Paula N Brown

Summary

Affiliation: British Columbia
Country: Canada

Publications

  1. pmc Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: collaborative study
    Paula N Brown
    Natural Health Products Research Group, Technology Centre and School of Health Sciences, British Columbia Institute of Technology, 3700 Willingdon Ave, Bumaby, BC, Canada
    J AOAC Int 91:694-701. 2008
  2. pmc Determination of anthocyanins in cranberry fruit and cranberry fruit products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation
    Paula N Brown
    University of British Columbia Okanagan, 3333 University Way, Kelowna, British Columbia, Canada V1V 1V7
    J AOAC Int 94:459-66. 2011
  3. ncbi Determination of ginsenoside content in Panax ginseng C.A. Meyer and Panax quinquefolius L. root materials and finished products by high-performance liquid chromatography with ultraviolet absorbance detection: interlaboratory study
    Paula N Brown
    British Columbia Institute of Technology, Centre for Applied Research and Innovation, Natural Health and Food Products Research Group, 3700 Willingdon Ave, Burnaby, British Columbia, Canada V5G 3H2
    J AOAC Int 96:12-9. 2013
  4. doi Optimization and single-laboratory validation study of a high-performance liquid chromatography (HPLC) method for the determination of phenolic Echinacea constituents
    Paula N Brown
    British Columbia Institute of Technology, 3700 Willingdon Avenue, Burnaby, BC, V5G 3H2, Canada
    Anal Bioanal Chem 397:1883-92. 2010
  5. ncbi Determination of ginsenoside content in Asian and North American ginseng raw materials and finished products by high-performance liquid chromatography: single-laboratory validation
    Paula N Brown
    British Columbia Institute of Technology, 3700 Willingdon Ave, Burnaby, BC V5G 3H2, Canada
    J AOAC Int 94:1391-9. 2011
  6. pmc Determination of major phenolic compounds in Echinacea spp. raw materials and finished products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation matrix extension
    Paula N Brown
    British Columbia Institute of Technology, 3700 Willingdon Ave, Burnaby, BC V5G 3H2, Canada
    J AOAC Int 94:1400-10. 2011
  7. doi Comparisons of large (Vaccinium macrocarpon Ait.) and small (Vaccinium oxycoccos L., Vaccinium vitis-idaea L.) cranberry in British Columbia by phytochemical determination, antioxidant potential, and metabolomic profiling with chemometric analysis
    Paula N Brown
    Department of Chemistry, University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada
    Planta Med 78:630-40. 2012
  8. doi Metabolomics for phytochemical discovery: development of statistical approaches using a cranberry model system
    Christina E Turi
    Department of Chemistry, University of British Columbia, 3247 University Way, Kelowna, British Columbia, Canada, V1V 1V7
    J Nat Prod 78:953-66. 2015
  9. doi Phytochemical diversity of cranberry (Vaccinium macrocarpon Aiton) cultivars by anthocyanin determination and metabolomic profiling with chemometric analysis
    Paula N Brown
    University of British Columbia, Okanagan Campus, 3333 University Way, Kelowna, British Columbia V1V 1V7, Canada
    J Agric Food Chem 60:261-71. 2012
  10. pmc Variation of Select Flavonols and Chlorogenic Acid Content of Elderberry Collected Throughout the Eastern United States
    Elizabeth Mudge
    Centre for Applied Research and Innovation, British Columbia Institute of Technology, 3700 Willingdon Ave, Burnaby, British Columbia, V5G 3H2, Canada
    J Food Compost Anal 47:52-59. 2016

Collaborators

Detail Information

Publications21

  1. pmc Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: collaborative study
    Paula N Brown
    Natural Health Products Research Group, Technology Centre and School of Health Sciences, British Columbia Institute of Technology, 3700 Willingdon Ave, Bumaby, BC, Canada
    J AOAC Int 91:694-701. 2008
    ....
  2. pmc Determination of anthocyanins in cranberry fruit and cranberry fruit products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation
    Paula N Brown
    University of British Columbia Okanagan, 3333 University Way, Kelowna, British Columbia, Canada V1V 1V7
    J AOAC Int 94:459-66. 2011
    ..42-27.14 microg/mL for P3Ar. For solid materials prepared by the described method, this translates to 0.06-3.65 mglg for C3Ga, 0.02-0.98 mg/g for C3Gl, 0.03-1.77 mg/g for C3Ar, 0.10-6.47 mg/g for P3Ga, and 0.04-2.71 mg/g for P3Ar...
  3. ncbi Determination of ginsenoside content in Panax ginseng C.A. Meyer and Panax quinquefolius L. root materials and finished products by high-performance liquid chromatography with ultraviolet absorbance detection: interlaboratory study
    Paula N Brown
    British Columbia Institute of Technology, Centre for Applied Research and Innovation, Natural Health and Food Products Research Group, 3700 Willingdon Ave, Burnaby, British Columbia, Canada V5G 3H2
    J AOAC Int 96:12-9. 2013
    ..Based on these results, the method is recommended for AOAC Official First Action for the determination of total ginsenosides in P. ginseng and P. quinquefolius root materials and powdered extracts...
  4. doi Optimization and single-laboratory validation study of a high-performance liquid chromatography (HPLC) method for the determination of phenolic Echinacea constituents
    Paula N Brown
    British Columbia Institute of Technology, 3700 Willingdon Avenue, Burnaby, BC, V5G 3H2, Canada
    Anal Bioanal Chem 397:1883-92. 2010
    ....
  5. ncbi Determination of ginsenoside content in Asian and North American ginseng raw materials and finished products by high-performance liquid chromatography: single-laboratory validation
    Paula N Brown
    British Columbia Institute of Technology, 3700 Willingdon Ave, Burnaby, BC V5G 3H2, Canada
    J AOAC Int 94:1391-9. 2011
    ..06, 1.25, 2.19, 1.24, 1.27, and 1.70 microg/mL, respectively. Quantitative determinations performed with eight test materials by two analysts over 3 days (n = 12) resulted in RSDr values that ranged from 1.11 to 7.61%...
  6. pmc Determination of major phenolic compounds in Echinacea spp. raw materials and finished products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation matrix extension
    Paula N Brown
    British Columbia Institute of Technology, 3700 Willingdon Ave, Burnaby, BC V5G 3H2, Canada
    J AOAC Int 94:1400-10. 2011
    ..Moench and E. angustifolia DC, degrades during sample preparation (extraction) and HPLC analysis. No significant degradation was observed over an extended testing period using the validated method...
  7. doi Comparisons of large (Vaccinium macrocarpon Ait.) and small (Vaccinium oxycoccos L., Vaccinium vitis-idaea L.) cranberry in British Columbia by phytochemical determination, antioxidant potential, and metabolomic profiling with chemometric analysis
    Paula N Brown
    Department of Chemistry, University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada
    Planta Med 78:630-40. 2012
    ..Through multivariate modeling, differentiation of the species was observed, and univariate statistical analysis was employed to provide a quality assessment of the models developed for the metabolomics data...
  8. doi Metabolomics for phytochemical discovery: development of statistical approaches using a cranberry model system
    Christina E Turi
    Department of Chemistry, University of British Columbia, 3247 University Way, Kelowna, British Columbia, Canada, V1V 1V7
    J Nat Prod 78:953-66. 2015
    ..Together these metabolomics tools represent an entirely new pipeline for phytochemical discovery. ..
  9. doi Phytochemical diversity of cranberry (Vaccinium macrocarpon Aiton) cultivars by anthocyanin determination and metabolomic profiling with chemometric analysis
    Paula N Brown
    University of British Columbia, Okanagan Campus, 3333 University Way, Kelowna, British Columbia V1V 1V7, Canada
    J Agric Food Chem 60:261-71. 2012
    ..Metabolomic profiling with chemometric analysis proved to be useful for characterizing metabonomic changes across cranberry varieties...
  10. pmc Variation of Select Flavonols and Chlorogenic Acid Content of Elderberry Collected Throughout the Eastern United States
    Elizabeth Mudge
    Centre for Applied Research and Innovation, British Columbia Institute of Technology, 3700 Willingdon Ave, Burnaby, British Columbia, V5G 3H2, Canada
    J Food Compost Anal 47:52-59. 2016
    ....
  11. doi Isolation and identification of mosquito (Aedes aegypti ) biting deterrent fatty acids from male inflorescences of breadfruit (Artocarpus altilis (Parkinson) Fosberg)
    A Maxwell P Jones
    Biology, University of British Columbia, Kelowna, British Columbia, Canada
    J Agric Food Chem 60:3867-73. 2012
    ..These results provide support for this traditional practice and indicate the potential of male breadfruit flowers and fatty acids as mosquito repellents...
  12. doi Determination of Phenolic Constituents in Echinacea Raw Materials and Dietary Supplements by HPLC-UV: Collaborative Study
    Paula N Brown
    British Columbia Institute of Technology, 3700 Willingdon Ave, Burnaby, BC, Canada V5G 3H2
    J AOAC Int 99:1197-203. 2016
    ..35% and a HorRat value of 1.45. The glycerite tincture showed poor interlaboratory precision with a HorRat value of 3.32, an RSDR of 21.8%, and reported total phenolic values ranging from 257 to 539 μg/mL. ..
  13. pmc The Importance of Method Selection in Determining Product Integrity for Nutrition Research
    Elizabeth M Mudge
    Centre for Applied Research and Innovation, British Columbia Institute of Technology, Burnaby, Canada and
    Adv Nutr 7:390-8. 2016
    ..This review summarizes advances in method selection, development, and validation regarding herbal supplement analysis and provides several documented examples of inappropriate method selection and application. ..
  14. doi Quantification of pyrrolizidine alkaloids in North American plants and honey by LC-MS: single laboratory validation
    Elizabeth M Mudge
    a Department of Applied Research, BC Institute of Technology, Burnaby, BC, Canada
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 32:2068-74. 2015
    ....
  15. ncbi Single-Laboratory Validation for the Determination of Flavonoids in Hawthorn Leaves and Finished Products by LC-UV
    Elizabeth M Mudge
    Centre for Applied Research and Innovation, British Columbia Institute of Technology, Burnaby, Canada
    Planta Med 82:1487-1492. 2016
    ..The method includes optimized extraction of samples without a prolonged drying process and reduced liquid chromatography separation time...
  16. pmc Optimization and single-laboratory validation of a method for the determination of flavonolignans in milk thistle seeds by high-performance liquid chromatography with ultraviolet detection
    Elizabeth Mudge
    Natural Health and Food Products Research Group, British Columbia Institute of Technology, 3700 Willingdon Avenue, Burnaby, BC, V5G 3H2, Canada
    Anal Bioanal Chem 407:7657-66. 2015
    ..It is recommended that this method be adopted as First Action Official Method status by AOAC International...
  17. doi Determination of β-N-methylamino-L-alanine, N-(2-aminoethyl)glycine, and 2,4-diaminobutyric acid in Food Products Containing Cyanobacteria by Ultra-Performance Liquid Chromatography and Tandem Mass Spectrometry: Single-Laboratory Validation
    W Broc Glover
    University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada, V1V 1V7
    J AOAC Int 98:1559-65. 2015
    ..The method described provides a rapid, accurate, and precise method to facilitate that screening process...
  18. doi Determination of Aloin A and Aloin B in Aloe vera Raw Materials and Finished Products by High-Performance Liquid Chromatography: Single-Laboratory Validation
    Paula N Brown
    BC Institute of Technology, Centre for Applied Research and Innovation, Department of Natural Health and Food Products Research, 3700 Willingdon Ave, Burnaby, BC, V5G 3H2, Canada
    J AOAC Int 97:1323-8. 2014
    ..4 to 108.9% with an RSDr of 0.23 to 3.84%. Based on the results of the SLV study, it is recommended that this method be evaluated for reproducibility through a collaborative study...
  19. doi Current initiatives for the validation of analytical methods for botanicals
    Paula N Brown
    Natural Health and Food Products Research Group, British Columbia Institute of Technology, 3700 Willingdon Avenue, Burnaby, British Columbia V5G 3H2, Canada Electronic address
    Curr Opin Biotechnol 25:124-8. 2014
    ..Analytical techniques and priority methods are influenced by the need for fast-screening techniques, the limited availability of reference material, market value, and the prevalence of contaminants in botanical supplements. ..
  20. doi A review of the chemistry of the genus Crataegus
    Jennifer E Edwards
    Chemistry, University of British Columbia Okanagan, 3333 University Way, Kelowna, British Columbia V1V 1V7, Canada
    Phytochemistry 79:5-26. 2012
    ..Reviewed herein are the botany, ethnobotany, and traditional use of hawthorn while focusing on the phytochemicals that have been reported in Crataegus species, and the variation in the described chemistry between individual species...
  21. ncbi Evaluation of the antiproliferative effects of Essiac on in vitro and in vivo models of prostate cancer compared to paclitaxel
    Andy Eberding
    Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, V6H 3Z6, Canada
    Nutr Cancer 58:188-96. 2007
    ..Ki-67 and PCNA expression was analyzed in treated tumors, but no difference in expression of either marker was observed. These evaluations suggest Essiac has no marked antiproliferative effect on the models tested...