Isabelle Boileau

Summary

Affiliation: Centre for Addiction and Mental Health
Country: Canada

Publications

  1. ncbi Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 27:1027-35. 2002
  2. ncbi Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada
    Arch Gen Psychiatry 63:1386-95. 2006
  3. doi Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:1776-80. 2008
  4. doi Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 62:873-6. 2008
  5. doi The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]-(+)-propyl-hexahydro-naphtho-oxazin and [11C]raclopride
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Addiction 108:953-63. 2013
  6. pmc Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study
    Isabelle Boileau
    Addiction Imaging Research Group, Vivian M Rakoff PET Imaging Centre, Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 32:1353-9. 2012
  7. doi Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    Brain 132:1366-75. 2009
  8. doi Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Synapse 64:417-20. 2010
  9. doi Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 28:9850-6. 2008
  10. ncbi Conditioned dopamine release in humans: a positron emission tomography [11C]raclopride study with amphetamine
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:3998-4003. 2007

Collaborators

Detail Information

Publications54

  1. ncbi Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 27:1027-35. 2002
    ..Mesolimbic DA might mediate interest in obtaining reward rather than reward, per se. Individual differences in amphetamine-induced DA release might be related to predispositions to drug and novelty seeking...
  2. ncbi Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada
    Arch Gen Psychiatry 63:1386-95. 2006
    ..A similar phenomenon, referred to as endogenous sensitization, is also believed to play a role in the emergence of positive symptoms in patients with schizophrenia...
  3. doi Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:1776-80. 2008
    ....
  4. doi Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration
    Junchao Tong
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Synapse 62:873-6. 2008
    ..We suggest that in vivo (+)-[11C]DTBZ binding in imaging studies is subject to competition by vesicular dopamine and, in this respect, is not a "stable" dopamine biomarker as is generally assumed...
  5. doi The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]-(+)-propyl-hexahydro-naphtho-oxazin and [11C]raclopride
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Addiction 108:953-63. 2013
    ....
  6. pmc Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study
    Isabelle Boileau
    Addiction Imaging Research Group, Vivian M Rakoff PET Imaging Centre, Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 32:1353-9. 2012
    ..Pharmacological studies are needed to establish whether normalization of D3 receptor function could reduce vulnerability to relapse in stimulant abuse...
  7. doi Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    Brain 132:1366-75. 2009
    ....
  8. doi Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Synapse 64:417-20. 2010
    ..Our data suggest that a low amphetamine dose is unlikely to cause sufficient DA depletion to detect increased (+)[11C]DTBZ binding and that a higher dose might be required...
  9. doi Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
    Isabelle Boileau
    Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 28:9850-6. 2008
    ..If correct, (+)[(11)C]DTBZ might be a useful imaging probe to correlate changes in brain dopamine stores and behavior in users of methamphetamine...
  10. ncbi Conditioned dopamine release in humans: a positron emission tomography [11C]raclopride study with amphetamine
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:3998-4003. 2007
    ..These results suggest that cues associated with amphetamine increase dopamine transmission, providing evidence that this system is involved in reward prediction in humans...
  11. pmc Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Brain 133:1779-97. 2010
    ....
  12. doi Dopamine response to psychosocial stress in humans and its relationship to individual differences in personality traits
    Ivonne Suridjan
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada
    J Psychiatr Res 46:890-7. 2012
    ..Previous studies have reported inter-individual variability in the dopamine (DA) response to stress. This variability might be related to individual differences in the vulnerability to experience the negative effect of stress...
  13. doi [¹¹C]-(+)-PHNO PET imaging of dopamine D(2/3) receptors in Parkinson's disease with impulse control disorders
    Doris E Payer
    Addictions Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Mov Disord 30:160-6. 2015
    ....
  14. pmc D3 dopamine receptor-preferring [11C]PHNO PET imaging in Parkinson patients with dyskinesia
    Doris E Payer
    From the Addictions Program D E P, I B, the Research Imaging Centre D E P, S J K, J T, P R, S H, A A W, I B, and the Human Brain Laboratory M G, S J K, Y F, Centre for Addiction and Mental Health, Toronto Campbell Family Mental Health Research Institute S J K, J T, P R, S H, A A W, I B, Toronto the Departments of Psychiatry D E P, S J K, J T, A A W, I B and Pharmacology S J K, University of Toronto and the Centre for Movement Disorders M G, J R A, Markham, Canada
    Neurology 86:224-30. 2016
    ..To investigate whether levodopa-induced dyskinesias (LID) are associated with D3 overexpression in levodopa-treated humans with Parkinson disease (PD)...
  15. ncbi Decreasing amphetamine-induced dopamine release by acute phenylalanine/tyrosine depletion: A PET/[11C]raclopride study in healthy men
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 29:427-32. 2004
    ..82, p<0.05). Together, the results provide the first direct evidence that APTD decreases stimulated DA release in human brain. APTD may be a suitable new tool for human neuropsychopharmacology research...
  16. pmc Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [11C]CURB
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Psychiatry, University of Toronto, Toronto, Ontario, Canada Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada Electronic address
    Biol Psychiatry 80:691-701. 2016
    ..However, the status of brain FAAH in cannabis use disorder is unknown...
  17. pmc Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [(11)C]CURB
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 35:1827-35. 2015
    ..Moreover, PF-04457845 is a highly potent FAAH inhibitor (>95% inhibition at 1 mg) in living human brain...
  18. pmc Occupancy of Dopamine D3 and D2 Receptors by Buspirone: A [11C]-(+)-PHNO PET Study in Humans
    Bernard Le Foll
    Translational Addiction Research Laboratory, Toronto, ON, Canada
    Neuropsychopharmacology 41:529-37. 2016
    ..Overall, the modest occupancy of DRD2 and DRD3 even at high acute doses of buspirone, yielding high levels of metabolites, suggests that buspirone may not be a good drug to preferentially block DRD3 in humans...
  19. pmc Low levels of astroglial markers in Parkinson's disease: relationship to α-synuclein accumulation
    Junchao Tong
    Human Brain Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Addiction Imaging Research Group, Campbell Family Mental Health Research Institute, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Electronic address
    Neurobiol Dis 82:243-53. 2015
    ..Should astrogliosis protect, to some extent, the degenerating substantia nigra from damage, therapeutics aimed at normalization of astrocyte reaction in PD could be helpful. ..
  20. pmc Elevation of dopamine induced by cigarette smoking: novel insights from a [11C]-+-PHNO PET study in humans
    Bernard Le Foll
    1 Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada 3 Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada 4 Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada 5 Department of Pharmacology, University of Toronto, Toronto, ON, Canada 6 Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, Toronto, ON, Canada 7 Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 39:415-24. 2014
    ..We propose that due to the robust effect of smoking on [(11)C]-(+)-PHNO binding, this radiotracer represents an ideal translational tool to investigate novel therapeutic strategies targeting DA transmission. ..
  21. pmc Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease
    Leigh Christopher
    Morton and Gloria Shulman Movement Disorder Unit and Edmond J Safra Program in Parkinson Disease, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada Division of Brain, Imaging, and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 77:269-80. 2015
    ..Our aim was to investigate whether dopamine dysfunction in these regions contributes to memory impairment in PD...
  22. doi Is brain gliosis a characteristic of chronic methamphetamine use in the human?
    Junchao Tong
    Human Brain Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Addiction Imaging Research Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Electronic address
    Neurobiol Dis 67:107-18. 2014
    ..However, a logistically more difficult quantitative histopathological study is needed to confirm whether glial changes occur or do not occur in brain of human methamphetamine (and amphetamine) users...
  23. pmc Heightened D3 dopamine receptor levels in cocaine dependence and contributions to the addiction behavioral phenotype: a positron emission tomography study with [11C]-+-PHNO
    Doris E Payer
    1 Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Research Imaging Centre and Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 39:311-8. 2014
    ..D3 upregulation is emerging as a biomarker in preclinical models of addiction, and human PET studies of this receptor system can help guide novel pharmacological strategies for treatment. ..
  24. pmc Mapping human brain fatty acid amide hydrolase activity with PET
    Pablo M Rusjan
    Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 33:407-14. 2013
    ..Simulations showed that [(11)C]CURB binding in healthy subjects is far from a flow-limited uptake...
  25. ncbi Stress-induced dopamine release in humans at risk of psychosis: a [11C]raclopride PET study
    Alexandra Soliman
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada
    Neuropsychopharmacology 33:2033-41. 2008
    ..Our findings suggest the presence of abnormalities in the dopamine response to stress in negative symptom schizotypy, and provide indirect evidence of a link to frontal function...
  26. ncbi Alcohol promotes dopamine release in the human nucleus accumbens
    Isabelle Boileau
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Synapse 49:226-31. 2003
    ..These findings support the hypothesis that mesolimbic dopamine activation is a common property of abused substances, possibly mediating their reinforcing effects...
  27. ncbi The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride
    Sean P Barrett
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada
    Synapse 54:65-71. 2004
    ..These results suggest that pleasurable drug experiences are associated with increased dopamine transmission in the dorsal striatum while unpleasant experiences may be related to decreased dopamine release in this region...
  28. pmc Heightened Dopaminergic Response to Amphetamine at the D3 Dopamine Receptor in Methamphetamine Users
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Neuropsychopharmacology 41:2994-3002. 2016
    ....
  29. doi Differential cardiovascular and hypothalamic pituitary response to amphetamine in male pathological gamblers versus healthy controls
    Martin Zack
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    J Psychopharmacol 29:971-82. 2015
    ..Extraversion predicted greater disinhibition in PGs. Noradrenergic disturbances may contribute to sensitized responses to stimulant challenge and disinhibition in PGs. ..
  30. pmc Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies
    Junchao Tong
    Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Cereb Blood Flow Metab 33:863-71. 2013
    ..However, compared with in vitro data, the latter PET measures underestimated regional contrast by ∼2-fold. Further studies are needed to address cause of the in vivo vs. in vitro nonproportionality...
  31. doi Brain serotonin transporter in human methamphetamine users
    Stephen J Kish
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 202:649-61. 2009
    ....
  32. pmc Distribution of vesicular monoamine transporter 2 protein in human brain: implications for brain imaging studies
    Junchao Tong
    Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:2065-75. 2011
    ....
  33. doi Corticotropin-releasing hormone and dopamine release in healthy individuals
    Doris Payer
    Research Imaging Centre, Centre for Addiction and Mental Health, 250 College St, Toronto, ON, Canada Addictions Division, Centre for Addiction and Mental Health, 100 Stokes St, Toronto, ON, Canada Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, 250 College St, Toronto, ON, Canada
    Psychoneuroendocrinology 76:192-196. 2016
    ....
  34. ncbi Inhibition of fatty acid amide hydrolase by BIA 10-2474 in rat brain
    Junchao Tong
    Research Imaging Centre, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada
    J Cereb Blood Flow Metab . 2016
    ..BIA 10-2474 proved to be a potent FAAH inhibitor with IC50s of 50-70 µg/kg (i.p.) in various brain regions. This information may be useful for determining the cause of the SAEs...
  35. doi Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada and Institute of Medical Science, Toronto, Ontario, Canada
    J Nucl Med 55:1993-7. 2014
    ..The aim of the study was to investigate the whole-body biodistribution and estimate the radiation dosimetry from (11)C-CURB scans in humans...
  36. pmc Combined insular and striatal dopamine dysfunction are associated with executive deficits in Parkinson's disease with mild cognitive impairment
    Leigh Christopher
    1 Morton and Gloria Shulman Movement Disorder Unit and E J Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, M5T 2S8, Canada
    Brain 137:565-75. 2014
    ..Furthermore, these findings suggest a crucial and direct role for dopaminergic modulation in the insula in facilitating cognitive function. ..
  37. pmc Stress-induced dopamine response in subjects at clinical high risk for schizophrenia with and without concurrent cannabis use
    Romina Mizrahi
    1 PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Faculty of Medicine, Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 39:1479-89. 2014
    ..Our finding does not support the cross-sensitization hypothesis, which posits greater dopaminergic reactivity to stress in CHR cannabis users, but adds to the growing body of literature showing reduced DA (stress) response in addiction. ..
  38. pmc Presentation of smoking-associated cues does not elicit dopamine release after one-hour smoking abstinence: A [11C]-(+)-PHNO PET study
    Lina Chiuccariello
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    PLoS ONE 8:e60382. 2013
    ....
  39. doi Increased stress-induced dopamine release in psychosis
    Romina Mizrahi
    Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Biol Psychiatry 71:561-7. 2012
    ..However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis...
  40. pmc Varenicline-Induced Elevation of Dopamine in Smokers: A Preliminary [(11)C]-(+)-PHNO PET Study
    Patricia Di Ciano
    Translational Addiction Research Laboratory, CAMH, Toronto, ON, Canada
    Neuropsychopharmacology 41:1513-20. 2016
    ..008) and reduced some craving measures. These findings provide the first evidence that varenicline is able to increase DA levels in the human brain, a factor that may contribute to its therapeutic efficacy. ..
  41. doi Do glutathione levels decline in aging human brain?
    Junchao Tong
    Human Brain Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8 Addiction Imaging Research Group, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Electronic address
    Free Radic Biol Med 93:110-7. 2016
    ..Since our findings, although suggestive, suffer from the generic limitations of all postmortem brain studies, we also suggest the need for "replication" investigations employing the new (1)H MRS imaging procedures in living human brain. ..
  42. pmc Rapid Recovery of Vesicular Dopamine Levels in Methamphetamine Users in Early Abstinence
    Isabelle Boileau
    Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 41:1179-87. 2016
    ..Further study is necessary to establish whether those users who could not maintain abstinence for the second scan might have a more severe and persistent dopamine deficiency and who could benefit from this medication. ..
  43. pmc Greater monoamine oxidase a binding in alcohol dependence
    Brittany A Matthews
    Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry and Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 75:756-64. 2014
    ....
  44. pmc Measuring cigarette smoking-induced cortical dopamine release: A [¹¹C]FLB-457 PET study
    Victoria C Wing
    Schizophrenia Division, Complex Mental Illness Program, and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health CAMH, Toronto, ON, Canada
    Neuropsychopharmacology 40:1417-27. 2015
    ..11)C]FLB-457 PET imaging may represent a useful tool to investigate individual differences in tobacco addiction severity and treatment response. ..
  45. pmc The fatty acid amide hydrolase C385A variant affects brain binding of the positron emission tomography tracer [11C]CURB
    Isabelle Boileau
    1 Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada 2 Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada 3 Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada 4 Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada 5 Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada 6 Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 35:1237-40. 2015
    ..We report evidence that the genetic variant rs324420 in FAAH is associated with measurable differences in brain FAAH binding as per PET [(11)C]CURB measurement...
  46. doi Methamphetamine use and schizophrenia: a population-based cohort study in California
    Russell C Callaghan
    Centre for Addiction and Mental Health, Toronto
    Am J Psychiatry 169:389-96. 2012
    ..This possibility is discounted in the Western literature. To investigate the relationship between drug use and later schizophrenia, the authors conducted a large-scale cohort study of drug users initially free of persistent psychosis...
  47. pmc Brain dopamine neurone 'damage': methamphetamine users vs. Parkinson's disease - a critical assessment of the evidence
    Stephen J Kish
    Human Brain Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada
    Eur J Neurosci . 2016
    ....
  48. pmc Lack of age-dependent decrease in dopamine D3 receptor availability: a [(11)C]-(+)-PHNO and [(11)C]-raclopride positron emission tomography study
    Shinichiro Nakajima
    Multimodal Imaging Group Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 35:1812-8. 2015
    ..41, P<0.001), and ventral striatum (r(68)=-0.43, P<0.001). In conclusion, in contrast with the age-dependent decrease in D2R availability, these findings suggest that D3R availability does not change with age. ..
  49. doi Effects of High Frequency Repeated Transcranial Magnetic Stimulation and Continuous Theta Burst Stimulation on Gambling Reinforcement, Delay Discounting, and Stroop Interference in Men with Pathological Gambling
    Martin Zack
    Neuroscience Research Department, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario M5S 2S1, Canada Electronic address
    Brain Stimul 9:867-875. 2016
    ..High-frequency rTMS of the medial prefrontal cortex (PFC) and continuous theta burst stimulation (cTBS) of the right dorsolateral PFC can reduce impulsive choice in healthy volunteers...
  50. doi Imaging the D3 dopamine receptor across behavioral and drug addictions: Positron emission tomography studies with [(11)C]-(+)-PHNO
    Isabelle Boileau
    Addiction Imaging Research Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Psychiatry, University of Toronto, Toronto, ON, Canada Electronic address
    Eur Neuropsychopharmacol 25:1410-20. 2015
    ..This technique has been used to demonstrate D3 up-regulation in humans, and can be applied to assess pharmacological interventions for development of D3-targeted strategies in addiction treatment. ..
  51. pmc The Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling Task
    Patricia Di Ciano
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Canada M5S 2S1
    PLoS ONE 10:e0136267. 2015
    ..Administration of those selective ligands did not affect decision making under the rGT. Only the D4 drug had modest effects on latency measures suggesting that D4 may contribute in some ways to decision making under this task. ..
  52. doi What is the role of the D3 receptor in addiction? A mini review of PET studies with [(11)C]-(+)-PHNO
    Doris Payer
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Addictions, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Schizophrenia Programs, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 52:4-8. 2014
    ..In this mini review we present recent human data suggesting that the D3 receptor may contribute to core features of addiction, and discuss the usefulness of the PET imaging probe [(11)C]-(+)-PHNO in investigating this question. ..
  53. doi Dopamine D3 receptor ligands for drug addiction treatment: update on recent findings
    Bernard Le Foll
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada Department of Family and Community Medicine, Pharmacology and Toxicology, Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada Electronic address
    Prog Brain Res 211:255-75. 2014
    ..The first results of clinical investigations are now being provided. Overall, those recent findings support further exploration of D3 ligands to treat drug addiction. ..
  54. ncbi Dopamine transmission in the human striatum during monetary reward tasks
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37212, USA
    J Neurosci 24:4105-12. 2004
    ..The implications of these results are discussed in relation to conflicting models of dopaminergic functioning arising from studies using electrophysiological and microdialysis techniques in animals...