Tara Gomes

Summary

Affiliation: Institute for Clinical Evaluative Sciences
Country: Canada

Publications

  1. doi request reprint Clinical and demographic characteristics of patients receiving different oral hypoglycemic agents
    Tara Gomes
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Pharmacoepidemiol Drug Saf 18:756-60. 2009
  2. pmc Reformulation of controlled-release oxycodone and pharmacy dispensing patterns near the US-Canada border
    Tara Gomes
    Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto ON M4N 3M5, Canada
    Open Med 6:e141-5. 2012
  3. pmc Rates of hemorrhage during warfarin therapy for atrial fibrillation
    Tara Gomes
    The Leslie Dan Faculty of Pharmacy, Universityof Toronto, Canada
    CMAJ 185:E121-7. 2013
  4. doi request reprint Progression through diabetes therapies among new elderly users of metformin: a population-based study
    T Gomes
    Institute for Clinical Evaluative Sciences The Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Diabet Med 30:e51-5. 2013
  5. doi request reprint The impact of federal warnings on publically funded desmopressin utilization among children in Ontario
    Tara Gomes
    The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    J Pediatr Urol 8:249-53. 2012
  6. doi request reprint Comparative adherence to oxybutynin or tolterodine among older patients
    Tara Gomes
    The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Eur J Clin Pharmacol 68:97-9. 2012
  7. doi request reprint Opioid dose and drug-related mortality in patients with nonmalignant pain
    Tara Gomes
    Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Arch Intern Med 171:686-91. 2011
  8. pmc Trends in opioid use and dosing among socio-economically disadvantaged patients
    Tara Gomes
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    Open Med 5:e13-22. 2011
  9. doi request reprint Risk of serious falls associated with oxybutynin and tolterodine: a population based study
    Tara Gomes
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
    J Urol 186:1340-4. 2011
  10. pmc Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study
    Tony Antoniou
    University of Toronto, Toronto, ON, Canada
    BMJ 343:d5228. 2011

Detail Information

Publications79

  1. doi request reprint Clinical and demographic characteristics of patients receiving different oral hypoglycemic agents
    Tara Gomes
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Pharmacoepidemiol Drug Saf 18:756-60. 2009
    ....
  2. pmc Reformulation of controlled-release oxycodone and pharmacy dispensing patterns near the US-Canada border
    Tara Gomes
    Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto ON M4N 3M5, Canada
    Open Med 6:e141-5. 2012
    ....
  3. pmc Rates of hemorrhage during warfarin therapy for atrial fibrillation
    Tara Gomes
    The Leslie Dan Faculty of Pharmacy, Universityof Toronto, Canada
    CMAJ 185:E121-7. 2013
    ..Our objective was to examine incident hemorrhagic events in a large population-based cohort of patients with atrial fibrillation who were starting treatment with warfarin...
  4. doi request reprint Progression through diabetes therapies among new elderly users of metformin: a population-based study
    T Gomes
    Institute for Clinical Evaluative Sciences The Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Diabet Med 30:e51-5. 2013
    ..To examine temporal changes in progression to second-line therapies among older patients with diabetes newly treated with metformin...
  5. doi request reprint The impact of federal warnings on publically funded desmopressin utilization among children in Ontario
    Tara Gomes
    The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    J Pediatr Urol 8:249-53. 2012
    ..To determine whether safety warnings issued by health regulatory agencies regarding desmopressin treatment influenced treatment rates among children...
  6. doi request reprint Comparative adherence to oxybutynin or tolterodine among older patients
    Tara Gomes
    The Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Eur J Clin Pharmacol 68:97-9. 2012
    ..To compare persistence of oxybutynin or tolterodine therapy among older patients newly prescribed one of these drugs...
  7. doi request reprint Opioid dose and drug-related mortality in patients with nonmalignant pain
    Tara Gomes
    Institute for Clinical Evaluative Sciences, G Wing 106, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Arch Intern Med 171:686-91. 2011
    ..However, the risk-benefit ratio of high-dose opioid therapy is not well characterized. The objective of this study was to characterize the relationship between opioid dose and opioid-related mortality...
  8. pmc Trends in opioid use and dosing among socio-economically disadvantaged patients
    Tara Gomes
    Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    Open Med 5:e13-22. 2011
    ..The objective of this study was to examine trends in opioid utilization for nonmalignant pain among recipients of social assistance and to explore the relation between dose of analgesic and mortality...
  9. doi request reprint Risk of serious falls associated with oxybutynin and tolterodine: a population based study
    Tara Gomes
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
    J Urol 186:1340-4. 2011
    ..We compared the short-term risk of falls among recipients of oxybutynin or tolterodine to treat urinary incontinence...
  10. pmc Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study
    Tony Antoniou
    University of Toronto, Toronto, ON, Canada
    BMJ 343:d5228. 2011
    ..To characterise the risk of admission to hospital for hyperkalaemia in elderly patients treated with trimethoprim-sulfamethoxazole in combination with spironolactone...
  11. doi request reprint Hospitalization for hemorrhage among warfarin recipients prescribed amiodarone
    Jason Lam
    Eli Lilly Canada Inc, Toronto, Canada
    Am J Cardiol 112:420-3. 2013
    ..Physicians should closely monitor patients who initiate amiodarone while receiving warfarin. ..
  12. pmc Risk of incident diabetes among patients treated with statins: population based study
    Aleesa A Carter
    Toronto General Hospital, Toronto, ON, Canada M5G 2C4
    BMJ 346:f2610. 2013
    ..To examine the risk of new onset diabetes among patients treated with different HMG-CoA reductase inhibitors (statins)...
  13. doi request reprint No increase in adverse events during aliskiren use among ontario patients receiving angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers
    Cameron J Gilbert
    Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 29:586-91. 2013
    ..The extent to which concomitant treatment increases the risk of these outcomes in routine clinical practice is unknown. We addressed this issue with the use of administrative databases...
  14. doi request reprint Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study
    Amit M Patel
    Western University and Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
    Ann Intern Med 158:869-76. 2013
    ..Clarithromycin and erythromycin, but not azithromycin, inhibit cytochrome P450 isoenzyme 3A4 (CYP3A4), and inhibition increases blood concentrations of statins that are metabolized by CYP3A4...
  15. doi request reprint Long-term analgesic use after low-risk surgery: a retrospective cohort study
    Asim Alam
    Department of Anesthesiology, University of Toronto, Ontario, Canada
    Arch Intern Med 172:425-30. 2012
    ..This study evaluated the risk of long-term analgesic use after low-risk surgery in older adults not previously prescribed analgesics...
  16. doi request reprint Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study
    Irfan A Dhalla
    St Michael s Hospital and Institute for Clinical Evaluative Sciences, Toronto, Ontario M5B 1W8, Canada
    Ann Intern Med 158:447-55. 2013
    ..Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension...
  17. doi request reprint New fibrate use and acute renal outcomes in elderly adults: a population-based study
    Ying Y Zhao
    Yale University School of Medicine, New Haven, Connecticut, USA
    Ann Intern Med 156:560-9. 2012
    ..Fibric acid derivatives (fibrates) have been shown to increase serum creatinine level in randomized trials...
  18. pmc Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study
    David N Juurlink
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    BMJ 339:b2942. 2009
    ..To compare the risk of acute myocardial infarction, heart failure, and death in patients with type 2 diabetes treated with rosiglitazone and pioglitazone...
  19. pmc A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
    David N Juurlink
    Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, 2075 Bayview Ave, Toronto, Ontario
    CMAJ 180:713-8. 2009
    ..Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance of this drug interaction is unknown...
  20. doi request reprint Self-Monitoring of Blood Glucose Levels: Evaluating the Impact of a Policy of Quantity Limits on Test-Strip Use and Costs
    Tara Gomes
    Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada Institute for Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada Electronic address
    Can J Diabetes 40:431-435. 2016
    ..To evaluate the impact of new quantity limits for blood glucose test strips (BGTS) in August 2013 on utilization patterns and costs in the elderly population of Ontario, Canada...
  21. doi request reprint Association of a Blood Glucose Test Strip Quantity-Limit Policy With Patient Outcomes: A Population-Based Study
    Tara Gomes
    Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada2The Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada3Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada4Department of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
    JAMA Intern Med . 2016
    ..Given their high costs, payers have considered implementing quantity limits for reimbursement of blood glucose test strips. The effect of these limits on patient outcomes is unknown...
  22. pmc Effect of a course-based intervention and effect of medical regulation on physicians' opioid prescribing
    Meldon Kahan
    Department of Family and Community Medicine, University of Toronto U of T, Ontario, Canada
    Can Fam Physician 59:e231-9. 2013
    ..To examine the effects of an intensive 2-day course on physicians' prescribing of opioids...
  23. doi request reprint Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study
    Tony Antoniou
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Arch Intern Med 170:1045-9. 2010
    ..The objective of this study was to characterize the risk of hyperkalemia-associated hospitalization in elderly patients who were being treated with trimethoprim-sulfamethoxazole along with either an ACEI or an ARB...
  24. ncbi request reprint Variations in costs and use of provincially-funded testosterone replacement therapy across Canada: a population-based study
    Mina Tadrous
    a Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada
    Expert Rev Pharmacoecon Outcomes Res 16:803-807. 2016
    ..Provincial drug-program policies for the reimbursement of testosterone replacement therapy (TRT) vary across Canada, which may result in marked regional variability in use...
  25. doi request reprint Novel Oral Anticoagulants and the Risk of Major Hemorrhage in Elderly Patients With Chronic Kidney Disease: A Nested Case-Control Study
    Ziv Harel
    Division of Nephrology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Electronic address
    Can J Cardiol 32:986.e17-22. 2016
    ..The novel oral anticoagulants, including dabigatran and rivaroxaban, differ in their degree of renal excretion...
  26. doi request reprint The appropriateness and persistence of testosterone replacement therapy in Ontario
    Diana Martins
    The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Pharmacoepidemiol Drug Saf . 2016
    ....
  27. pmc Varenicline and Risk of Self-Harm: A Nested Case-Control Study
    Mina Tadrous
    Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Canada
    PLoS ONE 11:e0163681. 2016
    ..Post-marketing reports describing suicidal behaviours have raised concerns about the safety of varenicline. However, whether varenicline imparts a higher risk of suicide relative to bupropion remains uncertain...
  28. doi request reprint Socioeconomic status and risk of hemorrhage during warfarin therapy for atrial fibrillation: A population-based study
    Alex M Cressman
    The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 170:133-40, 140.e1-3. 2015
    ..We examined the extent to which socioeconomic status influences the risk of hemorrhage in older individuals newly commencing warfarin therapy for atrial fibrillation...
  29. doi request reprint Risk of acute kidney injury from oral acyclovir: a population-based study
    Ngan N Lam
    Division of Nephrology, Western University, London, Ontario, Canada
    Am J Kidney Dis 61:723-9. 2013
    ..Similarly, AKI from oral acyclovir is described in case reports, but the risk in routine practice is unknown...
  30. doi request reprint Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study
    David N Juurlink
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Clin Toxicol (Phila) 50:390-5. 2012
    ..To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns...
  31. doi request reprint Beta-blockers and cardiovascular outcomes in dialysis patients: a cohort study in Ontario, Canada
    Abhijat Kitchlu
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Nephrol Dial Transplant 27:1591-8. 2012
    ..Beta-blockers may be cardioprotective in patients receiving chronic dialysis. We examined cardiovascular outcomes among incident dialysis patients receiving beta-blocker therapy...
  32. pmc Beta-blockers, trimethoprim-sulfamethoxazole, and the risk of hyperkalemia requiring hospitalization in the elderly: a nested case-control study
    Matthew A Weir
    University of Western Ontario, London, Ontario, Canada
    Clin J Am Soc Nephrol 5:1544-51. 2010
    ..The simultaneous use of beta adrenergic receptor blockers (beta-blockers) and trimethoprim-sulfamethoxazole (TMP-SMX) may confer a high risk of hyperkalemia...
  33. pmc Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study
    Tony Antoniou
    University of Toronto, Toronto, Department of Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Br J Clin Pharmacol 71:544-9. 2011
    ..We studied the risk of phenytoin toxicity following the prescription of trimethoprim/sulfamethoxazole (TMP/SMX), a commonly used antibiotic, among elderly patients receiving phenytoin...
  34. doi request reprint Predictors of Opioid-Related Death During Methadone Therapy
    Pamela Leece
    Public Health and Preventive Medicine, University of Toronto, Ontario, Canada, M5T 3 M7 Electronic address
    J Subst Abuse Treat 57:30-5. 2015
    ..3; 95% CI 2.0 to 14.0). Psychotropic drug use is associated with opioid-related death in patients receiving methadone. Mindfulness of these factors may reduce the risk of death among methadone recipients. ..
  35. pmc Prescription Stimulant Use and Hospitalization for Psychosis or Mania: A Population-Based Study
    Alex M Cressman
    From the Institute for Clinical Evaluative Sciences Department of Medicine, Faculty of Medicine, University of Toronto The Leslie Dan Faculty of Pharmacy Institute of Health Policy, Management and Evaluation Li Ka Shing Knowledge Institute Centre for Addiction and Mental Health Department of Medicine, St Michael s Hospital and Sunnybrook Research Institute, Toronto, Ontario, Canada
    J Clin Psychopharmacol 35:667-71. 2015
    ..Resumption of therapy is common, which may reflect a lack of awareness of the potential causative role of these drugs...
  36. pmc Rates of Anomalous Bupropion Prescriptions in Ontario, Canada
    Leah S Steele
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Family and Community Medicine, St Michael s Hospital, Toronto, Ontario, Canada Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Ann Fam Med 13:343-6. 2015
    ..Reports of bupropion misuse have increased since it was first reported in 2002. The purpose of this study was to explore trends in bupropion prescribing suggestive of misuse or diversion in Ontario, Canada...
  37. pmc A population-based study of the drug interaction between clopidogrel and angiotensin converting enzyme inhibitors
    Alex M Cressman
    The Institute for Clinical Evaluative Sciences, Toronto, Ontario
    Br J Clin Pharmacol 80:662-9. 2015
    ..The clinical implications of this potential drug interaction are unknown. The clinical consequences of the potential drug interaction between clopidogrel and prodrug ACE inhibitors were examined...
  38. pmc Safety of valproic acid in patients with chronic obstructive pulmonary disease: a population-based cohort study
    Tony Antoniou
    Department of Family and Community Medicine, St Michael s Hospital, Toronto, Canada Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Canada University of Toronto, Toronto, Canada Institute for Clinical Evaluative Sciences, Toronto, Canada
    Pharmacoepidemiol Drug Saf 24:256-61. 2015
    ..We therefore compared the risk of COPD exacerbation in older patients with COPD commencing treatment with either valproic acid or phenytoin, an anticonvulsant that does not affect HDAC...
  39. pmc Co-trimoxazole and sudden death in patients receiving inhibitors of renin-angiotensin system: population based study
    Michael Fralick
    Department of Internal Medicine, University of Toronto, Toronto, ON, Canada, M5G 2C4
    BMJ 349:g6196. 2014
    ..To determine whether the prescription of co-trimoxazole with an angiotensin converting enzyme inhibitor or angiotensin receptor blocker is associated with sudden death...
  40. doi request reprint Altered mental status in older adults with histamine2-receptor antagonists: a population-based study
    Davy Tawadrous
    Schulich School of Medicine, Western University, London, Canada Division of Nephrology, Western University, London, Ontario, Canada
    Eur J Intern Med 25:701-9. 2014
    ..Standard doses of histamine2-receptor antagonists (H2RAs) may induce altered mental status in older adults, especially in those with chronic kidney disease (CKD)...
  41. doi request reprint Oral bisphosphonate use in the elderly is not associated with acute kidney injury
    Andrew W Y Shih
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Kidney Int 82:903-8. 2012
    ..03), and no significant differences in other outcomes or in subgroups of patients with baseline chronic kidney disease. Thus, in this older population-based cohort, oral bisphosphonate use was not associated with acute kidney injury...
  42. doi request reprint The risk of hip fracture after initiating antihypertensive drugs in the elderly
    Debra A Butt
    Ellesmere Health Care Centre and The Scarborough Hospital, Scarborough, Ontario, Canada
    Arch Intern Med 172:1739-44. 2012
    ....
  43. doi request reprint Use of other opioids during methadone therapy: a population-based study
    Paul Kurdyak
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Addiction 107:776-80. 2012
    ..To determine the extent to which other opioids are prescribed to patients receiving methadone in Ontario, Canada...
  44. ncbi request reprint Thiazolidinediones and cardiovascular outcomes in older patients with diabetes
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    JAMA 298:2634-43. 2007
    ..However, the association between TZD use and cardiovascular events has not been adequately evaluated on a population level...
  45. doi request reprint Selective serotonin reuptake inhibitors and pulmonary arterial hypertension: a case-control study
    Irfan A Dhalla
    Department of Medicine, St Michael s Hospital, 30 Bond St, Toronto, ON, M5B 1W8, Canada
    Chest 141:348-53. 2012
    ..Animal and human studies suggest that selective serotonin reuptake inhibitors (SSRIs) might be useful for the prevention or treatment of pulmonary arterial hypertension...
  46. pmc Blood glucose test strips: options to reduce usage
    Tara Gomes
    Institute for Clinical Evaluative Sciences, Toronto, Ont
    CMAJ 182:35-8. 2010
    ..The impact of more focused public-payer policies for the use of blood glucose test strips may be substantial...
  47. pmc Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study
    Catherine M Kelly
    Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada
    BMJ 340:c693. 2010
    ..To characterise whether some selective serotonin reuptake inhibitor (SSRI) antidepressants reduce tamoxifen's effectiveness by inhibiting its bioactivation by cytochrome P450 2D6 (CYP2D6)...
  48. ncbi request reprint Interprovincial Variation in Antipsychotic and Antidepressant Prescriptions Dispensed in the Canadian Pediatric Population
    Nikita Arora
    McMaster University, Hamilton, Ontario, Canada
    Can J Psychiatry . 2016
    ..We examined recent national trends and interprovincial variation in dispensing of antipsychotic and antidepressant prescriptions to the Canadian pediatric population...
  49. doi request reprint Off-label use of inhaled tobramycin in Ontario, Canada
    Mina Tadrous
    St Michael s Hospital, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada The Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Thorax 71:862-4. 2016
    ..Our study found increasing prescriptions of inhaled tobramycin from 2007 to 2015 in the OPDP with approximately half of these claims being for off-label use, mostly among patients with COPD. ..
  50. doi request reprint Factors that may be influencing the rise in prescription testosterone replacement therapy in adult men: a qualitative study
    Alekhya Mascarenhas
    a St Michael s Hospital, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada
    Aging Male 19:90-5. 2016
    ..To explore and describe the factors that may be influencing the rise of prescribing and use of testosterone replacement therapy (TRT) in adult men...
  51. doi request reprint Self-Monitoring of Blood Glucose: Impact of Quantity Limits in Public Drug Formularies on Provincial Costs Across Canada
    Sandra R Knowles
    Leslie Dan Faculty of Pharmacy at the University of Toronto, Toronto, Ontario, Canada Department of Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Can J Diabetes . 2016
    ..We assessed the potential impact of BGTS quantity limits on utilization and costs for 6 publicly funded drug plans across Canada...
  52. pmc The Influence of Socioeconomic Status on Selection of Anticoagulation for Atrial Fibrillation
    Michelle Sholzberg
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    PLoS ONE 11:e0149142. 2016
    ..Without third-party insurance, access to marketed drugs is limited to those who can afford to pay. We examined this phenomenon in the context of anticoagulation for patients with nonvalvular atrial fibrillation (NVAF)...
  53. ncbi request reprint Professional Pharmacy Services and Patient Complexity: An Observational Study
    Teegan Aili Ignacy
    Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    J Pharm Pharm Sci 18:863-70. 2015
    ..To examine the association between the provision of professional pharmacy services (PPS) and patient complexity as determined by the number of distinct medications dispensed in Ontario...
  54. pmc Evaluating the Effectiveness of First-Time Methadone Maintenance Therapy Across Northern, Rural, and Urban Regions of Ontario, Canada
    Joseph K Eibl
    Northern Ontario School of Medicine Sudbury, Sudbury, Ontario, Canada JKE, DCM Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada TG, MMM, xc, DM, IAD, DNJ The Sunnybrook Research Institute DNJ, Department of Medicine MMM, IAD, Keenan Research Centre of the Li Ka Shing Knowledge Institute TG, MMM, IAD, St Michael s Hospital, Toronto, Ontario, Canada Department of Medicine MMM, IAD, DNJ, Pediatrics DNJ, Institute of Health Policy, Management, and Evaluation MMM, IAD, TG, DNJ, and the Leslie Dan Faculty of Pharmacy TG, MMM, University of Toronto, Toronto, Ontario, Canada and the Ontario Addiction Treatment Centres DCM, France
    J Addict Med 9:440-6. 2015
    ..Our objective was to determine the impact that a patient's geographic status has on the efficacy of first-time methadone maintenance therapy (MMT) retention...
  55. pmc Sex Differences in Dose Escalation and Overdose Death during Chronic Opioid Therapy: A Population-Based Cohort Study
    Eric Kaplovitch
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 10:e0134550. 2015
    ..The patients at greatest risk of death are those receiving high doses of opioids. Whether sex influences the risk of dose escalation or opioid-related mortality is unknown...
  56. doi request reprint The Ontario Drug Policy Research Network: bridging the gap between Research and Drug Policy
    Sobia Khan
    Li KaShing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada Electronic address
    Health Policy 117:392-8. 2014
    ..The described experiences will be valuable to those seeking to enhance evidence uptake in policymaking for immediate policy needs. ..
  57. pmc The burden of premature opioid-related mortality
    Tara Gomes
    Institute for Clinical and Evaluative Sciences, Toronto, ON, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada Leslie Dan Faculty of Pharmacy, Toronto, ON, Canada Sunnybrook Research Institute, Toronto, ON, Canada
    Addiction 109:1482-8. 2014
    ..We calculated temporal trends in the proportion of deaths attributable to opioids and estimated years of potential life lost (YLL) due to opioid-related mortality in Ontario, Canada...
  58. doi request reprint Rates of ischemic stroke during warfarin treatment for atrial fibrillation
    Jennifer M Tung
    From the Institute for Clinical Evaluative Sciences M M M, D N J, J M P, M K K, T G, Sunnybrook Research Institute D N J, Department of Medicine M K K, Institute of Health Policy, Management, and Evaluation M M M, D N J, J M P, M K K, T G, and Leslie Dan Faculty of Pharmacy J M T, M M M, T G, University of Toronto, Toronto, Ontario, Canada Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada M M M, T G Division of General Internal Medicine and Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada M K K and Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada J M P
    Stroke 46:1120-2. 2015
    ..Recent evidence suggests that there may be an increased risk of ischemic stroke immediately after warfarin initiation. We examined the rate of ischemic stroke among patients with atrial fibrillation newly started on warfarin therapy...
  59. doi request reprint Risk of overdose and death following codeine prescription among immigrants
    Joel G Ray
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Epidemiol Community Health 68:1057-63. 2014
    ..Additionally, there are reports of severe or fatal toxicity due to CYP2D6 ultrarapid hepatic metabolism of codeine to morphine among some ethnic groups, especially those from Eastern Africa...
  60. pmc Extended-release nifedipine and the risk of intestinal obstruction: a population-based study
    David N Juurlink
    The Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Sunnybrook Research Institute, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    BMJ Open 4:e005377. 2014
    ..To examine the risk of bowel obstruction in older adults during treatment with extended-release nifedipine compared with patients treated with amlodipine...
  61. pmc Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4
    Daniel Q Li
    Divisions of Nephrology Li, McArthur, Fleet, Shariff, Gandhi, Dixon, Garg and Clinical Pharmacology Kim, Department of Medicine, Western University, London, Ont Institute for Clinical Evaluative Sciences ICES Western McArthur, Juurlink, Shariff, Gomes, Dixon, Garg, London, Ont Lawson Health Research Institute Bailey, London Health Sciences Centre, London, Ont Sunnybrook Health Sciences Centre Juurlink, Toronto, Ont Li Ka Shing Knowledge Institute Gomes, Mamdani, St Michael s Hospital, Toronto, Ont Institute of Health Policy, Management and Evaluation Mamdani, University of Toronto, Toronto, Ont Department of Epidemiology and Biostatistics Gandhi, Western University, London, Ont
    CMAJ 187:174-80. 2015
    ..We studied whether concurrent use of clarithromycin and a statin not metabolized by CYP3A4 was associated with an increased frequency of serious adverse events...
  62. doi request reprint Opioid dose and risk of road trauma in Canada: a population-based study
    Tara Gomes
    Institute for Clinical Evaluative Sciences, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    JAMA Intern Med 173:196-201. 2013
    ..Use of opioids may predispose drivers to road trauma, yet the effect of opioid dose on this association is unknown...
  63. pmc Clustering of opioid prescribing and opioid-related mortality among family physicians in Ontario
    Irfan A Dhalla
    Department of Medicine, University of Toronto, Toronto, Ont
    Can Fam Physician 57:e92-6. 2011
    ..To examine whether variation in prescribing at the level of the individual physician is associated with opioid-related mortality...
  64. doi request reprint Ciprofloxacin-induced theophylline toxicity: a population-based study
    Tony Antoniou
    University of Toronto, Toronto, ON, Canada
    Eur J Clin Pharmacol 67:521-6. 2011
    ..We studied the risk of theophylline toxicity associated with the co-prescription of ciprofloxacin and theophylline...
  65. pmc Antiepileptic use for epilepsy and nonepilepsy disorders: A population-based study (1998-2013)
    Christine Leong
    From the College of Pharmacy, Faculty of Health Sciences, Apotex Centre C L, and the Manitoba Centre for Health Policy, Department of Community Health Sciences, College of Medicine M Y, University of Manitoba, Winnipeg Leslie Dan Faculty of Pharmacy M M M, T G, University of Toronto Institute for Clinical Evaluative Sciences M M M, T G, D N J, E M M Li Ka Shing Knowledge Institute of St Michael s Hospital M M M and Divisions of General Internal Medicine and Clinical Pharmacology D N J, Sunnybrook, Toronto, Canada
    Neurology 86:939-46. 2016
    ..To examine the trends in antiepileptic drug (AED) use among individuals living in Manitoba with and without a history of epilepsy...
  66. pmc The impact of drug reimbursement policy on rates of testosterone replacement therapy among older men
    Jolanta Piszczek
    Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 9:e98003. 2014
    ..The magnitude of this increase and the impact of formulary restrictions on testosterone prescribing are poorly characterized...
  67. pmc Proton pump inhibitors and hospitalization with hypomagnesemia: a population-based case-control study
    Jonathan Zipursky
    Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    PLoS Med 11:e1001736. 2014
    ..Some evidence suggests that proton pump inhibitors (PPIs) are an under-appreciated risk factor for hypomagnesemia. Whether hospitalization with hypomagnesemia is associated with use of PPIs is unknown...
  68. doi request reprint Risk of Osteoporotic Fractures With Angiotensin II Receptor Blockers Versus Angiotensin-Converting Enzyme Inhibitors in Hypertensive Community-Dwelling Elderly
    Debra A Butt
    Department of Family and Community Medicine, University of Toronto, Research Department, Toronto, Canada Family and Community Medicine, The Scarborough Hospital, Scarborough, Canada
    J Bone Miner Res 29:2483-8. 2014
    ..99; CI 0.78-1.25), other major osteoporotic (HR = 0.87; CI 0.75-1.01), and other osteoporotic fractures (HR = 0.90; CI 0.74-1.08)...
  69. doi request reprint Adverse cardiac events in older patients receiving venlafaxine: a population-based study
    Joanne M Ho
    Sunnybrook Health Sciences Centre, G Wing 106, 2075 Bayview Ave, Toronto, Ontario M4N 3M5, Canada
    J Clin Psychiatry 75:e552-8. 2014
    ..Venlafaxine is a commonly prescribed antidepressant, but whether its noradrenergic effects impart increased cardiovascular risk is unknown. We sought to examine the cardiac safety of venlafaxine relative to sertraline in older patients...
  70. pmc Effects of funding policy changes and health warnings on the use of erythropoiesis-stimulating agents
    Matthew A Weir
    University of Western Ontario, London University of Waterloo, Waterloo Institute for Clinical Evaluative Sciences University of Toronto Sunnybrook Health Sciences Centre and Applied Health Research Center, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    J Oncol Pract 8:179-83. 2012
    ..To characterize the effects of formulary changes and governmental safety warnings on use of erythropoiesis-stimulating agents (ESAs) in patients with cancer...
  71. doi request reprint The safety of proton pump inhibitors and clopidogrel in patients after stroke
    David N Juurlink
    Sunnybrook Research Institute, Toronto, Ontario, Canada
    Stroke 42:128-32. 2011
    ..evidence suggests that some proton pump inhibitors can attenuate the antiplatelet effect of clopidogrel. The significance of this potential drug interaction in patients with cerebrovascular disease is unknown...
  72. pmc The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers
    Alissa J Wright
    Department of Medicine, University of Toronto, Ont, Canada
    CMAJ 183:303-7. 2011
    ..We explored the risk of hypotension or shock requiring hospital admission following the simultaneous use of calcium-channel blockers and macrolide antibiotics...
  73. doi request reprint Preventing pressure ulcers in long-term care: a cost-effectiveness analysis
    Ba Pham
    TorontoHealth Economics and Technology Assessment Collaborative, Department of Health Policy Management andEvaluation, University of Toronto, 144 College Street, Toronto, Ontario, Canada
    Arch Intern Med 171:1839-47. 2011
    ..Pressure ulcers are common in many care settings, with adverse health outcomes and high treatment costs. We evaluated the cost-effectiveness of evidence-based strategies to improve current prevention practice in long-term care facilities...
  74. pmc Health status utilities and the impact of pressure ulcers in long-term care residents in Ontario
    Hla Hla Thein
    Toronto General Research Institute, University Health Network, Toronto, ON, Canada
    Qual Life Res 19:81-9. 2010
    ..To estimate health status utilities in long-term care (LTC) residents in Ontario, both with and without pressure ulcers (PUs), and to determine the impact of PU on health-related quality of life (HRQOL)...
  75. ncbi request reprint Adherence to multiple sclerosis disease-modifying therapies in Ontario is low
    Janice Wong
    Division of Neurology, The Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Can J Neurol Sci 38:429-33. 2011
    ..m. IFNβ-1a, Avonex), subcutaneous interferon beta-1a (s.c. IFNβ-1a, Rebif), subcutaneous interferon beta-1b (IFNβ-1b, Betaseron) or glatiramer acetate (Copaxone)...
  76. pmc Relationship of asthma management, socioeconomic status, and medication insurance characteristics to exacerbation frequency in children with asthma
    Wendy J Ungar
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Health Policy, Management, and Evaluation, University of Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Ann Allergy Asthma Immunol 106:17-23. 2011
    ..less than 25% of asthmatic children are well controlled...
  77. pmc Antipsychotic drug use in pregnancy: high dimensional, propensity matched, population based cohort study
    Simone N Vigod
    Women s College Research Institute Department of Psychiatry, University of Toronto, Toronto, Ontario M5S 1B2, Canada Institute for Clinical Evaluative Sciences, Toronto, Ontario M4N 3M5 Department of Psychiatry, Women s College Hospital University of Toronto, Toronto, Ontario
    BMJ 350:h2298. 2015
    ..To evaluate maternal medical and perinatal outcomes associated with antipsychotic drug use in pregnancy...
  78. doi request reprint Antipsychotic therapy and short-term serious events in older adults with dementia
    Paula A Rochon
    Department of Medicine, University of Toronto, Canada
    Arch Intern Med 168:1090-6. 2008
    ....
  79. doi request reprint Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristics
    Eric I Benchimol
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital of Sick Children, Toronto, Canada
    Am J Gastroenterol 103:1524-31. 2008
    ..This study assessed the clinical and radiologic characteristics of TMC in children with IBD...