Ernesto L Schiffrin

Summary

Affiliation: Clinical Research Institute of Montreal
Country: Canada

Publications

  1. ncbi request reprint Vascular endothelin in hypertension
    Ernesto L Schiffrin
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada
    Vascul Pharmacol 43:19-29. 2005
  2. ncbi request reprint Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment
    Ernesto L Schiffrin
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Montreal, Quebec, Canada
    Am J Hypertens 17:1192-200. 2004
  3. ncbi request reprint Peroxisome proliferator-activated receptors: vascular and cardiac effects in hypertension
    Ernesto L Schiffrin
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Ave West, Montreal, Quebec, Canada H2W 1R7
    Hypertension 42:664-8. 2003
  4. ncbi request reprint Vascular stiffening and arterial compliance. Implications for systolic blood pressure
    Ernesto L Schiffrin
    Canadian Institute of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 17:39S-48S. 2004
  5. ncbi request reprint From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension
    Ernesto L Schiffrin
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension and Hypertension Clinic, Clinical Research Institute of Montreal, Quebec, Canada H2W 1R7
    Am J Physiol Heart Circ Physiol 287:H435-46. 2004
  6. ncbi request reprint Peroxisome proliferator-activated receptors and cardiovascular remodeling
    Ernesto L Schiffrin
    Canadian Institute of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 288:H1037-43. 2005
  7. ncbi request reprint Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats
    Dierk H Endemann
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    Hypertension 43:1252-7. 2004
  8. ncbi request reprint Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling
    Qian Pu
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Hypertension 42:49-55. 2003
  9. ncbi request reprint Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction wtih the renin-angiotension system
    Marc Iglarz
    Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 17:597-603. 2004
  10. ncbi request reprint PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation
    Quy N Diep
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Hypertension 40:866-71. 2002

Collaborators

Detail Information

Publications95

  1. ncbi request reprint Vascular endothelin in hypertension
    Ernesto L Schiffrin
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada
    Vascul Pharmacol 43:19-29. 2005
    ....
  2. ncbi request reprint Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment
    Ernesto L Schiffrin
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Montreal, Quebec, Canada
    Am J Hypertens 17:1192-200. 2004
    ..Nevertheless, many patients with hypertension will be treated for decades; therefore, the potential long-term benefits of vascular protection might be quite important...
  3. ncbi request reprint Peroxisome proliferator-activated receptors: vascular and cardiac effects in hypertension
    Ernesto L Schiffrin
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Ave West, Montreal, Quebec, Canada H2W 1R7
    Hypertension 42:664-8. 2003
    ....
  4. ncbi request reprint Vascular stiffening and arterial compliance. Implications for systolic blood pressure
    Ernesto L Schiffrin
    Canadian Institute of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 17:39S-48S. 2004
    ..Interventions aimed at these targets may reduce vascular stiffness, lower systolic blood pressure, decrease the prevalence of ISH, and improve outcomes for patients (particularly older patients) with hypertension or other CV conditions...
  5. ncbi request reprint From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension
    Ernesto L Schiffrin
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension and Hypertension Clinic, Clinical Research Institute of Montreal, Quebec, Canada H2W 1R7
    Am J Physiol Heart Circ Physiol 287:H435-46. 2004
  6. ncbi request reprint Peroxisome proliferator-activated receptors and cardiovascular remodeling
    Ernesto L Schiffrin
    Canadian Institute of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 288:H1037-43. 2005
    ..Some side effects, such as weight gain, as well as documented aggravation of advanced heart failure through fluid retention by glitazones, may, however, limit their therapeutic application in prevention of cardiovascular disease...
  7. ncbi request reprint Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats
    Dierk H Endemann
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    Hypertension 43:1252-7. 2004
    ..These effects were attenuated by eplerenone, particularly in the salt-loaded state, underlining the pathophysiological role of aldosterone in salt-sensitive hypertension...
  8. ncbi request reprint Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling
    Qian Pu
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Hypertension 42:49-55. 2003
    ..Endothelin blockade may exert beneficial effects on vascular remodeling, fibrosis, oxidative stress, and adhesion molecule expression in aldosterone-induced hypertension...
  9. ncbi request reprint Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction wtih the renin-angiotension system
    Marc Iglarz
    Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 17:597-603. 2004
    ..The aim of this study was to investigate the involvement of angiotensin II and oxidative stress on cardiovascular damage induced by chronic subcutaneous aldosterone infusion in the absence of salt loading...
  10. ncbi request reprint PPARalpha activator effects on Ang II-induced vascular oxidative stress and inflammation
    Quy N Diep
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Hypertension 40:866-71. 2002
    ..These effects are associated with decreased oxidative stress and inflammation in the vascular wall...
  11. ncbi request reprint Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy
    Mario Fritsch Neves
    Clinical Research Institute of Montreal, QC, Canada
    Can J Physiol Pharmacol 83:999-1006. 2005
    ....
  12. ncbi request reprint Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction
    Farhad Amiri
    Experimental Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Circulation 110:2233-40. 2004
    ..To directly test the role of endothelium-derived ET-1 in cardiovascular pathophysiology, we specifically targeted expression of the human preproET-1 gene to the endothelium by using the Tie-2 promoter in C57BL/6 mice...
  13. ncbi request reprint Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice
    Eun A Ko
    1Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 292:H1789-95. 2007
    ....
  14. ncbi request reprint Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension
    Marc Iglarz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 42:737-43. 2003
    ..Taken together, these data indicate a modulatory role of PPAR activators on cardiac remodeling in mineralocorticoid-induced hypertension, in part associated with decreased ET-1 production...
  15. doi request reprint Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Hypertension 51:432-9. 2008
    ....
  16. ncbi request reprint Dual angiotensin-converting enzyme/neutral endopeptidase inhibition on cardiac and renal fibrosis and inflammation in DOCA-salt hypertensive rats
    Qian Pu
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 23:401-9. 2005
    ..The relative roles of angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) inhibition on cardiac and renal fibrosis in deoxycorticosterone acetate (DOCA)-salt hypertensive rats were studied...
  17. doi request reprint Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause
    Talin Ebrahimian
    Lady Davis Institute for Medical Research, McGill University, Quebec, Canada
    Am J Physiol Heart Circ Physiol 295:H1481-8. 2008
    ..Our data suggest that in a model of menopause, protective actions of TRX may be blunted, which could contribute to cardiac remodeling independently of oxidative stress and hypertension...
  18. ncbi request reprint Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats
    Rhian M Touyz
    Laboratory of Experimental Hypertension, bLaboratory of Experimental Cardiovascular Biology, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 20:1127-34. 2002
    ..In the present in vivo study, we investigated whether short-term inhibition of ERK1/2-dependent signaling pathways influences vascular function and blood pressure (BP) in spontaneously hypertensive rats (SHR)...
  19. ncbi request reprint PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats
    Quy N Diep
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Que, Canada H2W 1R7
    J Mol Cell Cardiol 36:295-304. 2004
    ..We tested the hypothesis that the PPAR alpha activator fenofibrate prevents myocardial inflammation and fibrosis in angiotensin (Ang) II-infused rats...
  20. doi request reprint Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats
    Asia Rehman
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Hypertension 59:291-9. 2012
    ....
  21. ncbi request reprint Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice
    Agostino Virdis
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 22:535-42. 2004
    ..Angiotensin (Ang) II stimulates vascular reactive oxygen species generation via NAD(P)H oxidase activation. We investigated whether vascular NAD(P)H oxidase influences structure and function of resistance arteries from Ang II-infused mice...
  22. ncbi request reprint Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Hypertension 49:341-6. 2007
    ....
  23. doi request reprint Effects of combined AT1 receptor antagonist/NEP inhibitor on vascular remodeling and cardiac fibrosis in SHRSP
    Qian Pu
    Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Hypertens 26:322-33. 2008
    ..We evaluated the effects of combining an angiotensin II type 1 (AT1) receptor blocker (ARB, valsartan) and a NEPI (CGS 25354) in comparison with a dual ACEI/NEPI (CGS 30440) in stroke-prone spontaneously hypertensive rats (SHRSP)...
  24. ncbi request reprint Spironolactone improves angiotensin-induced vascular changes and oxidative stress
    Agostino Virdis
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Hypertension 40:504-10. 2002
    ..Our findings suggest that aldosterone may mediate some of angiotensin II-induced vascular effects in hypertension, in part via increased oxidative stress...
  25. ncbi request reprint Effect of peroxisome proliferator-activated receptor-alpha and -gamma activators on vascular remodeling in endothelin-dependent hypertension
    Marc Iglarz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 23:45-51. 2003
    ..Thus, we investigated in vivo the interaction between PPARs and ET-1 in deoxycorticosterone acetate (DOCA)-salt rats that overexpress vascular ET-1...
  26. ncbi request reprint Angiotensin receptor blocker added to previous antihypertensive agents on arteries of diabetic hypertensive patients
    Carmine Savoia
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 48:271-7. 2006
    ....
  27. pmc Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress
    Talin Ebrahimian
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Hypertension 57:245-54. 2011
    ..In conclusion, MK2 plays a critical role in angiotensin II signaling, leading to hypertension, oxidative stress via activation of p47phox and inhibition of antioxidants, and vascular inflammation and proliferation...
  28. ncbi request reprint Small artery mechanics in hyperhomocysteinemic mice: effects of angiotensin II
    Mario F Neves
    Canadian Institutes of Health Research, Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    J Hypertens 22:959-66. 2004
    ..The purpose of this study was to evaluate whether mild hyperhomocysteinemia (H-Hcy) may increase vascular stiffness of small arteries...
  29. doi request reprint Protective role of vascular smooth muscle cell PPARγ in angiotensin II-induced vascular disease
    Chiara Marchesi
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Cardiovasc Res 97:562-70. 2013
    ..The goal of this study was to determine that vascular smooth muscle cell (VSMC) PPARγ exerts a vascular protective role beyond its metabolic effects...
  30. ncbi request reprint Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury
    Carolina De Ciuceis
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 25:2106-13. 2005
    ..We therefore investigated Ang II effects on vascular structure, function, and oxidant stress generation in this model...
  31. ncbi request reprint Attenuated responses to angiotensin II in follitropin receptor knockout mice, a model of menopause-associated hypertension
    Danesh Javeshghani
    Experimental Hypertension, Clinical Research Institute of Montreal, Quebec, 110 Pine Ave West, Montreal, H2W 1R7, Canada
    Hypertension 42:761-7. 2003
    ..Our findings suggest that vascular Ang II signaling is downregulated in female FORKO mice and that Ang II may not play an important role in blood pressure elevation in this model of menopause-associated hypertension...
  32. ncbi request reprint Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice
    Agostino Virdis
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 23:1352-7. 2003
    ..We evaluated the effect of hyperhomocystinemia and angiotensin (Ang) II on vascular function and structure in methylenetetrahydrofolate reductase knockout mice (Mthfr+/-)...
  33. ncbi request reprint Effect of amlodipine compared to atenolol on small arteries of previously untreated essential hypertensive patients
    Ernesto L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 15:105-10. 2002
    ..Whether the vascular protective effect of amlodipine will result in improved outcomes in hypertension remains to be demonstrated...
  34. doi request reprint Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome
    Chiara Marchesi
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine Rd, Montreal, Quebec H3T 1E2, Canada
    Hypertension 54:1384-92. 2009
    ....
  35. ncbi request reprint Angiotensin II induces vascular dysfunction without exacerbating blood pressure elevation in a mouse model of menopause-associated hypertension
    Danesh Javeshghani
    CIHR Multidisciplinary Research Group on Hypertension, Canada
    J Hypertens 24:1365-73. 2006
    ....
  36. doi request reprint Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors
    Catherine A Lemarié
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Circ Res 105:852-9. 2009
    ..However, mechanisms underlying crosstalk between Ang II type 1 receptor (AT(1)R) and mineralocorticoid receptor (MR) are mostly unknown...
  37. ncbi request reprint Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma
    Quy N Diep
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Montreal, Quebec, Canada
    Circulation 105:2296-302. 2002
    ..We tested the hypothesis that pioglitazone or rosiglitazone would prevent BP elevation and vascular dysfunction in angiotensin (Ang) II-infused rats by direct vascular effects...
  38. doi request reprint Countervailing vascular effects of rosiglitazone in high cardiovascular risk mice: role of oxidative stress and PRMT-1
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, QC, Canada
    Clin Sci (Lond) 118:583-92. 2010
    ....
  39. ncbi request reprint Effect of dual angiotensin converting enzyme/neutral endopeptidase inhibition, angiotensin converting enzyme inhibition, or AT1 antagonism on coronary microvasculature in spontaneously hypertensive rats
    Qian Pu
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Am J Hypertens 16:931-7. 2003
    ..This suggests a role for NEP inhibition added to blockade of the renin-angiotensin system that may explain the greater efficacy of omapatrilat...
  40. doi request reprint T regulatory lymphocytes prevent aldosterone-induced vascular injury
    Daniel A Kasal
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Hypertension 59:324-30. 2012
    ..Thus, Tregs suppress aldosterone-mediated vascular injury, in part through effects on innate and adaptive immunity, suggesting that aldosterone-induced vascular damage could be prevented by an immunomodulatory approach...
  41. ncbi request reprint Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats
    Fatiha Tabet
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 23:2005-12. 2005
    ....
  42. ncbi request reprint Peroxisome proliferator-activated receptor gamma regulates angiotensin II-stimulated phosphatidylinositol 3-kinase and mitogen-activated protein kinase in blood vessels in vivo
    Karim Benkirane
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Hypertension 47:102-8. 2006
    ..Effects of PPAR-gamma activators on these pathways could contribute to regression of vascular remodeling in models of hypertension and diabetes and, accordingly, in hypertensive diabetic patients...
  43. doi request reprint The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis
    Salvatore Mottillo
    Jewish General Hospital McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 56:1113-32. 2010
    ....
  44. ncbi request reprint Resistance artery mechanics and composition in angiotensin II-infused rats: effects of aldosterone antagonism
    Mario Fritsch Neves
    Multidisciplinary Research Group on Hypertension, Canadian Institutes of Health Research, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    J Hypertens 21:189-98. 2003
    ..Angiotensin (Ang) II stimulates aldosterone production, which may mediate some of the effects of Ang II...
  45. ncbi request reprint Role of angiotensin type-1 and angiotensin type-2 receptors in the expression of vascular integrins in angiotensin II-infused rats
    Pascal Brassard
    Experimental Hypertension Laboratory, Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Hypertension 47:122-7. 2006
    ..These results demonstrate that AT1 and AT2 receptors have countervailing effects on vascular integrin subunit expression that may influence their effects on vascular remodeling and extracellular matrix composition...
  46. ncbi request reprint Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats
    Qian Pu
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    J Hypertens 20:899-907. 2002
    ..Here, we studied the relative roles of NEP and ACE inhibition and their effect on resistance artery structure and function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats...
  47. ncbi request reprint Chronic kidney disease: effects on the cardiovascular system
    Ernesto L Schiffrin
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Circulation 116:85-97. 2007
    ..Prevention and treatment of cardiovascular disease are major considerations in the management of individuals with chronic kidney disease...
  48. ncbi request reprint PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1
    Karim Benkirane
    Clinical Institute of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 290:H390-7. 2006
    ..PPAR-gamma activation reduced ANG II-induced growth associated with inhibition of ERK 1/2, Akt, 4E-BP1, and SHIP2. Modulation of these pathways by PPAR-gamma activators may contribute to regression of vascular remodeling in hypertension...
  49. ncbi request reprint Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, QC, Canada
    Clin Sci (Lond) 112:375-84. 2007
    ....
  50. ncbi request reprint Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats
    Carmine Savoia
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 23:1037-45. 2005
    ..To test whether angiotensin II (Ang II) through the Ang II type 2 receptor (AT2R), downregulates RhoA/Rho kinase, which plays a role in AT1 receptor (AT1R)-mediated function...
  51. doi request reprint Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1
    Catherine A Lemarié
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 300:H745-53. 2011
    ..Taken together, these results demonstrate that Mthfr deficiency impairs EPC formation and increases EPC senescence by eNOS uncoupling and downregulation of SIRT1...
  52. doi request reprint Endothelin-1 overexpression exacerbates atherosclerosis and induces aortic aneurysms in apolipoprotein E knockout mice
    Melissa W Li
    From the Lady Davis Institute for Medical Research M W L, M O R M, T B, A R, K M, P P, E L S, Department of Medicine E L S, and Department of Oncology K M, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 33:2306-15. 2013
    ..ET-1 overexpression exacerbates high-fat diet-induced atherosclerosis in apolipoprotein E(-/-) (Apoe(-/-)) mice. ET-1-induced reactive oxygen species and inflammation may contribute to atherosclerosis progression and AAA development...
  53. ncbi request reprint Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support
    Michel White
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada, H1T 1C8
    Clin Sci (Lond) 110:483-9. 2006
    ..Short-term inotropic support improves functional status and reduces indices of inflammation and oxidative stress in patients with decompensated CHF...
  54. ncbi request reprint Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase
    Carmine Savoia
    Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Hypertens 24:2417-22. 2006
    ..We previously demonstrated that AT2R-mediated effects involve inhibition of the RhoA/Rho kinase pathway. However, molecular mechanisms underlying this phenomenon are unknown...
  55. doi request reprint T regulatory lymphocytes prevent angiotensin II-induced hypertension and vascular injury
    Tlili Barhoumi
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Hypertension 57:469-76. 2011
    ..Thus, Tregs suppress Ang II-mediated vascular injury in part through anti-inflammatory actions. Immune mechanisms modulate Ang II-induced blood pressure elevation, vascular oxidative stress, inflammation, and endothelial dysfunction...
  56. ncbi request reprint Vascular changes in hypertension in response to drug treatment: Effects of angiotensin receptor blockers
    Ernesto L Schiffrin
    Clinical Research Institute of Montreal, Montreal, Canada
    Can J Cardiol 18:15A-18A. 2002
    ..Improved outcomes in clinical trials using angiotensin-converting enzyme inhibitors and AT1 receptor antagonists may be a result of the vascular protective effects offered by these agents...
  57. ncbi request reprint Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells
    Rhian M Touyz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 22:1141-9. 2004
    ..The role of reactive oxygen species (ROS) in mitogen-activated protein kinase (MAPK) signaling by angiotensin (Ang) II and endothelin-1 (ET-1) in human vascular smooth muscle cells (VSMC) was investigated...
  58. ncbi request reprint SAM68: a downstream target of angiotensin II signaling in vascular smooth muscle cells in genetic hypertension
    Mohammed El Mabrouk
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada H2W 1R7
    Am J Physiol Heart Circ Physiol 286:H1954-62. 2004
    ..Our data demonstrate that PI3K and SAM68 are involved in ANG II signaling and that SAM68 is differentially regulated in VSMCs from SHR. These processes may contribute to the enhanced ANG II signaling and altered VSMC growth in SHR...
  59. doi request reprint Aldosterone: effects on the kidney and cardiovascular system
    Marie Briet
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
    Nat Rev Nephrol 6:261-73. 2010
    ....
  60. ncbi request reprint Inflammation in hypertension
    Carmine Savoia
    Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 15:152-8. 2006
    ..In this review we summarize the recent evidence that highlights the involvement of low-grade inflammation in the development and pathophysiology of hypertension...
  61. doi request reprint Preservation of endothelium-dependent relaxation in atherosclerotic mice with endothelium-restricted endothelin-1 overexpression
    Muhammad Oneeb Rehman Mian
    Lady Davis Institute for Medical Research M O R M, N I K, M W L, A L, P P, Y R, E L S, and Department of Medicine E L S, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Pharmacol Exp Ther 347:30-7. 2013
    ....
  62. doi request reprint Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy
    Chiara Marchesi
    Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    J Mol Med (Berl) 89:1103-11. 2011
    ....
  63. ncbi request reprint Redox-dependent MAP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation
    Rhian M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, QC H2W 1R7, Canada
    Can J Physiol Pharmacol 81:159-67. 2003
    ..These findings suggest that Ang II activates p38MAP kinase and ERK5 via redox-dependent cascades that are regulated by IGF-1R and EGFR transactivation. ERK1/2 regulation by Ang II is via redox-insensitive pathways...
  64. ncbi request reprint Persistent remodeling of resistance arteries in type 2 diabetic patients on antihypertensive treatment
    Dierk H Endemann
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 43:399-404. 2004
    ....
  65. doi request reprint Immune regulation and vascular inflammation in genetic hypertension
    Emilie C Viel
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 298:H938-44. 2010
    ....
  66. ncbi request reprint Long-term effects of the PPAR gamma activator pioglitazone on cardiac inflammation in stroke-prone spontaneously hypertensive rats
    Quy N Diep
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, QC, Canada
    Can J Physiol Pharmacol 82:976-85. 2004
    ..PPARgamma activation may play a preventive cardiovascular role by offsetting the cardiac inflammatory response as demonstrated in this genetic model of malignant hypertension...
  67. ncbi request reprint Inhibition of the renin angiotensin system: implications for the endothelium
    Carmine Savoia
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    Curr Diab Rep 6:274-8. 2006
    ....
  68. ncbi request reprint Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats
    Fatiha Tabet
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 44:200-8. 2004
    ..These effects may relate to differential activation of Ca2+ channels by H2O2 and *O2-. Enhanced activation of L-type Ca2+ channels and increased Ca2+ influx by H2O2 may contribute to increased Ca2+ signaling in VSMCs from SHR...
  69. ncbi request reprint Effect of AT(1) receptor blockade on cardiac apoptosis in angiotensin II-induced hypertension
    Quy N Diep
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada H2W 1R7
    Am J Physiol Heart Circ Physiol 282:H1635-41. 2002
    ..Bax and caspase 3 are involved in the apoptotic signaling pathway in this experimental paradigm...
  70. ncbi request reprint Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: role of endothelin-1
    Jeong Bae Park
    Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 15:164-9. 2002
    ..The ETA receptor antagonist prevented cardiac and aortic collagen deposition and aortic hypertrophy. This suggests a role for ET-1 in fibrosis of heart and large vessels in conditions associated with mineralocorticoid excess...
  71. ncbi request reprint Tyrosine kinase inhibition attenuates vasopressin-induced contraction of mesenteric resistance arteries: alterations in spontaneously hypertensive rats
    Dierk Endemann
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 40:123-32. 2002
    ..These processes do not seem to play an important role in AVP-induced hypercontractility in SHR with established hypertension...
  72. ncbi request reprint Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats
    Jeong Bae Park
    Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 15:78-84. 2002
    ..Our data suggest that oxidative stress plays an important role in vascular damage associated with severe hypertension in salt-loaded SHRSP...
  73. ncbi request reprint Fibrosis, matrix metalloproteinases, and inflammation in the heart of DOCA-salt hypertensive rats: role of ET(A) receptors
    Fatima Z Ammarguellat
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Quebec, Canada
    Hypertension 39:679-84. 2002
    ....
  74. ncbi request reprint Role of endothelin in human hypertension
    Rhian M Touyz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, QC H2W 1R7, Canada
    Can J Physiol Pharmacol 81:533-41. 2003
    ..Thus, targeting the endothelin system may have important therapeutic potential in the treatment of hypertension, particularly by contributing to the prevention of target organ damage and the management of cardiovascular disease...
  75. doi request reprint Aldosterone induces arterial stiffness in absence of oxidative stress and endothelial dysfunction
    Eyal Leibovitz
    Lady Davis Institute for Medical Research, Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Hypertens 27:2192-200. 2009
    ..We hypothesized that monocyte/macrophages modulate aldosterone effects on oxidative stress, endothelial function, and ultimately vascular stiffness...
  76. ncbi request reprint Good news for patients with type 2 diabetes: angiotensin receptor blocker treatment delays progression of diabetic nephropathy
    Ernesto L Schiffrin
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 11:173-5. 2002
  77. ncbi request reprint Vascular inflammation: a role in vascular disease in hypertension?
    Agostino Virdis
    Multidisciplinary Research Group on Hypertension, Quebec, Canada
    Curr Opin Nephrol Hypertens 12:181-7. 2003
    ....
  78. ncbi request reprint Aldosterone: a risk factor for vascular disease
    Mario Fritsch Neves
    Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Curr Hypertens Rep 5:59-65. 2003
    ....
  79. ncbi request reprint Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased C-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats
    Rhian M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, Canada
    Hypertension 39:479-85. 2002
    ..In conclusion, altered regulation of Ang II type 1 receptor-activated c-Src by Csk may be an important upstream modulator of abnormal ERK1/2 signaling in VSMCs from SHR...
  80. ncbi request reprint PPAR activation: a new target for the treatment of hypertension
    Eyal Leibovitz
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 50:120-5. 2007
    ..This review will discuss some of the evidence, both experimental and clinical, that suggests that activation of PPAR alpha and/or gamma in hypertension may exert beneficial cardiovascular protective effects...
  81. ncbi request reprint Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications
    Rhian M Touyz
    Kidney Research Centre, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, and Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Vascul Pharmacol 45:19-28. 2006
    ..The present chapter focuses on the role of PPARs in vascular biology and discusses the clinical implications of using PPAR agonists in the management of vascular disease...
  82. ncbi request reprint Role of the actin cytoskeleton in angiotensin II signaling in human vascular smooth muscle cells
    Rhian M Touyz
    Clinical Research Institute of Montreal, University of Montreal, Montreal, QC, Canada
    Can J Physiol Pharmacol 83:91-7. 2005
    ..Together, these studies suggest that the cytoskeleton may be a central point of crosstalk in growth- and redox-signaling pathways by Ang II, which may be important in the regulation of VSMC function...
  83. ncbi request reprint Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension
    Rita C A Tostes
    Department of Pharmacology, Instituto de Ciencias Biomedicas, Univeridade de Sao Paulo, Av Lineu Prestes 1524, Sao Paulo 05508 900, Brazil
    Clin Sci (Lond) 103:25S-30S. 2002
    ..These processes were attenuated by BMS 182874. Our findings suggest that renal damage in aldosterone-dependent hypertension is associated with inflammatory processes that are mediated in part via ET-1...
  84. ncbi request reprint Inflammation and vascular hypertrophy induced by angiotensin II: role of NADPH oxidase-derived reactive oxygen species independently of blood pressure elevation?
    Ernesto L Schiffrin
    Arterioscler Thromb Vasc Biol 23:707-9. 2003
  85. ncbi request reprint Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy
    Hiroshi Yokoyama
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Hypertens 18:922-9. 2005
    ....
  86. pmc The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension: Part II - Therapy
    N A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, BC, Canada
    Can J Cardiol 22:583-93. 2006
    ..To provide updated, evidence-based recommendations for the management of hypertension in adults...
  87. ncbi request reprint Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: Effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation
    Montserrat C Cruzado
    Department of Morphophysiology, School of Medicine, Universidad Nacional de Cuyo, Mendoza, Argentina
    Am J Hypertens 18:81-7. 2005
    ....
  88. ncbi request reprint The protective effects of angiotensin II blockade with olmesartan medoxomil on resistance vessel remodeling (The VIOS study): rationale and baseline characteristics
    Ronald D Smith
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiovasc Drugs 6:335-42. 2006
    ..Remodeling of small resistance vessels may be the earliest pathologic finding associated with hypertension. It may predate the onset of clinically apparent hypertension...
  89. ncbi request reprint ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats
    Glaucia E Callera
    Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo SP, Brazil
    Hypertension 43:872-9. 2004
    ....
  90. ncbi request reprint The angiotensin-endothelin relationship: does it play a role in cardiovascular and renal pathophysiology?
    Ernesto L Schiffrin
    J Hypertens 21:2245-7. 2003
  91. ncbi request reprint Multiple actions of angiotensin II in hypertension: benefits of AT1 receptor blockade
    Ernesto L Schiffrin
    J Am Coll Cardiol 42:911-3. 2003
  92. pmc Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats
    Emilie C Viel
    Lady Davis Institute for Medical Research, Montreal, QC, Canada H3T 1E2
    Am J Physiol Heart Circ Physiol 295:H281-8. 2008
    ..Our findings demonstrate the involvement of ET(A) receptor-modulated O(2)(*-) derived from XO and from mitochondrial oxidative enzymes in arteries from DOCA-salt rats...
  93. pmc Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR
    Fatiha Tabet
    Kidney Research Institute, OHRI University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada
    Circ Res 103:149-58. 2008
    ..We identify a novel redox-sensitive SHP-2-dependent pathway for Ang II in VSMCs. SHP-2 dysregulation by increased Nox1-derived ROS in SHR is associated with altered Ang II-AKT signaling...
  94. ncbi request reprint ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension
    Glaucia E Callera
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Hypertension 42:811-7. 2003
    ..5%. These in vivo findings indicate that increased vascular superoxide production is associated with activation of the endothelin system through ETA receptors in DOCA-salt hypertension, in apparently blood pressure-independent fashion...
  95. ncbi request reprint c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats
    Glaucia E Callera
    Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada
    Hypertension 46:1032-8. 2005
    ..Upregulation of c-Src signaling may be important in the profibrotic and proinflammatory actions of aldosterone in this genetic model of hypertension...