
    ..The role of CD8+ T cells in the immune response to airway challenge with an allergen is poorly understood...
  27. doi request reprint Role of the cystic fibrosis transmembrane conductance channel in human airway smooth muscle
    Marie Claire Michoud
    Meakins Christie Laboratories, Department of Medicine, McGill University, 3626 St Urbain, Montreal, PQ, H2X 2P2 Canada
    Am J Respir Cell Mol Biol 40:217-22. 2009
    ..In patients with CF, a dysfunctional CFTR channel could contribute to the asthma diathesis and gastrointestinal problems experienced by these patients...
  28. ncbi request reprint Interleukin-8: novel roles in human airway smooth muscle cell contraction and migration
    Vasanthi Govindaraju
    Seymoure Heisler Laboratory of the Montreal Chest Institute Research Center, McGill University, Montreal, Quebec, Canada H2X 2P2
    Am J Physiol Cell Physiol 291:C957-65. 2006
    ..These data suggest a potential role for IL-8 in causing abnormal airway structure and function in asthma and CF...
  29. doi request reprint The effects of repeated allergen challenge on airway smooth muscle structural and molecular remodeling in a rat model of allergic asthma
    Isabelle Labonté
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, QC, Canada H2X 2P2
    Am J Physiol Lung Cell Mol Physiol 297:L698-705. 2009
    ..05). Seven days after repeated challenges, features of remodeling were restored toward control levels. Allergen-induced hyperplasia of SM cells was associated with a loss of contractile phenotype, which was offset by the increase in mass...
  30. doi request reprint Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma
    Muhannad Hassan
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec H2X 2P2, Canada
    J Allergy Clin Immunol 125:1037-1045.e3. 2010
    ..The origin of the excess airway smooth muscle in asthma and when in the course of the disease it is acquired are uncertain...
  31. pmc Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4-TRIF pathway
    Karim H Shalaby
    Meakins Christie Laboratories, Research Institute of the McGill University Health Centre, Department of Medicine, McGill University, Montreal, Quebec H2X 2P2, Canada
    J Immunol 191:922-33. 2013
    ..Pollen extract does, however, activate TLR4, thereby enhancing airway inflammation, which is restrained by the TRIF-dependent pathway...
  32. ncbi request reprint The effects of extracellular purines and pyrimidines on human airway smooth muscle cells
    Vasanthi Govindaraju
    Seymour Heisler Laboratory of the Montreal Chest Institute Research Center, McGill University, University of Montreal Hospital Center PF, Quebec, Canada
    J Pharmacol Exp Ther 315:941-8. 2005
    ....
  33. ncbi request reprint CD4+ T cells migrate from airway to bone marrow after antigen inhalation in rats
    Susumu Isogai
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 113:455-61. 2004
    ..IL-5-producing T lymphocytes increase in rat bone marrow after inhalational challenge with allergen...
  34. pmc Time course of airway remodelling after an acute chlorine gas exposure in mice
    Stephanie A Tuck
    Meakins Christie Laboratories, McGill University, Montreal, Canada
    Respir Res 9:61. 2008
    ....
  35. doi request reprint IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo
    Anouk Lavoie-Lamoureux
    Departement de Sciences Cliniques, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 299:L472-82. 2010
    ..Overall, results from this study add to the link between Th2-driven inflammation and neutrophilia in the equine model and further extend the characterization of IL-4 effects on neutrophils...
  36. ncbi request reprint CD8+ alphabeta T cells can mediate late airway responses and airway eosinophilia in rats
    Susumu Isogai
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 114:1345-52. 2004
    ..The function of CD8+ T-cell subsets in mediating late allergic responses is incompletely understood...
  37. pmc Site of allergic airway narrowing and the influence of exogenous surfactant in the Brown Norway rat
    Sana Siddiqui
    Meakins Christie Laboratories, Department of Medicine, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS ONE 7:e29381. 2012
    ....
  38. pmc Combined forced oscillation and forced expiration measurements in mice for the assessment of airway hyperresponsiveness
    Karim H Shalaby
    Meakins Christie Laboratories, McGill University, Montreal QC, Canada
    Respir Res 11:82. 2010
    ..The objective of this study was to obtain NPFE and FOT measurements at baseline and following bronchoconstriction from a single cohort of mice using a combined system in order to assess both techniques through a refined approach...
  39. pmc Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration
    Laila A Al-Alwan
    Meakins Christie Laboratories and Respiratory Division, Department of Medicine, McGill University, Montreal, Quebec H2X 2P2, Canada
    J Immunol 191:2731-41. 2013
    ....
  40. pmc MAP kinases mediate interleukin-13 effects on calcium signaling in human airway smooth muscle cells
    Barry Moynihan
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 295:L171-7. 2008
    ..We conclude that IL-13 induces potentiation of Ca(2+) responses to contractile agonists by affecting mechanisms downstream of receptors. JNK and ERK MAPKs modulate these mechanisms...
  41. doi request reprint Effects of decorin and biglycan on human airway smooth muscle cell proliferation and apoptosis
    Michelle L D'Antoni
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 294:L764-71. 2008
    ..These studies demonstrate that different PGs have variable effects on ASM cell proliferation and apoptosis. Recently described decreases in Dcn in the asthmatic airway wall could potentially permit more exuberant ASM growth...
  42. doi request reprint Steroid-insensitive ERK1/2 activity drives CXCL8 synthesis and neutrophilia by airway smooth muscle
    Stephanie Robins
    Meakins Christie Laboratories, McGill University Heath Centre Research Institute, Montreal, Canada
    Am J Respir Cell Mol Biol 45:984-90. 2011
    ....
  43. pmc IL-22 contributes to TGF-β1-mediated epithelial-mesenchymal transition in asthmatic bronchial epithelial cells
    Jill R Johnson
    Meakins Christie Laboratories, McGill University, 3626 St, Urbain Street, Montreal, QC H2X 2P2, Canada
    Respir Res 14:118. 2013
    ..In this study, we evaluated the contribution of IL-22 to EMT in primary bronchial epithelial cells from healthy and asthmatic subjects...
  44. ncbi request reprint LY-294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] affects calcium signaling in airway smooth muscle cells independently of phosphoinositide 3-kinase inhibition
    Barbara Tolloczko
    Meakins Christie Laboratories, McGill University, 3626 St Urbain Street, Montreal, Quebec, Canada H2 2P2
    J Pharmacol Exp Ther 311:787-93. 2004
    ..We conclude that LY-294002 modulates Ca(2+) signaling in rat ASM independently of its action on PI3K by acting on, or upstream of, PLC, possibly by inhibiting CK2...
  45. ncbi request reprint Differences in airway cytokine profile in severe asthma compared to moderate asthma
    Joanne Shannon
    Montreal Chest Institute, Respiratory Division of McGill University Health Centre, Montreal, QC, Canada
    Chest 133:420-6. 2008
    ....
  46. ncbi request reprint Chronic asthma-induced airway remodeling is prevented by toll-like receptor-7/8 ligand S28463
    Pierre Camateros
    Department of Experimental Medicine, McGill University, Montreal, PQ, H3G 1A4 Canada
    Am J Respir Crit Care Med 175:1241-9. 2007
    ..We and others have previously shown that one of the Toll-like receptor (TLR)-7/8 ligands, the synthetic compound S28463 (resiquimod, R-848), is able to inhibit acute allergic asthma in mice...
  47. doi request reprint TH17 cytokines induce human airway smooth muscle cell migration
    Ying Chang
    Meakins Christie Laboratories and Respiratory Division, Department of Medicine McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 127:1046-53.e1-2. 2011
    ..T(H)17 cells and T(H)17-associated cytokines are involved in the pathogenesis of asthma and might also contribute to airway remodeling...
  48. doi request reprint Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure
    Harry Karmouty-Quintana
    Meakins Christie Laboratories, McGill University, Montreal, Canada
    Am J Physiol Lung Cell Mol Physiol 302:L736-45. 2012
    ..Airway remodeling is a cardinal feature of severe asthma. These results demonstrate that allergen-driven airway remodeling can be inhibited by FTY720, offering potential new therapies for the treatment of severe asthma...
  49. pmc The effects of interleukin-8 on airway smooth muscle contraction in cystic fibrosis
    Vasanthi Govindaraju
    Seymour Heisler Laboratory of the Montreal Chest Institute Research Center and Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Respir Res 9:76. 2008
    ..The aim of this work was to determine the responsiveness of airway smooth muscle to IL-8 in CF patients compared to non-CF individuals...
  50. pmc IFN-gamma, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13
    Barry J Moynihan
    Department of Medicine, McGill University, Montreal, Canada
    Respir Res 9:84. 2008
    ..We investigated the effects of pre-treatment with IL-4, IL-13 and IFN-gamma on the responses of HASM cells to IL-13...
  51. ncbi request reprint Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouse
    Seok Yong Eum
    Meakins Christie Laboratories and Respiratory Division, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Am J Respir Cell Mol Biol 28:25-32. 2003
    ....
  52. ncbi request reprint Downregulation of a disintegrin and metalloproteinase 33 by IFN-gamma in human airway smooth muscle cells
    Isao Ito
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada, H2X 2P2
    J Allergy Clin Immunol 119:89-97. 2007
    ..ADAM33 is expressed in airway smooth muscle (ASM) cells and is suggested to play a role in the function of these cells. However, there is little information on the regulation of ADAM33...
  53. doi request reprint How the airway smooth muscle in cystic fibrosis reacts in proinflammatory conditions: implications for airway hyper-responsiveness and asthma in cystic fibrosis
    Sarah McCuaig
    Meakins Christie Laboratories, McGill University Health Centre, Montreal, Quebec Canada
    Lancet Respir Med 1:137-47. 2013
    ..Increased understanding of the molecular mechanisms responsible for the altered smooth muscle physiology in patients with cystic fibrosis might provide insight into airway dysfunction in this disease. ..
  54. pmc Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in experimental asthma
    David Ramos-Barbon
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Clin Invest 115:1580-9. 2005
    ..Overall, our data demonstrate that activated CD4+ T cells drive ASM remodeling in experimental asthma and suggest that a direct cell-cell interaction participates in CD4+ T cell regulation of myocyte turnover and induction of remodeling...
  55. doi request reprint Insights into asthmatic airway remodelling through murine models
    Saba Al Heialy
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Respirology 16:589-97. 2011
    ..A better understanding of the mechanisms leading to airway remodelling in allergic diseases may lead to the identification of novel therapeutic strategies but validation in human subjects is required for potential targets...
  56. doi request reprint Differential effects of extracellular matrix and mechanical strain on airway smooth muscle cells from ovalbumin- vs. saline-challenged Brown Norway rats
    Stephanie M Pasternyk
    Meakins Christie Laboratories, McGill University Health Center, 3626 St Urbain Street, Montreal, Quebec, Canada H2X 2P2
    Respir Physiol Neurobiol 181:36-43. 2012
    ..Strain affected expression of β1-integrin differently in OVA vs. SAL ASMC. These data suggest that matrix and mechanical strain modulate ASMC number; these effects are differentially observed in OVA ASMC...
  57. doi request reprint Effects of decorin and biglycan on human airway smooth muscle cell adhesion
    Michelle L D'Antoni
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Matrix Biol 31:101-12. 2012
    ..Upregulation of cell surface receptor proteins, such as α(2) integrin subunit, may represent a compensatory mechanism to overcome poor adhesion induced by growth on these matrices...
  58. doi request reprint Allergen-induced airway remodeling in brown norway rats: structural and metabolic changes in glycosaminoglycans
    Narayanan Venkatesan
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Am J Respir Cell Mol Biol 46:96-105. 2012
    ..Our results suggest that GAG biosynthetic enzymes may be involved in the altered expression of GAGs in the airways and are potential targets for inhibiting excess PG-GAG deposition and the airway remodeling process in asthma...
  59. pmc Maternal allergen exposure reprograms the developmental lung transcriptome in atopic and normoresponsive rat pups
    Nicole Carpe
    Departments of Human Genetics, Montreal Children s Hospital Research Institute, McGill University, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 303:L899-911. 2012
    ..These different response patterns, if recapitulated in human fetal development, can contribute to long-term pulmonary health including interindividual susceptibility to asthma...
  60. ncbi request reprint Structural aspects of airway remodeling in asthma
    Sana Siddiqui
    Meakins Christie Laboratories, McGill University, 3626 St Urbain Street, Montreal, Quebec H2X 2P2, Canada
    Curr Allergy Asthma Rep 8:540-7. 2008
    ..The epidermal growth factor receptor's role in remodeling and its interaction with other potential causes of remodeling are discussed...
  61. doi request reprint ICOS-expressing CD4 T cells induced via TLR4 in the nasal mucosa are capable of inhibiting experimental allergic asthma
    Karim H Shalaby
    Meakins Christie Laboratories, Department of Medicine, McGill University and McGill University Health Centre Research Institute, Montreal, Quebec H2X 2P2, Canada
    J Immunol 189:2793-804. 2012
    ..Thus, our data indicate that expansion of resident ICOS-expressing CD4+ T cells of the cervical LNs by nasal mucosal TLR4 stimulation may inhibit the development of allergic lower airway disease in mice...
  62. doi request reprint Systemic inflammation and priming of peripheral blood leukocytes persist during clinical remission in horses with heaves
    Anouk Lavoie-Lamoureux
    Faculte de Medecine Veterinaire, Departement de Sciences Cliniques, U of Montreal, 3200 rue Sicotte St Hyacinthe, Quebec, Canada
    Vet Immunol Immunopathol 146:35-45. 2012
    ..To compare innate immune responses of peripheral blood leukocytes from healthy and asymptomatic heaves-affected horses...
  63. ncbi request reprint Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: role of eosinophils, IL-5, eotaxin, and IL-13
    Seok Yong Eum
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Canada
    J Allergy Clin Immunol 111:1049-61. 2003
    ..Whether glucocorticoids mediate their effects on AHR by inhibiting eotaxin and IL-5, 2 of the principal mediators of eosinophilia, or through IL-13, an important mediator of AHR, has not been established...
  64. ncbi request reprint Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling
    Berenice Herszberg
    Meakins Christie Laboratories, McGill University, 3626 Saint Urbain, Montreal, Quebec H2X 2P2, Canada
    J Allergy Clin Immunol 118:382-8. 2006
    ..Airway smooth muscle hyperplasia occurs in rodent models of experimental asthma, but the relevance of such finding to spontaneously occurring disease in large mammals is unknown...
  65. pmc Effects of a short course of inhaled corticosteroids in noneosinophilic asthmatic subjects
    Catherine Lemiere
    Hopital du Sacre Coeur de Montreal, Universite de Montreal, Montreal, Quebec
    Can Respir J 18:278-82. 2011
    ..Noneosinophilic asthma has been regarded as a distinct phenotype characterized by a poor response to inhaled corticosteroids (ICS)...
  66. ncbi request reprint Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes
    Catherine Lemiere
    Hopital du Sacre Coeur de Montreal, University of Montreal, Montreal, Quebec, Canada
    J Allergy Clin Immunol 118:1033-9. 2006
    ....
  67. pmc Genetic influences on asthma susceptibility in the developing lung
    Nicole Carpe
    Department of Human Genetics, McGill University, 4060 Saint Catherine West, Montreal, PQ, Canada
    Am J Respir Cell Mol Biol 43:720-30. 2010
    ..Innate differences in patterns of gene expression in developing lung that contribute to individual variation in respiratory phenotype are likely to contribute to the pathogenesis of asthma...
  68. ncbi request reprint Airway remodeling in allergen-challenged Brown Norway rats: distribution of proteoglycans
    Laura Pini
    Meakins Christie Labs, 3626 St Urbain Street, Montreal, QC, Canada
    Am J Physiol Lung Cell Mol Physiol 290:L1052-8. 2006
    ..Differences in the distribution of these molecules within the layers of the airway wall may reflect their specific functional roles...
  69. doi request reprint LTD₄ induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells
    Toby McGovern
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Am J Physiol Lung Cell Mol Physiol 299:L808-15. 2010
    ..These effects may contribute to epithelial-mediated airway remodeling in asthma and other conditions associated with cysteinyl leukotriene release...
  70. doi request reprint Identification of novel chromosomal regions associated with airway hyperresponsiveness in recombinant congenic strains of mice
    Pierre Camateros
    Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC, H3A 2T5, Canada
    Mamm Genome 21:28-38. 2010
    ..Our data identify several likely candidate genes from the 16 regions, including Ddr2, Hc, Fbn1, Flt3, Utrn, Enpp2, and Tsc...
  71. doi request reprint IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation
    Lucie Roussel
    Meakins Christie Laboratories, University Heath Centre Research Institute, Montreal, Quebec, Canada
    J Immunol 184:4531-7. 2010
    ..Therefore, preventing neutrophil recruitment by blocking the action of IL-17 on endothelial cells may prove to be highly beneficial in diseases in which neutrophilic inflammation plays a key role...
  72. pmc Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma
    Toby K McGovern
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Respir Res 11:138. 2010
    ..We hypothesized that Cl2-induced airway injury may be attenuated by antioxidant treatment, even after the initial injury...
  73. pmc The role of gamma delta T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice
    Hossein Koohsari
    Meakins Christie Laboratories, McGill University, Montreal, QC, Canada
    Respir Res 8:21. 2007
    ..Acute exposure to chlorine (Cl2) gas causes epithelial injury and airway dysfunction. gammadelta T cells are present in the mucosal surface of the airways and may contribute to the injury/repair response of the epithelium...
  74. ncbi request reprint IFN-gamma secretion by CD8T cells inhibits allergen-induced airway eosinophilia but not late airway responses
    Masaru Suzuki
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 109:803-9. 2002
    ..CD8+T cells can suppress allergen-induced late airway responses (LARs) and airway inflammation...
  75. pmc Probing the viscoelastic behavior of cultured airway smooth muscle cells with atomic force microscopy: stiffening induced by contractile agonist
    Benjamin A Smith
    Department of Physics, Nanoscience and Scanning Probe Microscopy Group, McGill University, Montreal, Quebec, Canada
    Biophys J 88:2994-3007. 2005
    ..Thus, our measurements appear to be particularly well suited for characterization of dynamic actin rheology during airway smooth muscle contraction...
  76. doi request reprint Prevalence of obstructive sleep apnea-hypopnea in severe versus moderate asthma
    Joanne Y Julien
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 124:371-6. 2009
    ..Previous studies have suggested a link between obstructive sleep apnea and poor asthma control, which may be mediated through airway inflammation, obesity, and other mechanisms...
  77. ncbi request reprint Effects of extracellular triphosphate nucleotides and nucleosides on airway smooth muscle cell proliferation
    Marie Claire Michoud
    Meakins Christie Laboratories and Montreal Chest Institute Research Center, McGill University, Montreal, Quebec, Canada
    Am J Respir Cell Mol Biol 27:732-8. 2002
    ..These data show that extracellular UTP, ATP, and their metabolites may affect airway remodeling by increasing or by reducing (P(2Y6) receptor) ASM cell proliferation...
  78. ncbi request reprint Increased expression of ADAM33 and ADAM8 with disease progression in asthma
    Susan C Foley
    Meakins Christie Laboratories, McGill University, Montreal Chest Institute, Montreal, Quebec, Canada
    J Allergy Clin Immunol 119:863-71. 2007
    ..ADAM8 is strongly induced by allergens and T(H)2 cytokines in the lung in experimental asthma...
  79. ncbi request reprint T cell cytokines: animal models
    James G Martin
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Paediatr Respir Rev 5:S47-51. 2004
    ....
  80. ncbi request reprint TNF-alpha and IFN-gamma inversely modulate expression of the IL-17E receptor in airway smooth muscle cells
    Stéphane Lajoie-Kadoch
    Meakins Christie Laboratories, McGill University, 3626 St Urbain Street, Montreal, Quebec, Canada H2X 2P2
    Am J Physiol Lung Cell Mol Physiol 290:L1238-46. 2006
    ..Our results suggest a potential proremodeling effect of IL-17E on airway smooth muscle cells through the induction of ECM and that its receptor is upregulated by proinflammatory conditions...
  81. pmc AEOL10150: a novel therapeutic for rescue treatment after toxic gas lung injury
    Toby McGovern
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, QC H2X 2P2, Canada
    Free Radic Biol Med 50:602-8. 2011
    ..AEOL10150 is an effective rescue treatment for Cl(2)-induced airway hyperresponsiveness, airway inflammation, injury-induced airway epithelial cell regeneration, and oxidative stress...
  82. ncbi request reprint Airway remodeling: lessons from animal models
    David Ramos-Barbon
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Clin Rev Allergy Immunol 27:3-21. 2004
    ..Experimental airway remodeling in animals should be an essential tool for treatment discovery in the near future...
  83. doi request reprint Overview of asthma; the place of the T cell
    Karim H Shalaby
    Meakins Christie Laboratories, Department of Medicine, McGill University, 3626 St Urbain, Montreal, Quebec H2X 2P2, Canada
    Curr Opin Pharmacol 10:218-25. 2010
    ..This suggests that the induction of asthma may be T-cell-mediated and allergen-triggered, whereas disease may be sustained and exacerbated by other mechanisms...
  84. ncbi request reprint Src modulates serotonin-induced calcium signaling by regulating phosphatidylinositol 4,5-bisphosphate
    Barbara Tolloczko
    Seymour Heisler Laboratory of Montreal Chest Institute Research Centre and Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada H2X 2P2
    Am J Physiol Lung Cell Mol Physiol 282:L1305-13. 2002
    ..Overall, these data demonstrate that, in rat tracheal smooth muscle cells, Src kinase modulates 5-HT-evoked cell contractility and Ca(2+) signaling by regulating PIP(2) levels and Ca(2+) influx...
  85. doi request reprint Sustained steroid release in pulmonary inflammation model
    Harry Karmouty-Quintana
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Biomaterials 31:6050-9. 2010
    ..These observations demonstrated that calcium pyrophosphate nanofibrous microspheres displayed in vivo controlled release properties, were well tolerated and did not accumulate in the lung...
  86. ncbi request reprint Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats
    Wagdi Almishri
    Meakins Christie Laboratories, McGill University, 3626 St Urbain St, Montreal, QC, Canada H2X 2P2
    J Pharmacol Exp Ther 313:64-9. 2005
    ..The potent in vitro DP2 receptor agonist 15R-methyl-PGD2 is also very active in vivo and should be a useful tool in examining the role of this receptor...
  87. pmc Could an increase in airway smooth muscle shortening velocity cause airway hyperresponsiveness?
    Sharon R Bullimore
    McGill Univ, Montreal, QC, Canada
    Am J Physiol Lung Cell Mol Physiol 300:L121-31. 2011
    ..We conclude that, if asthma involves an increase in ASM velocity, this could be an important factor in the associated AHR...
  88. ncbi request reprint Proliferative aspects of airway smooth muscle
    Stuart J Hirst
    Department of Asthma, Allergy and Respiratory Science, Guy s, King s and St Thomas School of Medicine, Guy s Hospital Campus, King s College London, United Kingdom
    J Allergy Clin Immunol 114:S2-17. 2004
    ..The maximum response of fluticasone propionate against thrombin-induced proliferation is increased when it is combined with salmeterol...
  89. ncbi request reprint IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle
    Seok Yong Eum
    Deparment of Microbiology, Yonsei University College of Medicine, Seoul, South Korea
    Am J Physiol Lung Cell Mol Physiol 288:L576-84. 2005
    ..Its effects on AHR are mediated independently of IL-5 and eotaxin and may involve a direct effect on ASM to augment its responsiveness...
  90. ncbi request reprint Differences in airway remodeling between subjects with severe and moderate asthma
    Carmela Pepe
    Meakins Christie Laboratories, Montreal H2X2P2, Québec CA
    J Allergy Clin Immunol 116:544-9. 2005
    ..Several studies have suggested an association between these changes and disease severity. The relationship between the extent of remodeling and lung function is not well defined...
  91. ncbi request reprint Airway smooth muscle cells express functional neurokinin-1 receptors and the nerve-derived preprotachykinin-a gene: regulation by passive sensitization
    Karim Maghni
    Research Centre, Sacré Coeur Hospital of Montréal, Respiratory Diseases Unit, Universite de Montreal, Quebec, Canada
    Am J Respir Cell Mol Biol 28:103-10. 2003
    ..In conclusion, both the PPT-A gene and NK-1 receptors are expressed by TSMC, which suggests the possibility of autocrine neuropeptidergic mechanisms in these cells. However, these mechanisms are not upregulated by passive sensitization...
  92. ncbi request reprint Increased glucocorticoid receptor-beta expression, but not decreased histone deacetylase 2, in severe asthma
    Celine Bergeron
    J Allergy Clin Immunol 117:703-5. 2006