Martin Lepage

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc The structural neural substrates of persistent negative symptoms in first-episode of non-affective psychosis: a voxel-based morphometry study
    Audrey Benoit
    Brain Imaging Group, Douglas Mental Health University Institute Verdun, QC, Canada
    Front Psychiatry 3:42. 2012
  2. doi request reprint Cognitive insight and verbal memory in first episode of psychosis
    Martin Lepage
    Douglas Mental Health University Institute and Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Verdun Quebec, H4H 1R3 Canada
    Eur Psychiatry 23:368-74. 2008
  3. ncbi request reprint Episodic memory bias and the symptoms of schizophrenia
    Martin Lepage
    Douglas Mental Health University Institute, Montreal, Quebec
    Can J Psychiatry 52:702-9. 2007
  4. doi request reprint Emotional face processing and flat affect in schizophrenia: functional and structural neural correlates
    M Lepage
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Verdun, Quebec, Canada
    Psychol Med 41:1833-44. 2011
  5. ncbi request reprint Associative memory encoding and recognition in schizophrenia: an event-related fMRI study
    Martin Lepage
    Brain Imaging Group, Douglas Hospital Research Centre, Verdun, Quebec, Canada
    Biol Psychiatry 60:1215-23. 2006
  6. doi request reprint Is there an association between neurocognitive performance and medication adherence in first episode psychosis?
    Martin Lepage
    Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Canada
    Early Interv Psychiatry 4:189-95. 2010
  7. doi request reprint Parietal cortex and episodic memory retrieval in schizophrenia
    Martin Lepage
    Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Canada
    Psychiatry Res 182:191-9. 2010
  8. ncbi request reprint Associative interference does not affect recognition memory in schizophrenia
    Martin Lepage
    Brain Imaging Group, Douglas Hospital Research Centre, Department of Psychiatry, McGill University 6875 boul LaSalle Verdun, Quebec, Canada
    Schizophr Res 80:185-96. 2005
  9. ncbi request reprint The interfering effect of related events on recognition memory discriminability: a functional magnetic resonance imaging study
    Martin Lepage
    Brain Imaging Group, Douglas Hospital Research Centre, McGill University, 6875 Boul LaSalle Verdun, Quebec, Canada H4H 1R3
    Brain Res Cogn Brain Res 22:429-37. 2005
  10. ncbi request reprint Prefrontal cortex contribution to associative recognition memory in humans: an event-related functional magnetic resonance imaging study
    Martin Lepage
    Brain Imaging Group, Douglas Hospital Research Centre, Quebec, Verdun, Canada
    Neurosci Lett 346:73-6. 2003

Detail Information

Publications87

  1. pmc The structural neural substrates of persistent negative symptoms in first-episode of non-affective psychosis: a voxel-based morphometry study
    Audrey Benoit
    Brain Imaging Group, Douglas Mental Health University Institute Verdun, QC, Canada
    Front Psychiatry 3:42. 2012
    ..Conclusion: Neural substrates of PNS are evident in FEP patients. A better understanding of the neural etiology of PNS may encourage the search for new medications and/or alternative treatments to better help those affected...
  2. doi request reprint Cognitive insight and verbal memory in first episode of psychosis
    Martin Lepage
    Douglas Mental Health University Institute and Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Verdun Quebec, H4H 1R3 Canada
    Eur Psychiatry 23:368-74. 2008
    ..These results suggest that cognitive insight, but not clinical insight, may rely on memory processes whereby current experiences are appraised based on previous ones...
  3. ncbi request reprint Episodic memory bias and the symptoms of schizophrenia
    Martin Lepage
    Douglas Mental Health University Institute, Montreal, Quebec
    Can J Psychiatry 52:702-9. 2007
    ..Memory measures sensitive to such biases may turn out to be stronger predictors of clinical and functional outcome...
  4. doi request reprint Emotional face processing and flat affect in schizophrenia: functional and structural neural correlates
    M Lepage
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Verdun, Quebec, Canada
    Psychol Med 41:1833-44. 2011
    ..Functional brain imaging studies have observed reduced limbic activity during facial emotion perception but few studies have examined the relation to flat affect severity...
  5. ncbi request reprint Associative memory encoding and recognition in schizophrenia: an event-related fMRI study
    Martin Lepage
    Brain Imaging Group, Douglas Hospital Research Centre, Verdun, Quebec, Canada
    Biol Psychiatry 60:1215-23. 2006
    ..We used an event-related functional Magnetic Resonance Imaging (fMRI) approach to examine the neural basis of the selective associative memory deficit in schizophrenia...
  6. doi request reprint Is there an association between neurocognitive performance and medication adherence in first episode psychosis?
    Martin Lepage
    Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Canada
    Early Interv Psychiatry 4:189-95. 2010
    ..We examined early medication adherence following admission to a specialized clinical programme for FEP...
  7. doi request reprint Parietal cortex and episodic memory retrieval in schizophrenia
    Martin Lepage
    Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Canada
    Psychiatry Res 182:191-9. 2010
    ....
  8. ncbi request reprint Associative interference does not affect recognition memory in schizophrenia
    Martin Lepage
    Brain Imaging Group, Douglas Hospital Research Centre, Department of Psychiatry, McGill University 6875 boul LaSalle Verdun, Quebec, Canada
    Schizophr Res 80:185-96. 2005
    ..These results provide further support for faulty associative memory processing in schizophrenia...
  9. ncbi request reprint The interfering effect of related events on recognition memory discriminability: a functional magnetic resonance imaging study
    Martin Lepage
    Brain Imaging Group, Douglas Hospital Research Centre, McGill University, 6875 Boul LaSalle Verdun, Quebec, Canada H4H 1R3
    Brain Res Cogn Brain Res 22:429-37. 2005
    ..Since this contrast was conducted using only correctly recognized trials, these findings could reflect an index of memory discriminability or saliency which could influence conscious recollection...
  10. ncbi request reprint Prefrontal cortex contribution to associative recognition memory in humans: an event-related functional magnetic resonance imaging study
    Martin Lepage
    Brain Imaging Group, Douglas Hospital Research Centre, Quebec, Verdun, Canada
    Neurosci Lett 346:73-6. 2003
    ..The latter could reflect the neural correlates of a recall-to-reject process, a pivotal process of associative recognition memory...
  11. ncbi request reprint Differential contribution of left and right prefrontal cortex to associative cued-recall memory: a parametric PET study
    Martin Lepage
    Brain Imaging Group, Douglas Hospital Research Centre, McGill University, 6875 Boul LaSalle, Verdun, Que, Canada H4H 1R3
    Neurosci Res 48:297-304. 2004
    ..These findings add further support for a bilateral prefrontal contribution to memory cued-recall tasks and point to differential roles of the two hemispheres...
  12. pmc Influence of emotional expression on memory recognition bias in schizophrenia as revealed by fMRI
    Karine Sergerie
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Schizophr Bull 36:800-10. 2010
    ..This study demonstrates that, despite an overall lower memory accuracy, emotional memory is intact in schizophrenia, although emotion-specific differences in brain activation exist, possibly reflecting different strategies...
  13. ncbi request reprint Selective abnormal modulation of hippocampal activity during memory formation in first-episode psychosis
    Amelie M Achim
    Brain Imaging Group, Douglas Hospital Research Centre FBC1, 6875 Boul LaSalle, Verdun, QC H4H 1R3, Canada
    Arch Gen Psychiatry 64:999-1014. 2007
    ..Memory is one of the cognitive functions most affected in schizophrenia, with deficits observed from the first episode of psychosis (FEP). Previous studies have indicated that some memory processes may be more affected than others...
  14. doi request reprint Fronto-temporal disconnectivity and clinical short-term outcome in first episode psychosis: a DTI-tractography study
    David Luck
    Brain Imaging Group, Douglas Mental Health University Institute, 6875 Boul LaSalle, Verdun H4H 1R3, Canada
    J Psychiatr Res 45:369-77. 2011
    ..These findings confirm that abnormal fronto-temporal connectivity contributes to the physiopathology of FEP and constitutes an early marker of clinical short-term outcome...
  15. doi request reprint Symptom attribution in first episode psychosis: a cortical thickness study
    Lisa Buchy
    Brain Imaging Group, Douglas Mental Health University Institute, Verdun, Canada
    Psychiatry Res 203:6-13. 2012
    ..Evidence for cortical thickness covariation in a variety of regions suggests partial independence in the neural architecture underlying attribution for different symptoms in FEP...
  16. ncbi request reprint Medial temporal lobe activations during associative memory encoding for arbitrary and semantically related object pairs
    Amelie M Achim
    Brain Imaging Group, Douglas Hospital Research Centre, Montreal, Canada
    Brain Res 1161:46-55. 2007
    ..Most importantly, this study suggests that associative processing can activate the MTL regardless of the pre-existence of an association between the items of a pair...
  17. doi request reprint The influence of contour fragmentation on recognition memory: an event-related potential study
    Mathieu B Brodeur
    Brain Imaging Group, Douglas Mental Health University Institute, FBC Pavilion, 6875 Boul, LaSalle, Verdun, Quebec, Canada
    Brain Cogn 76:115-22. 2011
    ..This ERP to fragmentation, the occipito-temporal N(frag), possibly reflects the brain response to encoding difficulty, and is thus predictive of recognition performance...
  18. doi request reprint Social cognitive markers of short-term clinical outcome in first-episode psychosis
    Tina Montreuil
    Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Montreal, Canada
    Clin Schizophr Relat Psychoses 4:105-14. 2010
    ....
  19. doi request reprint Functional neural substrates of self-reported physical anhedonia in non-clinical individuals and in patients with schizophrenia
    Philippe Olivier Harvey
    Douglas Mental Health University Institute, Montreal, Quebec, Canada
    J Psychiatr Res 44:707-16. 2010
    ....
  20. ncbi request reprint Social cognitive impairments in first episode psychosis
    Marie Claude Bertrand
    Department of Psychology, University of Montreal, 90 Vincent d Indy Avenue, Montreal, Quebec, Canada H2V 2S9
    Schizophr Res 95:124-33. 2007
    ..However, most have focused on a single aspect of social cognition, namely "theory of mind" and/or included patients with long standing illness...
  21. doi request reprint Selective pair recognition memory impairment with no response bias in schizophrenia
    David Luck
    Brain Imaging Group, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Canada, 6875 Boul LaSalle, Verdun, Quebec, Canada H4H 1R3
    Psychiatry Res 169:39-42. 2009
    ..The study also provides evidence that associative impairment may not result from decisional bias but rather from impairments in mnesic processes...
  22. doi request reprint Neural markers of remission in first-episode schizophrenia: a volumetric neuroimaging study of the hippocampus and amygdala
    Michael Bodnar
    Brain Imaging Group, Douglas Mental Health University Institute, Montreal, Canada
    Schizophr Res 122:72-80. 2010
    ..However, volumetric differences (namely, in the hippocampus) exhibit an ambiguous relationship with long-term outcome. So, we examined the relationship between hippocampus and amygdala volumes and early remission status...
  23. doi request reprint The bank of standardized stimuli (BOSS): comparison between French and English norms
    Mathieu B Brodeur
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Behav Res Methods 44:961-70. 2012
    ..The only significant group differences were found in viewpoint agreement and visual complexity. Overall, there was good concordance between the norms collected from French and English native speakers living in the same cultural setting...
  24. doi request reprint Functional magnetic resonance imaging correlates of memory encoding in relation to achieving remission in first-episode schizophrenia
    Michael Bodnar
    Douglas Mental Health University Institute, Frank B Common Pavilion, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada
    Br J Psychiatry 200:300-7. 2012
    ..Previous studies in schizophrenia have shown a strong relationship between memory deficits and a poor clinical outcome. However, no previous study has identified the functional neural correlates of memory encoding in relation to remission...
  25. doi request reprint Cortical thickness is associated with poor insight in first-episode psychosis
    Lisa Buchy
    Brain Imaging Group, Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Quebec, Canada H4H 1R3
    J Psychiatr Res 45:781-7. 2011
    ....
  26. doi request reprint The parahippocampal gyrus as a neural marker of early remission in first-episode psychosis: a voxel-based morphometry study
    Michael Bodnar
    Brain Imaging Group, Douglas Mental Health University Institute, Frank B Common Pavilion, Montreal, Quebec, Canada
    Clin Schizophr Relat Psychoses 4:217-28. 2011
    ..No previous study has examined neuroimaging markers in relation to early remission...
  27. pmc The dorsolateral prefrontal cortex plays a role in self-initiated elaborative cognitive processing during episodic memory encoding: rTMS evidence
    Colin Hawco
    Department of Neurology and Neurosurgery, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e73789. 2013
    ..These results suggest the left DLPFC may be involved in the self-initiation of memory strategy use, and individuals may utilize different neural networks depending on their use of encoding strategies. ..
  28. ncbi request reprint Modulation of memory formation by stimulus content: specific role of the medial prefrontal cortex in the successful encoding of social pictures
    Philippe Olivier Harvey
    McGill University, Quebec, Canada
    J Cogn Neurosci 19:351-62. 2007
    ..The modulation of the mPFC by social information in a memory encoding context could be associated with the initiation of self-referential processes whose contribution is to enhance memory formation...
  29. ncbi request reprint Influence of emotional expression on memory recognition bias: a functional magnetic resonance imaging study
    Karine Sergerie
    Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 62:1126-33. 2007
    ..Here we investigated the behavioral and neural-related modulation of response bias by emotion...
  30. ncbi request reprint A process-specific functional dissociation of the amygdala in emotional memory
    Karine Sergerie
    McGill University, Montreal, Quebec, Canada
    J Cogn Neurosci 18:1359-67. 2006
    ..Thus, this study demonstrates a hemispheric dissociation of amygdala involvement in different stages of emotional memory in humans...
  31. doi request reprint From the brain to bad behaviour and back again: neurocognitive and psychobiological mechanisms of driving while impaired by alcohol
    Thomas G Brown
    Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Drug Alcohol Rev 28:406-18. 2009
    ..These shortcomings reflect the baffling heterogeneity in the DWI population and the limited focus of much existing DWI recidivism research to psychosocial, psychological and substance use correlates...
  32. pmc Relation between emotional face memory and social anhedonia in schizophrenia
    Philippe Olivier Harvey
    Douglas Mental Health University Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
    J Psychiatry Neurosci 34:102-10. 2009
    ..We explored potential links between emotional memory and social anhedonia severity in patients with schizophrenia and in healthy individuals...
  33. doi request reprint Impairment in verbal memory observed in first episode psychosis patients with persistent negative symptoms
    Cindy L Hovington
    Prevention and Early Intervention Program for Psychoses, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Schizophr Res 147:223-9. 2013
    ..All three-memory domains remained stable over time. Hence, in comparison to non-PNS patients, FEP patients with PNS appear to have greater (selective) verbal memory impairments throughout the first year of treatment...
  34. doi request reprint Memory for everyday actions in schizophrenia
    Mathieu B Brodeur
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada
    Schizophr Res 114:71-8. 2009
    ..However, the fact that their performance was reduced considerably during source recognition relative to healthy volunteers suggests that the beneficial effect provided by enactment was mostly implicit...
  35. doi request reprint Duration of untreated psychosis is associated with orbital-frontal grey matter volume reductions in first episode psychosis
    Ashok K Malla
    Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Montreal, Canada
    Schizophr Res 125:13-20. 2011
    ..Equivocal evidence exists regarding association between longer DUP and neuro-anatomical changes such as, reduced grey matter volume in specific regions in the brain and deficits in neurocognitive functions...
  36. ncbi request reprint Episodic memory impairment in Huntington's disease: a meta-analysis
    Alonso Montoya
    Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Canada
    Neuropsychologia 44:1984-94. 2006
    ..Only slight memory impairment was observed in the presymptomatic subjects. The results show that deficits in recognition memory must be accounted for in future models of memory impairment in HD...
  37. doi request reprint Structural neural correlates of impairments in social cognition in first episode psychosis
    Marie Claude Bertrand
    Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Soc Neurosci 3:79-88. 2008
    ..We concluded that structural abnormalities within the MSN may account for the social cognitive deficits present in some psychiatric disorders, such as schizophrenia...
  38. pmc Source retrieval is not properly differentiated from object retrieval in early schizophrenia: an fMRI study using virtual reality
    Colin Hawco
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Canada
    Neuroimage Clin 7:336-46. 2015
    ..Patients with schizophrenia have a deficit in the neural circuits which facilitate source memory, which may underlie both the deficits in this domain and be related to auditory hallucinations. ..
  39. pmc Identifying persistent negative symptoms in first episode psychosis
    Cindy L Hovington
    Prevention and Early Intervention Program for Psychoses, PEPP Montreal, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    BMC Psychiatry 12:224. 2012
    ..We also contrasted those definitions to the Proxy for the Deficit Syndrome (PDS) to identify deficit syndrome (DS) in the same FEP cohort...
  40. doi request reprint Diffusion tensor imaging tractography of the fornix and belief confidence in first-episode psychosis
    Lisa Buchy
    Brain Imaging Group, Douglas Mental Health University Institute, Canada
    Schizophr Res 137:80-4. 2012
    ....
  41. doi request reprint Cognitive markers of short-term clinical outcome in first-episode psychosis
    Michael Bodnar
    Douglas Mental Health University Institute, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Br J Psychiatry 193:297-304. 2008
    ..Symptomatic ratings at 1 or more years following initiation of treatment have been related to cognition in first-episode psychosis. However, the relationship between cognition and early outcome remains unclear...
  42. doi request reprint Disrupted integrity of the fornix in first-episode schizophrenia
    David Luck
    Brain Imaging Group, Douglas Mental Health University Institute, Verdun, Canada
    Schizophr Res 119:61-4. 2010
    ..No significant correlations were found between FA values and clinical and sociodemographic data in FES patients. These findings revealed slight alterations along the fornix in early stage of schizophrenia...
  43. doi request reprint Neural markers of early remission in first-episode schizophrenia: a volumetric neuroimaging study of the parahippocampus
    Michael Bodnar
    Douglas Mental Health University Institute, Montreal, Canada
    Psychiatry Res 201:40-7. 2012
    ..A smaller parahippocampal cortex may represent a neural marker in FES patients who do not achieve remission after 1 year of treatment...
  44. doi request reprint A 12-month outcome study of insight and symptom change in first-episode psychosis
    Lisa Buchy
    Brain Imaging Group, Douglas Mental Health University Institute, Verdun, Quebec, Canada
    Early Interv Psychiatry 4:79-88. 2010
    ..Secondly, in an exploratory analysis, we aimed to identify quantitatively distinct insight trajectory groups, and to describe the impact of psychopathology over time on the different trajectory groups...
  45. ncbi request reprint Cognitive and clinical moderators of recognition memory in schizophrenia: a meta-analysis
    Marc Pelletier
    Brain Imaging Group, Douglas Hospital Research Centre, 6875 Boul LaSalle, Verdun, Quebec, Canada H4H 1R3
    Schizophr Res 74:233-52. 2005
    ..Thus, a recognition memory deficit moderated by both cognitive and clinical variables is clearly present in schizophrenia...
  46. doi request reprint DUI offenders who delay relicensing: a quantitative and qualitative investigation
    Thomas G Brown
    Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Traffic Inj Prev 9:109-18. 2008
    ..This investigation compares the characteristics of DR offenders with those offenders who do not delay (NoDR). In addition, the rationales of DR offenders for delaying relicensing are explored qualitatively...
  47. ncbi request reprint Apomorphine effects on episodic memory in young healthy volunteers
    Alonso Montoya
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Verdun, Quebec, Canada
    Neuropsychologia 46:292-300. 2008
    ..We were interested in assessing whether apomorphine (Apo), a drug used extensively in clinical research as a probe of DA function, has an effect on episodic memory test performance in healthy volunteers...
  48. doi request reprint Neural activity related to self-initiating elaborative semantic encoding in associative memory
    Colin Hawco
    Douglas Mental Health University Institute, 6875 LaSalle Blvd, Montreal, Qubeec, Canada H4H 1R3
    Neuroimage 67:273-82. 2013
    ..We suggest that the DLPFC is the most likely candidate region for the self-initiation of elaborative encoding while the supramarginal activity is likely related to attentional effects...
  49. pmc Medial prefrontal cortex activity during memory encoding of pictures and its relation to symptomatic improvement after citalopram treatment in patients with major depression
    Martin Roy
    Douglas Mental Health University Institute, Montreal, Quebec, Canada
    J Psychiatry Neurosci 35:152-62. 2010
    ..In this study, we sought to identify brain regions whose activity, measured during the encoding of pictures, predicted symptomatic improvement after 8 weeks of citalopram treatment...
  50. doi request reprint Mammary cancer bone metastasis follow-up using multimodal small-animal MR and PET imaging
    Louis Doré-Savard
    Département de Physiologie et Biophysique, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Nucl Med 54:944-52. 2013
    ..Thus, the main purpose of this study was to longitudinally monitor bone tumor progression using PET/MR image coregistration to improve noninvasive imaging-assisted diagnoses...
  51. ncbi request reprint Episodic memory-related activation in schizophrenia: meta-analysis
    Amelie M Achim
    Brain Imaging Group, Douglas Hospital Research Centre FBCI, 6875 Boulevard LaSalle, Verdun, Quebec H4H 1R3, Canada
    Br J Psychiatry 187:500-9. 2005
    ..Numerous studies have examined the neural correlates of episodic memory deficits in schizophrenia, yielding both consistencies and discrepancies in the reported patterns of results...
  52. pmc North-American norms for name disagreement: pictorial stimuli naming discrepancies
    Mary O'Sullivan
    Department of Kinesiology, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e47802. 2012
    ..The sources of disagreement should be examined carefully as they help to provide an explanation of errors and inconsistencies of many concepts during picture naming tasks...
  53. ncbi request reprint A face to remember: emotional expression modulates prefrontal activity during memory formation
    Karine Sergerie
    Brain Imaging Group, Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    Neuroimage 24:580-5. 2005
    ..This study sheds new light on the current controversy regarding the hemispheric lateralization of PFC in memory encoding...
  54. ncbi request reprint Neurocognitive characteristics of DUI recidivists
    Marie Claude Ouimet
    Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Accid Anal Prev 39:743-50. 2007
    ..Development of a DUI-specific neurocognitive assessment and greater understanding of how neurocognitive status influences DUI risk could lead to remediation strategies better adapted to the individual characteristics of recidivists...
  55. pmc The effect of second-generation antipsychotics on hippocampal volume in first episode of psychosis: longitudinal study
    Michael Bodnar
    PhD, Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Montreal, Canada Department of Psychology, McGill University, Montreal, Canada
    BJPsych Open 2:139-146. 2016
    ..Current neuroscience literature has related treatment with aripiprazole to improved memory performance and subcellular changes in the hippocampus...
  56. doi request reprint Examining cortical thickness in male and female DWI offenders
    Katarina Dedovic
    Douglas Hospital Research Centre, Montreal, Canada Department of Psychology, University of California, Los Angeles, USA Electronic address
    Neurosci Lett 619:189-95. 2016
    ..Thus, for these male DWI drivers, interventions that could impact PCC could be most advantageous. Continued multidimensional sex analysis of the neural characteristics of male and female DWI offenders is warranted. ..
  57. doi request reprint Polygenic Risk Score associated with specific symptom dimensions in first-episode psychosis
    Sarojini M Sengupta
    Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada Department of Psychiatry, McGill University, Ludmer Research and Training Building, 1033 Pine Ave West, Montreal, Quebec H3A 1A1, Canada Electronic address
    Schizophr Res . 2016
    ..They also demonstrate that it is important to note the dynamic changes of symptoms over time when trying to refine the relationship between genetic factors and phenotypes...
  58. doi request reprint Preliminary studies on the role and reactions of tetrakis(hydroxymethyl)phosphonium chloride in polyacrylamide gel dosimeters
    Mahbod Sedaghat
    Centre d imagerie moléculaire de Sherbrooke, Departement de Medecine Nucleaire et Radiobiologie, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Phys Med Biol 57:5981-94. 2012
    ....
  59. pmc Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms
    Michael Bodnar
    Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Montreal, Canada Department of Psychology, McGill University, Montreal, Canada
    PLoS ONE 9:e101372. 2014
    ....
  60. doi request reprint Anxiety symptoms severity and short-term clinical outcome in first-episode psychosis
    Tina C Montreuil
    Prevention and Early Intervention Program for Psychoses PEPP Montréal, Montreal, Canada
    Early Interv Psychiatry 7:5-11. 2013
    ..A secondary objective explored the relation between the PANSS single item subscale 'anxiety' item and the total score value of the HARS...
  61. doi request reprint Investigating potential physicochemical errors in polymer gel dosimeters
    Mahbod Sedaghat
    Centre d imagerie moléculaire de Sherbrooke, Departement de Medecine Nucleaire et Radiobiologie, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Phys Med Biol 56:6083-107. 2011
    ..Data obtained by a set of small calibration vials are compared to those obtained from larger phantoms, and potential physicochemical causes of deviations between them are identified...
  62. pmc Impact of drug size on brain tumor and brain parenchyma delivery after a blood-brain barrier disruption
    Marie Blanchette
    Departement de Medecine Nucleaire et Radiobiologie, Centre d imagerie moléculaire de Sherbrooke, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Cereb Blood Flow Metab 34:820-6. 2014
    ..Our study clearly showed that the time window and the extent of delivery across the intact, as well as permeabilized BTB and BBB are influenced by drug size...
  63. doi request reprint TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis
    Ammar Albanna
    Department of Psychiatry, McGill University, Canada
    Schizophr Res 152:124-9. 2014
    ..However, its exact role in modulating the schizophrenia phenotype is not known...
  64. ncbi request reprint Dorsolateral prefrontal cortex involvement in memory post-retrieval monitoring revealed in both item and associative recognition tests
    Amelie M Achim
    Brain Imaging Group, Douglas Hospital Research Centre, Verdun, Quebec, Canada H4H 1R3
    Neuroimage 24:1113-21. 2005
    ..This study provides strong evidence that DLPFC activation supports post-retrieval monitoring across different types of recognition tasks...
  65. ncbi request reprint Neural correlates of memory for items and for associations: an event-related functional magnetic resonance imaging study
    Amelie M Achim
    McGill University and Douglas Hospital Research Centre, Quebec, Canada
    J Cogn Neurosci 17:652-67. 2005
    ....
  66. ncbi request reprint Decrease and increase in brain activity during visual perceptual priming: an fMRI study on similar but perceptually different complex visual scenes
    François Blondin
    Brain Imaging Group, Douglas Hospital Research Centre and Department of Psychiatry, McGill University, 6875 Boul LaSalle, Verdun, Que, Canada
    Neuropsychologia 43:1887-900. 2005
    ..In sum, priming effects can also occur for complex visual scenes that are intrinsically different from each other although similar in their composition...
  67. doi request reprint Cannabis use and anticipatory pleasure as reported by subjects with early psychosis and community controls
    Clifford M Cassidy
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Schizophr Res 137:39-44. 2012
    ..Individuals with low anticipatory pleasure may preferentially engage in behaviours associated with immediate reward such as cannabis use...
  68. doi request reprint Symmetry brings an impression of familiarity but does not improve recognition memory
    Mathieu B Brodeur
    Douglas Mental Health University Institute, Canada
    Acta Psychol (Amst) 137:359-70. 2011
    ..In conclusion, our results show that symmetry does not enhance mnemonic processes but instead induces a response bias leading individuals to judge such stimuli as having been seen...
  69. ncbi request reprint An fMRI study on memory discriminability for complex visual scenes
    François Blondin
    Brain Imaging Group, Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    Hum Brain Mapp 29:1159-69. 2008
    ..These activations were associated with a condition, in which the stimuli were more salient in memory and thus could represent the perceptual salience of items in memory...
  70. pmc On the functional significance of the P1 and N1 effects to illusory figures in the notch mode of presentation
    Mathieu Brodeur
    Department of Psychiatry, Douglas Mental Health McGill University Institute, Montreal, Quebec, Canada
    PLoS ONE 3:e3505. 2008
    ..Conversely, the fact that the N1 effect was also obtained with real figures indicates that this effect may be due to more global processes related to depth segmentation or surface/object perception...
  71. pmc Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis
    Clifford Cassidy
    Douglas Mental Health University Institute, Montreal, Que, Canada
    J Psychiatry Neurosci 39:31-9. 2014
    ..The brief illness duration of an FEP sample makes it well suited for studying the effects of genetic variation...
  72. ncbi request reprint Is associative recognition more impaired than item recognition memory in Schizophrenia? A meta-analysis
    Amelie M Achim
    Douglas Hospital Research Centre, McGill University, Montreal, Que, Canada
    Brain Cogn 53:121-4. 2003
    ..04) for associative recognition relative to item recognition. This study supports the hypothesis of a specific conscious recollection deficit underlying episodic memory impairment in schizophrenia...
  73. pmc The Bank of Standardized Stimuli (BOSS), a new set of 480 normative photos of objects to be used as visual stimuli in cognitive research
    Mathieu B Brodeur
    Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 5:e10773. 2010
    ..This set of objects, the Bank Of Standardized Stimuli (BOSS), was created specifically to meet the needs of scientists in cognition, vision and psycholinguistics who work with photo stimuli...
  74. doi request reprint Insight in first episode psychosis: who is measuring what?
    Constantin Tranulis
    Douglas Hospital Research Center, Montreal, Quebec, Canada
    Early Interv Psychiatry 2:34-41. 2008
    ..To compare different self-administered or clinician-rated insight scales in an FEP population...
  75. ncbi request reprint Benefits of enriched intervention compared with standard care for patients with recent-onset psychosis: a metaanalytic approach
    Philippe Olivier Harvey
    Prevention and Early Intervention Program for Psychoses, Douglas Mental Health University Institute, Montreal, Quebec
    Can J Psychiatry 52:464-72. 2007
    ..To assess the effectiveness of enriched intervention (EI) on symptomatic and functional outcomes, compared with standard care (SC)...
  76. pmc Brain imaging and cognitive dysfunctions in Huntington's disease
    Alonso Montoya
    Brain Imaging Group, Douglas Hospital Research Centre, McGill University, Montreal, Que
    J Psychiatry Neurosci 31:21-9. 2006
    ....
  77. doi request reprint Examining the effects of two factors on working memory maintenance of bound information in schizophrenia
    David Luck
    INSERM U 666, Physiopathologie Clinique et Expérimentale de la Schizophrénie, Departement de Psychiatrie, Hopital Civil, Strasbourg Cedex, France
    J Int Neuropsychol Soc 15:597-605. 2009
    ..Patients' ability to remember temporal occurrence of stimuli was not affected. Together, these results suggest that in patients with schizophrenia, binding processes in WM are not specifically disturbed...
  78. ncbi request reprint Assessment of single and bound features in a working memory task in schizophrenia
    David Luck
    INSERM U 666, Physiopathologie Clinique et Expérimentale de la Schizophrénie, Departement de Psychiatrie, Hopital Civil, 67091 Strasbourg Cedex, France
    Schizophr Res 100:153-60. 2008
    ..Thus, not all form of binding are disturbed in schizophrenia...
  79. doi request reprint Neurocognition and neuroimaging of persistent negative symptoms of schizophrenia
    Cindy L Hovington
    Douglas Mental Health University Institute, Frank B Common Pavilion, 6875 LaSalle Blvd, Verdun, Quebec, H4H 1R3, Canada
    Expert Rev Neurother 12:53-69. 2012
    ..Cognitive domains, such as memory, are impaired and appear to be predominantly related to PNS. Hence, PNS do appear to have neuroimaging and neurocognitive correlates and warrant further research...
  80. ncbi request reprint Neural correlates of 'functional' symptoms in neurology
    Alonso Montoya
    Brain Imaging Group, Research Centre, Douglas Hospital, McGill University, Montreal, Canada
    Funct Neurol 21:193-7. 2006
    ..Future studies, assessing patients at different phases of their illness and using newer techniques such as functional MRI, are needed to extend current findings on functional symptoms...
  81. ncbi request reprint Neural correlates of dual task interference in rapid visual streams: an fMRI study
    Walter S Marcantoni
    Centre Hospitalier de l Université de Montré al, Que, Montreal, Canada
    Brain Cogn 53:318-21. 2003
    ....
  82. ncbi request reprint Distributed self in episodic memory: neural correlates of successful retrieval of self-encoded positive and negative personality traits
    Philippe Fossati
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada M6A 2E1
    Neuroimage 22:1596-604. 2004
    ..Our results indicate that personally relevant words may signal important emotional clues and support the notion of a widely distributed set of brain regions involved in maintaining the concepts of self...
  83. ncbi request reprint Memory and schizophrenia
    Martin Lepage
    Can J Psychiatry 52:691-2. 2007
  84. ncbi request reprint Investigation and analysis of ferrous sulfate polyvinyl alcohol (PVA) gel dosimeter
    Brendan Hill
    Centre for Medical, Health and Environmental Physics, Queensland University of Technology, Brisbane, Queensland 4000, Australia
    Phys Med Biol 47:4233-46. 2002
    ..Fe(SO4)2 PVA gel with and without the addition of xylenol orange was demonstrated to have a G value of approximately 20 ions/100 eV and with sucrose approximately 24 ions/100 eV...
  85. pmc Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2310, USA
    Magn Reson Imaging 25:1-13. 2007
    ....
  86. ncbi request reprint Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model
    Thomas E Yankeelov
    Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232 2675, USA
    Magn Reson Imaging 23:519-29. 2005
    ..This allows for acquiring images with higher spatial resolution and/or SNR, and therefore, increased ability to probe tissue heterogeneity...
  87. ncbi request reprint [Neural correlates of the hedonic capacity: a marker of vulnerability for psychiatric diseases?]
    Philippe Olivier Harvey
    Med Sci (Paris) 23:1096-8. 2007