Graham Dellaire

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. pmc Reading, writing, and repair: the role of ubiquitin and the ubiquitin-like proteins in DNA damage signaling and repair
    Jordan B Pinder
    Department of Pathology, Dalhousie University Halifax, NS, Canada
    Front Genet 4:45. 2013
  2. ncbi request reprint High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced DNA repair foci
    Graham Dellaire
    Departments of Pathology and Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada
    Cell Cycle 8:3750-69. 2009
  3. ncbi request reprint KAP1 depletion increases PML nuclear body number in concert with ultrastructural changes in chromatin
    Rosemarie Kepkay
    Department of Pathology, Dalhousie University, Halifax, NS, Canada
    Cell Cycle 10:308-22. 2011
  4. doi request reprint Heterochromatin and the DNA damage response: the need to relax
    Kendra L Cann
    Department of Pathology, Dalhousie University, Halifax, NS, Canada
    Biochem Cell Biol 89:45-60. 2011
  5. doi request reprint The translation initiation factor 3 subunit eIF3K interacts with PML and associates with PML nuclear bodies
    Jayme Salsman
    Department of Pathology, Dalhousie University, P O Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
    Exp Cell Res 319:2554-65. 2013
  6. doi request reprint Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking
    David N Langelaan
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Biochim Biophys Acta 1828:1471-83. 2013
  7. doi request reprint The Zebrafish Xenograft Platform: Evolution of a Novel Cancer Model and Preclinical Screening Tool
    Jaime Wertman
    Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada, B3H 4R2
    Adv Exp Med Biol 916:289-314. 2016
  8. pmc Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia
    Victoria L Bentley
    Pathology, Dalhousie University, Halifax, NS
    Haematologica 100:70-6. 2015
  9. pmc Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing
    Jordan Pinder
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada
    Nucleic Acids Res 43:9379-92. 2015
  10. doi request reprint Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models
    Vinothkumar Rajan
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada, B3H 4R2
    Methods Mol Biol 1451:171-89. 2016

Collaborators

  • Denis J Dupre
  • Andrew P Weng
  • Dale Corkery
  • Jan K Rainey
  • Yael Ziv
  • Yi Qun Kuang
  • Jayme Salsman
  • Jason N Berman
  • Jordan Pinder
  • Jordan B Pinder
  • Vinothkumar Rajan
  • Sara Lahsaee
  • Jaime Wertman
  • Chansey J Veinotte
  • Saima M Sidik
  • Victoria L Bentley
  • David N Langelaan
  • Cassandra L A Hawco
  • Kathleen M Attwood
  • Rosemarie Kepkay
  • Kendra L Cann
  • Livia E Anthes
  • Alice Holly
  • John R Rohde
  • Marissa A LeBlanc
  • Karen Bedard
  • Md Imam Uddin
  • Brenda Tse
  • Aaron W Banks
  • Estelle Marchal
  • Alexander E G Baker
  • Tyler Reddy
  • Alison Thompson
  • Yosef Shiloh

Detail Information

Publications15

  1. pmc Reading, writing, and repair: the role of ubiquitin and the ubiquitin-like proteins in DNA damage signaling and repair
    Jordan B Pinder
    Department of Pathology, Dalhousie University Halifax, NS, Canada
    Front Genet 4:45. 2013
    ....
  2. ncbi request reprint High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced DNA repair foci
    Graham Dellaire
    Departments of Pathology and Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada
    Cell Cycle 8:3750-69. 2009
    ..Together these data provide the first ultrastructural comparison of gamma-H2A.X and MRN DNA repair foci, which are structurally dynamic over time and strikingly similar in organisation...
  3. ncbi request reprint KAP1 depletion increases PML nuclear body number in concert with ultrastructural changes in chromatin
    Rosemarie Kepkay
    Department of Pathology, Dalhousie University, Halifax, NS, Canada
    Cell Cycle 10:308-22. 2011
    ..Together these data implicate KAP1-dependent changes in chromatin structure as one possible mechanism by which ATM may regulate PML NB number in response to DNA damage...
  4. doi request reprint Heterochromatin and the DNA damage response: the need to relax
    Kendra L Cann
    Department of Pathology, Dalhousie University, Halifax, NS, Canada
    Biochem Cell Biol 89:45-60. 2011
    ....
  5. doi request reprint The translation initiation factor 3 subunit eIF3K interacts with PML and associates with PML nuclear bodies
    Jayme Salsman
    Department of Pathology, Dalhousie University, P O Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
    Exp Cell Res 319:2554-65. 2013
    ....
  6. doi request reprint Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking
    David N Langelaan
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Biochim Biophys Acta 1828:1471-83. 2013
    ....
  7. doi request reprint The Zebrafish Xenograft Platform: Evolution of a Novel Cancer Model and Preclinical Screening Tool
    Jaime Wertman
    Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada, B3H 4R2
    Adv Exp Med Biol 916:289-314. 2016
    ..The zebrafish xenotransplantation model is a unique and effective tool for the study of cancer cell biology. ..
  8. pmc Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia
    Victoria L Bentley
    Pathology, Dalhousie University, Halifax, NS
    Haematologica 100:70-6. 2015
    ..The zebrafish xenotransplantation platform provides a novel cost-effective means of tailoring leukemia therapy in real time. ..
  9. pmc Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing
    Jordan Pinder
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada
    Nucleic Acids Res 43:9379-92. 2015
    ..Thus, the nuclear domain knock-in screen that we describe provides a simple means of rapidly evaluating methods and small molecules that have the potential to enhance Cas9-mediated HDR. ..
  10. doi request reprint Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models
    Vinothkumar Rajan
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada, B3H 4R2
    Methods Mol Biol 1451:171-89. 2016
    ..This chapter highlights using transgenic- and xenograft-based models in zebrafish to study a specific leukemogenic mutation and analyze therapeutic responses in vivo. ..
  11. doi request reprint Estrogen receptor alpha (ESR1)-signaling regulates the expression of the taxane-response biomarker PRP4K
    Sara Lahsaee
    Departments of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Cell Res 340:125-31. 2016
    ..Thus, PRP4K is novel estrogen regulated kinase, and its levels can be reduced by 4-OHT in ER+ breast cancer cells altering their response to taxanes. ..
  12. pmc Shigella infection interferes with SUMOylation and increases PML-NB number
    Saima M Sidik
    Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada
    PLoS ONE 10:e0122585. 2015
    ..All Shigella-induced alterations to the SUMOylation system are dependent upon a T3SS. Thus, we demonstrate that Shigella uses one or more T3SS effectors to influence both PML-NB number and the SUMOylation machinery in human cells. ..
  13. doi request reprint Synthesis and biological evaluation of prodigiosene conjugates of porphyrin, estrone and 4-hydroxytamoxifen
    Cassandra L A Hawco
    Department of Chemistry, Dalhousie University, PO Box 15000, Halifax, Nova Scotia B3H 4R2, Canada
    Bioorg Med Chem 21:5995-6002. 2013
    ..The 4-hydroxytamoxifen conjugates exhibit nanomolar range activity against the MCF-7 breast cancer cell line, paving the way to expand the scope and connectivity of prodigiosene-tamoxifen conjugates. ..
  14. pmc Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization
    Yi Qun Kuang
    Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 7:e40522. 2012
    ..Our results demonstrate that modulation of the functions of a chaperone can affect signal transduction at the cell surface...
  15. ncbi request reprint Beyond repair foci: subnuclear domains and the cellular response to DNA damage
    Graham Dellaire
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Cell Cycle 6:1864-72. 2007
    ..These changes in the nuclear landscape, the topic of this review, appear to be intimately linked to the cellular response to DNA damage and may prove as useful as repair foci in elucidating mechanisms of DNA repair...