Martin Zack

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi request reprint A D2 antagonist enhances the rewarding and priming effects of a gambling episode in pathological gamblers
    Martin Zack
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 32:1678-86. 2007
  2. doi request reprint Subtyping pathological gamblers on the basis of affective motivations for gambling: relations to gambling problems, drinking problems, and affective motivations for drinking
    Sherry H Stewart
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Psychol Addict Behav 22:257-68. 2008
  3. ncbi request reprint Diazepam dose-dependently increases or decreases implicit priming of alcohol associations in problem drinkers
    Martin Zack
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Alcohol Alcohol 41:604-10. 2006
  4. ncbi request reprint Contingent gambling-drinking patterns and problem drinking severity moderate implicit gambling-alcohol associations in problem gamblers
    Martin Zack
    University of Toronto, Toronto, Ontario, Canada
    J Gambl Stud 21:325-54. 2005
  5. ncbi request reprint Negative affect words prime beer consumption in young drinkers
    Martin Zack
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Addict Behav 31:169-73. 2006
  6. doi request reprint Effects of the atypical stimulant modafinil on a brief gambling episode in pathological gamblers with high vs. low impulsivity
    M Zack
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Psychopharmacol 23:660-71. 2009
  7. ncbi request reprint Amphetamine primes motivation to gamble and gambling-related semantic networks in problem gamblers
    Martin Zack
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
    Neuropsychopharmacology 29:195-207. 2004
  8. ncbi request reprint Effects of negative and positive mood phrases on priming of alcohol words in young drinkers with high and low anxiety sensitivity
    Martin Zack
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Exp Clin Psychopharmacol 11:176-85. 2003
  9. pmc Context effects and false memory for alcohol words in adolescents
    Martin Zack
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1
    Addict Behav 34:327-30. 2009
  10. ncbi request reprint Anxiety and explicit alcohol-related memory in problem drinkers
    Martin Zack
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Addict Behav 27:331-43. 2002

Collaborators

Detail Information

Publications33

  1. ncbi request reprint A D2 antagonist enhances the rewarding and priming effects of a gambling episode in pathological gamblers
    Martin Zack
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 32:1678-86. 2007
    ..The findings provide direct experimental evidence that the D2 substrate modulates gambling reinforcement in pathological gamblers...
  2. doi request reprint Subtyping pathological gamblers on the basis of affective motivations for gambling: relations to gambling problems, drinking problems, and affective motivations for drinking
    Sherry H Stewart
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Psychol Addict Behav 22:257-68. 2008
    ..The findings validate this empirical approach to subtyping gamblers and suggest consistency of motives across addictive behaviors...
  3. ncbi request reprint Diazepam dose-dependently increases or decreases implicit priming of alcohol associations in problem drinkers
    Martin Zack
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Alcohol Alcohol 41:604-10. 2006
    ..Previous research suggested that high doses of benzodiazepines may dampen NEG-ALC priming. The present study tested this possibility and the role of motivation for alcohol in this process...
  4. ncbi request reprint Contingent gambling-drinking patterns and problem drinking severity moderate implicit gambling-alcohol associations in problem gamblers
    Martin Zack
    University of Toronto, Toronto, Ontario, Canada
    J Gambl Stud 21:325-54. 2005
    ..Such associations can promote drinking and its attendant effects (e.g., poor decision-making) in problem gamblers, and thus, may contribute to co-morbid gambling and alcohol use disorders...
  5. ncbi request reprint Negative affect words prime beer consumption in young drinkers
    Martin Zack
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Addict Behav 31:169-73. 2006
    ..Anxiety sensitivity was unrelated to drinking in any condition. Even unobtrusive exposure to negative affect cues can prime drinking behavior in young drinkers, and this effect is tied to the severity of alcohol problems...
  6. doi request reprint Effects of the atypical stimulant modafinil on a brief gambling episode in pathological gamblers with high vs. low impulsivity
    M Zack
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Psychopharmacol 23:660-71. 2009
    ..These findings for modafinil appear to fit well with a growing literature demonstrating bi-directional effects of D2 agonists as a function of trait impulsivity. Impulsivity could critically moderate medication response in PG...
  7. ncbi request reprint Amphetamine primes motivation to gamble and gambling-related semantic networks in problem gamblers
    Martin Zack
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
    Neuropsychopharmacology 29:195-207. 2004
    ..This study provides experimental evidence that psychostimulant-like neurochemical activation is an important component of gambling addiction...
  8. ncbi request reprint Effects of negative and positive mood phrases on priming of alcohol words in young drinkers with high and low anxiety sensitivity
    Martin Zack
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Exp Clin Psychopharmacol 11:176-85. 2003
    ..A general association between negative mood priming and severity of alcohol problems also emerged...
  9. pmc Context effects and false memory for alcohol words in adolescents
    Martin Zack
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1
    Addict Behav 34:327-30. 2009
    ..These context-dependent biases may contribute to exaggerations in perceived drinking norms previously found to predict alcohol misuse in young drinkers...
  10. ncbi request reprint Anxiety and explicit alcohol-related memory in problem drinkers
    Martin Zack
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Addict Behav 27:331-43. 2002
    ..g., craving, expectancies) to alcohol stimuli in anxious problem drinkers...
  11. ncbi request reprint Parallel roles for dopamine in pathological gambling and psychostimulant addiction
    Martin Zack
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, M5S 2S1, Canada
    Curr Drug Abuse Rev 2:11-25. 2009
    ..Suggestions for future research include isolating the roles of DA receptor subtypes in PG, and parallel within-subject assessment of DA manipulations on gambling and psychostimulant reinforcement in PG subjects and controls...
  12. pmc Stress and alcohol cues exert conjoint effects on go and stop signal responding in male problem drinkers
    Martin Zack
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Neuropsychopharmacology 36:445-58. 2011
    ..Treatments that optimize prefrontal catecholamine transmission may deter relapse by reducing disinhibitory effects of salient eliciting stimuli...
  13. ncbi request reprint Effects of abstinence and smoking on information processing in adolescent smokers
    M Zack
    Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 153:249-57. 2001
    ..Although adolescent smokers appear to display some of the hallmark features of dependence, the biological and behavioral effects of smoking in this population are poorly understood...
  14. ncbi request reprint Effects of drink-stress sequence and gender on alcohol stress response dampening in high and low anxiety sensitive drinkers
    Martin Zack
    Clinical Neuroscience Section, Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada
    Alcohol Clin Exp Res 31:411-22. 2007
    ..High AS males' predominant social-evaluative concerns further implied that alcohol SRD to a social stressor (i.e., a speech) would be relatively stronger in high AS males than in high AS females...
  15. doi request reprint Escalating doses of transdermal nicotine in heavy smokers: effects on smoking behavior and craving
    Peter Selby
    Nicotine Dependence Clinic, Addictions Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Clin Psychopharmacol 33:667-74. 2013
    ..Titrating doses of NRT to effect with brief intervention hold promise as an effective clinical strategy to assist heavily dependent psychiatrically ill smokers to change their smoking behavior. ..
  16. doi request reprint Effects of stress and alcohol cues in men with and without problem gambling and alcohol use disorder
    Lindsay Steinberg
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Drug Alcohol Depend 119:46-55. 2011
    ..This study examined subjective-motivational, cognitive and physiological effects of stress and alcohol cues in subjects with PG, alcohol use disorder (AD), co-occurring PG and AD (CO), and healthy controls (HC)...
  17. doi request reprint Alcohol selectively impairs negative self-relevant associations in young drinkers
    V Bess Aramakis
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Psychopharmacol 26:221-31. 2012
    ..Preferential impairment of negative self-relevant associations may decrease perceived vulnerability under alcohol and increase risk for alcohol problems in young drinkers...
  18. doi request reprint The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]-(+)-propyl-hexahydro-naphtho-oxazin and [11C]raclopride
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Addiction 108:953-63. 2013
    ....
  19. doi request reprint Modafinil increases reward salience in a slot machine game in low and high impulsivity pathological gamblers
    Kelly Smart
    Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario M5S 2S1, Canada
    Neuropharmacology 73:66-74. 2013
    ..Clinically, modafinil may deter pathological gamblers from chasing losses but also encourage them to continue betting rather than quit while they are ahead. Whether low-dose modafinil confers more uniform benefits deserves investigation...
  20. doi request reprint Differential cardiovascular and hypothalamic pituitary response to amphetamine in male pathological gamblers versus healthy controls
    Martin Zack
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    J Psychopharmacol 29:971-82. 2015
    ..Extraversion predicted greater disinhibition in PGs. Noradrenergic disturbances may contribute to sensitized responses to stimulant challenge and disinhibition in PGs. ..
  21. ncbi request reprint Brain reward system activity in major depression and comorbid nicotine dependence
    Laura Cardenas
    Centre for Addiction and Mental Health, Sunnybrook and Women s College Health Sciences Centre Sunnybrook campus, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1
    J Pharmacol Exp Ther 302:1265-71. 2002
    ..Severity of depression was significantly correlated with increased rewarding effects of d-amph. Thus, although the BRS may be dysfunctional in MDD subjects, chronic nicotine use does not modify response to d-amph...
  22. doi request reprint Haloperidol modifies instrumental aspects of slot machine gambling in pathological gamblers and healthy controls
    Anne Marie Tremblay
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Canada
    Addict Biol 16:467-84. 2011
    ..Indirect enhancement of DA transmission may reduce undue reward-related responding in PG subjects...
  23. ncbi request reprint Acute subjective and physiological responses to smoking in adolescents
    W A Corrigall
    Smoking and Nicotine Dependence Research and Clinical Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada
    Addiction 96:1409-17. 2001
    ..To determine the topography of cigarette smoking and the subjective and physiological effects of abstinence and nicotine in adolescents who smoke on a daily versus a non-daily basis...
  24. doi request reprint [¹¹C]-(+)-PHNO PET imaging of dopamine D(2/3) receptors in Parkinson's disease with impulse control disorders
    Doris E Payer
    Addictions Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Mov Disord 30:160-6. 2015
    ....
  25. doi request reprint The impact of chronic bupropion on plasma cotinine and on the subjective effects of ad lib smoking: a randomized controlled trial in unmotivated smokers
    Sarwar Hussain
    Clinical Neuroscience, Centre for Addiction and Mental Health, 33 Russell St, Toronto, ON, Canada M5S 2S1
    Addict Behav 35:164-7. 2010
    ..This study is among the first to systematically investigate the effect of chronic bupropion administration, free from the confounding effect of the smoker's motivation to quit smoking...
  26. doi request reprint Effects of High Frequency Repeated Transcranial Magnetic Stimulation and Continuous Theta Burst Stimulation on Gambling Reinforcement, Delay Discounting, and Stroop Interference in Men with Pathological Gambling
    Martin Zack
    Neuroscience Research Department, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario M5S 2S1, Canada Electronic address
    Brain Stimul 9:867-875. 2016
    ..High-frequency rTMS of the medial prefrontal cortex (PFC) and continuous theta burst stimulation (cTBS) of the right dorsolateral PFC can reduce impulsive choice in healthy volunteers...
  27. ncbi request reprint Implicit activation of alcohol concepts by negative affective cues distinguishes between problem drinkers with high and low psychiatric distress
    M Zack
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Abnorm Psychol 108:518-31. 1999
    ..Results corroborate in vivo cue reactivity studies and indicate a functional difference between problem drinkers with high and low PD...
  28. pmc Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study
    Isabelle Boileau
    Addiction Imaging Research Group, Vivian M Rakoff PET Imaging Centre, Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 32:1353-9. 2012
    ..Pharmacological studies are needed to establish whether normalization of D3 receptor function could reduce vulnerability to relapse in stimulant abuse...
  29. ncbi request reprint Low-dose diazepam primes motivation for alcohol and alcohol-related semantic networks in problem drinkers
    C X Poulos
    Clinical Neuroscience Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Behav Pharmacol 15:503-12. 2004
    ..These findings provide direct evidence that the GABA-BZ system plays an important role in alcohol reinforcement in problem drinkers...
  30. ncbi request reprint The SCL-90 factor structure in comorbid substance abusers
    M Zack
    Addiction Research Foundation, Toronto, Ontario, Canada
    J Subst Abuse 10:85-101. 1998
    ..These findings are consistent with previous studies that obtained a single predominant factor, and suggest that the SCL-90 primarily taps general psychiatric distress in comorbid substance abusers...
  31. ncbi request reprint Clinical use of benzodiazepines and decreased memory activation in anxious problem drinkers
    M Zack
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Alcohol Clin Exp Res 23:174-82. 1999
    ..Degree of activation also correlated with a drug's affinity for the BZD receptor. These preliminary results suggest that BZD-induced amnesia may contribute to the therapeutic effects of these drugs in anxious problem drinkers...
  32. doi request reprint Development and psychometric evaluation of a three-dimensional Gambling Motives Questionnaire
    Sherry H Stewart
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Addiction 103:1110-7. 2008
    ..5 years) were selected to fill two groups according to scores on the South Oaks Gambling Screen: probable pathological gamblers (PPG; n = 154) and non-pathological gamblers (NPG; n = 39)...
  33. ncbi request reprint Implicit and explicit alcohol-related cognitions
    Reinout W Wiers
    Department of Experimental Psychology, Faculty of Psychology, Universiteit Maastricht, Maastricht, The Netherlands
    Alcohol Clin Exp Res 26:129-37. 2002
    ..Wiers); and (6) Negative affective cues and associative cognition in problem drinkers (Martin Zack). Comments were provided by the discussant Marvin Krank...