Nicole Le Saux
Affiliation: Children's Hospital of Eastern Ontario
- Invasive Haemophilus influenzae type b infections in vaccinated and unvaccinated children in Canada, 2001-2003David Scheifele
British Columbia s Children s Hospital, 4500 Oak St, Vancouver BC V6H 3N1
CMAJ 172:53-6. 2005..We report on the causes of Hib infections among vaccinated and unvaccinated children between 2001 and 2003 in Canada...
- Antimicrobial stewardship in pediatrics: focusing on the challenges clinicians faceJennifer Bowes
Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON K1H 8 L1, Canada
BMC Pediatr 14:212. 2014..The objectives of the study were to determine fundamental knowledge of principles, approach to antimicrobial use through the clinical vignettes and to identify perceived challenges in decreasing antimicrobial use...
- Invasive candidiasis in low birth weight preterm infants: risk factors, clinical course and outcome in a prospective multicenter study of cases and their matched controlsMichelle Barton
Division of Microbiology, Hospital for Sick Children, University of Toronto, Room 3654, Atrium, 555 University Ave, Toronto, ON M5G 1X8, Canada
BMC Infect Dis 14:327. 2014..This multicenter prospective study of invasive candidiasis (IC) was carried out to determine the risk factors for, incidence of, clinical and laboratory features, treatment and outcome of IC in infants of birth weight <1250 g...
- Molecular characterization of rotavirus isolates from select Canadian pediatric hospitalsAndrew McDermid
National Microbiology Laboratory, Winnipeg, Canada
BMC Infect Dis 12:306. 2012..Secondly we identified rotavirus strains that differed genetically from those included in the vaccines and which could affect vaccine effectiveness...
- The hidden costs and characteristics of childhood rotavirus emergency visits in CanadaNicole Le Saux
Department of Pediatrics, Children s Hospital of Eastern Ontario and CHEO Research Institute, Ottawa, Ontario, Canada
Pediatr Infect Dis J 31:159-63. 2012..Our objective was to describe rotavirus ED visits to include healthcare utilization pre- and postvisit to estimate true societal costs...
- Antimicrobial use in febrile children diagnosed with respiratory tract illness in an emergency departmentN Le Saux
Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Canada
Pediatr Infect Dis J 18:1078-80. 1999....
- Substantial morbidity for hospitalized children with community-acquired rotavirus infections: 2005-2007 IMPACT surveillance in Canadian hospitalsNicole Le Saux
Division of Infectious Diseases, CHEO Research Institute, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
Pediatr Infect Dis J 29:879-82. 2010..6%) had significant dehydration, almost one-fifth (19%) had clinical sepsis and 7% had seizures at presentation. The median hospital stay was 3.4 days. Severe clinical presentations are less commonly described in surveillance programs...
- A randomized, double-blind, placebo-controlled noninferiority trial of amoxicillin for clinically diagnosed acute otitis media in children 6 months to 5 years of ageNicole Le Saux
Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ont
CMAJ 172:335-41. 2005..In this double-blind noninferiority trial, we compared clinical improvement rates at 14 days for children (6 months to 5 years of age) with acute otitis media who were randomly assigned to receive amoxicillin or placebo...
- The treatment of acute bacterial sinusitis: no change is good medicineNicole Le Saux
Department of Infectious Diseases, Children s Hospital of Eastern Ontario, Ottawa, Ont
CMAJ 178:865-6. 2008
- Decrease in hospital admissions for febrile seizures and reports of hypotonic-hyporesponsive episodes presenting to hospital emergency departments since switching to acellular pertussis vaccine in Canada: a report from IMPACTNicole Le Saux
Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
Pediatrics 112:e348. 2003..We hypothesized that the change would result in a decrease in hospitalization rates for seizures and reports of hypotonic-hyporesponsive episodes (HHEs) temporally related to pertussis vaccination...
- Shorter courses of parenteral antibiotic therapy do not appear to influence response rates for children with acute hematogenous osteomyelitis: a systematic reviewNicole Le Saux
Department of Pediatrics, University of Ottawa, Ontario, Canada
BMC Infect Dis 2:16. 2002..Currently, there is no consensus on the route and duration of antimicrobial therapy to treat AHO...
- Evaluating the benefits of antimicrobial prophylaxis to prevent urinary tract infections in children: a systematic reviewN Le Saux
Thomas C Chalmers Centre for Systematic Reviews, Children s Hospital of Eastern Ontario Research Institute, Ottawa
CMAJ 163:523-9. 2000..The aim of this review was to systematically examine the available evidence for the effectiveness of this intervention...
- Effect of point of care information on inpatient management of bronchiolitisW James King
Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
BMC Pediatr 7:4. 2007..We studied the effects of access to point-of-care medical evidence in a computerised physician order entry system (CPOE) on management and clinical outcome of children with bronchiolitis...
- A point prevalence survey of health care-associated infections in Canadian pediatric inpatientsKatie Rutledge-Taylor
Canadian Field Epidemiology Program, Public Health Agency of Canada, Ottawa, Ontario, Canada
Am J Infect Control 40:491-6. 2012..The objective of this point prevalence study was to assess the burden of HAIs in the Canadian pediatric population, updating results reported from a similar study conducted in 2002...
- Empyema associated with community-acquired pneumonia: a Pediatric Investigator's Collaborative Network on Infections in Canada (PICNIC) studyJoanne M Langley
Department of Pediatrics, Dalhousie University, Halifax, Canada
BMC Infect Dis 8:129. 2008..We reviewed the epidemiology and clinical management of empyema at 8 pediatric hospitals in a period before the widespread implementation of universal infant heptavalent pneumococcal vaccine programs in Canada...
- Profile of serogroup Y meningococcal infections in Canada: Implications for vaccine selectionNicole Le Saux
Children s Hospital of Eastern Ontario Research Institute and the University of Ottawa, Ottawa, Ontario
Can J Infect Dis Med Microbiol 20:e130-4. 2009..In the present paper, recent surveillance data on invasive meningococcal disease across Canada are summarized...
- Factors influencing childhood influenza immunizationVincent J Grant
Department of Pediatrics, Children s Hospital of Eastern Ontario and the University of Ottawa, Ottawa, Ont
CMAJ 168:39-41. 2003..7, 95% confidence interval [CI] 1.8-12.6). Children of parents who discussed immunization with a physician were more likely to be immunized than those who had not discussed immunization with a physician (OR 6.8, 95% CI 2.4-19.2)...
- Characteristics and outcome of infants with candiduria in neonatal intensive care - a Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) studyJoan L Robinson
Department of Pediatrics, Alberta Children s Hospital Calgary, Alberta, Canada
BMC Infect Dis 9:183. 2009..There is limited information in the literature on the presentation and prognosis of candidal urinary tract infection (UTI) in infants in the neonatal intensive care unit (NICU)...
- Healthcare-Associated Clostridium difficile Infections and Strain Diversity in Pediatric Hospitals in the Canadian Nosocomial Infection Surveillance Program, 2007-2011Nicole Le Saux
Children s Hospital of Eastern Ontario, University of Ottawa, Ontario, Canada
J Pediatric Infect Dis Soc 4:e151-4. 2015..2/10,000 patient days in 2011 (p < 0.001). Of 169 isolates, the most common North American Pulsed-Field (NAP) types were NAP4 (n = 43; (25.4%), and NAP1 (n = 25;14.8%) while 55 (32.6%) were non-assigned NAP types. ..
- Community-acquired lobar pneumonia in children in the era of universal 7-valent pneumococcal vaccination: a review of clinical presentations and antimicrobial treatment from a Canadian pediatric hospitalAnne Rowan-Legg
Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Canada
BMC Pediatr 12:133. 2012....
- Maternal respiratory syncytial virus antibody titers: season and children matterNicole Le Saux
Division of Infectious Diseases, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
Pediatr Infect Dis J 22:563-4. 2003..Mean antibody titers were significantly higher between April and September and significantly higher in women who already had children at home...
- A systematic review of the effectiveness of antimicrobial rinse-free hand sanitizers for prevention of illness-related absenteeism in elementary school childrenEmily Meadows
Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
BMC Public Health 4:50. 2004..Currently, alternative hand hygiene techniques are being considered, and one such technique is the use of antimicrobial rinse-free hand sanitizers...
- A Comparison of group A Streptococcus versus Streptococcus pneumoniae pneumoniaNawal Al-Kaabi
Chalmers Research Group, Statistical Division, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
Pediatr Infect Dis J 25:1008-12. 2006..St reptococcus pyogenes is an uncommon cause of community-acquired pneumonia in children. Further, its clinical course in comparison to pneumonia caused by Streptococcus pneumonia has not been previously highlighted...
- Miller Fisher syndrome in a toddler with influenza A (pH1N1) infectionCecilia T Costiniuk
University of Ottawa, Faculty of Medicine, Division of Infectious Diseases, Ottawa, Ontario, Canada
J Child Neurol 26:385-8. 2011..During pandemics, one may expect to see an increased incidence of uncommon neurologic complications of influenza...
- Fifteen-year-old girl with fever, headache and vomitingRebecca Sherlock
Department of Paediatrics, Infectious Disease, The Children s Hospital of Eastern Ontario, Ottawa, Canada
Pediatr Infect Dis J 21:439, 449-50. 2002
- Lack of evidence of encephalopathy related to pertussis vaccine: active surveillance by IMPACT, Canada, 1993-2002Dorothy L Moore
Montreal Children s Hospital, McGill University Health Centre, Quebec, Canada
Pediatr Infect Dis J 23:568-71. 2004..Seven cases of encephalopathy began within 7 days after pertussis vaccination, but a more likely cause was found in each instance. No attributable case followed administration of >6.5 million doses of vaccine...
- The Pediatric Investigators Collaborative Network on Infections in Canada study of predictors of hospitalization for respiratory syncytial virus infection for infants born at 33 through 35 completed weeks of gestationBarbara J Law
Department of Pediatrics and Child Health, University of Manitoba and the Winnipeg Health Sciences Center, Winnipeg, Canada
Pediatr Infect Dis J 23:806-14. 2004..This study sought to identify independent risk factors for hospitalization for RSV infection...
- Antibiotic therapy to prevent the development of asymptomatic middle ear effusion in children with acute otitis media: a meta-analysis of individual patient dataLaura Koopman
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
Arch Otolaryngol Head Neck Surg 134:128-32. 2008..To determine predictors of the development of asymptomatic middle ear effusion (MEE) in children with acute otitis media (AOM) and to assess the effect of antibiotic therapy in preventing the development of MEE in these children...
- Predictors of pain and/or fever at 3 to 7 days for children with acute otitis media not treated initially with antibiotics: a meta-analysis of individual patient dataMaroeska M Rovers
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, PO Box 85060, 3508 AB Utrecht, The Netherlands
Pediatrics 119:579-85. 2007..The goal was to determine the predictors of a prolonged course for children with acute otitis media...
- Surveillance for influenza admissions among children hospitalized in Canadian immunization monitoring program active centers, 2003-2004Dorothy L Moore
Infectious Diseases Division, Montreal Children s Hospital, McGill University Health Centre, Montreal, Quebec, Canada
Pediatrics 118:e610-9. 2006....