Timothy G Geary

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Progress and challenges in the discovery of macrofilaricidal drugs
    Timothy G Geary
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue QC, H9X 3V9, Canada
    Expert Rev Anti Infect Ther 9:681-95. 2011
  2. doi request reprint Haemonchus contortus: Applications in Drug Discovery
    T G Geary
    McGill University, Quebec, Canada Electronic address
    Adv Parasitol 93:429-63. 2016
  3. pmc A Step Toward Eradication of Human Filariases in Areas Where Loa Is Endemic
    Timothy G Geary
    Institute of Parasitology, McGill University, Ste Anne de Bellevue, QC, Canada
    MBio 7:e00456-16. 2016
  4. pmc First analysis of the secretome of the canine heartworm, Dirofilaria immitis
    James Geary
    Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Parasit Vectors 5:140. 2012
  5. doi request reprint Are new anthelmintics needed to eliminate human helminthiases?
    Timothy G Geary
    Institute of Parasitology, McGill University, Quebec, Canada
    Curr Opin Infect Dis 25:709-17. 2012
  6. doi request reprint Evidence for macrocyclic lactone anthelmintic resistance in Dirofilaria immitis
    Timothy G Geary
    Institute of Parasitology, McGill University, Ste Anne de Bellevue, QC, Canada
    Top Companion Anim Med 26:186-92. 2011
  7. doi request reprint A new approach for anthelmintic discovery for humans
    Timothy G Geary
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, QC H9X 3V9, Canada
    Trends Parasitol 28:176-81. 2012
  8. ncbi request reprint Macrocyclic lactone anthelmintics: spectrum of activity and mechanism of action
    Timothy G Geary
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, QC H9X 3V9, Canada
    Curr Pharm Biotechnol 13:866-72. 2012
  9. ncbi request reprint Nonpeptide ligands for peptidergic G protein-coupled receptors
    Timothy G Geary
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, QC, Canada
    Adv Exp Med Biol 692:10-26. 2010
  10. doi request reprint Unresolved issues in anthelmintic pharmacology for helminthiases of humans
    Timothy G Geary
    Institute of Parasitology, McGill University, Montreal, QC, Canada H9X 3V9
    Int J Parasitol 40:1-13. 2010

Collaborators

  • Teresa M Kubiak
  • R Prichard
  • John W McCall
  • Byron L Blagburn
  • Christian Epe
  • Andrew S Peregrine
  • Ronald Kaminsky
  • Armando Jardim
  • Mary M Stevenson
  • Joseph A Dent
  • Byung H Lee
  • John Horton
  • Joseph Kamgno
  • Claudia Kleinman
  • P L Olliaro
  • Gilles Fecteau
  • Catherine Bourguinat
  • Yovany Moreno
  • Maeghan O'Neill
  • Lucienne Tritten
  • Charles D Mackenzie
  • Cristina Ballesteros
  • Jianguo Xia
  • James Geary
  • Kathy Keller
  • Steven A Williams
  • Weam I Zaky
  • Guangyan Zhou
  • Andrew Moorhead
  • Erica Burkman
  • David P Thompson
  • Rajesh M Valanparambil
  • Rudolf Schenker
  • Vanessa Dufour
  • Mifong Tam
  • Mariela Segura
  • Elizabeth Ruiz-Lancheros
  • Anne E Schwab
  • Aaron G Maule
  • Utami DiCosty
  • Kevin L Blair
  • Scott Timmins
  • Scott D McCall
  • Tom McTier
  • Michael Dzimianski
  • Abdelmoneim Mansour
  • Damian Clarke
  • James Carmichael
  • Marc S Kraus
  • Jose Alberto Montoya-Alonso
  • Regina Lizundia
  • Louis Létourneau
  • Janice L Liotta
  • Alice C Y Lee
  • Tara Paterson
  • Elena Carreton Gomez
  • Dwight D Bowman
  • Jason Drake
  • Aron Bhan
  • Hubert Smith
  • Susan J Alexander-Bowman
  • Philip T LoVerde
  • Erich W Zinser
  • Jerry W Bowman
  • Claudia Wever
  • Robin N Beech
  • Doug Whitten
  • Nicole Madrill
  • Mohamed Satti
  • Charles Mackenzie
  • Dalen Agnew
  • Selwyn A Headley
  • Pierre Paul Gros
  • Tita N Walter
  • Charles Viau
  • Abdel Francis
  • Rajesh Valanparambil
  • Jonathan Solomon
  • Michel Boussinesq
  • Joseph F Nabhan
  • Paul Baillargeon
  • Andreas J Schwab
  • S Kevin Li
  • Norman F H Ho
  • John A Gerlach
  • Sharon K Mensch
  • Thomas J Vidmar
  • Chris Li
  • Eileen M Thomas
  • Angela Mousley

Detail Information

Publications39

  1. doi request reprint Progress and challenges in the discovery of macrofilaricidal drugs
    Timothy G Geary
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue QC, H9X 3V9, Canada
    Expert Rev Anti Infect Ther 9:681-95. 2011
    ..In particular, the lack of convenient, validated animal models in an antifilarial drug discovery pathway is an unresolved issue...
  2. doi request reprint Haemonchus contortus: Applications in Drug Discovery
    T G Geary
    McGill University, Quebec, Canada Electronic address
    Adv Parasitol 93:429-63. 2016
    ..This chapter summarizes the use of H. contortus for anthelmintic discovery, offers a perspective on current strategies in this area and suggests research challenges that could lead to improvements in the anthelmintic discovery process. ..
  3. pmc A Step Toward Eradication of Human Filariases in Areas Where Loa Is Endemic
    Timothy G Geary
    Institute of Parasitology, McGill University, Ste Anne de Bellevue, QC, Canada
    MBio 7:e00456-16. 2016
    ..loa microfilaria that can be detected in blood and urine and may form the basis for such an assay. Further work will reveal whether this discovery will smooth the path to achieve filariasis eradication...
  4. pmc First analysis of the secretome of the canine heartworm, Dirofilaria immitis
    James Geary
    Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Parasit Vectors 5:140. 2012
    ..Differences in protein secretion among nematodes in vivo may relate to the ecological niche of each parasite and the pathological changes that they induce...
  5. doi request reprint Are new anthelmintics needed to eliminate human helminthiases?
    Timothy G Geary
    Institute of Parasitology, McGill University, Quebec, Canada
    Curr Opin Infect Dis 25:709-17. 2012
    ..This review considers the attributes of anthelmintics that favor or limit attainment of the scaled-up plans for elimination, and highlights situations for which new or reformulated drugs may be needed...
  6. doi request reprint Evidence for macrocyclic lactone anthelmintic resistance in Dirofilaria immitis
    Timothy G Geary
    Institute of Parasitology, McGill University, Ste Anne de Bellevue, QC, Canada
    Top Companion Anim Med 26:186-92. 2011
    ....
  7. doi request reprint A new approach for anthelmintic discovery for humans
    Timothy G Geary
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, QC H9X 3V9, Canada
    Trends Parasitol 28:176-81. 2012
    ..Implementation of this strategy in biodiversity-rich but resource-constrained settings can help build sustainable local capacity for drug discovery...
  8. ncbi request reprint Macrocyclic lactone anthelmintics: spectrum of activity and mechanism of action
    Timothy G Geary
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, QC H9X 3V9, Canada
    Curr Pharm Biotechnol 13:866-72. 2012
    ..Studies on IVM in model organisms have contributed greatly to our understanding of ML pharmacology, but our understanding of the basis for differences among species and among MLs in potency and spectrum remains far from complete...
  9. ncbi request reprint Nonpeptide ligands for peptidergic G protein-coupled receptors
    Timothy G Geary
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, QC, Canada
    Adv Exp Med Biol 692:10-26. 2010
    ..A consideration of the knowledge gained from the process as conducted for mammalian peptidergic systems can inform and illuminate promising strategies for the discovery of new drugs for the treatment and control of pests and parasites...
  10. doi request reprint Unresolved issues in anthelmintic pharmacology for helminthiases of humans
    Timothy G Geary
    Institute of Parasitology, McGill University, Montreal, QC, Canada H9X 3V9
    Int J Parasitol 40:1-13. 2010
    ..Furthermore, a better understanding of their clinical pharmacology will enable improved therapy and could contribute to the discovery of new products...
  11. ncbi request reprint Ivermectin 20 years on: maturation of a wonder drug
    Timothy G Geary
    Leveraging and Scientific Liaison, Pfizer Animal Health, 300 412, 7000 Portage Road, Kalamazoo, MI 49001, USA
    Trends Parasitol 21:530-2. 2005
    ..Although much remains to be learned about how the drug works and how resistance to it will develop, it has earned the title of "wonder drug"...
  12. doi request reprint Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype
    Catherine Bourguinat
    Institute of Parasitology, McGill University, 21 111 Lakeshore Road, Sainte Anne de Bellevue, H9X3V9, Quebec, Canada
    Vet Parasitol 176:374-81. 2011
    ..Further studies are required to confirm ML resistance in heartworm populations. However, the genetic changes observed in this study may be useful as a marker to monitor for ML resistance in D. immitis...
  13. pmc Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi
    Yovany Moreno
    Institute of Parasitology, McGill University Macdonald Campus, Sainte Anne de Bellevue, Quebec, Canada H9X 3V9
    Proc Natl Acad Sci U S A 107:20120-5. 2010
    ..Under in vivo conditions, the rapid microfilarial clearance induced by IVM treatment is proposed to result from suppression of the ability of the parasite to secrete proteins that enable evasion of the host immune system...
  14. doi request reprint Genetic polymorphism in Dirofilaria immitis
    Catherine Bourguinat
    Institute of Parasitology, McGill University, 21 111 Lakeshore Road, Sainte Anne de Bellevue, H9X3V9 Quebec, Canada
    Vet Parasitol 176:368-73. 2011
    ..Differences in F coefficients were observed between the groups. D. immitis was found to be genetically heterogeneous. This genetic heterogeneity has implication for the development of genetically selected strains of the parasite...
  15. pmc Analysis of the mdr-1 gene in patients co-infected with Onchocerca volvulus and Loa loa who experienced a post-ivermectin serious adverse event
    Catherine Bourguinat
    Institute of Parasitology, McGill University, Sainte Anne de Bellevue, Quebec, Canada
    Am J Trop Med Hyg 83:28-32. 2010
    ..An association of high Loa mf load and a genetic predisposition to altered IVM distribution could be involved in IVM SAEs...
  16. pmc The Effects of Ivermectin on Brugia malayi Females In Vitro: A Transcriptomic Approach
    Cristina Ballesteros
    Institute of Parasitology, Centre for Host Parasite Interactions, McGill University, Sainte Anne de Bellevue, Quebec, Canada
    PLoS Negl Trop Dis 10:e0004929. 2016
    ..However, the mechanisms responsible for reduced production of microfilariae are poorly understood...
  17. doi request reprint Dirofilaria immitis exhibits sex- and stage-specific differences in excretory/secretory miRNA and protein profiles
    Lucienne Tritten
    Institute of Parasitology and Centre for Host Parasite Interactions, McGill University, 21, 111 Lakeshore Road, Sainte Anne de Bellevue, QC, H9X 3V9, Canada
    Vet Parasitol 232:1-7. 2016
    ..Exosomal proteins were well represented, dominated by cytoskeletal proteins, metabolic enzymes, zeta polypeptide, and chaperones...
  18. ncbi request reprint Structure-activity relationships of an inhibitory nematode FMRFamide-related peptide, SDPNFLRFamide (PF1), on Ascaris suum muscle
    Jerry W Bowman
    Pharmacia Animal Health, 7000 Portage Road, Kalamazoo, MI 49001 0199, USA
    Int J Parasitol 32:1765-71. 2002
    ..suum muscle membranes allowed the unambiguous conclusion that the N-terminal lysine is absolutely required for activation of the chloride channel and excludes interaction with the SDPNFLRFamide receptor...
  19. doi request reprint Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans
    Elizabeth Ruiz-Lancheros
    Institute of Parasitology, McGill University, Macdonald Campus, 21111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    Int J Parasitol 41:455-61. 2011
    ..The permeability properties of the C. elegans cuticle may be more restrictive than those of adult parasites, calling into question primary anthelmintic screening strategies that rely on this model organism...
  20. ncbi request reprint FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A.4 heterologously expressed in mammalian cells
    Teresa M Kubiak
    Animal Health Global Discovery Research, Pfizer Inc, Kalamazoo, MI 49007, USA
    Biopolymers 90:339-48. 2008
    ..The matching of the FLP-18 peptides with their receptor(s) allows for the evaluation of the pharmacology of this system in the worm in vivo...
  21. doi request reprint Production and analysis of immunomodulatory excretory-secretory products from the mouse gastrointestinal nematode Heligmosomoides polygyrus bakeri
    Rajesh M Valanparambil
    1 Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada 2 Department of Medicine, McGill University, Montreal, Quebec, Canada 3 Centre for Host Parasite Interactions, Institute of Parasitology, McGill University, Ste Anne de Bellevue, Quebec, Canada
    Nat Protoc 9:2740-54. 2014
    ..The protocol will be useful to investigators studying the host-parasite interface and identifying and analyzing helminth-derived molecules with therapeutic potential. ..
  22. ncbi request reprint Biophysical characterization of a large conductance anion channel in hypodermal membranes of the gastrointestinal nematode, Ascaris suum
    Kevin L Blair
    Pharmacia Corporation, Mailstop 7923 25 410, Kalamazoo, MI 49007 4940, USA
    Comp Biochem Physiol A Mol Integr Physiol 134:805-18. 2003
    ..suum hypodermal membranes provides a low energy pathway for organic anion excretion from the hypodermal compartment, followed by diffusion across the aqueous channels of the cuticle matrix...
  23. ncbi request reprint Development of antiparasitic drugs in the 21st century
    Timothy G Geary
    Pfizer Animal Health, 7000 Portage Road, Kalamazoo, MI 49001, USA
    Vet Parasitol 115:167-84. 2003
    ..Nonetheless, there are many new opportunities to expand the research horizons of veterinary parasitology to strengthen the case for retaining a significant presence in the animal health industry...
  24. pmc An In Vitro/In Vivo Model to Analyze the Effects of Flubendazole Exposure on Adult Female Brugia malayi
    Maeghan O'Neill
    Institute of Parasitology, McGill University, Ste Anne de Bellevue, Quebec, Canada
    PLoS Negl Trop Dis 10:e0004698. 2016
    ..Although FLBZ exposure clearly damaged the parasites, exposed worms recovered and were viable 8 weeks after treatment. ..
  25. pmc Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections
    Guangyan Zhou
    Institute of Parasitology, McGill University, Sainte Anne de Bellevue, Quebec, Canada
    PLoS Negl Trop Dis 10:e0004624. 2016
    ..To the best of our knowledge, this study is the first comprehensive meta-analysis of host transcriptome profiles during helminth infections. ..
  26. pmc Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni
    Vanessa Dufour
    Centre for Host Parasite Interactions, Institute of Parasitology, McGill University Macdonald Campus, Sainte Anne de Bellevue, Quebec, Canada
    PLoS Pathog 9:e1003586. 2013
    ..mansoni, an unprecedented finding in parasitic flatworms. Further work is needed to elucidate the roles of GluCl receptors in schistosomes and to explore their potential as drug targets...
  27. pmc Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products
    Yovany Moreno
    Institute of Parasitology, McGill University, Ste Anne de Bellevue, Quebec, Canada
    PLoS Negl Trop Dis 2:e326. 2008
    ..Little is known about the composition and variability of products released at different developmental stages and their contribution to parasite survival and progression of the infection...
  28. pmc Proteomic analysis of excretory-secretory products of Heligmosomoides polygyrus assessed with next-generation sequencing transcriptomic information
    Yovany Moreno
    Institute of Parasitology and Centre for Host Parasite Interactions, McGill University, Ste Anne de Bellevue, Quebec, Canada
    PLoS Negl Trop Dis 5:e1370. 2011
    ..polygyrus biology. In addition, the methods and analyses presented here are applicable to study biochemical and molecular aspects of the host-parasite relationship in species for which sequence information is not available...
  29. ncbi request reprint Neuropeptide G-protein-coupled receptors, their cognate ligands and behavior in Caenorhabditis elegans
    Timothy G Geary
    Pfizer Animal Health, Veterinary Medicine Pharmaceuticals Discovery Research, 7000 Portage Road, Kalamazoo, MI 49001, USA
    Trends Pharmacol Sci 26:56-8. 2005
    ..These studies suggest that these peptide GPCRs are legitimate targets for the discovery of novel anthelmintic agents...
  30. pmc Profiling the macrofilaricidal effects of flubendazole on adult female Brugia malayi using RNAseq
    Maeghan O'Neill
    Institute of Parasitology, Centre for Host Parasite Interactions, McGill University, 21, 111 Lakeshore Road, Sainte Anne de Bellevue, Quebec H9X 3V9, Canada
    Int J Parasitol Drugs Drug Resist 6:288-296. 2016
    ..These data support the hypothesis that FLBZ acts predominantly on rapidly dividing cells, and provides a basis for selecting molecular markers of drug-induced damage which may be of use in predicting efficacious FLBZ regimens...
  31. pmc Possible pathogenic pathways in the adverse clinical events seen following ivermectin administration to onchocerciasis patients
    Charles D Mackenzie
    Filarial Diseases Unit, Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA and Biological Imaging Center, Western Michigan University, Kalamazoo, MI 49008, USA
    Filaria J 2:S5. 2003
    ..However, the possibility of genetic predispositions to pathology should also be considered...
  32. doi request reprint Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance
    Catherine Bourguinat
    Institute of Parasitology, McGill University, 21111 Lakeshore Road, Sainte Anne de Bellevue, QC H9X 3V9, Canada
    Vet Parasitol 210:167-78. 2015
    ..These data provide unequivocal proof of ML resistance in D. immitis and identify genetic markers that could be used to monitor for ML resistance in heartworms. ..
  33. doi request reprint Association of BoLA DRB3 and DQA1 alleles with susceptibility to Neospora caninum and reproductive outcome in Quebec Holstein cattle
    Anne E Schwab
    Departement des Sciences Cliniques, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Vet Parasitol 165:136-40. 2009
    ..caninum. However, an association of allele DRB3*1001 and allele DRB3*2703 with resistance and susceptibility to pregnancy loss, irrespective of infection status, was identified...
  34. ncbi request reprint Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals
    Erich W Zinser
    Pharmacia Animal Health, Kalamazoo, MI 49001 0019, USA
    J Vet Pharmacol Ther 25:241-50. 2002
    ..the alpha7 CNS subtype. PHQ anthelmintics are nicotinic cholinergic antagonists in both nematodes and mammals, and this mechanism appears to underlie both their efficacy and toxicity...
  35. ncbi request reprint Marcfortine and paraherquamide class of anthelmintics: discovery of PNU-141962
    Byung H Lee
    Animal Health Discovery Research, Kalamazoo, MI 49001, USA
    Curr Top Med Chem 2:779-93. 2002
    ..This review describes the chemistry, efficacy and mode of action of PNU-141962...
  36. ncbi request reprint The changing landscape of antiparasitic drug discovery for veterinary medicine
    Timothy G Geary
    Trends Parasitol 20:449-55. 2004
    ..Novel drugs are needed to combat drug resistance and for currently non-addressed problems. At the center of the future for this field, however, lies the need for more support into the basic research on the biology of parasites...
  37. doi request reprint Drug discovery: fresh hope to can the worms
    Roger K Prichard
    Nature 452:157-8. 2008
  38. ncbi request reprint Molecular helminthology: an integrated approach
    Philip T LoVerde
    School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214, USA
    Am J Trop Med Hyg 66:346-7. 2002
  39. ncbi request reprint Neuropeptide signaling systems - potential drug targets for parasite and pest control
    Aaron G Maule
    Parasitology Research Group, School of Biology and Biochemistry, Queen s University Belfast, Belfast BT9 7BL, UK
    Curr Top Med Chem 2:733-58. 2002
    ..Moreover, there is now increasing evidence of cross-phyla activity for individual FaRPs, providing clear signals of opportunities for target selection and the identification and development of broad-spectrum drugs...