Francois Lamontagne

Summary

Country: Canada

Publications

  1. doi request reprint Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial
    Francois Lamontagne
    Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Intensive Care Med 42:542-50. 2016
  2. pmc Publication bias in animal research: a systematic review protocol
    Matthias Briel
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    Syst Rev 2:23. 2013
  3. doi request reprint Corticosteroid use in the intensive care unit: a survey of intensivists
    Francois Lamontagne
    Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Can J Anaesth 60:652-9. 2013
  4. doi request reprint Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: a meta-analysis of randomized controlled trials
    Francois Lamontagne
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 25:420-35. 2010
  5. doi request reprint Systematic review of reviews including animal studies addressing therapeutic interventions for sepsis
    Francois Lamontagne
    Clinical Research Centre Étienne Le Bel and Department of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Crit Care Med 38:2401-8. 2010
  6. doi request reprint Vasopressor administration and sepsis: a survey of Canadian intensivists
    Francois Lamontagne
    Centre de Recherche Clinique Étienne Le Bel and Department of Medicine, Universite de Sherbrooke, Sherbrooke, Canada
    J Crit Care 26:532.e1-7. 2011
  7. doi request reprint Clinical outcomes, predictors, and prevalence of anterior pituitary disorders following traumatic brain injury: a systematic review
    Francois Lauzier
    1Centre de recherche du CHU de Québec, Santé des populations et pratiques optimales en santé, Universite Laval, Quebec, QC, Canada 2Division of Critical Care, Department of Anesthesiology, Universite Laval, Quebec, QC, Canada 3Department of Medicine, Universite Laval, Quebec, QC, Canada 4Department of Family Medicine and Emergency Medicine, Universite Laval, Quebec, QC, Canada 5Centre de recherche du CSSS Alphonse Desjardins CHAU de Lévis, Levis, QC, Canada 6Centre de Recherche Clinique Étienne Le Bel, Universite de Sherbrooke, Sherbrooke, QC, Canada 7Department of Social and Preventive Medicine, Universite Laval, Quebec, QC, Canada 8Hôpital du Sacré Coeur de Montréal Research Center, Department of Medicine, Universite de Montreal, Montreal, QC, Canada 9Hôpital du Sacré Coeur de Montréal Research Center, Department of Critical Care Medicine, Universite de Montreal, Montreal, QC, Canada 10 Centre de Recherche du CHU de Québec, Endocrinology and Nephrology, Universite Laval, Quebec, QC,
    Crit Care Med 42:712-21. 2014
  8. pmc The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness
    Jesse W Delaney
    Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada
    Crit Care 20:75. 2016
  9. doi request reprint Consent in critical care trials: a survey of Canadian research ethics boards and critical care researchers
    Mark Duffett
    McMaster Children s Hospital, Hamilton, Ontario, Canada
    J Crit Care 26:533.e11-22. 2011
  10. pmc Pathogens and antimicrobial susceptibility profiles in critically ill patients with bloodstream infections: a descriptive study
    Rachel D Savage
    Dalla Lana School of Public Health Savage, University of Toronto Sunnybrook Health Sciences Centre Savage, Fowler, Rishu, Daneman, Toronto, Ont Division of Critical Care Medicine Fowler, Department of Medicine Institute of Health Policy, Management and Evaluation Fowler, Daneman, University of Toronto, Toronto, Ont Division of Critical Care Medicine Bagshaw, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta Departments of Medicine and Clinical Epidemiology and Biostatistics Cook, McMaster University, Hamilton, Ont Division of Critical Care Medicine Dodek, Reynolds, Department of Medicine, University of British Columbia Center for Health Evaluation and Outcome Sciences Dodek, St Paul s Hospital, Vancouver, BC Department of Critical Care Medicine Hall, Faculty of Medicine, Dalhousie University Nova Scotia Health Authority Hall, Halifax, NS Section of Critical Care Medicine Kumar, Department of Medicine Departments of Medical Microbiology and of Pharmacology and Therapeutics Kumar, University of Manitoba, Winnipeg, Man Centre de recherche du Centre hospitalier universitaire de Sherbrooke Lamontagne, Sherbrooke, Que Service de médecine interne Lamontagne, Departement de Medecine, Universite de Sherbrooke, Sherbrooke, Que Axe Santé des populations et pratiques optimales en santé Lauzier, Germany
    CMAJ Open 4:E569-E577. 2016

Detail Information

Publications37

  1. doi request reprint Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial
    Francois Lamontagne
    Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Intensive Care Med 42:542-50. 2016
    ..We conducted the Optimal Vasopressor Titration (OVATION) pilot trial to inform the design of a larger trial examining the effect of lower versus higher mean arterial pressure (MAP) targets for vasopressor therapy in shock...
  2. pmc Publication bias in animal research: a systematic review protocol
    Matthias Briel
    Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
    Syst Rev 2:23. 2013
    ..We aim to comprehensively summarize and update the evidence base on systematic reviews and meta-analyses of animal studies, their methodological quality and assessment of publication bias in particular...
  3. doi request reprint Corticosteroid use in the intensive care unit: a survey of intensivists
    Francois Lamontagne
    Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Can J Anaesth 60:652-9. 2013
    ..The efficacy of systemic corticosteroids in many critical illnesses remains uncertain. Our primary objective was to survey intensivists in North America about their perceived use of corticosteroids in clinical practice...
  4. doi request reprint Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: a meta-analysis of randomized controlled trials
    Francois Lamontagne
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 25:420-35. 2010
    ..We sought to determine whether systemic corticosteroids reduce hospital mortality from these illnesses...
  5. doi request reprint Systematic review of reviews including animal studies addressing therapeutic interventions for sepsis
    Francois Lamontagne
    Clinical Research Centre Étienne Le Bel and Department of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Crit Care Med 38:2401-8. 2010
    ..We assessed literature reviews of therapeutic interventions for sepsis that include animal experiments for explicit appraisals of the risk of bias and clinical relevance...
  6. doi request reprint Vasopressor administration and sepsis: a survey of Canadian intensivists
    Francois Lamontagne
    Centre de Recherche Clinique Étienne Le Bel and Department of Medicine, Universite de Sherbrooke, Sherbrooke, Canada
    J Crit Care 26:532.e1-7. 2011
    ..We surveyed Canadian intensivists to document self-reported vasopressor titration strategies for patients with septic shock...
  7. doi request reprint Clinical outcomes, predictors, and prevalence of anterior pituitary disorders following traumatic brain injury: a systematic review
    Francois Lauzier
    1Centre de recherche du CHU de Québec, Santé des populations et pratiques optimales en santé, Universite Laval, Quebec, QC, Canada 2Division of Critical Care, Department of Anesthesiology, Universite Laval, Quebec, QC, Canada 3Department of Medicine, Universite Laval, Quebec, QC, Canada 4Department of Family Medicine and Emergency Medicine, Universite Laval, Quebec, QC, Canada 5Centre de recherche du CSSS Alphonse Desjardins CHAU de Lévis, Levis, QC, Canada 6Centre de Recherche Clinique Étienne Le Bel, Universite de Sherbrooke, Sherbrooke, QC, Canada 7Department of Social and Preventive Medicine, Universite Laval, Quebec, QC, Canada 8Hôpital du Sacré Coeur de Montréal Research Center, Department of Medicine, Universite de Montreal, Montreal, QC, Canada 9Hôpital du Sacré Coeur de Montréal Research Center, Department of Critical Care Medicine, Universite de Montreal, Montreal, QC, Canada 10 Centre de Recherche du CHU de Québec, Endocrinology and Nephrology, Universite Laval, Quebec, QC,
    Crit Care Med 42:712-21. 2014
    ..To assess the clinical outcomes, predictors, and prevalence of anterior pituitary disorders following traumatic brain injury...
  8. pmc The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness
    Jesse W Delaney
    Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada
    Crit Care 20:75. 2016
    ..Our objective was to describe the use of corticosteroids in these patients and investigate predictors of steroid prescription and clinical outcomes, adjusting for both baseline and time-dependent factors...
  9. doi request reprint Consent in critical care trials: a survey of Canadian research ethics boards and critical care researchers
    Mark Duffett
    McMaster Children s Hospital, Hamilton, Ontario, Canada
    J Crit Care 26:533.e11-22. 2011
    ..We compared the attitudes and beliefs of Canadian research ethics boards (REBs) and intensive care unit researchers toward the use of various consent models for a low-risk randomized controlled trial...
  10. pmc Pathogens and antimicrobial susceptibility profiles in critically ill patients with bloodstream infections: a descriptive study
    Rachel D Savage
    Dalla Lana School of Public Health Savage, University of Toronto Sunnybrook Health Sciences Centre Savage, Fowler, Rishu, Daneman, Toronto, Ont Division of Critical Care Medicine Fowler, Department of Medicine Institute of Health Policy, Management and Evaluation Fowler, Daneman, University of Toronto, Toronto, Ont Division of Critical Care Medicine Bagshaw, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta Departments of Medicine and Clinical Epidemiology and Biostatistics Cook, McMaster University, Hamilton, Ont Division of Critical Care Medicine Dodek, Reynolds, Department of Medicine, University of British Columbia Center for Health Evaluation and Outcome Sciences Dodek, St Paul s Hospital, Vancouver, BC Department of Critical Care Medicine Hall, Faculty of Medicine, Dalhousie University Nova Scotia Health Authority Hall, Halifax, NS Section of Critical Care Medicine Kumar, Department of Medicine Departments of Medical Microbiology and of Pharmacology and Therapeutics Kumar, University of Manitoba, Winnipeg, Man Centre de recherche du Centre hospitalier universitaire de Sherbrooke Lamontagne, Sherbrooke, Que Service de médecine interne Lamontagne, Departement de Medecine, Universite de Sherbrooke, Sherbrooke, Que Axe Santé des populations et pratiques optimales en santé Lauzier, Germany
    CMAJ Open 4:E569-E577. 2016
    ..Collating and reporting routine data on clinical isolate testing may offer more timely information about resistance patterns than traditional surveillance network methods...
  11. doi request reprint Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients
    Nick Daneman
    1Division of Infectious Diseases, Department of Medicine and Clinical Epidemiology, Sunnybrook Health Sciences Centre, University of Toronto and Adjunct Scientist, Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 2Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 3Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada 4Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St Paul s Hospital and University of British Columbia, Vancouver, BC, Canada 5Department of Critical Care Medicine, Dalhousie University and the Capital District, Health Authority, Halifax, NS, Canada 6Sections of Critical Care Medicine and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada 7Department of Medicine, Centre de recherche du CHU de Sherbrooke, Universite de Sherbrooke, Sherbrooke, QC, Canada 8Centre de recherche du CHU de Québec, Axe Santé des populations et pratiques optimales en santé, Division de soins intensifs adultes, départements de médecine et d anesthésiologie, Universite Laval, Quebec, QC, Canada 9Departments of Surgery and Critical Care Medicine
    Crit Care Med 44:256-64. 2016
    ....
  12. pmc The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study
    Rachel D Savage
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 11:e0154944. 2016
    ..Further research is warranted to improve early diagnostic and risk prediction methods in candidemic patients. ..
  13. doi request reprint Quality of reporting of surveys in critical care journals: a methodologic review
    Mark Duffett
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 40:441-9. 2012
    ..Adequate reporting is needed to judge methodologic quality and assess the risk of bias of surveys. The objective of this study is to describe the methodology and quality of reporting of surveys published in five critical care journals...
  14. doi request reprint High-frequency oscillation in early acute respiratory distress syndrome
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada
    N Engl J Med 368:795-805. 2013
    ....
  15. doi request reprint Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*
    Wendy Lim
    1Department of Medicine, McMaster University, Hamilton, ON, Canada 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada 3Research Center of the CHU de Québec, Population Health and Optimal Health Practices Research Unit, Quebec, QC, Canada 4Division of Critical Care, Department of Medicine, Quebec, QC, Canada 5Section of Critical Care, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada 6Section of Hematology Medical Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada 7Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada 8Division of Critical Care, Department of Medicine, Centre de Recherche Clinique Étiene Le Bel, Universite de Sherbrooke, Sherbrooke, QC, Canada 9Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St Paul s Hospital and University of British Columbia, Vancouver, BC, Canada 10Department of Critical Care, University of Ottawa, Ottawa, ON, Canada 11Department of Anesthesia, Queen Elizabeth II Health Sciences Centre, 12Department of Critical Care, University of Michigan
    Crit Care Med 43:401-10. 2015
    ..To identify risk factors for failure of anticoagulant thromboprophylaxis in critically ill patients in the ICU...
  16. doi request reprint Nonleg venous thrombosis in critically ill adults: a nested prospective cohort study
    Francois Lamontagne
    Centre de Recherche Clinique Etienne Le Bel, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    JAMA Intern Med 174:689-96. 2014
    ..The risk of nonleg deep venous thromboses (NLDVTs), predisposing factors, and the association between NLDVTs and pulmonary embolism (PE) or death are unclear...
  17. pmc Competing Risk Analysis for Evaluation of Dalteparin Versus Unfractionated Heparin for Venous Thromboembolism in Medical-Surgical Critically Ill Patients
    Guowei Li
    From the Department of Clinical Epidemiology and Biostatistics GL, DC, MAHL, GG, MC, DHA, AH, SDW, LT Department of Medicine DC, MAHL, GG, AH St Joseph s Healthcare Hamilton, McMaster University, Hamilton, ON DC, MAHL, MC, AH, LT Centre de recherche du CHU de Sherbrooke et Université de Sherbrooke, Sherbrooke, QC FL Interdepartmental Division of Critical Care Medicine, Departments of Medicine and Physiology, and Institute for Health Policy, Management and Evaluation, University of Toronto NDF Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital NDF Toronto General Research Institute, Toronto, ON, Canada NDF Critical Care and Trauma Division, The George Institute, Sydney, Australia SF King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia YMA Australian and New Zealand Intensive Care Research Centre RB, DC School of Public Health and Preventive Medicine, Monash University, Melbourne, Germany
    Medicine (Baltimore) 94:e1479. 2015
    ..The findings from the competing risk method are in accordance with results from the cause-specific analysis.clinicaltrials.gov Identifier: NCT00182143...
  18. doi request reprint Nonbeneficial treatment Canada: definitions, causes, and potential solutions from the perspective of healthcare practitioners*
    James Downar
    1Divisions of Critical Care and Palliative Care, Department of Medicine, University of Toronto, Toronto, ON, Canada 2Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada 3Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AL 4Division of Critical Care, Department of Medicine, University of Toronto, Toronto, ON, Canada 5Centre de Recherche Étienne Le Bel, Universite de Sherbrooke, Sherbrooke, QC, Canada 6Interdepartmental Division of Critical Care, University of Toronto, and Keenan Research Centre and the Li KaShing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada 7Department of Emergency Medicine and Critical Care, Lakeridge Health, Oshawa, ON, Canada 8Departments of Surgery and Critical Care Medicine, Faculty of Medicine and Dentistry, University of Ottawa, Ottawa, ON, Canada 9Department of Medicine, McMaster University, Hamilton, ON, Canada 10Division of Critical Care, Department of Anesthesiology, Universite Laval, Quebec, QC, Canada 11Research Center of the Centre Hospitalier Universitaire CHU de Québec, Axe Sante des Populations Pratiques Optimales en Sante
    Crit Care Med 43:270-81. 2015
    ....
  19. pmc Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial
    Nick Daneman
    Division of Infectious Diseases and Clinical Epidemiology, Sunnybrook Health Sciences Centre, University of Toronto and Adjunct Scientist, Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5, Canada
    Trials 16:173. 2015
    ..Bacteremia is a leading cause of mortality and morbidity in critically ill adults. No previous randomized controlled trials have directly compared shorter versus longer durations of antimicrobial treatment in these patients...
  20. pmc Vasopressor Use for Severe Hypotension-A Multicentre Prospective Observational Study
    Francois Lamontagne
    Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS ONE 12:e0167840. 2017
    ..Our aim was to measure MAP values during vasopressor therapy in Canadian intensive care units (ICUs) and to compare these with stated practices and guidelines...
  21. doi request reprint Blood pressure targets for vasopressor therapy: a systematic review
    Frédérick D'Aragon
    Department of Anaesthesia, Division of Critical Care, McMaster University and Departments of Medicine, and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario Centre Hospitalier Universitaire de Québec Research Center, Population Health and Optimal Health Practices, Division of Critical Care Medicine, Department of Anesthesiology, Department of Medicine, Universite Laval, Quebec, Québec and Department of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland Department of Anesthesiology, University of Ottawa, and Department of Pharmacy, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada Département de Réanimation Médicale et de Médecine Hyperbare, Centre Hospitalier Universitaire Angers, Angers, France Centre Hospitalier Universitaire de Québec Research Center, Population Health and Optimal Health Practices, Division of Critical Care Medicine, Department of Anesthesiology, Universite Laval, Quebec, Quebec Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton and Li Ka Shing Knowledge Institute, St Michaels Hospital, University of Toronto, Toronto, Ontario and Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Département de Médicine, Rutgers University
    Shock 43:530-9. 2015
    ..Further rigorous research is needed to establish an evidence base for vasopressor administration in this population. ..
  22. doi request reprint The occurrence and impact of bacterial organisms complicating critical care illness associated with 2009 influenza A(H1N1) infection
    John Muscedere
    Department of Medicine, Queen s University, Kingston, ON, Canada
    Chest 144:39-47. 2013
    ....
  23. pmc Implementation and Evaluation of a Wiki Involving Multiple Stakeholders Including Patients in the Promotion of Best Practices in Trauma Care: The WikiTrauma Interrupted Time Series Protocol
    Patrick M Archambault
    Département de Médecine Familiale et Médecine d Urgence, Universite Laval, Quebec, QC, Canada
    JMIR Res Protoc 4:e21. 2015
    ....
  24. pmc Early mobilization of critically ill adults: a survey of knowledge, perceptions and practices of Canadian physicians and physiotherapists
    Karen K Y Koo
    Department of Medicine Koo, Western University, London, Ont Department of Pediatrics Choong Department of Medicine Choong, Cook, Guyatt, Meade Department of Clinical Epidemiology and Biostatistics Choong, Cook, Guyatt, Meade, McMaster University, Hamilton, Ont Department of Medicine Herridge, Burns, University of Toronto Hamilton General Hospital Newman, Meade, Hamilton, Ont University Health Network Lo, Toronto General Hospital, Toronto, Ont Centre de recherche du Centre hospitalier universitaire de Sherbrooke and Université de Sherbrooke Lamontagne, Sherbrooke, Que Swedish Medical Group Koo, Priestap, Campbell, Seattle, Wash
    CMAJ Open 4:E448-E454. 2016
    ..We carried out a survey to assess current knowledge, perceptions and practices of Canadian physicians and physiotherapists with respect to acquired weakness and early mobilization in adults in the intensive care unit (ICU)...
  25. doi request reprint Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA 303:865-73. 2010
    ....
  26. ncbi request reprint A framework for resolving disagreement during end of life care in the critical care unit
    Karen Choong
    Department of Pediatrics and Critical Care, McMaster Children s Hospital, McMaster University, Hamilton, Ontario
    Clin Invest Med 33:E240-53. 2010
    ..Such disagreements can cause tension and moral distress among families and clinicians...
  27. pmc Inconsistent definitions for intention-to-treat in relation to missing outcome data: systematic review of the methods literature
    Mohamad Alshurafa
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    PLoS ONE 7:e49163. 2012
    ....
  28. doi request reprint Corticosteroids as adjunctive therapy in severe blastomycosis-induced acute respiratory distress syndrome in an immunosuppressed patient
    Mireille Plamondon
    Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, Canada
    Clin Infect Dis 51:e1-3. 2010
    ....
  29. doi request reprint Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury
    Ron Wald
    Division of Nephrology, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    Kidney Int 88:897-904. 2015
    ..No safety signal was evident in either arm. Our findings can inform the design of a large-scale effectiveness randomized control trial...
  30. pmc What really matters in end-of-life discussions? Perspectives of patients in hospital with serious illness and their families
    John J You
    Departments of Medicine, Clinical Epidemiology and Biostatistics You, McMaster University, Hamilton, Ont Division of Critical Care Medicine Dodek, St Paul s Hospital Center for Health Evaluation and Outcome Sciences Dodek, University of British Columbia, Vancouver, BC Centre de Recherche Clinique Hôpital Universitaire de Sherbrooke Lamontagne, Universite de Sherbrooke, Sherbrooke, Qué Divisions of Critical Care and Palliative Care Downar, Department of Medicine, University of Toronto Department of Critical Care Medicine and Sunnybrook Research Institute Sinuff, Sunnybrook Health Sciences Centre Interdepartmental Division of Critical Care Medicine Sinuff, University of Toronto, Toronto, Ont Clinical Evaluation Research Unit, Department of Medicine Jiang, Day, Heyland, Kingston General Hospital, Kingston, Ont Department of Community Health and Epidemiology Heyland, Queen s University, Kingston, Ont
    CMAJ 186:E679-87. 2014
    ..The guideline-recommended elements to include in discussions about goals of care with patients with serious illness are mostly based on expert opinion. We sought to identify which elements are most important to patients and their families...
  31. doi request reprint Barriers to goals of care discussions with seriously ill hospitalized patients and their families: a multicenter survey of clinicians
    John J You
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    JAMA Intern Med 175:549-56. 2015
    ..Interventions to improve care are more likely to succeed if tailored to existing barriers...
  32. doi request reprint Clinical trial design in acute lung injury--issues and controversies
    Maureen O Meade
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, Health Sciences Centre, 1280 Main Street West, Hamilton, Ontario, Canada
    Semin Respir Crit Care Med 34:516-21. 2013
    ..The third section discusses the quest for ideal Study Outcomes. The final section presents Interpretation Controversies, such as early stopping of clinical trials. ..
  33. doi request reprint Predictive value of S-100β protein for prognosis in patients with moderate and severe traumatic brain injury: systematic review and meta-analysis
    Eric Mercier
    Centre de Recherche du Centre Hospitalier Universitaire de Québec, Hopital de l Enfant Jesus, Traumatologie Urgence Soins Intensifs, Trauma Emergency Critical Care Medicine, Universite Laval, Quebec City, QC, Canada
    BMJ 346:f1757. 2013
    ..To determine the ability and accuracy of the S-100β protein in predicting prognosis after a moderate or severe traumatic brain injury...
  34. doi request reprint Nitric oxide donors in sepsis: a systematic review of clinical and in vivo preclinical data
    Francois Lamontagne
    Division of Critical Care, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Shock 30:653-9. 2008
    ..g., mortality, pulmonary hypertension, tissue/organ perfusion, etc.) but also lowered blood pressure. We conclude that our findings warrant further animal experimentation designed to maximize clinical relevance...
  35. pmc β-Blockers in sepsis: protocol for a systematic review and meta-analysis of randomised control trials
    Erick H Duan
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    BMJ Open 6:e012466. 2016
    ..The objective of this systematic review is to determine the efficacy and safety of β-blockers in adults with sepsis using data from randomised control trials...
  36. doi request reprint Premature Discontinuation of Randomized Trials in Critical and Emergency Care: A Retrospective Cohort Study
    Stefan Schandelmaier
    1Department of Clinical Research, Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland 2Department of Medicine, Academy of Swiss Insurance Medicine, University Hospital Basel, Basel, Switzerland 3Cochrane Switzerland, Institute of Social and Preventive Medicine IUMSP, Lausanne University Hospital, Lausanne, Switzerland 4Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada 5Department of Medicine, McMaster University, Hamilton, Ontario, Canada 6German Cochrane Centre, Medical Center University of Freiburg, Freiburg, Germany 7Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland 8Centre de Recherche Clinique du Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, Sherbrooke, Canada 9Department of Health and Society, Austrian Federal Institute for Health Care, Vienna, Austria 10Departments of Urology and Public Health, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 11Department of Internal Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile 12Evidence Based Dentistry Unit, Faculty of Dentistry, Universidad de Chile, France
    Crit Care Med 44:130-7. 2016
    ..To assess the extent that recruitment challenges lead to randomized clinical trial discontinuation, we compared the discontinuation of acute care and nonacute care randomized clinical trials...
  37. doi request reprint Heparin-induced thrombocytopenia in the critically ill: interpreting the 4Ts test in a randomized trial
    Mark Crowther
    St Joseph s Healthcare, Critical Care Research Office, Hamilton, Ontario, Canada
    J Crit Care 29:470.e7-15. 2014
    ..Interobserver agreement on 4Ts scoring is uncertain in this setting...