- Role of epigenetics in cancer initiation and progressionFlora Chik
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
Adv Exp Med Biol 720:91-104. 2011..Last but not least, with therapeutics intervention in mind, we will highlight the importance of balance in the design of epigenetic based anti-cancer therapeutic strategies...
- Synergistic anti-breast cancer effect of a combined treatment with the methyl donor S-adenosyl methionine and the DNA methylation inhibitor 5-aza-2'-deoxycytidineFlora Chik
Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6, Canada and
Carcinogenesis 35:138-44. 2014..Combination of drugs acting on the DNA methylation machinery at different levels is proposed as a new strategy for epigenetic therapy of cancer. ..
- Pharmacological methyl group donors block skeletal metastasis in vitro and in vivoNicholas Shukeir
Department of Medicine, McGill University Health Center, Montreal, QC, Canada
Br J Pharmacol 172:2769-81. 2015..In the present study, we examined whether methyl supplementation with the universal methyl donor S-adenosylmethionine (SAM) inhibits prostate cancer associated skeletal metastasis...
- Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitorsFlora Chik
Department of Pharmacology and Therapeutics, McGill University Medical School, Montreal, Quebec, Canada
Carcinogenesis 32:224-32. 2011..These data have implications on the design of new DNA methyltransferase inhibitor and on the proper utilization of current inhibitors...