Pablo Rusjan

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. doi request reprint Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 28:9850-6. 2008
  2. pmc Mapping human brain fatty acid amide hydrolase activity with PET
    Pablo M Rusjan
    Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 33:407-14. 2013
  3. ncbi request reprint An automated method for the extraction of regional data from PET images
    Pablo Rusjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Psychiatry Res 147:79-89. 2006
  4. pmc Quantitation of translocator protein binding in human brain with the novel radioligand [18F]-FEPPA and positron emission tomography
    Pablo M Rusjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:1807-16. 2011
  5. ncbi request reprint Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 29:400-10. 2008
  6. doi request reprint Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 66:1304-12. 2009
  7. pmc Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study
    Julia Sacher
    Vivian M Rakoff PET Imaging Centre, Toronto, Canada
    J Cereb Blood Flow Metab 32:443-6. 2012
  8. doi request reprint Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    Brain 132:1366-75. 2009
  9. pmc Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease
    Ji Hyun Ko
    Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Hum Brain Mapp 34:1591-604. 2013
  10. doi request reprint Monoamine oxidase A binding in the prefrontal and anterior cingulate cortices during acute withdrawal from heavy cigarette smoking
    Ingrid Bacher
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College St, Toronto, ON, Canada
    Arch Gen Psychiatry 68:817-26. 2011

Collaborators

Detail Information

Publications42

  1. doi request reprint Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 28:9850-6. 2008
    ..If correct, (+)[(11)C]DTBZ might be a useful imaging probe to correlate changes in brain dopamine stores and behavior in users of methamphetamine...
  2. pmc Mapping human brain fatty acid amide hydrolase activity with PET
    Pablo M Rusjan
    Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 33:407-14. 2013
    ..Simulations showed that [(11)C]CURB binding in healthy subjects is far from a flow-limited uptake...
  3. ncbi request reprint An automated method for the extraction of regional data from PET images
    Pablo Rusjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Psychiatry Res 147:79-89. 2006
    ....
  4. pmc Quantitation of translocator protein binding in human brain with the novel radioligand [18F]-FEPPA and positron emission tomography
    Pablo M Rusjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:1807-16. 2011
    ..The excellent identifiability of V(T) values obtained from an unconstrained 2-CM with data from a 2-hour scan support the use of V(T) as an appropriate and feasible outcome measure for [(18)F]-FEPPA...
  5. ncbi request reprint Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 29:400-10. 2008
    ..This differential binding of agonist vs. antagonist radioligand, especially in the critically important region of the limbic striatum/pallidum, offers new avenues to investigate the role of the dopamine system in health and disease...
  6. doi request reprint Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence
    Jeffrey H Meyer
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 66:1304-12. 2009
    ..The relationship between MAO-A levels and selective serotonin reuptake inhibitor (SSRI) treatment, recovery, and recurrence in MDD is unknown...
  7. pmc Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study
    Julia Sacher
    Vivian M Rakoff PET Imaging Centre, Toronto, Canada
    J Cereb Blood Flow Metab 32:443-6. 2012
    ..007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels...
  8. doi request reprint Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    Brain 132:1366-75. 2009
    ....
  9. pmc Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease
    Ji Hyun Ko
    Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    Hum Brain Mapp 34:1591-604. 2013
    ..These observations provide important insights on the pathophysiology of cognitive dysfunction in PD...
  10. doi request reprint Monoamine oxidase A binding in the prefrontal and anterior cingulate cortices during acute withdrawal from heavy cigarette smoking
    Ingrid Bacher
    Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College St, Toronto, ON, Canada
    Arch Gen Psychiatry 68:817-26. 2011
    ..Dysphoria during cigarette withdrawal predicts relapse. It is unknown whether MAO-A binding increases during early cigarette withdrawal...
  11. doi request reprint The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychotics
    Romina Mizrahi
    Centre for Addiction and Mental Health, PET Centre, Toronto, ON, Canada
    Int J Neuropsychopharmacol 12:715-21. 2009
    ..90 (S.D.=15.33), an effect that was sustained for 6 months. This sustained improvement was observed despite very high levels of DA D2 occupancy (82-99%), in contrast to the effects of antagonist antipsychotics on subjective well-being...
  12. doi request reprint Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:1776-80. 2008
    ....
  13. doi request reprint The dopamine D2 receptors in high-affinity state and D3 receptors in schizophrenia: a clinical [11C]-(+)-PHNO PET study
    Ariel Graff-Guerrero
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Neuropsychopharmacology 34:1078-86. 2009
    ..It is possible that receptors with high affinity are not accessible by [(11)C]-(+)-PHNO because they are occupied by endogenous dopamine, a possibility that can be ruled out in future experiments...
  14. doi request reprint Effects of antipsychotics on D3 receptors: a clinical PET study in first episode antipsychotic naive patients with schizophrenia using [11C]-(+)-PHNO
    Romina Mizrahi
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 131:63-8. 2011
    ..11)C]-(+)-PHNO offer new opportunities for exploring the potential therapeutic significance of the D(3) receptor in schizophrenia and the action of antipsychotics...
  15. doi request reprint Extrastriatal dopaminergic dysfunction in tourette syndrome
    Thomas D L Steeves
    Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada
    Ann Neurol 67:170-81. 2010
    ..A substantial body of evidence has also accrued to implicate regions outside the striatum in the generation of tics...
  16. pmc D3 dopamine receptor-preferring [11C]PHNO PET imaging in Parkinson patients with dyskinesia
    Doris E Payer
    From the Addictions Program D E P, I B, the Research Imaging Centre D E P, S J K, J T, P R, S H, A A W, I B, and the Human Brain Laboratory M G, S J K, Y F, Centre for Addiction and Mental Health, Toronto Campbell Family Mental Health Research Institute S J K, J T, P R, S H, A A W, I B, Toronto the Departments of Psychiatry D E P, S J K, J T, A A W, I B and Pharmacology S J K, University of Toronto and the Centre for Movement Disorders M G, J R A, Markham, Canada
    Neurology 86:224-30. 2016
    ..To investigate whether levodopa-induced dyskinesias (LID) are associated with D3 overexpression in levodopa-treated humans with Parkinson disease (PD)...
  17. pmc Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease
    Leigh Christopher
    Morton and Gloria Shulman Movement Disorder Unit and Edmond J Safra Program in Parkinson Disease, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada Division of Brain, Imaging, and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 77:269-80. 2015
    ..Our aim was to investigate whether dopamine dysfunction in these regions contributes to memory impairment in PD...
  18. pmc Combined insular and striatal dopamine dysfunction are associated with executive deficits in Parkinson's disease with mild cognitive impairment
    Leigh Christopher
    1 Morton and Gloria Shulman Movement Disorder Unit and E J Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, M5T 2S8, Canada
    Brain 137:565-75. 2014
    ..Furthermore, these findings suggest a crucial and direct role for dopaminergic modulation in the insula in facilitating cognitive function. ..
  19. pmc Voxel-based imaging of translocator protein 18 kDa (TSPO) in high-resolution PET
    Ji Hyun Ko
    Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    J Cereb Blood Flow Metab 33:348-50. 2013
    ..We also showed its proof-of-concept in a patient with possible meningioma showing increased [(18)F]-FEPPA total distribution volume...
  20. ncbi request reprint First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study
    Matthaus Willeit
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 33:279-89. 2008
    ..11)C]-(+)-PHNO PET might be a superior measure for release of endogenous dopamine than PET employing conventional D(2/3) antagonist radioligands...
  21. doi request reprint [¹¹C]-(+)-PHNO PET imaging of dopamine D(2/3) receptors in Parkinson's disease with impulse control disorders
    Doris E Payer
    Addictions Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Mov Disord 30:160-6. 2015
    ....
  22. doi request reprint Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada and Institute of Medical Science, Toronto, Ontario, Canada
    J Nucl Med 55:1993-7. 2014
    ..The aim of the study was to investigate the whole-body biodistribution and estimate the radiation dosimetry from (11)C-CURB scans in humans...
  23. doi request reprint Whole-body distribution and radiation dosimetry of 11C-(+)-PHNO, a D2/3 agonist ligand
    Romina Mizrahi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Nucl Med 53:1802-6. 2012
    ..Using PET, we measured the whole-body distribution of (11)C-(+)-PHNO ((11)C-(+)-4-propyl-9-hydroxynaphthoxazine), a D(2/3) agonist, as a function of time in adult subjects in order to determine the internal radiation dose...
  24. pmc Analysis of variance in neuroreceptor ligand imaging studies
    Ji Hyun Ko
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e23298. 2011
    ..The test will therefore allow us to reliably test hypotheses in the smaller sample sizes often used in explorative PET studies...
  25. doi request reprint Elevated brain monoamine oxidase A binding in the early postpartum period
    Julia Sacher
    Vivian M Rakoff PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Arch Gen Psychiatry 67:468-74. 2010
    ..However, MAO-A levels have never been measured in the early postpartum period...
  26. doi request reprint Similar striatal D2/D3 dopamine receptor availability in adults with Tourette syndrome compared with healthy controls: A [(11) C]-(+)-PHNO and [(11) C]raclopride positron emission tomography imaging study
    Elia Abi-Jaoude
    Department of Psychiatry, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Hum Brain Mapp 36:2592-601. 2015
    ..Consistent with previous findings, [(11) C]-(+)-PHNO localized preferentially to ventral striatal, D3 receptor-rich regions, in contrast to [(11) C]raclopride, which localized preferentially in the dorsal striatum...
  27. pmc Imaging neuroinflammation in gray and white matter in schizophrenia: an in-vivo PET study with [18F]-FEPPA
    Miran Kenk
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Schizophr Bull 41:85-93. 2015
    ....
  28. pmc Stress-induced dopamine response in subjects at clinical high risk for schizophrenia with and without concurrent cannabis use
    Romina Mizrahi
    1 PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Faculty of Medicine, Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 39:1479-89. 2014
    ..Our finding does not support the cross-sensitization hypothesis, which posits greater dopaminergic reactivity to stress in CHR cannabis users, but adds to the growing body of literature showing reduced DA (stress) response in addiction. ..
  29. pmc Dopamine response to psychosocial stress in chronic cannabis users: a PET study with [11C]-+-PHNO
    Romina Mizrahi
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 38:673-82. 2013
    ..566, p=0.044), with no effect in any other brain region. In conclusion, despite an increase in striatal BP(ND) observed during the control task, chronic cannabis use is not associated with alterations in stress-induced DA release...
  30. ncbi request reprint Positron emission tomography quantification of [11C]-(+)-PHNO binding in the human brain
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 27:857-71. 2007
    ..This study demonstrates that [11C]-(+)-PHNO can be used for the quantitative measurement of D2/3 densities and should enable further studies of potential D2/3 dysregulation in several important psychiatric and neurologic illnesses...
  31. pmc Dopamine D2 and D3 binding in people at clinical high risk for schizophrenia, antipsychotic-naive patients and healthy controls while performing a cognitive task
    Ivonne Suridjan
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ont
    J Psychiatry Neurosci 38:98-106. 2013
    ..Preclinical studies in animal models of psychosis have shown a selective increase of D2 high as the common factor in psychosis, and the D3 receptor has been suggested to be involved in the pathophysiology of schizophrenia...
  32. pmc Imaging Striatal Microglial Activation in Patients with Parkinson's Disease
    Yuko Koshimori
    Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Hospital Network, University of Toronto, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 10:e0138721. 2015
    ..While this PET study showed no evidence of increased striatal TSPO expression in PD patients, the current findings provide some insights on the possible interactions between rs6791 polymorphism and neuroinflammation in PD. ..
  33. pmc Relationship of monoamine oxidase-A distribution volume to postpartum depression and postpartum crying
    Julia Sacher
    1 CAMH Research Imaging Centre, Campbell Family Mental Health Research Institute, CAMH, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada 2 Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada 3 Clinic of Cognitive Neurology, University of Leipzig and Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Neuropsychopharmacology 40:429-35. 2015
    ..These findings also argue for clinical trials in PPD with the newer, well-tolerated MAO-A inhibitor antidepressants. ..
  34. doi request reprint Convergent effects of acute stress and glucocorticoid exposure upon MAO-A in humans
    Alexandra Soliman
    CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    J Neurosci 32:17120-7. 2012
    ..Since MAO-A metabolizes monoamines, this phenomenon may explain why acute stressors benefit healthy animals even though chronic stress is associated with illness...
  35. ncbi request reprint Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [11C]DASB positron emission tomography
    Aristotle N Voineskos
    Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, ON, M5T 1R8, Canada
    Psychopharmacology (Berl) 193:539-45. 2007
    ..11)C]N,N-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine positron emission tomography ([(11)C]DASB PET) is currently the best method available to quantify 5-HTT occupancy in humans...
  36. pmc Investing in the future: stimulation of the medial prefrontal cortex reduces discounting of delayed rewards
    Sang Soo Cho
    1 Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada 2 Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, ON, Canada
    Neuropsychopharmacology 40:546-53. 2015
    ....
  37. pmc Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: a [11C]FLB 457 PET study
    Ji Hyun Ko
    PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Neuroimage 46:516-21. 2009
    ..These results may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson's disease and schizophrenia...
  38. ncbi request reprint Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophrenia
    Romina Mizrahi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5S 2S1
    Am J Psychiatry 164:630-7. 2007
    ..The authors present the first double-blind controlled study to examine the relationship between striatal and extrastriatal dopamine D(2) receptor binding potential and occupancy values and adverse subjective experience...
  39. pmc Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [11C]CURB
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Psychiatry, University of Toronto, Toronto, Ontario, Canada Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada Electronic address
    Biol Psychiatry 80:691-701. 2016
    ..However, the status of brain FAAH in cannabis use disorder is unknown...
  40. pmc Greater monoamine oxidase a binding in perimenopausal age as measured with carbon 11-labeled harmine positron emission tomography
    Paraskevi Vivien Rekkas
    Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    JAMA Psychiatry 71:873-9. 2014
    ..After declines in estrogen level, MAO-A density may be elevated for a month or longer, and repeated declines in estrogen level occur with greater magnitude during perimenopause...
  41. pmc Serotonin2A receptor binding potential in people with aggressive and violent behaviour
    Jeffrey H Meyer
    Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 33:499-508. 2008
    ..The objective of this study was to investigate prefrontal cortex 5-HT2A binding potential (BPND), an index of 5-HT2A density, in an unbiased sample of people with violent aggressive behaviour...
  42. pmc Microglial activation in Parkinson's disease using [18F]-FEPPA
    Christine Ghadery
    Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    J Neuroinflammation 14:8. 2017
    ..Positron emission tomography (PET) radioligand targeting TSPO allows for the quantification of neuroinflammation in vivo...