Brigitte Guérin

Summary

Country: Canada

Publications

  1. pmc Comparative study of 64Cu/NOTA-[D-Tyr6,βAla11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging
    Patrick Fournier
    Centre d imagerie moléculaire de Sherbrooke CIMS, Department of Nuclear Medicine and Radiobiology, Universite de Sherbrooke, 3001, 12th North Avenue, Sherbrooke, Quebec, J1H 5N4, Canada
    EJNMMI Res 2:8. 2012
  2. doi request reprint Total solid-phase synthesis of NOTA-functionalized peptides for PET imaging
    Brigitte Guérin
    Centre d imagerie moléculaire de Sherbrooke CIMS, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4
    Org Lett 12:280-3. 2010
  3. doi request reprint [Lys(DOTA)4]BVD15, a novel and potent neuropeptide Y analog designed for Y1 receptor-targeted breast tumor imaging
    Brigitte Guérin
    Department of Nuclear Medicine and Radiobiology, Centre d imagerie moléculaire de Sherbrooke, Universite de Sherbrooke, Quebec, Canada
    Bioorg Med Chem Lett 20:950-3. 2010
  4. doi request reprint Novel radiolabeled peptides for breast and prostate tumor PET imaging: (64)Cu/and (68)Ga/NOTA-PEG-[D-Tyr(6),βAla(11),Thi(13),Nle(14)]BBN(6-14)
    Patrick Fournier
    Centre d imagerie moléculaire de Sherbrooke CIMS, Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, Canada, J1H 5N4
    Bioconjug Chem 23:1687-93. 2012
  5. pmc Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men
    Denis P Blondin
    Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4
    Nat Commun 8:14146. 2017
  6. doi request reprint Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes
    Denis P Blondin
    Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, Quebec, Canada
    Diabetes 64:2388-97. 2015
  7. doi request reprint (68)Ga/DOTA- and (64)Cu/NOTA-phthalocyanine conjugates as fluorescent/PET bimodal imaging probes
    Elena Ranyuk
    Centre d imagerie moléculaire de Sherbrooke CIMS, Departments of Nuclear Medicine and Radiobiology and Pharmacology, Faculty of Medicine and Health Sciences, Université de Sherbrooke 3001 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4
    Bioconjug Chem 24:1624-33. 2013
  8. doi request reprint Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans
    Denis P Blondin
    Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada
    Cell Metab . 2017
  9. doi request reprint Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates
    Samia Ait-Mohand
    Centre d imagerie moléculaire de Sherbrooke, Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 3001, 12th North Avenue Sherbrooke, Qubec, Canada, J1H 5N4
    Bioconjug Chem 22:1729-35. 2011
  10. pmc Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity
    Frédéric Couture
    Institut de Pharmacologie de Sherbrooke, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4 Department of Surgery Urology Division, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Biomed Res Int 2015:824014. 2015

Collaborators

  • Andre C Carpentier
  • Roger Lecomte
  • Francois Haman
  • Francois Benard
  • Hasrat Ali
  • Yves L Dory
  • Anna Kwiatkowska
  • Jean Patrice Baillargeon
  • Simon Labbe
  • Fernanda Marques
  • Jurg Bahler
  • Cara L Ferreira
  • B Paquette
  • Denis P Blondin
  • Samia Ait-Mohand
  • Serge Phoenix
  • Eric E Turcotte
  • Christophe Noll
  • Denis Richard
  • Margaret Kunach
  • Frédéric Couture
  • Johan E van Lier
  • Véronique Dumulon-Perreault
  • Patrick Fournier
  • Christine Levesque
  • Elena Ranyuk
  • Jude Beaudoin
  • Frédérique Frisch
  • Michel Paquette
  • Robert Day
  • Nematallah Mansour
  • Jean François Nadon
  • Samira Osati
  • Hans C Tingelstad
  • Kristina Rochon
  • Louis Gendron
  • Roxane Desjardins
  • Svetlana V Selivanova
  • Arnaud Proteau-Gagné
  • Klaus Klarskov
  • Nicole Cauchon
  • Witold A Neugebauer
  • Réjean Lebel
  • Elena R Ranyuk
  • Beata Jastrzebska
  • Thi Thanh Hà Dao
  • Veronique Blais
  • Sébastien Grastilleur
  • Guillaume Langlois
  • Jeffrey V Leyton
  • Simon Beaudoin
  • Jayden A Sader
  • Alexander Zyuzin
  • Kevin Ly
  • Lyne Caouette
  • Helena Senta
  • Eric Lavallée
  • Eric Turcotte
  • Stephen C Cunnane
  • Stéphanie Dubreuil
  • Erik J van Lier
  • Farrah Jean-Denis
  • Lucie Bouffard
  • François D'Anjou
  • Céline Denis
  • Geneviève Tremblay
  • Seda Ekici
  • Pierre Julien Albert
  • Yves Bérubé-Lauzière
  • Mélissa Roy
  • Fevzi Daldal
  • Rejean Langlois
  • Sebastien Tremblay
  • Sheel C Dodani
  • Raphaël Ioannoni
  • Christopher J Chang
  • Garry E Kiefer
  • Luis López-Maury
  • Paul Jurek
  • J Oliver McIntyre
  • Martin Lepage
  • Hélène Therriault
  • Emanuel Escher

Detail Information

Publications32

  1. pmc Comparative study of 64Cu/NOTA-[D-Tyr6,βAla11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging
    Patrick Fournier
    Centre d imagerie moléculaire de Sherbrooke CIMS, Department of Nuclear Medicine and Radiobiology, Universite de Sherbrooke, 3001, 12th North Avenue, Sherbrooke, Quebec, J1H 5N4, Canada
    EJNMMI Res 2:8. 2012
    ..In this study, a 64Cu-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid [NOTA]-monomer and two NOTA-dimers of [D-Tyr6,βAla11, Thi13, Nle14]bombesin(6-14) ] [BBN(6-14)] were compared...
  2. doi request reprint Total solid-phase synthesis of NOTA-functionalized peptides for PET imaging
    Brigitte Guérin
    Centre d imagerie moléculaire de Sherbrooke CIMS, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4
    Org Lett 12:280-3. 2010
    ..Deprotection and cleavage of the resin-bound NOTA peptides were performed with use of trifluoroacetic acid (TFA) in the presence of thioanisole and water to give free NOTA peptides...
  3. doi request reprint [Lys(DOTA)4]BVD15, a novel and potent neuropeptide Y analog designed for Y1 receptor-targeted breast tumor imaging
    Brigitte Guérin
    Department of Nuclear Medicine and Radiobiology, Centre d imagerie moléculaire de Sherbrooke, Universite de Sherbrooke, Quebec, Canada
    Bioorg Med Chem Lett 20:950-3. 2010
    ..Our data suggest that [Lys(DOTA)(4)]BVD15 (K(i)=63+/-25 nM vs. K(i)=39+/-34 nM for BVD15) is a potent NPY analog suitable for radiolabeling with metallo positron emitters for PET imaging of breast cancer...
  4. doi request reprint Novel radiolabeled peptides for breast and prostate tumor PET imaging: (64)Cu/and (68)Ga/NOTA-PEG-[D-Tyr(6),βAla(11),Thi(13),Nle(14)]BBN(6-14)
    Patrick Fournier
    Centre d imagerie moléculaire de Sherbrooke CIMS, Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, Canada, J1H 5N4
    Bioconjug Chem 23:1687-93. 2012
    ..Considering their good imaging characteristics, both (64)Cu/NOTA-PEG-BBN(6-14) and (68)Ga/NOTA-PEG-BBN(6-14) are promising candidates for GRPR-targeted PET imaging of breast and prostate cancers...
  5. pmc Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men
    Denis P Blondin
    Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4
    Nat Commun 8:14146. 2017
    ..These findings show that cold-stimulated BAT can contribute to the clearance of DFA from circulation but its contribution is not as significant as the heart, liver, skeletal muscles or white adipose tissues...
  6. doi request reprint Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes
    Denis P Blondin
    Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, Quebec, Canada
    Diabetes 64:2388-97. 2015
    ..These results show that cold-induced NEFA uptake and oxidative metabolism are not defective in type 2 diabetes despite reduced glucose uptake per BAT volume and BAT "whitening." ..
  7. doi request reprint (68)Ga/DOTA- and (64)Cu/NOTA-phthalocyanine conjugates as fluorescent/PET bimodal imaging probes
    Elena Ranyuk
    Centre d imagerie moléculaire de Sherbrooke CIMS, Departments of Nuclear Medicine and Radiobiology and Pharmacology, Faculty of Medicine and Health Sciences, Université de Sherbrooke 3001 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4
    Bioconjug Chem 24:1624-33. 2013
    ..Fluorescence and PET imaging confirmed the potential of these novel conjugates to act as bimodal probes. ..
  8. doi request reprint Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans
    Denis P Blondin
    Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada
    Cell Metab . 2017
    ..Together, these findings show that intracellular TG lipolysis is critical for BAT thermogenesis and provides experimental evidence for a reciprocal role of BAT thermogenesis and shivering in cold-induced thermogenesis in humans...
  9. doi request reprint Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates
    Samia Ait-Mohand
    Centre d imagerie moléculaire de Sherbrooke, Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 3001, 12th North Avenue Sherbrooke, Qubec, Canada, J1H 5N4
    Bioconjug Chem 22:1729-35. 2011
    ..Our data also show that (64)Cu-labeled NOTA- and PCTA-BBN peptide conjugates are promising radiotracers for PET imaging of many human cancers overexpressing the GRP receptor...
  10. pmc Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity
    Frédéric Couture
    Institut de Pharmacologie de Sherbrooke, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4 Department of Surgery Urology Division, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Biomed Res Int 2015:824014. 2015
    ....
  11. doi request reprint Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans
    Margaret Kunach
    Department of Medicine, Division of Endocrinology, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Diabetes 64:2432-41. 2015
    ..We conclude that early cardiac DFA uptake is higher in men driven by change in postprandial chylomicron-TG level but that increase in 6-h postprandial cardiac DFA partitioning nevertheless occurs with IGT both in men and women. ..
  12. pmc Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men
    Denis P Blondin
    Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, Quebec, Canada
    J Physiol 593:701-14. 2015
    ..Although BAT glucose uptake per volume of tissue is important, the bulk of glucose turnover during cold exposure is mediated by skeletal muscle metabolic activation even when shivering is minimized...
  13. doi request reprint Improved cardiac function and dietary fatty acid metabolism after modest weight loss in subjects with impaired glucose tolerance
    Sébastien M Labbé
    Division of Endocrinology, Department of Medicine, Universite de Sherbrooke, Quebec, Canada and
    Am J Physiol Endocrinol Metab 306:E1388-96. 2014
    ..Modest weight loss corrects the exaggerated myocardial channeling of dietary fatty acids and improves myocardial energy substrate metabolism and function in IGT subjects...
  14. doi request reprint PET imaging using 64Cu-labeled sulfophthalocyanines: synthesis and biodistribution
    Elena R Ranyuk
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4
    Bioorg Med Chem Lett 21:7470-3. 2011
    ..5%ID/g). The biological data suggest that PET imaging with [(64)Cu]CuPc can be used to establish structure-PDT efficacy relationships for Pc-based photosensitizers...
  15. doi request reprint Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects
    Christophe Noll
    Division of Endocrinology, Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Diabetes 64:3690-9. 2015
    ..Very short-term caloric and saturated fat dietary restrictions do not lead to the same changes in organ-specific DFA metabolism as those associated with weight loss in subjects with IGT...
  16. pmc Increased brown adipose tissue oxidative capacity in cold-acclimated humans
    Denis P Blondin
    Faculty of Health Sciences D P B, H C T, F H, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5 Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Québec S M L, D R, Universite Laval, Quebec City, Quebec, Canada G1V 4G5 Department of Medicine C N, M K, S P, A C C, Centre de Recherche Clinique Etienne Le Bel, Universite de Sherbrooke, Sherbrooke, Quebec, Canada and Department of Nuclear Medicine and Radiobiology S P, B G, E E T, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    J Clin Endocrinol Metab 99:E438-46. 2014
    ..Although many mammalian models have demonstrated the phenotypic flexibility of this tissue through chronic cold exposure, little is known about the metabolic plasticity of BAT in humans...
  17. doi request reprint Phthalocyanine-peptide conjugates: receptor-targeting bifunctional agents for imaging and photodynamic therapy
    Elena Ranyuk
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Med Chem 56:1520-34. 2013
    ..These findings warrant further in vivo studies to evaluate the potential of this conjugate as photosensitizer for photodynamic therapy (PDT) of cancers overexpressing the GRP receptor. ..
  18. doi request reprint Impact of dianionic and dicationic linkers on tumor uptake and biodistribution of [64 Cu]Cu/NOTA peptide-based GRPR antagonists
    Nematallah Mansour
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke and Sherbrooke Molecular Imaging Centre, Centre de recherche du CHUS CRCHUS, Sherbrooke, Canada
    J Labelled Comp Radiopharm . 2017
    ..Considering their adequate imaging characteristics, [64 Cu]-NOTA-LK-RM26 bearing APCA- and AHDA-linkers are promising candidates for GRPR-targeted PET imaging prostate cancer...
  19. doi request reprint Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography
    Sébastien M Labbé
    Division of Endocrinology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
    Am J Physiol Endocrinol Metab 300:E445-53. 2011
    ..This novel noninvasive method to determine tissue dietary fatty acid distribution in humans should prove useful in the study of the mechanisms leading to lipotoxicity...
  20. pmc Normal postprandial nonesterified fatty acid uptake in muscles despite increased circulating fatty acids in type 2 diabetes
    Sébastien M Labbé
    Centre de Recherche Clinique Etienne Le Bel, Quebec, Canada
    Diabetes 60:408-15. 2011
    ..Postprandial plasma nonesterified fatty acid (NEFA) appearance is increased in type 2 diabetes. Our objective was to determine whether skeletal muscle uptake of plasma NEFA is abnormal during the postprandial state in type 2 diabetes...
  21. doi request reprint BODIPY-17α-ethynylestradiol conjugates: Synthesis, fluorescence properties and receptor binding affinities
    Samira Osati
    Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H5N4, Canada
    Bioorg Med Chem Lett . 2016
    ..The highest RBA for the ERα was observed with the EE2-BODIPY conjugate (7) featuring a linear eight carbon spacer chain. Cell uptake studies and in vivo imaging experiments in an ER-positive mouse tumor model are in progress...
  22. doi request reprint Synthesis of Gly-ψ[(Z)CF═CH]-Phe, a Fluoroalkene Dipeptide Isostere, and Its Incorporation into a Leu-enkephalin Peptidomimetic
    Jean François Nadon
    Laboratoire de synthèse supramoléculaire, Departement de Chimie, Faculté des sciences Département de pharmacologie physiologie, Département d Anesthésiologie, and Département de Médecine Nucléaire et Radiobiologie, Faculte de Medecine et des Sciences de la Sante, Centre de recherche du CHUS, Quebec Pain Research Network, and Institut de Pharmacologie de Sherbrooke, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada
    ACS Chem Neurosci 8:40-49. 2017
    ..The lipophilicity (LogD7.4) of the active analog was also measured. It appears that fluoroalkenes are almost as efficient at increasing the lipophilicity as normal alkenes...
  23. pmc PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation
    Christine Levesque
    Department of Surgery Urology Division and Faculté de Médecine et Sciences de la Santé, Universite de Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada
    Oncotarget 6:3680-93. 2015
    ..We conclude that PACE4 peptidomimetic inhibitors could result in stable and potent drugs for a novel therapeutic strategy for prostate cancer. ..
  24. pmc Copper transport and regulation in Schizosaccharomyces pombe
    Jude Beaudoin
    Departement de Biochimie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Rue Jean Mignault, Sherbrooke, QC, Canada, J1E 4K8
    Biochem Soc Trans 41:1679-86. 2013
    ..It is foreseeable that identification of novel meiotic copper-related proteins will serve as stepping stones to unravel fundamental aspects of copper homoeostasis. ..
  25. pmc PACE4-based molecular targeting of prostate cancer using an engineered ⁶⁴Cu-radiolabeled peptide inhibitor
    Frédéric Couture
    Institut de Pharmacologie de Sherbrooke, Department of Surgery Urology Division, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Neoplasia 16:634-43. 2014
    ....
  26. doi request reprint Radioisotopic Purity of Sodium Pertechnetate 99mTc Produced with a Medium-Energy Cyclotron: Implications for Internal Radiation Dose, Image Quality, and Release Specifications
    Svetlana V Selivanova
    Sherbrooke Molecular Imaging Center, CRCHUS, Sherbrooke, Quebec, Canada Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada and
    J Nucl Med 56:1600-8. 2015
    ..To take advantage of this capability, evaluation of the radioisotopic purity of 99mTc produced at medium energy (20-24 MeV) and its impact on image quality and dosimetry was required...
  27. doi request reprint Development of bifunctional chelates bearing hydroxamate arms for highly efficient (64)Cu radiolabeling
    Samia Ait-Mohand
    Department of Nuclear Medicine and Radiobiology, Universite de Sherbrooke, 3001 12th North Avenue Sherbrooke, Quebec J1H 5N4, Canada
    Org Lett 16:4512-5. 2014
    ..The corresponding radiochemical complexes showed high stability, low residual activity in various tissues, and fast clearance in normal mice. The ability to conjugate DOTHA2 to both a small peptide and a large protein is also reported. ..
  28. pmc Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity
    Arnaud Proteau-Gagné
    Laboratoire de Chimie Supramoleculaire, Departement de Chimie, Universite de Sherbrooke, Nord Sherbrooke, QC, Canada
    Bioorg Med Chem Lett 23:5267-9. 2013
    ....
  29. pmc Increased myocardial uptake of dietary fatty acids linked to cardiac dysfunction in glucose-intolerant humans
    Sébastien M Labbé
    Department of Medicine, Division of Endocrinology, Centre de Recherche Clinique Etienne Lebel, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Diabetes 61:2701-10. 2012
    ....
  30. doi request reprint Phthalocyanine-peptide conjugates via palladium-catalyzed cross-coupling reactions
    Hasrat Ali
    Centre d imagerie moléculaire de Sherbrooke CIMS, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Quebec, Canada J1H 5N4
    J Org Chem 76:1887-90. 2011
    ..Using these methods, a series of peptides monofunctionalized with Pc at the N/C-terminal position or on a phenylalanine side chain was obtained in good yields and characterized...
  31. pmc Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells
    Jude Beaudoin
    Départements de Biochimie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 286:34356-72. 2011
    ..Taken together, the data reveal that Mfc1 serves to transport copper for accurate and timely meiotic differentiation under copper-limiting conditions...
  32. doi request reprint New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging
    Beata Jastrzebska
    Centre d Imagerie Moleculaire de Sherbrooke and Department of Nuclear Medicine and Radiobiology, Universite de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada
    J Med Chem 52:1576-81. 2009
    ..This compound and control compounds were successfully tested in an animal model bearing two tumors with different levels of MMP-2 activity...