B K Christensen

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi Dual cytoarchitectonic trends: an evolutionary model of frontal lobe functioning and its application to psychopathology
    B K Christensen
    Department of Psychiatry, University of Toronto, Ontario, ON
    Can J Psychiatry 45:247-56. 2000
  2. ncbi Impact of haloperidol, a dopamine D2 antagonist, on cognition and mood
    Huma Saeedi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Res 85:222-31. 2006
  3. ncbi Wechsler Adult Intelligence Scale-Third Edition short form for index and IQ scores in a psychiatric population
    Bruce K Christensen
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Psychol Assess 19:236-40. 2007
  4. doi Visual selective attention among persons with schizophrenia: the distractor ratio effect
    Ava Elahipanah
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Schizophr Res 105:61-7. 2008
  5. pmc Exploring the connectivity between the cerebellum and motor cortex in humans
    Zafiris J Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Physiol 557:689-700. 2004
  6. ncbi Neurophysiological evidence for disturbances of conflict processing in patients with schizophrenia
    Heather E McNeely
    Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
    J Abnorm Psychol 112:679-88. 2003
  7. doi Grasping behavior in schizophrenia suggests selective impairment in the dorsal visual pathway
    Jelena P King
    St Joseph s Healthcare Hamilton, 100 West 5th Street, Hamilton, Ontario, Canada
    J Abnorm Psychol 117:799-811. 2008
  8. ncbi Neurophysiological evidence of cognitive inhibition anomalies in persons with major depressive disorder
    Heather E McNeely
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada
    Clin Neurophysiol 119:1578-89. 2008
  9. ncbi Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
    J Clin Psychiatry 63:992-7. 2002
  10. doi Correspondences between theory of mind, jumping to conclusions, neuropsychological measures and the symptoms of schizophrenia
    Todd S Woodward
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychiatry Res 170:119-23. 2009

Detail Information

Publications51

  1. ncbi Dual cytoarchitectonic trends: an evolutionary model of frontal lobe functioning and its application to psychopathology
    B K Christensen
    Department of Psychiatry, University of Toronto, Ontario, ON
    Can J Psychiatry 45:247-56. 2000
    ..To introduce and discuss an evolutionary model of frontal lobe functioning (the dual cytoarchitectonic trends theory [DTT]) and its application to understanding the neurobiology of schizophrenia and anxiety disorders...
  2. ncbi Impact of haloperidol, a dopamine D2 antagonist, on cognition and mood
    Huma Saeedi
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Res 85:222-31. 2006
    ..The present results suggest that DA D(2) blockade, as induced by haloperidol, produces important deficits that extend beyond motor or endocrine changes...
  3. ncbi Wechsler Adult Intelligence Scale-Third Edition short form for index and IQ scores in a psychiatric population
    Bruce K Christensen
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Psychol Assess 19:236-40. 2007
    ..Expanding on previous short forms, the current SF8 maximizes the breadth of information and reduces administration time while maintaining the original WAIS-III factor structure...
  4. doi Visual selective attention among persons with schizophrenia: the distractor ratio effect
    Ava Elahipanah
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Schizophr Res 105:61-7. 2008
    ..These results demonstrate that search selectivity as a function of the relative frequency of distractors is unimpaired among patients with schizophrenia...
  5. pmc Exploring the connectivity between the cerebellum and motor cortex in humans
    Zafiris J Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Physiol 557:689-700. 2004
    ..The third experiment showed that the interaction between CBI and LICI reduced CBI. Collectively, these findings suggest that cerebellar stimulation results in changes to both inhibitory and excitatory neurones in the human motor cortex...
  6. ncbi Neurophysiological evidence for disturbances of conflict processing in patients with schizophrenia
    Heather E McNeely
    Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
    J Abnorm Psychol 112:679-88. 2003
    ..These results provide evidence for the existence of altered neural processes associated with conflict processing that may be associated with dysfunction of the anterior cingulate and prefrontal cortex in patients with schizophrenia...
  7. doi Grasping behavior in schizophrenia suggests selective impairment in the dorsal visual pathway
    Jelena P King
    St Joseph s Healthcare Hamilton, 100 West 5th Street, Hamilton, Ontario, Canada
    J Abnorm Psychol 117:799-811. 2008
    ..These results suggest disrupted dorsal brain circuitry in SCZ but relatively intact ventral circuitry...
  8. ncbi Neurophysiological evidence of cognitive inhibition anomalies in persons with major depressive disorder
    Heather E McNeely
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada
    Clin Neurophysiol 119:1578-89. 2008
    ..The neural correlates of inhibitory deficits for emotional semantic material in persons with major depressive disorder (MDD) were investigated...
  9. ncbi Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
    J Clin Psychiatry 63:992-7. 2002
    ..We treated patients experiencing their first episode of schizophrenia with a single daily dose of quetiapine to achieve a transient daily peak of D(2) receptor blockade, to determine if this would lead to an antipsychotic response...
  10. doi Correspondences between theory of mind, jumping to conclusions, neuropsychological measures and the symptoms of schizophrenia
    Todd S Woodward
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychiatry Res 170:119-23. 2009
    ..Implications of these results are that impairments in elaboration may underlie the commonly observed correlation between ToM and negative symptoms, but argue against a common neurocognitive system for JTC, ToM and positive symptoms...
  11. ncbi The role of cortical inhibition in the pathophysiology and treatment of schizophrenia
    Zafiris J Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Brain Res Rev 56:427-42. 2007
    ..We will conclude by reviewing the role of CI as a mechanism mediating the therapeutic action of antipsychotic medications...
  12. ncbi Evidence for impaired mnemonic strategy use among patients with schizophrenia using the part-list cuing paradigm
    Bruce K Christensen
    Neuropsychology Lab, Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Schizophr Res 85:1-11. 2006
    ..In this task, presentation of retrieval cues in the form of a subset of studied words typically impairs recall of the remaining items. This impairment is thought to reflect a disruption of participants' natural retrieval strategies...
  13. doi Increased cortical inhibition in persons with schizophrenia treated with clozapine
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    J Psychopharmacol 22:203-9. 2008
    ..Our results also confirm previous findings suggesting that deficits in CI are related to the severity of psychotic symptoms in persons with schizophrenia...
  14. ncbi Reduced cerebellar inhibition in schizophrenia: a preliminary study
    Zafiris J Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, University of Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 162:1203-5. 2005
    ..The authors' goal was to use transcranial magnetic stimulation to measure cerebellar inhibition, a proxy of cerebellar activity, as the principal output of the cerebellum is inhibitory...
  15. ncbi Handedness in pedophilia and hebephilia
    James M Cantor
    Law and Mental Health Program, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Arch Sex Behav 34:447-59. 2005
    ....
  16. ncbi Treatment response to olanzapine and haloperidol and its association with dopamine D receptor occupancy in first-episode psychosis
    Robert B Zipursky
    Department of Psychiatry, University of Toronto, Ontario
    Can J Psychiatry 50:462-9. 2005
    ..We undertook this study to determine whether response to the atypical antipsychotic olanzapine occurs at lower levels of D2 receptor occupancy...
  17. ncbi The effects of repetitive transcranial magnetic stimulation on cortical inhibition in healthy human subjects
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Exp Brain Res 174:403-12. 2006
    ..Baseline physiological characteristics may be further explored as a method to select patients who may benefit from rTMS treatment...
  18. doi Dysfunctional neural plasticity in patients with schizophrenia
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Arch Gen Psychiatry 65:378-85. 2008
    ..In schizophrenia, dysfunctional neural plasticity has been proposed as a key pathophysiological mechanism...
  19. ncbi Intelligence, memory, and handedness in pedophilia
    James M Cantor
    Law and Mental Health Program, Centre for Addiction and Mental Health CAMH, Toronto, ON, Canada
    Neuropsychology 18:3-14. 2004
    ..Pedophilia was also related to non-right-handedness even after covarying age and IQ. These results suggest that pedophilia is linked to early neurodevelopmental perturbations...
  20. ncbi Self-reported head injuries before and after age 13 in pedophilic and nonpedophilic men referred for clinical assessment
    Ray Blanchard
    Law and Mental Health Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Arch Sex Behav 32:573-81. 2003
    ....
  21. ncbi Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation
    Zafiris J Daskalakis
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, Toronto Western General Hospital, University of Toronto, Ontario, Canada
    Arch Gen Psychiatry 59:347-54. 2002
    ....
  22. pmc Social cognition mediates illness-related and cognitive influences on social function in patients with schizophrenia-spectrum disorders
    Jean Addington
    Department of Psychiatry, University of Toronto, Toronto, Canada
    J Psychiatry Neurosci 35:49-54. 2010
    ..The objective of the current study was to use structural equation modelling to test the hypothesis that the relation between cognitive performance and social function is mediated by patients' social cognitive abilities...
  23. ncbi Quantitative reanalysis of aggregate data on IQ in sexual offenders
    James M Cantor
    Law and Mental Health Program, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Psychol Bull 131:555-68. 2005
    ..Results confirm the association between IQ and sexual offending and suggest that previous discrepancies are attributable to how many pedophilic individuals were in each sample...
  24. ncbi Transcranial magnetic stimulation: a new investigational and treatment tool in psychiatry
    Zafiris J Daskalakis
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, 7th Floor Clarke Division, University of Toronto, 250 College Street, Toronto, Ontario, Canada
    J Neuropsychiatry Clin Neurosci 14:406-15. 2002
    ..The most serious side effect of high-frequency rTMS is seizures. TMS represents an exciting new frontier in neuroscience research, providing insights into the pathophysiology and treatment of various neuropsychiatric disorders...
  25. ncbi Retrospective self-reports of childhood accidents causing unconsciousness in phallometrically diagnosed pedophiles
    Ray Blanchard
    Law and Mental Health Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Arch Sex Behav 31:511-26. 2002
    ..This finding suggests that pedophilia may be influenced by genetic factors, which are manifested in women as an increased risk of psychiatric problems, and in their sons, as an increased risk of erotic interest in children...
  26. ncbi Cerebral white matter deficiencies in pedophilic men
    James M Cantor
    Law and Mental Health Program, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    J Psychiatr Res 42:167-83. 2008
    ....
  27. ncbi Effect of antipsychotics on cortical inhibition using transcranial magnetic stimulation
    Zafiris J Daskalakis
    Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 170:255-62. 2003
    ..Therefore, single administration of an antipsychotic has no effect on CI or resting motor threshold. Whether chronic, repeated administration of antipsychotics has effects on CI requires further investigation...
  28. pmc Actigraphic measurement of the effects of single-dose haloperidol and olanzapine on spontaneous motor activity in normal subjects
    Michael Kiang
    Schizophrenia Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 28:293-9. 2003
    ..To quantitatively examine the effects of haloperidol and olanzapine on spontaneous motor activity in normal subjects...
  29. doi Visual-spatial episodic memory in schizophrenia: A multiple systems framework
    Todd A Girard
    Department of Psychology, Ryerson University, Toronto, Ontario M5B 2K3, Canada
    Neuropsychology 24:368-78. 2010
    ..This study employed a multiple-systems framework derived from the rodent literature to investigate visual-spatial memory abilities associated with schizophrenia...
  30. doi Visual search performance among persons with schizophrenia as a function of target eccentricity
    Ava Elahipanah
    University of Toronto, Toronto, Canada
    Neuropsychology 24:192-8. 2010
    ..These results support the hypothesis that a narrower visual span may underlie impaired visual search performance among patients with schizophrenia...
  31. ncbi Inhibitory deficits for negative information in persons with major depressive disorder
    Mark A Lau
    Center for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychol Med 37:1249-59. 2007
    ..The authors posit the theory that inhibitory dysfunction may influence the degree to which activated self-schemas result in the production of depressive cognition...
  32. ncbi Effects of catecholamine depletion on D2 receptor binding, mood, and attentiveness in humans: a replication study
    Nicolaas P L G Verhoeff
    Kunin Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Posluns Building, 7th Floor, Room 762, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Pharmacol Biochem Behav 74:425-32. 2003
    ..These changes were not correlated with the D(2)RBP increments. The results of this study are overall consistent with previous findings by our group using the same methodology in a different cohort of six healthy subjects...
  33. pmc The mechanisms of interhemispheric inhibition in the human motor cortex
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Physiol 543:317-26. 2002
    ..In contrast, the mechanisms mediating short interval intracortical inhibition are probably different from those mediating long interval intracortical inhibition and interhemispheric inhibition although these systems appear to interact...
  34. ncbi Apathy in schizophrenia: clinical correlates and association with functional outcome
    Michael Kiang
    Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Schizophr Res 63:79-88. 2003
    ..It was not associated with observed interest in playing a video game or performance on a simulated clerical task...
  35. ncbi Recovery of cognitive function after traumatic brain injury: a multilevel modeling analysis of Canadian outcomes
    Bruce K Christensen
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Arch Phys Med Rehabil 89:S3-15. 2008
    ..To ascertain patterns of cognitive recovery during the first year after traumatic brain injury (TBI). Specifically, differential recovery across cognitive domains was investigated...
  36. doi Cognitive function and brain structure in females with a history of adolescent-onset anorexia nervosa
    Harold T Chui
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Pediatrics 122:e426-37. 2008
    ....
  37. ncbi An automated method to determine the transcranial magnetic stimulation-induced contralateral silent period
    Zafiris J Daskalakis
    Centre for Addiction and Mental Health, Schizophrenia and Continuing Care Program, University of Toronto, Ontario, Canada
    Clin Neurophysiol 114:938-44. 2003
    ..The determination of the return of voluntary motor activity is typically accomplished via visual inspection of the electromyography (EMG) waveform and may be subject to inaccuracy on the part of the rater...
  38. ncbi Neurophysiological evidence of error-monitoring deficits in patients with schizophrenia
    Claude Alain
    Rotman Research Institute of Baycrest Centre for Geriatric Care, Department of Psychology, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Cereb Cortex 12:840-6. 2002
    ..These findings provide neuro-physiological evidence indicating that deficits in error monitoring in schizophrenia arise from a disruption of error-detection processes, possibly attributable to anterior cingulate dysfunction...
  39. ncbi Reduced directed forgetting for negative words suggests schizophrenia-related disinhibition of emotional cues
    R E Patrick
    Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, ON, Canada
    Psychol Med 43:2289-99. 2013
    ..Therefore, it is important to evaluate the performance of persons with SCZ using tasks designed to index the resolution between competing emotional and cognitive determinants of goal-directed behaviour...
  40. doi Clarifying problems and offering solutions for correlated error when assessing the validity of selected-subtest short forms
    Todd A Girard
    Department of Psychology, Ryerson University, Toronto, Ontario, Canada
    Psychol Assess 20:76-80. 2008
    ....
  41. ncbi Caudate volume changes in first episode psychosis parallel the effects of normal aging: a 5-year follow-up study
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 58:185-8. 2002
    ..Both groups demonstrated a significant 9% decline in caudate volume. We were unable to replicate previous reports of caudate enlargement in patients receiving antipsychotic treatment...
  42. ncbi Use of the Personality Assessment Inventory (PAI) in individuals with traumatic brain injury
    Christine Till
    Department of Psychology, York University, Toronto, Ontario, Canada
    Brain Inj 23:655-65. 2009
    ..To evaluate the extent to which the Personality Assessment Inventory (PAI) is confounded by symptoms that are transdiagnostic between psychopathology and neurological sequelae...
  43. ncbi Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET
    J Tauscher
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Neuropsychopharmacology 24:522-30. 2001
    ..Hence, careful age matching may be recommended for future studies using PET and [11C]WAY-100635 to examine 5-HT1A receptors...
  44. ncbi Lower dopamine transporter binding potential in striatum during depression
    J H Meyer
    PET Imaging Centre, and Mood Division, Centre for Addiction and Mental Health, Department of Psychiatry and University of Toronto, 250 College St, Toronto, Ont. M5T1R8, Canada
    Neuroreport 12:4121-5. 2001
    ..Lower DAT BP itself reduces extracellular clearance of dopamine. Patients who did not decrease their striatal DAT BP failed to compensate for low dopamine and showed greater impairment on dopamine related tests...
  45. ncbi The efficacy of cognitive behavior therapy in the treatment of emotional distress after acquired brain injury
    Cheryl L Bradbury
    Toronto Rehabilitation Institute, Toronto, ON, Canada
    Arch Phys Med Rehabil 89:S61-8. 2008
    ..To evaluate the efficacy of cognitive behavior therapy (CBT), adapted to meet the unique needs of individuals with acquired brain injury (ABI), and modified for both group and telephone delivery...
  46. ncbi Bupropion occupancy of the dopamine transporter is low during clinical treatment
    Jeffrey H Meyer
    Department of Psychiatry, PET Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Psychopharmacology (Berl) 163:102-5. 2002
    ..The validity of this mechanism has been questioned because the affinity of bupropion for the DAT is quite low...
  47. ncbi Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: a randomized, double-blind trial of olanzapine versus low doses of haloperidol
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Am J Psychiatry 161:985-95. 2004
    ..This study compares the neurocognitive effects of olanzapine and low doses of haloperidol in patients with first-episode psychosis...
  48. ncbi Stable deficits in gray matter volumes following a first episode of schizophrenia
    Robert B Zipursky
    Schizophr Res 71:515-6. 2004
  49. ncbi Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA
    Biol Psychiatry 59:97-105. 2006
    ..Neurocognitive deficits are severe in first-episode psychosis...
  50. ncbi A longitudinal study of neurocognitive function in individuals at-risk for psychosis
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Schizophr Res 88:26-35. 2006
    ..The time course and predictive value of cognitive deficits in the development of psychosis has not been established...
  51. ncbi Volumetric MRI measurement of caudate nuclei in antipsychotic-naive patients suffering from a first episode of psychosis
    Sitra Tauscher-Wisniewski
    Department of Neuropsychiatry for Children and Adolescents, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Psychiatr Res 39:365-70. 2005
    ..441). In contrast to previous studies in patients treated with typical neuroleptics, this cross-sectional MRI study did not find significant differences in CNV of neuroleptic-naive first-episode patients compared to healthy controls...