Hans Knecht

Summary

Country: Canada

Publications

  1. pmc Genomic Instability: The Driving Force behind Refractory/Relapsing Hodgkin's Lymphoma
    Hans Knecht
    Division d Hématologie, Departement de Medecine, CHUS, Universite de Sherbrooke, Quebec, J1H 5N4, Canada
    Cancers (Basel) 5:714-25. 2013
  2. doi request reprint The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells
    H Knecht
    Département de Médicine, CHUS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Leukemia 23:565-73. 2009
  3. doi request reprint 3D Telomere FISH defines LMP1-expressing Reed-Sternberg cells as end-stage cells with telomere-poor 'ghost' nuclei and very short telomeres
    Hans Knecht
    Division of Haematology Oncology, CHUS University Hospital, 3001 12th Avenue North, Sherbrooke, Quebec, Canada
    Lab Invest 90:611-9. 2010
  4. doi request reprint 3D structural and functional characterization of the transition from Hodgkin to Reed-Sternberg cells
    Hans Knecht
    Division d Hématologie, CHUS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Ann Anat 192:302-8. 2010
  5. doi request reprint 3D imaging of telomeres and nuclear architecture: An emerging tool of 3D nano-morphology-based diagnosis
    Hans Knecht
    Division of Haematology Oncology, Department of Medicine, CHUS, University of Sherbrooke, Sherbrooke, QC, Canada
    J Cell Physiol 226:859-67. 2011
  6. pmc 3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps"
    Hans Knecht
    CHUS, Universite de Sherbrooke, Quebec, Canada
    BMC Cell Biol 11:99. 2010
  7. pmc Three-dimensional Telomere Signatures of Hodgkin- and Reed-Sternberg Cells at Diagnosis Identify Patients with Poor Response to Conventional Chemotherapy
    Hans Knecht
    Division d Hématologie, Departement de Medecine, CHUS, Universite de Sherbrooke, Quebec, Canada
    Transl Oncol 5:269-77. 2012
  8. ncbi request reprint The Use of 3D Telomere FISH for the Characterization of the Nuclear Architecture in EBV-Positive Hodgkin's Lymphoma
    Hans Knecht
    Division of Hematology, Department of Medicine, Jewish General Hospital, McGill University, 3755, Chemin de la Cote Ste Catherine, Montreal, Quebec, Canada, H3T 1E2
    Methods Mol Biol 1532:93-104. 2017

Collaborators

Detail Information

Publications8

  1. pmc Genomic Instability: The Driving Force behind Refractory/Relapsing Hodgkin's Lymphoma
    Hans Knecht
    Division d Hématologie, Departement de Medecine, CHUS, Universite de Sherbrooke, Quebec, J1H 5N4, Canada
    Cancers (Basel) 5:714-25. 2013
    ..Therapeutic approaches should take these findings into account. ..
  2. doi request reprint The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells
    H Knecht
    Département de Médicine, CHUS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Leukemia 23:565-73. 2009
    ..Our findings allow a mechanistic 3D understanding of the transition of H to RS cells...
  3. doi request reprint 3D Telomere FISH defines LMP1-expressing Reed-Sternberg cells as end-stage cells with telomere-poor 'ghost' nuclei and very short telomeres
    Hans Knecht
    Division of Haematology Oncology, CHUS University Hospital, 3001 12th Avenue North, Sherbrooke, Quebec, Canada
    Lab Invest 90:611-9. 2010
    ....
  4. doi request reprint 3D structural and functional characterization of the transition from Hodgkin to Reed-Sternberg cells
    Hans Knecht
    Division d Hématologie, CHUS, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Ann Anat 192:302-8. 2010
    ..Our findings are consistent with the hypothesis that distinct 3D telomere changes and shelterin disruption represent a common pathogenetic denominator in the generation of Reed-Sternberg cells...
  5. doi request reprint 3D imaging of telomeres and nuclear architecture: An emerging tool of 3D nano-morphology-based diagnosis
    Hans Knecht
    Division of Haematology Oncology, Department of Medicine, CHUS, University of Sherbrooke, Sherbrooke, QC, Canada
    J Cell Physiol 226:859-67. 2011
    ..This article will review current and future avenues in the assessment of diagnostic patient samples...
  6. pmc 3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps"
    Hans Knecht
    CHUS, Universite de Sherbrooke, Quebec, Canada
    BMC Cell Biol 11:99. 2010
    ..In vitro and in vivo formation of RS-cells is associated with the increase of very short telomeres including "t-stumps", telomere loss, telomeric aggregate formation and the generation of "ghost nuclei"...
  7. pmc Three-dimensional Telomere Signatures of Hodgkin- and Reed-Sternberg Cells at Diagnosis Identify Patients with Poor Response to Conventional Chemotherapy
    Hans Knecht
    Division d Hématologie, Departement de Medecine, CHUS, Universite de Sherbrooke, Quebec, Canada
    Transl Oncol 5:269-77. 2012
    ..This specific three-dimensional telomere Q-FISH signature identifies these highly aggressive mononuclear H cells at the first diagnostic biopsy and thus may offer a new molecular marker to optimize initial treatment...
  8. ncbi request reprint The Use of 3D Telomere FISH for the Characterization of the Nuclear Architecture in EBV-Positive Hodgkin's Lymphoma
    Hans Knecht
    Division of Hematology, Department of Medicine, Jewish General Hospital, McGill University, 3755, Chemin de la Cote Ste Catherine, Montreal, Quebec, Canada, H3T 1E2
    Methods Mol Biol 1532:93-104. 2017
    ..LMP1 mediates multinuclearity through downregulation of shelterin proteins, in particular telomere repeat binding factor 2 (TRF2)...