Eva d'Hennezel

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    Rebecca S McHugh
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:311-23. 2002
  2. ncbi request reprint The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases
    G J Prud'homme
    Department of Pathology, McGill University, 3775 University St, Room B13, Montreal, Quebec, H3A 2B4, Canada
    J Autoimmun 14:23-42. 2000
  3. pmc CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence
    Ekaterina Yurchenko
    Department of Microbiology and Immunology, McGill University, Montreal, H3A 2B4, Canada
    J Exp Med 203:2451-60. 2006
  4. pmc IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease
    Eva d'Hennezel
    Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, H3A 2B4, QC, Quebec, Canada
    J Transl Med 8:113. 2010
  5. pmc Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo
    Ekaterina Yurchenko
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e35572. 2012
  6. pmc Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance
    Mara Kornete
    Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada
    Front Immunol 3:165. 2012
  7. pmc Distinct translational control in CD4+ T cell subsets
    Eva Bjur
    Department of Microbiology and Immunology, McGill University, Montreal, Canada
    PLoS Genet 9:e1003494. 2013
  8. pmc Immune Regulation in T1D and T2D: Prospective Role of Foxp3+ Treg Cells in Disease Pathogenesis and Treatment
    Mara Kornete
    Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada FOCIS Center of Excellence, Research Institute of the McGill University Health Center, Montreal, QC, Canada
    Front Endocrinol (Lausanne) 4:76. 2013
  9. doi request reprint Environmental sensing and regulation of gene expression in CD4+ T cell subsets
    Ciriaco A Piccirillo
    Department of Microbiology and Immunology, FOCIS Center of Excellence in Translational Immunology, Microbiome and Disease Tolerance Centre, McGill University and the Research Institute of the McGill University Health Centre, Montreal, QC, Canada H3G 1A4 Electronic address
    Curr Opin Immunol 25:564-70. 2013
  10. doi request reprint Regulatory T cells in health and disease
    Ciriaco A Piccirillo
    Department of Microbiology and Immunology, Center for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada
    Cytokine 43:395-401. 2008

Collaborators

Detail Information

Publications52

  1. ncbi request reprint CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    Rebecca S McHugh
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:311-23. 2002
    ..Importantly, antibodies to GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset...
  2. ncbi request reprint The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases
    G J Prud'homme
    Department of Pathology, McGill University, 3775 University St, Room B13, Montreal, Quebec, H3A 2B4, Canada
    J Autoimmun 14:23-42. 2000
    ....
  3. pmc CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence
    Ekaterina Yurchenko
    Department of Microbiology and Immunology, McGill University, Montreal, H3A 2B4, Canada
    J Exp Med 203:2451-60. 2006
    ..Thus, this study shows that CCR5 directs the homing of CD4+CD25+ nTreg cells to L. major-infected dermal sites where they promote the establishment of infection and long-term survival of the parasite in the immune host...
  4. pmc IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease
    Eva d'Hennezel
    Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, H3A 2B4, QC, Quebec, Canada
    J Transl Med 8:113. 2010
    ..We then move on to describe how this data can be translated to applications for human autoimmune diseases by using IL-2 as a therapeutic agent to restore Treg cell fitness, numbers and functions...
  5. pmc Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo
    Ekaterina Yurchenko
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e35572. 2012
    ..Overall, inflammatory signals modulate mTOR signalling and influence the stability of the Foxp3(+) nT(REG) cell phenotype...
  6. pmc Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance
    Mara Kornete
    Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada
    Front Immunol 3:165. 2012
    ..Finally, we will discuss the therapeutic potential of tolerogenic DCs for the induction of tolerance in autoimmune diseases...
  7. pmc Distinct translational control in CD4+ T cell subsets
    Eva Bjur
    Department of Microbiology and Immunology, McGill University, Montreal, Canada
    PLoS Genet 9:e1003494. 2013
    ..Unexpectedly, eIF4E also affects Foxp3 expression and thereby lineage identity. Thus, mRNA-specific translational control directs both common and distinct cellular processes in CD4(+) T cell subsets...
  8. pmc Immune Regulation in T1D and T2D: Prospective Role of Foxp3+ Treg Cells in Disease Pathogenesis and Treatment
    Mara Kornete
    Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada FOCIS Center of Excellence, Research Institute of the McGill University Health Center, Montreal, QC, Canada
    Front Endocrinol (Lausanne) 4:76. 2013
    ....
  9. doi request reprint Environmental sensing and regulation of gene expression in CD4+ T cell subsets
    Ciriaco A Piccirillo
    Department of Microbiology and Immunology, FOCIS Center of Excellence in Translational Immunology, Microbiome and Disease Tolerance Centre, McGill University and the Research Institute of the McGill University Health Centre, Montreal, QC, Canada H3G 1A4 Electronic address
    Curr Opin Immunol 25:564-70. 2013
    ..Recent studies show that distinct translational programs orchestrate cellular processes in various immune cell types, including CD4(+) T cell subsets. ..
  10. doi request reprint Regulatory T cells in health and disease
    Ciriaco A Piccirillo
    Department of Microbiology and Immunology, Center for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada
    Cytokine 43:395-401. 2008
    ....
  11. ncbi request reprint Control of type 1 autoimmune diabetes by naturally occurring CD4+CD25+ regulatory T lymphocytes in neonatal NOD mice
    C A Piccirillo
    Departments of Microbiology and Immunology, McGill University, 3775 University Street, Room 408, Lyman Duff Medical Building, Montreal, QC, Canada H3A 2B4
    Ann N Y Acad Sci 1051:72-87. 2005
    ..Thus, CD4(+)CD25(+) T cell-mediated regulation is operative in the prediabetic neonatal T cell repertoire and can suppress the diabetogenic process and control the onset of T1D...
  12. ncbi request reprint Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells
    Ciriaco A Piccirillo
    Host Resistance Laboratory, Department of Microbiology and Immunology, McGill University, Montreal, H3A 2B4, Canada
    Trends Immunol 25:374-80. 2004
  13. ncbi request reprint Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance
    Ciriaco A Piccirillo
    Department of Microbiology and Immunology, Host Resistance Laboratory, McGill University, Montreal, Que, Canada H3A 2B4
    Semin Immunol 16:81-8. 2004
    ..We propose the existence of two general subsets of CD4(+)CD25(+) Treg cells, naturally-occurring and induced, that differ in their origin, developmental and activation requirements, and mechanism of action...
  14. pmc Acquired Omenn-like syndrome, a novel posttransplant autoaggression syndrome reversed by rapamycin
    Donald C Vinh
    Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada
    Clin Vaccine Immunol 19:109-12. 2012
    ..We identified a profound FOXP3(+) regulatory T cell defect that coincided with hyperinflammatory T cell responses which were reversible with rapamycin in vitro...
  15. doi request reprint CD4+Foxp3+ regulatory T cells in the control of autoimmunity: in vivo veritas
    Ciriaco A Piccirillo
    Department of Microbiology and Immunology, and Center for the Study of Host Resistance, McGill University and the Research Institute of the McGill University Health Center, Montreal, QC, Canada H3A 2B4
    Curr Opin Immunol 20:655-62. 2008
    ..Here, we summarize research characterizing the functional dynamics of CD4+Foxp3+ Treg cells in the control of autoimmunity in rodents and humans...
  16. ncbi request reprint Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes
    Michael Tritt
    Department of Microbiology and Immunology, McGill Center for the Study of Host Resistance, McGill University, 3775 University St, Room 510, Lyman Duff Medical Building, Montreal, QC, Canada
    Diabetes 57:113-23. 2008
    ....
  17. doi request reprint Control of type 1 diabetes by CD4+Foxp3+ regulatory T cells: lessons from mouse models and implications for human disease
    Evridiki Sgouroudis
    Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada, H3A 2B4
    Diabetes Metab Res Rev 25:208-18. 2009
    ..Recent advances in the use of CD4(+)Foxp3(+) T(reg) cellular therapy to promote immunological tolerance in the absence of long-term generalized immunosuppression are also presented...
  18. ncbi request reprint Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice
    Evridiki Sgouroudis
    Department of Microbiology and Immunology, and McGill Center for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada
    J Immunol 181:6283-92. 2008
    ....
  19. doi request reprint IL-2 production by dendritic cells promotes Foxp3(+) regulatory T-cell expansion in autoimmune-resistant NOD congenic mice
    Evridiki Sgouroudis
    Departments of Microbiology and Immunology and Medicine, FOCIS Center of Excellence, McGill University and Research Institute of the McGill University Health Center, Montreal, Quebec, Canada
    Autoimmunity 44:406-14. 2011
    ..Our results show that Il2 gene variation may imprint DCs to favor T-cell regulation of autoimmunity...
  20. doi request reprint Single-cell analysis of the human T regulatory population uncovers functional heterogeneity and instability within FOXP3+ cells
    Eva d'Hennezel
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Immunol 186:6788-97. 2011
    ..These results open a path to an extensive study of the functional heterogeneity of CD4(+)CD25(High)FOXP3(+) T(reg) cells and warrant caution in the sole use of FOXP3 as a clinical marker for monitoring of immune regulation in humans...
  21. doi request reprint IL-2 contributes to maintaining a balance between CD4+Foxp3+ regulatory T cells and effector CD4+ T cells required for immune control of blood-stage malaria infection
    Floriana Berretta
    Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, H3G 1A4 Canada
    J Immunol 186:4862-71. 2011
    ..Collectively, these data demonstrate that the ability to control and eliminate P. chabaudi AS infection is due to a tight balance between natural Treg cells and effector CD4(+) Th1 cells, a balance regulated in part by IL-2...
  22. ncbi request reprint Cell line-dependent internalization pathways and intracellular trafficking determine transfection efficiency of nanoparticle vectors
    Kimberly L Douglas
    Department of Biomedical Engineering, McGill University, Montreal, Que, Canada
    Eur J Pharm Biopharm 68:676-87. 2008
    ....
  23. pmc Cardiolipin binds to CD1d and stimulates CD1d-restricted γδ T cells in the normal murine repertoire
    Mélanie Dieudé
    Division of Rheumatology, Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec H3G 1A4, Canada
    J Immunol 186:4771-81. 2011
    ..We propose that CL-responsive γδ T cells play a role in immune surveillance during infection and tissue injury...
  24. ncbi request reprint Ubiquitous expression of mRFP-1 in vivo by site-directed transgenesis
    Ekaterina Yurchenko
    Department of Microbiology and Immunology, McGill University, Montreal, H3A 2B4, Canada
    Transgenic Res 16:29-40. 2007
    ..In summary, our results demonstrate that a controlled strategy of transgenesis provides an effective means of ubiquitously expressing fluorescent proteins in vivo...
  25. doi request reprint Phenotypic characterization and functional analysis of human tumor immune infiltration after mechanical and enzymatic disaggregation
    Cécile Grange
    Research Center, Centre hospitalier de l Université de Montréal CRCHUM, Hopital Notre Dame, Université de Montréal and Institut du Cancer de Montréal, Montreal, Quebec, Canada
    J Immunol Methods 372:119-26. 2011
    ..In conclusion, mechanical tissue disaggregation by Medimachine™ appears to be optimal to maintain phenotypic and functional TIIC features...
  26. ncbi request reprint T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex
    Martin Giroux
    Institute of Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada
    J Immunol 179:4492-502. 2007
    ....
  27. pmc Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response
    Josie Ursini-Siegel
    Goodman Cancer Centre and Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    Cancer Res 70:7776-87. 2010
    ..We reveal a novel role for tumor cell-derived ShcA in the establishment and maintenance of an immunosuppressive state...
  28. doi request reprint ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice
    Mara Kornete
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Immunol 188:1064-74. 2012
    ..Overall, ICOS is critical for the homeostasis and functional stability of Foxp3(+) Tregs in prediabetic islets and maintenance of T1D protection...
  29. pmc Functional evaluation of the role of C-type lectin domain family 16A at the chromosome 16p13 locus
    H Zouk
    Endocrine Genetics Laboratory, McGill University Health Center, Montreal Children s Hospital Research Institute, McGill University, QC, Montreal, Canada Department of Human Genetics, McGill University, QC, Montreal, Canada
    Clin Exp Immunol 175:485-97. 2014
    ..In conclusion, CLEC16A may not be involved in T cell co-stimulation. Additional studies on CLEC16A, accounting for its ER localization, are needed to uncover its biological role. ..
  30. doi request reprint Altered T helper 17 responses in children with food allergy
    Khalid Bin Dhuban
    Department of Microbiology and Immunology and FOCIS Center of Excellence, McGill University and the Research Institute of the McGill University Health Center, Montreal, Que, Canada
    Int Arch Allergy Immunol 162:318-22. 2013
    ..While a central role for the T helper (Th) 1/Th2 axis in food allergy has been established, the Th17 response in food-allergic humans has not been addressed...
  31. doi request reprint The immunogenetics of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
    Eva d'Hennezel
    Department of Microbiologyand Immunology, McGill University, Montreal, Quebec, Canada
    J Med Genet 49:291-302. 2012
    ..In this review, the genetic, immunological and clinical characteristics of IPEX syndrome are described, and the impact of heritable mutations on the function of Treg cells highlighted...
  32. doi request reprint Functional plasticity in human FOXP3(+) regulatory T cells: implications for cell-based immunotherapy
    Eva d'Hennezel
    Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada
    Hum Vaccin Immunother 8:1001-5. 2012
    ....
  33. ncbi request reprint Immune modulation by plasmid DNA-mediated cytokine gene transfer
    Ciriaco A Piccirillo
    Department of Pathology, McGill University, Room B13, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada
    Curr Pharm Des 9:83-94. 2003
    ..Plasmid-based intramuscular gene transfer has great therapeutic potential in the areas of autoimmune and inflammatory disorders...
  34. doi request reprint Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives
    Jessica Godin-Ethier
    Research Centre, Centre hospitalier de l Université de Montréal CRCHUM, Hopital Notre Dame, Université de Montréal and Institut du Cancer de Montréal, Montreal, Quebec, Canada
    Clin Cancer Res 17:6985-91. 2011
    ..Consequently, IDO inhibition seems a promising approach for cancer immunotherapy...
  35. doi request reprint Critical co-stimulatory pathways in the stability of Foxp3+ Treg cell homeostasis in Type I diabetes
    Mara Kornete
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    Autoimmun Rev 11:104-11. 2011
    ..This review will focus on recent advances on the roles of B7 family members in regulating Treg cell development, function and homeostasis during tolerance induction and organ-specific autoimmunity...
  36. ncbi request reprint The TGF-beta1/Foxp3 regulatory axis in immune self-tolerance: implications for health and disease
    Michal Pyzik
    Department of Microbiology and Immunology and Strategic Training Centre in Infectious Diseases and Autoimmunity, McGill University, Montreal, QC, Canada, H3A 2B4
    Inflamm Allergy Drug Targets 5:167-77. 2006
    ..Thus, comprehension and delimitation of those processes predict the development of novel therapies for the treatment of infectious and autoimmune diseases, cancer and graft rejection...
  37. doi request reprint Analysis of human FOXP3+ Treg cells phenotype and function
    Eva d'Hennezel
    Center for the Study of Host Resistance, Montreal, QC, Canada
    Methods Mol Biol 707:199-218. 2011
    ..This approach enabled us to compare their phenotype and function at the single-cell level and to uncover the functional heterogeneity that exists among the CD4(+)FOXP3(+) T( Reg ) cell population in human PBMC...
  38. doi request reprint CD4+ Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation
    Ekaterina Yurchenko
    Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada
    Eur J Immunol 41:3455-66. 2011
    ..Thus, functional alterations in T(REG) cells provoke dysregulated CD4(+) and γδ T-cell responses to commensal antigens in the intestine...
  39. ncbi request reprint Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles
    Kimberly L Douglas
    Department of Biomedical Engineering, McGill University, 3775 University St, Montreal, QC, Canada H3A 2B4
    J Control Release 115:354-61. 2006
    ..Overall, alginate inclusion improved the vector properties of chitosan-based nanoparticles, demonstrating superior transfection ability while maintaining biocompatibility and low toxicity...
  40. ncbi request reprint TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets
    M Pyzik
    Department of Microbiology and Immunology and Strategic Training Centre in Infectious Diseases and Autoimmunity, McGill University, Montreal, Quebec, Canada
    J Leukoc Biol 82:335-46. 2007
    ....
  41. pmc CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
    Ciriaco A Piccirillo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    J Exp Med 196:237-46. 2002
    ..Collectively, these results demonstrate that CD4(+)CD25(+) suppressor function can occur independently of TGF-beta1...
  42. ncbi request reprint Control of T cell activation by CD4+CD25+ suppressor T cells
    Ethan M Shevach
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Novartis Found Symp 252:24-36; discussion 36-44, 106-14. 2003
    ..Multiple methods of manipulating both the numbers of CD4+CD25+ suppressor T cells and their activation status are now available and will rapidly be applied to therapy of autoimmune, infectious and malignant diseases...
  43. pmc Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    Qizhi Tang
    Department of Surgery, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, San Francisco, CA 94143 0540, USA
    Immunity 28:687-97. 2008
    ..Together, these results suggest intra-islet Treg cell dysfunction secondary to defective IL-2 production is a root cause of the progressive breakdown of self-tolerance and the development of diabetes in nonobese diabetic mice...
  44. ncbi request reprint Activation requirements for the induction of CD4+CD25+ T cell suppressor function
    Angela M Thornton
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 20892 1892, USA
    Eur J Immunol 34:366-76. 2004
    ..These studies support the view that activation of CD25(+) T cells requires IL-2/IL-4 for their survival/differentiation into effector cells, but is independent of CD28/CTLA-4-mediated costimulation...
  45. ncbi request reprint The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells
    Matthias Hesse
    Laboratories of Parasitic Diseases and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:3157-66. 2004
    ..Thus, innate effectors and regulatory T cells producing IL-10 cooperate to reduce morbidity and prolong survival in schistosomiasis...
  46. ncbi request reprint Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function
    Angela M Thornton
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:6519-23. 2004
    ....
  47. pmc CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells
    Paul A Antony
    Division of Surgery, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2591-601. 2005
    ..These findings reveal that Th cells can help break tolerance to a persisting self-Ag and treat established tumors through an IL-2-dependent mechanism, but requires simultaneous absence of naturally occurring T(reg) cells to be effective...
  48. pmc Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C
    Tobias Manigold
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 107:4424-32. 2006
    ..This result suggests that HCV infection alters the population of Foxp3(+)CD4(+)CD25(+) T(Reg) cells...
  49. ncbi request reprint Gene therapy with plasmids encoding cytokine- or cytokine receptor--IgG chimeric proteins
    Ciriaco A Piccirillo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 215:153-70. 2003
  50. ncbi request reprint CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:502-7. 2002
    ....
  51. ncbi request reprint TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation
    Marika C Kullberg
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 35:2886-95. 2005
    ....
  52. ncbi request reprint Functional dynamics of naturally occurring regulatory T cells in health and autoimmunity
    Megan K Levings
    Department of Surgery, University of British Columbia and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver V6H 3Z6, Canada
    Adv Immunol 92:119-55. 2006
    ....