Yushan Wang

Summary

Affiliation: Defence Research and Development Canada
Country: Canada

Publications

  1. ncbi request reprint alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor (AMPAR) endocytosis is essential for N-methyl-D-aspartate-induced neuronal apoptosis
    Yushan Wang
    Brain Research Centre and Department of Medicine, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    J Biol Chem 279:41267-70. 2004
  2. doi request reprint Effect of acute soman exposure on GABA(A) receptors in rat hippocampal slices and cultured hippocampal neurons
    Yushan Wang
    Defence R and D Canada Suffield, Station Main, Medicine Hat, P O Box 4000, Alberta T1A8K6, Canada
    Neurotox Res 20:343-50. 2011
  3. doi request reprint Role of the sodium hydrogen exchanger in maitotoxin-induced cell death in cultured rat cortical neurons
    Yushan Wang
    Defence Research and Development Canada Suffield, Medicine Hat, Alberta T1A 8K6, Canada
    Toxicon 54:95-102. 2009
  4. ncbi request reprint Protective effects of N-methyl-D-aspartate receptor antagonism on VX-induced neuronal cell death in cultured rat cortical neurons
    Yushan Wang
    Canada West Bioscience Inc, Camrose, Alberta, Canada
    Neurotox Res 13:163-72. 2008
  5. doi request reprint Cyclooxygenase-2 contributes to VX-induced cell death in cultured cortical neurons
    Catherine C Tenn
    DRDC Suffield, Station Main, Medicine Hat, Alberta, Canada
    Toxicol Lett 210:71-7. 2012
  6. doi request reprint Attenuation of maitotoxin-induced cytotoxicity in rat aortic smooth muscle cells by inhibitors of Na+/Ca2+ exchange, and calpain activation
    Robert Frew
    Defence Research and Development Canada Suffield, Medicine Hat, Alberta, Canada
    Toxicon 51:1400-8. 2008
  7. doi request reprint High-Fidelity Simulation of Primary Blast: Direct Effects on the Head
    Thomas W Sawyer
    1 Defence Research and Development Canada, Medicine Hat, Alberta, Canada
    J Neurotrauma 33:1181-93. 2016
  8. ncbi request reprint VX-induced cell death involves activation of caspase-3 in cultured rat cortical neurons
    Catherine C Tenn
    Medical Therapy Group, DRDC Suffield, P O Box 4000, Station Main, Medicine Hat, Alberta T1A 8K6, Canada
    Neurosci Lett 417:155-9. 2007
  9. ncbi request reprint The Effect of Underwater Blast on Aggregating Brain Cell Cultures
    Thomas W Sawyer
    1 Defence Research and Development Canada, Suffield Research Center, Medicine Hat, Alberta, Canada
    J Neurotrauma . 2016
  10. ncbi request reprint NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1
    Martina Metzler
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Neurosci 27:2298-308. 2007

Collaborators

  • Thomas W Sawyer
  • Catherine C Tenn
  • Morgan H Sheng
  • Xian Min Yu
  • Frederic Dorandeu
  • Lidong Liu
  • Tak Pan Wong
  • Gholamreza Ahmadian
  • Robert Frew
  • Martina Metzler
  • William Ju
  • Jie Lu
  • Qinghua Wang
  • Fang Liu
  • Lin Pei
  • Frank J S Lee
  • Tracy M Weiss
  • Peggy Nelson
  • Nagat Bissada
  • Jeffrey Helm
  • John C Roder
  • Lili Liu
  • Kevin Cheng
  • Michael R Hayden
  • John Georgiou
  • Lu Gan
  • Sang Hyoung Lee
  • Kurt Lingenhoehl
  • Michael Wyszynski
  • Mario F Pozza
  • Changiz Taghibiglou
  • Yves P Auberson
  • Anthone W Dunah
  • Hyman B Niznik
  • Sheng Xue
  • Brian Vukusic
  • Nadege Chery

Detail Information

Publications14

  1. ncbi request reprint alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor (AMPAR) endocytosis is essential for N-methyl-D-aspartate-induced neuronal apoptosis
    Yushan Wang
    Brain Research Centre and Department of Medicine, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    J Biol Chem 279:41267-70. 2004
    ....
  2. doi request reprint Effect of acute soman exposure on GABA(A) receptors in rat hippocampal slices and cultured hippocampal neurons
    Yushan Wang
    Defence R and D Canada Suffield, Station Main, Medicine Hat, P O Box 4000, Alberta T1A8K6, Canada
    Neurotox Res 20:343-50. 2011
    ..Regardless of the exact mechanism, the observation that soman induces rapid GABA(A)R endocytosis may have significant implications in the development of effective countermeasures against soman-induced seizures...
  3. doi request reprint Role of the sodium hydrogen exchanger in maitotoxin-induced cell death in cultured rat cortical neurons
    Yushan Wang
    Defence Research and Development Canada Suffield, Medicine Hat, Alberta T1A 8K6, Canada
    Toxicon 54:95-102. 2009
    ..Furthermore, knockdown of NHE1 by SiRNA transfection suppressed MTX-induced cell death in human embryonic kidney (HEK) cells. Together, these results suggest that NHE1 plays a major role in MTX-induced neurotoxicity...
  4. ncbi request reprint Protective effects of N-methyl-D-aspartate receptor antagonism on VX-induced neuronal cell death in cultured rat cortical neurons
    Yushan Wang
    Canada West Bioscience Inc, Camrose, Alberta, Canada
    Neurotox Res 13:163-72. 2008
    ..Based on their therapeutic effects, NMDAR antagonists may be beneficial in the treatment of VX-induced neurotoxicities...
  5. doi request reprint Cyclooxygenase-2 contributes to VX-induced cell death in cultured cortical neurons
    Catherine C Tenn
    DRDC Suffield, Station Main, Medicine Hat, Alberta, Canada
    Toxicol Lett 210:71-7. 2012
    ..These findings indicate that the increase in COX-2 activity may contribute to the mechanism of VX-induced neurotoxicity in cultured rat cortical neuron...
  6. doi request reprint Attenuation of maitotoxin-induced cytotoxicity in rat aortic smooth muscle cells by inhibitors of Na+/Ca2+ exchange, and calpain activation
    Robert Frew
    Defence Research and Development Canada Suffield, Medicine Hat, Alberta, Canada
    Toxicon 51:1400-8. 2008
    ..These results suggest that MTX targets the Na(+)/Ca(2+) exchanger and causes it to operate in reverse mode (Na(+) efflux/Ca(2+) influx), thus leading to calpain activation, NCX cleavage, secondary Ca(2+) overload and cell death...
  7. doi request reprint High-Fidelity Simulation of Primary Blast: Direct Effects on the Head
    Thomas W Sawyer
    1 Defence Research and Development Canada, Medicine Hat, Alberta, Canada
    J Neurotrauma 33:1181-93. 2016
    ....
  8. ncbi request reprint VX-induced cell death involves activation of caspase-3 in cultured rat cortical neurons
    Catherine C Tenn
    Medical Therapy Group, DRDC Suffield, P O Box 4000, Station Main, Medicine Hat, Alberta T1A 8K6, Canada
    Neurosci Lett 417:155-9. 2007
    ..These data suggested that in rat cortical neurons, VX-induced cell death via a programmed cell death pathway that involves changes in caspase-3 protease...
  9. ncbi request reprint The Effect of Underwater Blast on Aggregating Brain Cell Cultures
    Thomas W Sawyer
    1 Defence Research and Development Canada, Suffield Research Center, Medicine Hat, Alberta, Canada
    J Neurotrauma . 2016
    ..This study has mechanistic implications for the study of primary blast-induced traumatic brain injury and supports the thesis that underwater blast may cause subtle changes in the brains of submerged individuals...
  10. ncbi request reprint NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1
    Martina Metzler
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Neurosci 27:2298-308. 2007
    ..These findings may provide novel insights into the cellular mechanisms underlying enhanced NMDA-induced excitotoxicity in Huntington's disease...
  11. ncbi request reprint Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity
    Lidong Liu
    Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Science 304:1021-4. 2004
    ..These results demonstrate that distinct NMDAR subunits are critical factors that determine the polarity of synaptic plasticity...
  12. pmc Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD
    Gholamreza Ahmadian
    National Research Center for Genetic Engineering and Biotechnology, Tehran, Iran
    EMBO J 23:1040-50. 2004
    ....
  13. ncbi request reprint Control of synaptic strength, a novel function of Akt
    Qinghua Wang
    Programme in Brain and Behaviour Research, Research Institute of the Hospital for Sick Children, University of Toronto, 555 University Avenue, M5G 1X8, Toronto, Ontario, Canada
    Neuron 38:915-28. 2003
    ..This work also provides evidence for the rapid regulation of neurotransmitter receptor numbers in the postsynaptic domain by direct receptor phosphorylation as an important means of producing synaptic plasticity...
  14. ncbi request reprint Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor
    Frank J S Lee
    Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Toronto, M5T 1R8, Ontario, Canada
    Cell 111:219-30. 2002
    ..While one interaction is involved in the inhibition of NMDA receptor-gated currents, the other is implicated in the attenuation of NMDA receptor-mediated excitotoxicity through a PI-3 kinase-dependent pathway...