Serge Gauthier

Summary

Country: Canada

Publications

  1. doi Commentary on "Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease." A Canadian perspective
    Serge Gauthier
    McGill Center for Studies in Aging, McGill University, Montreal, Quebec, Canada
    Alzheimers Dement 7:330-2. 2011
  2. doi Priorities for research consortia on Alzheimer's disease
    Serge Gauthier
    McGill University, Montreal, Canada
    Alzheimers Dement 6:359-62. 2010
  3. pmc White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and Alzheimer's disease
    Jared Rowley
    Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging MCSA, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e74776. 2013
  4. doi The nature of episodic memory deficits in MCI with and without vascular burden
    Sylvia Villeneuve
    Research Center, Institut Universitaire de Geriatrie de Montreal, Montreal, Canada
    Neuropsychologia 49:3027-35. 2011
  5. doi Benefits of combined cholinesterase inhibitor and memantine treatment in moderate-severe Alzheimer's disease
    Serge Gauthier
    McGill Centre for Studies in Aging, Alzheimer s Disease Research Unit, Montreal, Quebec, Canada
    Alzheimers Dement 9:326-31. 2013
  6. doi A 10-year perspective on donepezil
    Laksanun Cheewakriengkrai
    McGill Center for Studies in Aging, Montreal, Canada
    Expert Opin Pharmacother 14:331-8. 2013
  7. ncbi Working memory and control of attention in persons with Alzheimer's disease and mild cognitive impairment
    Sylvie Belleville
    Research CenterInstitut Universitaire de Geriatrie de Montreal, Montreal, PQ, Canada
    Neuropsychology 21:458-69. 2007
  8. doi The association between depressive and cognitive symptoms in amnestic mild cognitive impairment
    Carol Hudon
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Int Psychogeriatr 20:710-23. 2008
  9. doi The assessment of recognition memory using the Remember/Know procedure in amnestic mild cognitive impairment and probable Alzheimer's disease
    Carol Hudon
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Brain Cogn 70:171-9. 2009
  10. doi Effects of rivastigmine on common symptomatology of Alzheimer's disease (EXPLORE)
    Serge Gauthier
    McGill Centre for Studies of Aging, Montreal, Quebec, Canada
    Curr Med Res Opin 26:1149-60. 2010

Collaborators

Detail Information

Publications52

  1. doi Commentary on "Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease." A Canadian perspective
    Serge Gauthier
    McGill Center for Studies in Aging, McGill University, Montreal, Quebec, Canada
    Alzheimers Dement 7:330-2. 2011
    ....
  2. doi Priorities for research consortia on Alzheimer's disease
    Serge Gauthier
    McGill University, Montreal, Canada
    Alzheimers Dement 6:359-62. 2010
    ....
  3. pmc White matter abnormalities and structural hippocampal disconnections in amnestic mild cognitive impairment and Alzheimer's disease
    Jared Rowley
    Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging MCSA, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e74776. 2013
    ..The severity of white matter degeneration appears to be higher in advanced clinical stages, supporting the construct that these abnormalities are part of the pathophysiological processes of Alzheimer's disease. ..
  4. doi The nature of episodic memory deficits in MCI with and without vascular burden
    Sylvia Villeneuve
    Research Center, Institut Universitaire de Geriatrie de Montreal, Montreal, Canada
    Neuropsychologia 49:3027-35. 2011
    ..Overall, results indicate that the presence of vascular burden in MCI is associated with selective impairment of strategic memory processes...
  5. doi Benefits of combined cholinesterase inhibitor and memantine treatment in moderate-severe Alzheimer's disease
    Serge Gauthier
    McGill Centre for Studies in Aging, Alzheimer s Disease Research Unit, Montreal, Quebec, Canada
    Alzheimers Dement 9:326-31. 2013
    ..Clinical studies and post hoc analyses have investigated the use of combination therapy for the treatment of Alzheimer's disease (AD). We review the evidence for the short- and long-term efficacy of combination therapy in AD...
  6. doi A 10-year perspective on donepezil
    Laksanun Cheewakriengkrai
    McGill Center for Studies in Aging, Montreal, Canada
    Expert Opin Pharmacother 14:331-8. 2013
    ..Its efficacy has been approved for use in mild-to-moderate AD stage for improvement of symptoms for 10 years, and now it is also approved for use in severe stage...
  7. ncbi Working memory and control of attention in persons with Alzheimer's disease and mild cognitive impairment
    Sylvie Belleville
    Research CenterInstitut Universitaire de Geriatrie de Montreal, Montreal, PQ, Canada
    Neuropsychology 21:458-69. 2007
    ..These data suggest that control of attention tasks can track AD at a preclinical stage and that impairment increases gradually during the preclinical phase of AD...
  8. doi The association between depressive and cognitive symptoms in amnestic mild cognitive impairment
    Carol Hudon
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Int Psychogeriatr 20:710-23. 2008
    ..Depressive symptoms are frequently observed in older adults with mild cognitive impairment (MCI). However, little is known regarding the cognitive characteristics of this important subgroup...
  9. doi The assessment of recognition memory using the Remember/Know procedure in amnestic mild cognitive impairment and probable Alzheimer's disease
    Carol Hudon
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Brain Cogn 70:171-9. 2009
    ..On the other measures, response bias was comparable between the groups. Overall, this study indicates that the R/K procedure can characterize different aspects of recognition memory performance in persons with aMCI or AD...
  10. doi Effects of rivastigmine on common symptomatology of Alzheimer's disease (EXPLORE)
    Serge Gauthier
    McGill Centre for Studies of Aging, Montreal, Quebec, Canada
    Curr Med Res Opin 26:1149-60. 2010
    ..To evaluate, in a real-world clinical setting, the efficacy of rivastigmine in the management of six symptoms commonly associated with Alzheimer's disease (AD)...
  11. doi Effects of donepezil on activities of daily living: integrated analysis of patient data from studies in mild, moderate and severe Alzheimer's disease
    Serge Gauthier
    McGill Center for Studies in Aging, Douglas Mental Health University Institute, Douglas Hospital, Verdun, QC, Canada
    Int Psychogeriatr 22:973-83. 2010
    ....
  12. doi Real-life effectiveness and tolerability of the rivastigmine transdermal patch in patients with mild-to-moderate Alzheimer's disease: the EMBRACE study
    Serge Gauthier
    McGill Centre for Studies of Aging, Douglas Hospital, Montreal, Quebec, Canada
    Curr Med Res Opin 29:989-1000. 2013
    ..To assess the real-life effectiveness and tolerability of the rivastigmine transdermal patch in patients with mild-to-moderate Alzheimer's disease (AD) in Canada...
  13. pmc Recommendations of the 4th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD4)
    Serge Gauthier
    McGill Center for Studies in Aging, Montreal, QC
    Can Geriatr J 15:120-6. 2012
    ....
  14. doi Management of behavioral problems in Alzheimer's disease
    Serge Gauthier
    Alzheimer s Disease and Related Disorders Unit, McGill Center for Studies in Aging, Douglas Mental Health University Institute, Montreal, Canada
    Int Psychogeriatr 22:346-72. 2010
    ..Pharmacological treatment options, such as antipsychotics, antidepressants, anticonvulsants, cholinesterase inhibitors and memantine, need careful consideration of the benefits and limitations of each drug class...
  15. doi Cognitive complaint in mild cognitive impairment and Alzheimer's disease
    Francis Clément
    Centre de recherche de l Institut universitaire de geriatrie de Montreal, Montreal, Canada
    J Int Neuropsychol Soc 14:222-32. 2008
    ....
  16. doi Switching cholinesterase inhibitors in older adults with dementia
    Fadi Massoud
    Centre Hospitalier de l Universite de Montreal CHUM, Hopital Notre Dame, Service de Geriatrie, Montreal, Quebec, Canada
    Int Psychogeriatr 23:372-8. 2011
    ..These agents differ in their individual mechanisms of action and pharmacokinetic properties. Switching ChEIs can be a reasonable option in cases of intolerance or lack of clinical benefit...
  17. doi Abnormal temporal dynamics of visual attention in Alzheimer's disease and in dementia with Lewy bodies
    Frederic Peters
    Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    Neurobiol Aging 33:1012.e1-10. 2012
    ..More generally, these findings reinforce the notion that deficits of attentional control processes are more severe in DLB patients as compared with DAT patients...
  18. ncbi Improvement of episodic memory in persons with mild cognitive impairment and healthy older adults: evidence from a cognitive intervention program
    Sylvie Belleville
    Institut Universitaire de Geriatrie de Montreal, Montreal, Canada
    Dement Geriatr Cogn Disord 22:486-99. 2006
    ..These results suggest that persons with MCI can improve their performance on episodic memory when provided with cognitive training...
  19. doi Single- and multiple-domain amnestic mild cognitive impairment: two sides of the same coin?
    Simona Maria Brambati
    Centre de Recherche, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    Dement Geriatr Cogn Disord 28:541-9. 2009
    ....
  20. doi Measuring the impact of cognitive and psychosocial interventions in persons with mild cognitive impairment with a randomized single-blind controlled trial: rationale and design of the MEMO+ study
    Nathalie Bier
    Centre de Recherche, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec H3W 1W4, Canada
    Int Psychogeriatr 27:511-25. 2015
    ..The MEMO+ study is a randomized, controlled, single-blind trial designed to test the efficacy, specificity, and long-term effect of a cognitive training intervention and a psychosocial intervention in persons with MCI...
  21. doi Resting state executive control network adaptations in amnestic mild cognitive impairment
    Liyong Wu
    Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, QC, Canada McGill Centre for Studies in Aging MCSA, McGill University, Montreal, QC, Canada Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
    J Alzheimers Dis 40:993-1004. 2014
    ..6454, p = 0.017). Coexistence between connectivity declines and recruitment of brain regions outside the RS-ECN as reported here fits a brain reserve conceptual framework in which brain networks undergo remodeling in aMCI individuals. ..
  22. pmc Dissociation between brain amyloid deposition and metabolism in early mild cognitive impairment
    Liyong Wu
    Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e47905. 2012
    ..We used the concept of early MCI (EMCI) and late MCI (LMCI) as defined by the Alzheimer's disease Neuroimaging Initiative (ADNI)-Go in order to compare the biomarker profile between EMCI and LMCI...
  23. doi Can we do better in developing new drugs for Alzheimer's disease?
    Serge Gauthier
    Department of Psychiatry, Neurology and Neurosurgery, McGill Center for Studies in Aging, McGill University, Montreal, Quebec, Canada
    Alzheimers Dement 5:489-91. 2009
    ....
  24. doi Pharmacotherapy of Parkinson disease dementia and Lewy body dementia
    Serge Gauthier
    McGill Center for Studies in Aging, Montreal, Quebec, Canada
    Front Neurol Neurosci 24:135-9. 2009
    ..Primary care practitioners play an essential role in the diagnosis and management of patients with these conditions...
  25. doi In vivo characterization of metabotropic glutamate receptor type 5 abnormalities in behavioral variant FTD
    Antoine Leuzy
    Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, McGill University, 6825 LaSalle Blvd, Montreal, QC, H4H 1R3, Canada
    Brain Struct Funct 221:1387-402. 2016
    ..This study suggests that glutamate excitotoxicity may play a role in the pathogenesis of bvFTD and that [(11)C]ABP688 may prove a suitable marker of glutamatergic neurotransmission in vivo. ..
  26. pmc Epistasis analysis links immune cascades and cerebral amyloidosis
    Andrea L Benedet
    Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, 6825 LaSalle Blvd, H4H 1R3, Montreal, QC, Canada
    J Neuroinflammation 12:227. 2015
    ....
  27. pmc Imaging in vivo glutamate fluctuations with [(11)C]ABP688: a GLT-1 challenge with ceftriaxone
    Eduardo R Zimmer
    1 Translational Neuroimaging Laboratory TNL, McGill Center for Studies in Aging, Douglas Mental Health University Institute, Verdun, Quebec, Canada 2 Alzheimer s Disease Research Unit, McGill Centre for Studies in Aging, McGill University, Montreal, Quebec, Canada 3 Department of Biochemistry, Federal University of Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    J Cereb Blood Flow Metab 35:1169-74. 2015
    ..This interesting property of mGluR5 allosteric binding sites has potential applications for assessing the role of glutamate in the pathogenesis of neuropsychiatric conditions...
  28. doi Use of amyloid PET across the spectrum of Alzheimer's disease: clinical utility and associated ethical issues
    Antoine Leuzy
    Translational Neuroimaging Laboratory TNL, Douglas Mental Health University Institute, Montreal, Canada
    Amyloid 21:143-8. 2014
    ..As the field moves toward adoption of a pro-disclosure stance for amyloid imaging findings, it is imperative that a broad range of stakeholders be involved to ensure the appropriateness of emerging policies and protocols. ..
  29. doi Executive functions in mild cognitive impairment: emergence and breakdown of neural plasticity
    Francis Clément
    Centre de recherche de l Institut universitaire de geriatrie de Montreal, Montreal, Canada
    Cortex 49:1268-79. 2013
    ..Our goal was to test the effect of disease severity on the brain activation associated with two executive processes: manipulation and divided attention...
  30. doi Ethical issues in Alzheimer's disease: an overview
    Antoine Leuzy
    McGill Centre for Studies in Aging, Douglas Mental Health University Institute, Montreal, QC, Canada
    Expert Rev Neurother 12:557-67. 2012
    ..There will be new drugs in the near future, some of which will delay progression from prodromal stages to dementia, but their use will require careful stopping rules...
  31. doi Executive function deficits in persons with mild cognitive impairment: a study with a Tower of London task
    Constant Rainville
    Centre de Recherche, Institut Universitaire de Geriatrie de Montreal, Montreal, QC, Canada
    J Clin Exp Neuropsychol 34:306-24. 2012
    ..In qualitative analysis, T- MCI decliners produced significantly more rule breakings than the stable MCI and controls. A dysfunction in self-monitoring is a characteristic feature of persons with MCI...
  32. doi Use of biomarkers in clinical trials of Alzheimer disease: from concept to application
    Liyong Wu
    McGill Centre for Studies in Aging MCSA, McGill University, Montreal, QC, Canada
    Mol Diagn Ther 15:313-25. 2011
    ..Clinical trials for every clinical stage of AD would benefit from quantification and standardization of biomarkers. However, this is still a work in progress...
  33. ncbi A large, naturalistic, community-based study of rivastigmine in mild-to-moderate AD: the EXTEND Study
    Serge Gauthier
    McGill Centre for Studies in Aging, Douglas Hospital, Montreal, Quebec, Canada
    Curr Med Res Opin 22:2251-65. 2006
    ....
  34. ncbi Mild cognitive impairment
    Serge Gauthier
    McGill Center for Studies in Aging, Douglas Hospital, Montreal, Quebec, Canada
    Lancet 367:1262-70. 2006
    ..Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia...
  35. ncbi Outcomes for assessment of symptomatic and stabilization/disease modifying drugs
    Serge Gauthier
    Alzheimer Disease Research Unit, McGill Centre for Studies in Aging, Verdun, Quebec, Canada
    Can J Neurol Sci 34:S23-6. 2007
    ..Delaying progression to disease milestones may offer additional validity to these studies. It is unclear if biological and neuroimaging markers will add to the clinical evidence...
  36. doi Hippocampus and amygdala volumes from magnetic resonance images in children: Assessing accuracy of FreeSurfer and FSL against manual segmentation
    Dorothee Schoemaker
    McGill Centre for Studies in Aging, McGill University, Montreal, QC, Canada Douglas Hospital Research Centre, Psychiatry Department, McGill University, Montreal, QC, Canada
    Neuroimage 129:1-14. 2016
    ..Visual inspection by an informed individual and, if necessary, manual correction of automated segmentation outputs are important to ensure validity of volumetric results and interpretation of related findings. ..
  37. pmc Tracking neuroinflammation in Alzheimer's disease: the role of positron emission tomography imaging
    Eduardo Rigon Zimmer
    Translational Neuroimaging Laboratory TNL, McGill Center for Studies in Aging MCSA, Douglas Mental Health University Institute, Montreal, QC H4H 1R3, Canada
    J Neuroinflammation 11:120. 2014
    ....
  38. pmc Prevention strategies for Alzheimer's disease
    Serge Gauthier
    McGill Center for Studies in Aging, McGill University, Montreal, Canada
    Transl Neurodegener 1:13. 2012
    ..This will be done first in carriers of dominantly inherited early onset AD. As this research takes place networks of memory clinics must prepare to transfer new knowledge to persons interested in a preventive approach to AD...
  39. doi MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical research
    Eduardo R Zimmer
    Translational Neuroimaging Laboratory TNL, McGill Center for Studies in Aging, Douglas Mental Health University Institute, Montreal, Quebec, Canada PET unit, Montreal Neurological Institute MNI, Montreal, Quebec, Canada Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Trends Neurosci 37:629-41. 2014
    ..This review highlights what we have learned from microPET imaging in Tg models displaying amyloid and tau pathology, and anticipates cutting-edge applications with high translational value to clinical research. ..
  40. doi Cerebrolysin in mild-to-moderate Alzheimer's disease: a meta-analysis of randomized controlled clinical trials
    Serge Gauthier
    McGill Center for Studies in Aging, Montreal, Que, Canada
    Dement Geriatr Cogn Disord 39:332-47. 2015
    ..The aim of this study was to provide a systematic and quantitative summary of benefit and risk of Cerebrolysin in patients with mild-to-moderate Alzheimer's disease (AD) and to avoid major deficiencies of an earlier meta-analysis...
  41. doi Recollection and familiarity in aging individuals with mild cognitive impairment and Alzheimer's disease: a literature review
    Dorothee Schoemaker
    McGill Centre for Studies in Aging, 6828 LaSalle Boulevard, Montreal, H4H 1R3, Canada
    Neuropsychol Rev 24:313-31. 2014
    ..Together with clinical features, methodological factors are taken into consideration in the interpretation of findings. ..
  42. pmc Managing discontinuation syndrome in patients with dementia
    Serge Gauthier
    McGill Center for Studies in Aging, Montreal, Que
    J Psychiatry Neurosci 31:72. 2006
  43. ncbi Reliability and validity of the Safety Assessment Scale for people with dementia living at home
    Courval Louise de Poulin
    Department of Family Medicine, McGill University, Cote des Neiges, Montreal
    Can J Occup Ther 73:67-75. 2006
    ..With the recent funding changes in health care services, more seniors with dementia are cared for in their homes and the nature of their condition puts them at higher risk for accidents and injuries...
  44. ncbi Pharmacotherapy of Alzheimer disease
    Dennis Seow
    Alzheimer Disease Research Unit, McGill Centre for Studies in Aging, Montreal, Quebec
    Can J Psychiatry 52:620-9. 2007
    ..To systematically review published clinical trials of the pharmacotherapy of Alzheimer disease (AD)...
  45. ncbi Does vascular MCI progress at a different rate than does amnestic MCI?
    Serge Gauthier
    McGill Centre for Studies in Aging, McGill University, Montreal, Canada
    Int Psychogeriatr 15:257-9. 2003
    ..The issues to be resolved prior to the use of a survival design for conversion from vascular MCI to dementia will be discussed...
  46. pmc Recognition and management of neuropsychiatric complications in Parkinson's disease
    Florian Ferreri
    Alzheimer s Disease Research Unit, McGill Centre for Studies in Aging, Douglas Hospital, Verdun, Quebec, Canada
    CMAJ 175:1545-52. 2006
    ..In this article, we review the key clinical features of neuropsychiatric complications in Parkinson's disease as well as what is known about their epidemiologic characteristics, risk factors, pathophysiologic features and management...
  47. ncbi Emergent complications following donepezil switchover to galantamine in three cases of dementia with Lewy bodies
    Nadeem H Bhanji
    Clinical Pharmacology Unit, Allan Memorial Institute, McGill University Health Centre, 1025 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    J Neuropsychiatry Clin Neurosci 17:552-5. 2005
    ..In this study, complications (insomnia, dyskinesias, agitation, and delirium) occurred in three patients switched from donepezil to galantamine. The authors describe evidence-based recommendations for ChEI switchover in DLB...
  48. doi Current and future management of Alzheimer's disease
    Serge Gauthier
    McGill Center for Studies in Aging, Douglas Institute for Mental Health, Montreal, Quebec, Canada
    Alzheimers Dement 4:S48-50. 2008
    ..There are multiple research opportunities for better understanding and treatment of this condition. Ongoing cohort studies developed under Leon Thal's leadership will facilitate this process...
  49. pmc Advances in the pharmacotherapy of Alzheimer's disease
    Serge Gauthier
    Alzheimer s Disease Research Unit at the McGill Centre for Studies in Aging, McGill University, Montreal, Que
    CMAJ 166:616-23. 2002
  50. ncbi Strategies for continued successful treatment of Alzheimer's disease: switching cholinesterase inhibitors
    Serge Gauthier
    McGill Centre for Studies in Aging, Verdun, Quebec, Canada
    Curr Med Res Opin 19:707-14. 2003
    ..The panel also aimed to reach consensus on 'whom to switch', 'when to switch' and 'how to switch'. The key findings from that meeting are reported in this review...
  51. pmc Expression of melanotransferrin isoforms in human serum: relevance to Alzheimer's disease
    Richard R Desrosiers
    Laboratoire de Medecine Moleculaire, Hopital Sainte Justine, Universite du Quebec a Montreal, C P 8888, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3P8
    Biochem J 374:463-71. 2003
    ..These data also indicate that human serum melanotransferrin levels are unchanged in subjects with Alzheimer's disease...
  52. ncbi Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease
    Serge Gauthier
    Alzheimer s Disease Research Unit, McGill Centre for Studies in Aging, Verdun, Quebec, Canada
    Int Psychogeriatr 14:389-404. 2002
    ..This subanalysis of a large, double-blind, placebo-controlled trial examined the prevalence of behavioral symptoms in moderate to severe Alzheimer's disease (AD), and the effect of treatment with donepezil...