Jeffrey Atkinson

Summary

Affiliation: Brock University
Country: Canada

Publications

  1. doi request reprint The location and behavior of alpha-tocopherol in membranes
    Jeffrey Atkinson
    Department of Chemistry, Brock University, St Catharines, Ont, Canada
    Mol Nutr Food Res 54:641-51. 2010
  2. ncbi request reprint Fluorescent tocopherols as probes of inter-vesicular transfer catalyzed by the alpha-tocopherol transfer protein
    Jeffrey K Atkinson
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada
    Ann N Y Acad Sci 1031:324-7. 2004
  3. ncbi request reprint Tocopherols and tocotrienols in membranes: a critical review
    Jeffrey Atkinson
    Department of Chemistry and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St Catharines, Ontario, Canada
    Free Radic Biol Med 44:739-64. 2008
  4. pmc The contribution of surface residues to membrane binding and ligand transfer by the α-tocopherol transfer protein (α-TTP)
    Wen Xiao Zhang
    Department of Chemistry, Brock University, St Catharines, Ontario, Canada L2S3A1
    J Mol Biol 405:972-88. 2011
  5. ncbi request reprint Ligand specificity in the CRAL-TRIO protein family
    Candace Panagabko
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada, L2S 3A1
    Biochemistry 42:6467-74. 2003
  6. ncbi request reprint Preparation of fluorescent tocopherols for use in protein binding and localization with the alpha-tocopherol transfer protein
    Phillip Nava
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ont, Canada L2S 3A1
    Bioorg Med Chem 14:3721-36. 2006
  7. pmc Synthesis and characterization of BODIPY-alpha-tocopherol: a fluorescent form of vitamin E
    Ryan West
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada L2S 3A1
    J Org Chem 75:2883-92. 2010
  8. doi request reprint Effect of bilayer phospholipid composition and curvature on ligand transfer by the alpha-tocopherol transfer protein
    Wen Xiao Zhang
    Department of Chemistry, Centre for Biotechnology, Brock University, 500 Glenridge Ave, St Catharines, ON L2S 3A1, Canada
    Lipids 44:631-41. 2009
  9. pmc Inhibition of oxidative metabolism of tocopherols with omega-N-heterocyclic derivatives of vitamin E
    Stephan Ohnmacht
    Department of Chemistry and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St Catharines, Ont, Canada L2S 3A1
    Bioorg Med Chem 16:7631-8. 2008
  10. ncbi request reprint Molecular determinants of heritable vitamin E deficiency
    Samantha Morley
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada, L2S 3A1
    Biochemistry 43:4143-9. 2004

Collaborators

  • Stephen R Wassall
  • Norbert Kucerka
  • Shamshad Cockcroft
  • Bo Li
  • Derek A Pratt
  • Gonzalo Cosa
  • Richard M Epand
  • Achim Stocker
  • Keith Williams
  • Candace Panagabko
  • Drew Marquardt
  • Matilda Baptist
  • Danny Manor
  • Samantha Morley
  • Wen Xiao Zhang
  • Mikel Ghelfi
  • Ryan West
  • Thad A Harroun
  • Stephan Ohnmacht
  • John Katsaras
  • Phillip Nava
  • Justin A Williams
  • Matt Cecchini
  • Heather Gordon
  • Brad J Van Oosten
  • Lynn Ulatowski
  • Solomon Fixon-Owoo
  • Jonathan D Nickels
  • Jacob J Kinnun
  • Irina Pogozheva
  • Varsha Thakur
  • Andrei Lomize
  • Grant Frahm
  • Robert Parker
  • Razvan Simionescu
  • Sara Chirico
  • Diana Shineman
  • Bernhard Mani
  • A Joffre Mercier
  • Patrick Cassolato
  • Mike Lowe
  • Thomas N Sabado
  • Marta Hernandez
  • Frédéric Levasseur
  • Markus Klose
  • Paul Fields
  • Rachel Parsons
  • Huangshu Lei
  • Steve Neely

Detail Information

Publications20

  1. doi request reprint The location and behavior of alpha-tocopherol in membranes
    Jeffrey Atkinson
    Department of Chemistry, Brock University, St Catharines, Ont, Canada
    Mol Nutr Food Res 54:641-51. 2010
    ..Physical methodologies are then described to elucidate the nature of the interaction of alpha-tocopherol with PUFA and to establish that the vitamin and PUFA-containing phospholipids co-localize in non-raft domains...
  2. ncbi request reprint Fluorescent tocopherols as probes of inter-vesicular transfer catalyzed by the alpha-tocopherol transfer protein
    Jeffrey K Atkinson
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada
    Ann N Y Acad Sci 1031:324-7. 2004
    ..The presence of hTTP substantially increases the rate of AO-alpha-tocopherol transfer over the uncatalyzed spontaneous rate...
  3. ncbi request reprint Tocopherols and tocotrienols in membranes: a critical review
    Jeffrey Atkinson
    Department of Chemistry and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St Catharines, Ontario, Canada
    Free Radic Biol Med 44:739-64. 2008
    ..We hope that it will assist researchers when designing new experiments and when critically assessing the results, in turn providing a more thorough understanding of the biochemistry of tocols...
  4. pmc The contribution of surface residues to membrane binding and ligand transfer by the α-tocopherol transfer protein (α-TTP)
    Wen Xiao Zhang
    Department of Chemistry, Brock University, St Catharines, Ontario, Canada L2S3A1
    J Mol Biol 405:972-88. 2011
    ..Mutation of selected basic residues (R192H, K211A, and K217A) had little effect on transfer rates, indicating no significant involvement of nonspecific electrostatic interactions with membranes...
  5. ncbi request reprint Ligand specificity in the CRAL-TRIO protein family
    Candace Panagabko
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada, L2S 3A1
    Biochemistry 42:6467-74. 2003
    ..Further, ligand promiscuity observed within this family suggests that caution should be exercised when suggesting protein function(s) from measurements utilizing a single ligand...
  6. ncbi request reprint Preparation of fluorescent tocopherols for use in protein binding and localization with the alpha-tocopherol transfer protein
    Phillip Nava
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ont, Canada L2S 3A1
    Bioorg Med Chem 14:3721-36. 2006
    ..Thus, compounds have been prepared that allow the investigation of the rate of alpha-TTP-mediated inter-membrane transfer of alpha-tocopherol and to investigate the mechanism of alpha-TTP function at membranes of different composition...
  7. pmc Synthesis and characterization of BODIPY-alpha-tocopherol: a fluorescent form of vitamin E
    Ryan West
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada L2S 3A1
    J Org Chem 75:2883-92. 2010
    ....
  8. doi request reprint Effect of bilayer phospholipid composition and curvature on ligand transfer by the alpha-tocopherol transfer protein
    Wen Xiao Zhang
    Department of Chemistry, Centre for Biotechnology, Brock University, 500 Glenridge Ave, St Catharines, ON L2S 3A1, Canada
    Lipids 44:631-41. 2009
    ..These results point to hydrophobic features of alpha-TTP dominating the binding energy between protein and membrane...
  9. pmc Inhibition of oxidative metabolism of tocopherols with omega-N-heterocyclic derivatives of vitamin E
    Stephan Ohnmacht
    Department of Chemistry and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St Catharines, Ont, Canada L2S 3A1
    Bioorg Med Chem 16:7631-8. 2008
    ..05). Thus, 1 may be a useful adjuvant to the therapeutic use of non-alpha-tocopherols...
  10. ncbi request reprint Molecular determinants of heritable vitamin E deficiency
    Samantha Morley
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada, L2S 3A1
    Biochemistry 43:4143-9. 2004
    ..These findings suggest the possibility that the AVED syndrome may not arise from an inability of TTP to bind or to transfer alpha tocopherol, but rather from defects in other activities of the protein...
  11. doi request reprint Tocopherol activity correlates with its location in a membrane: a new perspective on the antioxidant vitamin E
    Drew Marquardt
    Department of Physics, Brock University, St Catharines, Ontario L2S 3A1, Canada
    J Am Chem Soc 135:7523-33. 2013
    ..Importantly, our results suggest that measurements of aToc oxidation kinetics, and its products, should be revisited by taking into consideration the physical properties of the membrane in which the vitamin resides...
  12. doi request reprint Dimyristoyl phosphatidylcholine: a remarkable exception to α-tocopherol's membrane presence
    Drew Marquardt
    Department of Physics, Brock University, St Catharines, Ontario L2S 3A1, Canada
    J Am Chem Soc 136:203-10. 2014
    ....
  13. doi request reprint Besting vitamin E: sidechain substitution is key to the reactivity of naphthyridinol antioxidants in lipid bilayers
    Bo Li
    Department of Chemistry, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    J Am Chem Soc 135:1394-405. 2013
    ..In fact, naphthyridinols with sidechains of eight or more carbons had affinities for TTP which were similar to, and in one case 10-fold better than, α-TOH...
  14. doi request reprint 2,2'-Bis(monoacylglycero) PO4 (BMP), but Not 3,1'-BMP, increases membrane curvature stress to enhance α-tocopherol transfer protein binding to membranes
    Matilda Baptist
    Chemistry and Centre for Biotechnology, Brock University, St Catharines, Canada
    Lipids 50:323-8. 2015
    ..TTP binding to membranes is increased by the curvature-inducing lipid BMP. α-TTP binds to membranes with greater affinity when they contain the 2,2'-BMP versus 3,1'-BMP isomers. ..
  15. doi request reprint Assignment of the 1H and 13C NMR of tocotrienols
    Stephan Ohnmacht
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, L2S 3A1, Canada
    Magn Reson Chem 46:287-94. 2008
    ..Herein we report multidimensional NMR data (HSQC, COSY, ADEQUATE(1,1), C--H HMBC, and NOESY) that have allowed us to assign the identity of almost all the resonances for alpha-, beta-, gamma-, and delta-tocotrienol...
  16. doi request reprint Synthesis and characterization of a fluorescent probe for α-tocopherol suitable for fluorescence microscopy
    Mikel Ghelfi
    Department of Chemistry, Brock University, St Catharines, ON L2S 3A1, Canada
    Bioorg Med Chem 24:2754-61. 2016
    ..The final fluorophore thienyl-ene-BODIPY-α-tocopherol, 2, binds to recombinant human α-TTP with a Kd=8.7±1.1nM and is a suitable probe for monitoring the secretion of α-tocopherol from cultured Mcf7#189 cells. ..
  17. ncbi request reprint Ligand and membrane-binding behavior of the phosphatidylinositol transfer proteins PITPα and PITPβ
    Matilda Baptist
    a Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, ON L2A 3S1, Canada
    Biochem Cell Biol 94:528-533. 2016
    ..However, both PITPα and PITPβ demonstrated a preference for highly curved membrane surfaces during ligand transfer. In other words, ligand transfer rate was higher when the accepting vesicles were highly curved...
  18. pmc Vitamin E Circular Dichroism Studies: Insights into Conformational Changes Induced by the Solvent's Polarity
    Drew Marquardt
    Department of Physics, Brock University, St Catharines, ON L2S 3A1, Canada
    Membranes (Basel) 6:. 2016
    ..Differences across solvents indicate that hydrogen bonding is a key contributor to CD spectra at 200 nm. These results are a first step in examining the hydrogen bonding abilities of vitamin E in a lipid bilayer...
  19. ncbi request reprint Expression and refolding of recombinant human alpha-tocopherol transfer protein capable of specific alpha-tocopherol binding
    Candace Panagabko
    Department of Chemistry and Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada
    Protein Expr Purif 24:395-403. 2002
    ..The resulting purification scheme provides recombinant alpha-TTP in good yield and purity for investigation of both its structure and its binding affinities for different ligands including natural and synthetic tocols...
  20. ncbi request reprint Preparation and biological assessment of hydroxycinnamic acid amides of polyamines
    Solomon Fixon-Owoo
    Department of Chemistry, Brock University, St Catharines, L2S3A1, Ontario, Canada
    Phytochemistry 63:315-34. 2003
    ..We conclude from this work that while the coumaric acid polyamine conjugates are active when directly applied to neuroreceptors, they show no overt toxicity when ingested by insect larvae...