James C Engert

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc BRCA2 variants and cardiovascular disease in a multi-ethnic study
    Kevin Zbuk
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    BMC Med Genet 13:56. 2012
  2. ncbi request reprint Identification of a chromosome 8p locus for early-onset coronary heart disease in a French Canadian population
    James C Engert
    McGill University Health Centre, Montreal, Quebec, Canada
    Eur J Hum Genet 16:105-14. 2008
  3. doi request reprint Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Canada
    Circ Cardiovasc Genet 3:454-61. 2010
  4. doi request reprint K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Hum Mutat 29:689-94. 2008
  5. pmc Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects
    Zari Dastani
    Cardiovascular Genetics Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada
    Eur J Hum Genet 18:342-7. 2010
  6. pmc Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol
    Guillaume Pare
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Am J Hum Genet 80:673-82. 2007
  7. doi request reprint Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans
    Yohan Bosse
    Laval Hospital Research Center, Laval University, Pavillon Margeritte d Youville, Chemin Sainte Foy, Quebec, QC, Canada
    Hum Genet 125:305-18. 2009
  8. doi request reprint Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1147-50. 2008
  9. doi request reprint Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs
    Christine G St Germaine
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Am J Cardiol 105:1740-5. 2010
  10. ncbi request reprint Common polymorphisms in the promoter of the visfatin gene (PBEF1) influence plasma insulin levels in a French-Canadian population
    Swneke D Bailey
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada H3A 1A1
    Diabetes 55:2896-902. 2006

Collaborators

Detail Information

Publications25

  1. pmc BRCA2 variants and cardiovascular disease in a multi-ethnic study
    Kevin Zbuk
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    BMC Med Genet 13:56. 2012
    ..We therefore tested the association of BRCA2 variants with clinical cardiovascular disease (CVD)...
  2. ncbi request reprint Identification of a chromosome 8p locus for early-onset coronary heart disease in a French Canadian population
    James C Engert
    McGill University Health Centre, Montreal, Quebec, Canada
    Eur J Hum Genet 16:105-14. 2008
    ..In conclusion, a genome-wide scan and additional fine mapping provide evidence for a locus on chromosome 8 that contributes to CHD in a French Canadian population...
  3. doi request reprint Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Canada
    Circ Cardiovasc Genet 3:454-61. 2010
    ..Because INSIG2 plays an important role in cholesterol biosynthesis, we hypothesized that human INSIG2 variants might play a role in the regulation of plasma lipid and lipoprotein levels...
  4. doi request reprint K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Hum Mutat 29:689-94. 2008
    ..These results suggest that this coding variant in the squalene synthase gene influences plasma cholesterol levels, possibly by affecting the intracellular production of cholesterol...
  5. pmc Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects
    Zari Dastani
    Cardiovascular Genetics Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada
    Eur J Hum Genet 18:342-7. 2010
    ..Our data constitute additional evidence for a locus on chromosome 16q23-24 that affects HDL-C levels in two independent French-Canadian studies...
  6. pmc Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol
    Guillaume Pare
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Am J Hum Genet 80:673-82. 2007
    ..Using an independent validation sample of 806 individuals, we confirm the EDN1 association (P<.005), whereas the LCAT association was nonsignificant (P=.12)...
  7. doi request reprint Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans
    Yohan Bosse
    Laval Hospital Research Center, Laval University, Pavillon Margeritte d Youville, Chemin Sainte Foy, Quebec, QC, Canada
    Hum Genet 125:305-18. 2009
    ..The low cost associated with a pooling-based GWAS clearly justifies its use in screening for genetic determinants of complex diseases...
  8. doi request reprint Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1147-50. 2008
    ..The present study investigated the role of two FTO SNPs (rs17817449 and rs1421085) in adiposity, insulin sensitivity, and body weight regulation, including energy intake and expenditure...
  9. doi request reprint Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs
    Christine G St Germaine
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Am J Cardiol 105:1740-5. 2010
    ....
  10. ncbi request reprint Common polymorphisms in the promoter of the visfatin gene (PBEF1) influence plasma insulin levels in a French-Canadian population
    Swneke D Bailey
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada H3A 1A1
    Diabetes 55:2896-902. 2006
    ..002). These SNPs were also associated with fasting glucose (P <or= 0.02). In addition, a more distal SNP (rs7789066) was significantly associated with the apolipoprotein B component of VLDL (P = 0.012)...
  11. pmc Correction of population stratification in large multi-ethnic association studies
    David Serre
    Genome Quebec Innovation Centre, McGill University, Montreal, Quebec, Canada
    PLoS ONE 3:e1382. 2008
    ..Unfortunately such a recruitment strategy is likely to complicate the study design and to generate concerns regarding population stratification...
  12. pmc The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study
    Ron Do
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    PLoS Med 8:e1001106. 2011
    ..We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors...
  13. doi request reprint The genetics of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2, TCAP, and PLN
    Marika Hirtle-Lewis
    Department of Biology, McGill University, Montreal, Quebec, Canada The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Clin Cardiol 36:628-33. 2013
    ..The goal of this study was to identify mutations in genes associated with DCM in a Québec study sample including familial and nonfamilial DCM cases...
  14. doi request reprint Variation at the DPP4 locus influences apolipoprotein B levels in South Asians and exhibits heterogeneity in Europeans related to BMI
    Swneke D Bailey
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Diabetologia 57:738-45. 2014
    ..Genetic studies of lipid levels have focused on Europeans; a study in South Asians could identify novel genes...
  15. pmc Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol
    Zari Dastani
    Cardiovascular Research Laboratories, Division of Cardiology, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    BMC Med Genet 8:79. 2007
    ..In Niemann-Pick patients, SMPD1 gene defects are reported to be associated with a severe reduction in plasma high-density lipoprotein (HDL) cholesterol...
  16. pmc Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study
    Swneke D Bailey
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes Care 33:2250-3. 2010
    ..Thiazolidinediones are used to treat type 2 diabetes. Their use has been associated with peripheral edema and congestive heart failure-outcomes that may have a genetic etiology...
  17. ncbi request reprint Genetics of high-density lipoproteins
    Zari Dastani
    Cardiovascular Genetics Laboratory, Division of Cardiology, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec, Canada
    Curr Opin Cardiol 21:329-35. 2006
    ..The present review focuses on genetic aspects of high-density lipoprotein metabolism, with genomic approaches used to identify genes that regulate high-density lipoproteins in humans...
  18. pmc Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels
    Iulia Iatan
    Department of Biochemistry, Cardiovascular Research Laboratories, Cardiology Division, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec, Canada
    Circ Cardiovasc Genet 2:467-75. 2009
    ..We therefore investigated the effect of human PCSK5 genetic variants on plasma HDL-C levels...
  19. doi request reprint Association Between Family History, a Genetic Risk Score, and Severity of Coronary Artery Disease in Patients With Premature Acute Coronary Syndromes
    Waseem Hindieh
    From the Department of Medicine, McGill University, Montreal, Quebec, Canada W H, L P, C L, J C E, G T Department of Medicine, University of Toronto, Toronto, Ontario, Canada A C, H A L and McGill University Health Center Research Institute, Montreal, QC, Canada L D, J C E
    Arterioscler Thromb Vasc Biol 36:1286-92. 2016
    ..We sought to determine whether the presence of these risk factors, either individually or together, was associated with a higher burden of angiographic coronary artery disease...
  20. pmc Lipoprotein(a) Interactions With Low-Density Lipoprotein Cholesterol and Other Cardiovascular Risk Factors in Premature Acute Coronary Syndrome (ACS)
    Mehdi Afshar
    Department of Medicine, McGill University, Montreal, Quebec, Canada Preventive and Genomic Cardiology, McGill University Health Center and Research Institute, Montreal, Quebec, Canada
    J Am Heart Assoc 5:. 2016
    ..Identifying interactions between Lp(a) and other risk factors could identify individuals at increased risk for Lp(a)-mediated disease...
  21. ncbi request reprint Effect of apoC-III gene polymorphisms on the lipoprotein-lipid profile of viscerally obese men
    Charles Couillard
    Department of Food Sciences and Nutrition, Laval University, Sainte Foy, Quebec, Canada, G1K 7P4
    J Lipid Res 44:986-93. 2003
    ..Results of the present study support the notion of a hypertriglyceridemic effect associated with the apoC-III SstI polymorphism that could modulate the magnitude of the dyslipidemic state in abdominally obese patients...
  22. ncbi request reprint Evidence for a gene influencing high-density lipoprotein cholesterol on chromosome 4q31.21
    Zari Dastani
    Department of Medicine, McGill University, Montreal, Canada
    Arterioscler Thromb Vasc Biol 26:392-7. 2006
    ..To identify novel genes regulating plasma HDL-C levels, we investigated 13 multigenerational French Canadian families with an average of 12 affected individuals per family for genome-wide signals, which we subsequently fine mapped...
  23. pmc Utility of a genetic risk score to predict recurrent cardiovascular events 1 year after an acute coronary syndrome: A pooled analysis of the RISCA, PRAXY, and TRIUMPH cohorts
    Christopher Labos
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
    Atherosclerosis 242:261-7. 2015
    ..We sought to determine whether a GRS would predict early recurrent cardiovascular events within 1 year of ACS...
  24. ncbi request reprint 5' flanking variants of resistin are associated with obesity
    James C Engert
    Montreal Genome Centre, McGill University Health Centre Research Institute, Montreal, Canada
    Diabetes 51:1629-34. 2002
    ..In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples...
  25. doi request reprint NLRP7 in the spectrum of reproductive wastage: rare non-synonymous variants confer genetic susceptibility to recurrent reproductive wastage
    Christiane Messaed
    Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal, Quebec, Canada
    J Med Genet 48:540-8. 2011
    ....