Francis Beaudry

Summary

Country: Canada

Publications

  1. ncbi Determination of glucosamine in horse plasma by liquid chromatography tandem mass spectrometry
    Francis Beaudry
    Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte, St Hyacinthe, Quebec, Canada J2S 2M2
    Biomed Chromatogr 22:1-4. 2008
  2. ncbi Determination of chlortetracycline in swine plasma by LC-ESI/MS/MS
    Francis Beaudry
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, University of Montreal, St Hyacinthe, Canada
    Biomed Chromatogr 19:523-8. 2005
  3. ncbi Development of a rapid and sensitive LC-ESI/MS/MS assay for the quantification of propofol using a simple off-line dansyl chloride derivatization reaction to enhance signal intensity
    Francis Beaudry
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, University of Montreal, C P 5000, St Hyacinthe, Que, Canada J2S 7C6
    J Pharm Biomed Anal 39:411-7. 2005
  4. ncbi Determination of substance P in rat spinal cord by high-performance liquid chromatography electrospray quadrupole ion trap mass spectrometry
    Francis Beaudry
    Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte, St Hyacinthe, Quebec, Canada J2S 2M2
    Biomed Chromatogr 20:1344-50. 2006
  5. doi Quantitative determination of capsaicin, a transient receptor potential channel vanilloid 1 agonist, by liquid chromatography quadrupole ion trap mass spectrometry: evaluation of in vitro metabolic stability
    Francis Beaudry
    Groupe de Recherche en Pharmacologie Animale du Québec GREPAQ, Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, University of Montreal, Saint Hyacinthe, Quebec, Canada J2S 2M2
    Biomed Chromatogr 23:204-11. 2009
  6. doi Identification, characterization and quantification of specific neuropeptides in rat spinal cord by liquid chromatography electrospray quadrupole ion trap mass spectrometry
    Francis Beaudry
    Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, University of Montreal, Saint Hyacinthe, Quebec, Canada
    Biomed Chromatogr 23:940-50. 2009
  7. doi Stability comparison between sample preparation procedures for mass spectrometry-based targeted or shotgun peptidomic analysis
    Francis Beaudry
    Groupe de recherche en pharmacologie animal du Québec GREPAQ, Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada J2S 2M2
    Anal Biochem 407:290-2. 2010
  8. ncbi Development of a LC-ESI/MS/MS assay for the quantification of vanillin using a simple off-line dansyl chloride derivatization reaction to enhance signal intensity
    Francis Beaudry
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, University of Montreal, St Hyacinthe, Quebec, Canada
    Biomed Chromatogr 21:113-5. 2007
  9. ncbi Determination of eugenol in rat plasma by liquid chromatography-quadrupole ion trap mass spectrometry using a simple off-line dansyl chloride derivatization reaction to enhance signal intensity
    Francis Beaudry
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, University of Montreal, St Hyacinthe, Canada
    Biomed Chromatogr 20:1216-22. 2006
  10. ncbi Electrospray ionization suppression, a physical or a chemical phenomenon?
    Francis Beaudry
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, University of Montreal, St Hyacinthe, Canada
    Biomed Chromatogr 20:200-5. 2006

Collaborators

Detail Information

Publications55

  1. ncbi Determination of glucosamine in horse plasma by liquid chromatography tandem mass spectrometry
    Francis Beaudry
    Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte, St Hyacinthe, Quebec, Canada J2S 2M2
    Biomed Chromatogr 22:1-4. 2008
    ..4 ng/mL (n=6). This LC-ESI/MS/MS method for the determination of glucosamine in horse plasma provided results within generally accepted criteria used for bioanalytical assay...
  2. ncbi Determination of chlortetracycline in swine plasma by LC-ESI/MS/MS
    Francis Beaudry
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, University of Montreal, St Hyacinthe, Canada
    Biomed Chromatogr 19:523-8. 2005
    ..1, 8.4 and 7.4% and 95.1, 102.1 and 97.1%, respectively. This LC-ESI/MS/MS method for the determination of chlortetracycline in swine plasma has been proven to be within generally accepted criteria used for bioanalytical assay...
  3. ncbi Development of a rapid and sensitive LC-ESI/MS/MS assay for the quantification of propofol using a simple off-line dansyl chloride derivatization reaction to enhance signal intensity
    Francis Beaudry
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, University of Montreal, C P 5000, St Hyacinthe, Que, Canada J2S 7C6
    J Pharm Biomed Anal 39:411-7. 2005
    ..Routine analysis with the novel method provided accurate results and enhanced the detection levels of plasma and blood concentrations of propofol to better characterize the in vivo biodisposition of propofol...
  4. ncbi Determination of substance P in rat spinal cord by high-performance liquid chromatography electrospray quadrupole ion trap mass spectrometry
    Francis Beaudry
    Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte, St Hyacinthe, Quebec, Canada J2S 2M2
    Biomed Chromatogr 20:1344-50. 2006
    ..In conclusion, a rapid and sensitive LC-ESI/MS/MS method was developed to identify and quantify substance P in rat spinal cord...
  5. doi Quantitative determination of capsaicin, a transient receptor potential channel vanilloid 1 agonist, by liquid chromatography quadrupole ion trap mass spectrometry: evaluation of in vitro metabolic stability
    Francis Beaudry
    Groupe de Recherche en Pharmacologie Animale du Québec GREPAQ, Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, University of Montreal, Saint Hyacinthe, Quebec, Canada J2S 2M2
    Biomed Chromatogr 23:204-11. 2009
    ..Results suggest very rapid degradation with T(1/2) ranging from 2.3 to 4.1 min and high clearance values suggesting that drug bioavailability will be considerably reduced, consequently affecting drug response and efficacy...
  6. doi Identification, characterization and quantification of specific neuropeptides in rat spinal cord by liquid chromatography electrospray quadrupole ion trap mass spectrometry
    Francis Beaudry
    Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, University of Montreal, Saint Hyacinthe, Quebec, Canada
    Biomed Chromatogr 23:940-50. 2009
    ..The results obtained show that the method provides adequate figures of merit to support targeted peptidomic studies aimed to determine neuropeptide regulation in animal neuropathic and chronic pain models...
  7. doi Stability comparison between sample preparation procedures for mass spectrometry-based targeted or shotgun peptidomic analysis
    Francis Beaudry
    Groupe de recherche en pharmacologie animal du Québec GREPAQ, Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada J2S 2M2
    Anal Biochem 407:290-2. 2010
    ..25% trifluoroacetic acid solution...
  8. ncbi Development of a LC-ESI/MS/MS assay for the quantification of vanillin using a simple off-line dansyl chloride derivatization reaction to enhance signal intensity
    Francis Beaudry
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, University of Montreal, St Hyacinthe, Quebec, Canada
    Biomed Chromatogr 21:113-5. 2007
    ..This LC-ESI/MS/MS method for the determination of vanillin in rat plasma provided results within generally accepted criteria used for bioanalytical assay...
  9. ncbi Determination of eugenol in rat plasma by liquid chromatography-quadrupole ion trap mass spectrometry using a simple off-line dansyl chloride derivatization reaction to enhance signal intensity
    Francis Beaudry
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, University of Montreal, St Hyacinthe, Canada
    Biomed Chromatogr 20:1216-22. 2006
    ..In conclusion, a rapid and sensitive LC-ESI/MS/MS method using a derivatization agent was developed to enhance signal intensity of eugenol...
  10. ncbi Electrospray ionization suppression, a physical or a chemical phenomenon?
    Francis Beaudry
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, University of Montreal, St Hyacinthe, Canada
    Biomed Chromatogr 20:200-5. 2006
    ..The salts and the charged species influence the conductivity and the surface tension of the droplets and modify the equilibrium between the two main forces involved during the electrospray process, resulting in an erratic spray behavior...
  11. ncbi Development of an electrospray ionization mass spectrometric method for the quantification of theophylline in horse serum
    Francis Beaudry
    Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, University of Montreal, St Hyacinthe, QC, Canada
    Biomed Chromatogr 19:643-8. 2005
    ..9%, respectively. This LC-ESI/MS/MS method for the determination of theophylline in horse serum has been proved to within generally accepted criteria used for bioanalytical assay and was used successfully during clinical investigation...
  12. ncbi Quantitative analysis of bucillamine in blood using high-performance liquid chromatography-mass spectrometry technique
    Francis Beaudry
    University of Montreal, Faculty of Veterinary Medicine, Department of Veterinary Biomedecine, St Hyacinthe, Quebec, Canada J2S 7C6
    Biomed Chromatogr 18:805-12. 2004
    ..1, 8.4 and 7.3%; 113.3, 104.9 and 103.9%, respectively, and the intra-batch precision and accuracy at low, medium and high concentrations were 7.7, 5.4 and 2.7%; 105.1, 111.9 and 113.2%, respectively...
  13. pmc Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia
    Marie Chantal Giroux
    Department of Veterinary Biomedicine, University of Montreal, Saint Hyacinthe, Quebec, Canada
    Exp Anim 65:63-75. 2016
    ....
  14. doi Antinociceptive effects of eugenol evaluated in a monoiodoacetate-induced osteoarthritis rat model
    Catherine E Ferland
    Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 rue Sicotte, Saint Hyacinthe, Québec J2S 2 M2, Canada
    Phytother Res 26:1278-85. 2012
    ..These results suggest a therapeutic potential of eugenol to alleviate osteoarthritis-related pain...
  15. doi Intrathecal [6]-gingerol administration alleviates peripherally induced neuropathic pain in male Sprague-Dawley rats
    Marie Lou Gauthier
    Groupe de recherche en pharmacologie animal du Québec GREPAQ, Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Phytother Res 27:1251-4. 2013
    ..001) and thermal hyperalgesia after 30 min, 2 h and 4 h (p < 0.05, p < 0.01 and p < 0.01). These promising results illustrate that [6]-gingerol could alleviate neuropathic pain by acting centrally at the level of the spinal cord...
  16. doi Determination of specific neuropeptides modulation time course in a rat model of osteoarthritis pain by liquid chromatography ion trap mass spectrometry
    Catherine E Ferland
    Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 rue Sicotte, Saint Hyacinthe, Québec J2S2M2, Canada
    Neuropeptides 45:423-9. 2011
    ..05). Preclinical drug evaluations using this model should be conducted between 7 and 21 days post injection when the lesions resemble most to human osteoarthritis...
  17. pmc Anesthetic properties of propofol in African clawed frogs (Xenopus laevis)
    Sarah A Guénette
    Department of Veterinary, Faculty of Veterinary Medicine, Saint Hyacinthe, Quebec, Canada
    J Am Assoc Lab Anim Sci 47:35-8. 2008
    ....
  18. pmc Assessment of stability of ketamine-xylazine preparations with or without acepromazine using high performance liquid chromatography-mass spectrometry
    Aurore Dodelet-Devillers
    Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte, Saint Hyacinthe, Quebec J2S 2M2
    Can J Vet Res 80:86-9. 2016
    ..In conclusion, when diluted in physiological saline, ketamine-xylazine cocktails can be stored for 3 mo, whereas undiluted cocktails can lose efficacy over 3 mo at room temperature. Storage at 4°C could preserve drug stability. ..
  19. pmc In vivo therapeutic efficacy and pharmacokinetics of colistin sulfate in an experimental model of enterotoxigenic Escherichia coli infection in weaned pigs
    Mohamed Rhouma
    Chaire de Recherche en Salubrité des Viandes CRSV, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, QC, J2S 7C6, Canada
    Vet Res 47:58. 2016
    ..coli and did not prevent pig weight loss. Further studies are needed in field conditions, to better characterize CS therapeutic regimen efficacy and bacterial resistance dissemination. ..
  20. pmc Anti-inflammatory response of dietary vitamin E and its effects on pain and joint structures during early stages of surgically induced osteoarthritis in dogs
    Mohamed Rhouma
    Research Group in Animal Pharmacology of Quebec GREPAQ, Département de biomédecine vétérinaire Rhouma, Troncy, Beaudry, Chorfi and Département de sciences cliniques El Warrak, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte Street, P O Box 5000, Saint Hyacinthe, Quebec J2S 7C6
    Can J Vet Res 77:191-8. 2013
    ..This is the first time that a study in dogs with OA using a supplement with a high dose of vitamin E showed a reduction in inflammation joint markers and histological expression, as well as a trend to improving signs of pain. ..
  21. pmc Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis
    Pascale Rialland
    Research Group in Animal Pharmacology of Quebec GREPAQ, Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, Universite de Montreal, PO Box 5000, St Hyacinthe, Quebec J2S 7C6, Canada
    Can J Vet Res 77:66-74. 2013
    ..0004), CSOM (P = 0.006), and MA (P = 0.02) improved significantly from D0 to D90. In general, the balanced control diet could have contributed to reduced OA symptoms, an effect that was subsequently amplified by the GLM diet. ..
  22. ncbi Pharmacokinetics of eugenol and its effects on thermal hypersensitivity in rats
    Sarah Annie Guénette
    Universite de Montreal, Faculte de Medecine Veterinaire, Département de Biomédecine Vétérinaire et de Pathologie and Microbiologie, Saint Hyacinthe, QC, Canada
    Eur J Pharmacol 562:60-7. 2007
    ..6.1+/-0.53 s, P<0.01). These results support the hypothesis that eugenol may alleviate neuropathic pain and that the cumulative effect of the drug may be in part responsible for this effect following repeated daily administrations...
  23. pmc Pharmacologic parameters of MS222 and physiologic changes in frogs (Xenopus laevis) after immersion at anesthetic doses
    Vanessa Lalonde-Robert
    Faculty of Veterinary Medicine, Department of Veterinary Biomedicine, Saint Hyacinthe, Canada
    J Am Assoc Lab Anim Sci 51:464-8. 2012
    ..2 h. We conclude that MS222 administered at 1 or 2 g/mL via immersion bath for 20 min is an effective anesthetic that can be used for surgical procedures of less than 30 or 60 min, respectively, in Xenopus leavis...
  24. doi Intrathecal eugenol administration alleviates neuropathic pain in male Sprague-Dawley rats
    Ludivine Lionnet
    Universite de Montreal, Faculte de Medecine Veterinaire, Département de Biomédecine Vétérinaire, Saint Hyacinthe, QC, Canada
    Phytother Res 24:1645-53. 2010
    ..The results support the hypothesis that eugenol may alleviate neuropathic pain, both allodynia and hyperalgesia, by acting centrally most probably at the level of the dorsal horn of the spinal cord where vanilloid receptors can be found...
  25. doi Association between sensitisation and pain-related behaviours in an experimental canine model of osteoarthritis
    Pascale Rialland
    Groupe de Recherche en Pharmacologie Animale du Québec GREPAQ, Department of Biomedical Sciences, Faculty of Veterinary Medicine, Universite de Montreal, Saint Hyacinthe, QC J2S 7C6, Canada Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Montreal, QC H2L 4M1, Canada
    Pain 155:2071-9. 2014
    ..This study establishes the strong interest to implement QST as a predictor of canine osteoarthritis pain symptoms explained by pain sensitisation...
  26. pmc Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats
    Daphnée Veilleux-Lemieux
    Laval University, Direction of Veterinary Services, Quebec, Quebec, Canada
    J Am Assoc Lab Anim Sci 52:567-70. 2013
    ....
  27. doi Targeted liquid chromatography quadrupole ion trap mass spectrometry analysis of tachykinin related peptides reveals significant expression differences in a rat model of neuropathic pain
    Floriane Pailleux
    Groupe de recherche en pharmacologie animal du Québec GREPAQ, Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Neuropeptides 47:261-71. 2013
    ..05). The β-tachykinin₅₈₋₇₁, SP and C-terminal SP metabolites could potentially serve as biomarkers in early drug discovery...
  28. doi Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes
    Marie Claude Duhamel
    Groupe de recherche en pharmacologie animal du Québec GREPAQ, Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Biomed Chromatogr 24:868-77. 2010
    ..These findings combined with a low K(m) value may indicate that medetomidine can competitively inhibit the metabolism of these drugs and consequently significantly impair metabolic clearance...
  29. pmc Bilateral central pain sensitization in rats following a unilateral thalamic lesion may be treated with high doses of ketamine
    Aude Castel
    Department of Veterinary Biomedicine, Saint Hyacinthe, Quebec, Canada
    BMC Vet Res 9:59. 2013
    ..A very small hemorrhage was created by injecting a collagenase solution in the right ventral posterolateral thalamic nucleus. Following the establishment of the neuropathy, ketamine was evaluated as a therapeutic drug for this condition...
  30. doi Characterization of [6]-gingerol metabolism in rat by liquid chromatography electrospray tandem mass spectrometry
    Marie Lou Gauthier
    Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Quebec, Canada
    Biomed Chromatogr 25:1150-8. 2011
    ..Three main phase I metabolites and four phase II metabolites were identified by HPLC-MS/MS and HPLC-MSD TOF. However, the results suggest that glucuronidation of hydroxylated [6]-gingerol is the primary metabolite excreted in rat urine...
  31. doi Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in a rat model of neuropathic pain
    Francis Beaudry
    Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, University of Montreal, Saint Hyacinthe, QC, Canada
    Phytother Res 24:525-30. 2010
    ..In conclusion, vanillin is bioavailable and seems to have an alleviating effect on mechanical allodynia, and not on hyperalgesia, when evaluated with a chronic constriction nerve injury rat model of neuropathic pain...
  32. pmc Early dexamethasone treatment after implantation of a sciatic-nerve cuff decreases the concentration of substance P in the lumbar spinal cord of rats with neuropathic pain
    Francis Beaudry
    Universite de Montreal, Faculte de Medecine Veterinaire, Départements de Biomédecine Vétérinaire et de Pathologie et Microbiologie, Saint Hyacinthe, Quebec
    Can J Vet Res 71:90-7. 2007
    ..Our results suggest that in the early stages of neuropathic pain induced by an inflammatory process, dexamethasone may be a useful treatment and that substance P plays an important role in pain perception...
  33. doi In vitro metabolism of specific CYP2D and CYP3A opioid substrates using rat liver S9 fractions and mass spectrometry reveal a severe metabolic impairment with increasing age
    Sabrin Fuad Salmin
    Groupe de recherche en pharmacologie animal du Québec GREPAQ, Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Biomed Chromatogr 31:. 2017
    ..Moreover, metabolic stabilities of codeine and oxycodone in rat liver S9 fractions were significantly greater for the 18-month-old rats. This study suggests that there is an impairment of CYP2D and CYP3A metabolism in aging rats...
  34. pmc Physiological and pharmacokinetic effects of multilevel caging on Sprague Dawley rats under ketamine-xylazine anesthesia
    Aurore Dodelet-Devillers
    Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, University of Montreal, Saint Hyacinthe, Quebec, Canada
    Exp Anim 65:383-392. 2016
    ..Increasing cage sizes, while having a positive impact on wellbeing in rats, can alter anesthetic drug metabolism and thus modify anesthesia parameters and associated physiological processes...
  35. pmc Alleviation of chronic neuropathic pain by environmental enrichment in mice well after the establishment of chronic pain
    Pascal Vachon
    Department of Veterinary Biomedicine, University of Montreal, Faculty of Veterinary Medicine, St Hyacinthe, Quebec, Canada
    Behav Brain Funct 9:22. 2013
    ..The focus of this study was to evaluate the impact of environmental enrichment or impoverishment in mice three months after induction of chronic neuropathic pain...
  36. ncbi Enhancing the uptake of dextromethorphan in the CNS of rats by concomitant administration of the P-gp inhibitor verapamil
    Jean Francois Marier
    MDS Pharma Services, Ville St Laurent Montreal, Quebec, Canada, H4R 2N6
    Life Sci 77:2911-26. 2005
    ..This change is most likely related to an inhibition of P-gp or other transporters located in the BBB since the biodisposition of DM in plasma remained unaffected by verapamil treatments...
  37. pmc Plasma concentrations of buprenorphine following a single subcutaneous administration of a sustained release formulation of buprenorphine in sheep
    Chiara Zullian
    Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec J2S 2M2 Zullian, Dodelet Devillers, Beaudry, Vachon AccelLab Preclinical Research, Boisbriand, Quebec J7H 1N8 Lema, Lavoie
    Can J Vet Res 80:250-3. 2016
    ..1 mg/kg BW of SR buprenorphine in sheep. However the effective analgesic plasma threshold still needs to be determined in sheep. ..
  38. pmc Colistin in Pig Production: Chemistry, Mechanism of Antibacterial Action, Microbial Resistance Emergence, and One Health Perspectives
    Mohamed Rhouma
    Chaire de Recherche Industrielle du CRSNG en Salubrité des Viandes, Faculte de Medecine Veterinaire, Universite de Montreal, Saint HyacintheQC, Canada Groupe de Recherche et d Enseignement en Salubrité Alimentaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint HyacintheQC, Canada Centre de Recherche en Infectiologie Porcine et Avicole, Faculte de Medecine Veterinaire, Universite de Montreal, Saint HyacintheQC, Canada
    Front Microbiol 7:1789. 2016
    ..We also detail and discuss the One Health approach and propose guidelines for colistin resistance management...
  39. doi Characterization of xylazine metabolism in rat liver microsomes using liquid chromatography-hybrid triple quadrupole-linear ion trap-mass spectrometry
    David St Germain Lavoie
    Groupe de recherche en pharmacologie animal du Québec GREPAQ, Département de Biomédicine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Biomed Chromatogr 27:882-8. 2013
    ..Further experiments with ketamine and ketoconazole strongly supported that the metabolism of xylazine to its main metabolite is mediated by CYP3A in rat liver microsomes...
  40. doi Investigation of the metabolic biotransformation of substance P in liver microsomes by liquid chromatography quadrupole ion trap mass spectrometry
    Floriane Pailleux
    Groupe de recherche en pharmacologie animal du Québec GREPAQ, Département de Biomédicine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Biomed Chromatogr 27:39-47. 2013
    ..Consequently, the metabolic profile of each species is distinctive and may have a significant impact on biomolecular mechanisms involved in specific pathophysiological changes...
  41. pmc Comparison of the selection of antimicrobial resistance in fecal Escherichia coli during enrofloxacin administration with a local drug delivery system or with intramuscular injections in a swine model
    Romain Béraud
    Department of Clinical Sciences, Faculte de Medecine Veterinaire, Universite de Montreal
    Can J Vet Res 72:311-9. 2008
    ..This could represent another advantage of LDDS usage compared to long-lasting systemic administration of fluoroquinolones...
  42. ncbi Eugenol for anesthesia of African clawed frogs (Xenopus laevis)
    Sarah A Guénette
    Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, Saint Hyacinthe, Quebec, Canada
    Vet Anaesth Analg 34:164-70. 2007
    ..To determine the level of anesthesia attained in Xenopus laevis frogs with eugenol at different doses and by different routes of administration...
  43. doi Resistance to colistin: what is the fate for this antibiotic in pig production?
    Mohamed Rhouma
    Chaire de Recherche en Salubrité des Viandes CRSV, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, QC, Canada Groupe de recherche et d enseignement en salubrité alimentaire GRESA, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, QC, Canada Centre de recherche en infectiologie porcine et avicole CRIPA, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, QC, Canada
    Int J Antimicrob Agents 48:119-26. 2016
    ..Moreover, the search for competitive alternatives to using colistin with swine is of paramount importance to preserve the effectiveness of this antibiotic for the treatment of MDR-GNB infections in human medicine. ..
  44. pmc Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model
    Colombe Otis
    Groupe de Recherche en Pharmacologie Animale du Québec GREPAQ, Department of Biomedical Sciences, Faculty of Veterinary Medicine, Universite de Montreal, 1500 des Vétérinaires Street, P O Box 5000, St Hyacinthe, Quebec, J2S 7C6, Canada
    Arthritis Res Ther 18:150. 2016
    ....
  45. pmc The fecal presence of enterotoxin and F4 genes as an indicator of efficacy of treatment with colistin sulfate in pigs
    Mohamed Rhouma
    Chaire de recherche industrielle du CRSNG en salubrité des viandes CRSV, Faculté de médecine vétérinaire Université de Montréal, 3200 rue Sicotte, Saint Hyacinthe, QC, J2S 7C6, Canada
    BMC Microbiol 17:6. 2017
    ..Challenge was performed using 109 CFU of an ETEC: F4 strain, and treatment was conducted using oral CS at the dose of 50,000 IU/kg. The fecal presence of genes encoding for STa, STb, LT, F4 and F18 was detected using PCR...
  46. ncbi Hemodynamic effects of an intravenous infusion of medetomidine at six different dose regimens in isoflurane-anesthetized dogs
    Johanna Kaartinen
    Faculty of Veterinary Medicine, Universite de Montreal, Groupe de Recherche en Pharmacologie Animaledu Québec, Department of Veterinary Biomedicine, 1500 Rue des vétérinaires, Saint Hyacinthe, QC, Canada
    Vet Ther 11:E1-16. 2010
    ..5, 1.0, 1.7, 4.0, and 12.0 ug/kg-1, respectively. The four lowest doses induced limited and transient changes in heart rate, mean arterial pressure, and CI. Further investigation into potential perioperative uses of MED CRI is warranted...
  47. doi Quantitative mass spectrometry analysis reveals that deletion of the TRPV1 receptor in mice alters substance P and neurokinin A expression in the central nervous system
    Floriane Pailleux
    Groupe de Recherche en Pharmacologie Animal du Québec, Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte, CP 5000, Saint Hyacinthe, QC J2S 7C6, Canada
    Neurochem Res 37:2678-85. 2012
    ..These results clearly demonstrate that TPRV1 null mice exhibit lower SP and NKA concentrations in the central nervous system. The deficit of thermal responses may also be related to the down-regulations of SP and NKA...
  48. doi Internal standard strategies for relative and absolute quantitation of peptides in biological matrices by liquid chromatography tandem mass spectrometry
    Floriane Pailleux
    Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Biomed Chromatogr 26:881-91. 2012
    ..Moreover, this review will focus on the importance of precision and accuracy in order to adequately establish analysis threshold to detect peptide expression differences...
  49. doi Analysis of Staphylococcus enterotoxin B using differential isotopic tags and liquid chromatography quadrupole ion trap mass spectrometry
    Khanh Dang Bao
    Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Biomed Chromatogr 26:1049-57. 2012
    ..9-91.1% range. Overall, the results presented in this manuscript show that proteomics-based methods can be effectively used to detect, confirm and quantify SEB in food matrices...
  50. pmc Efficacy of a 5-day extended therapy program during lactation with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus
    Jean Philippe Roy
    Departement de Sciences Cliniques, Faculte de Medecine Veterinaire, Universite de Montreal, 3200, rue Sicotte, CP 5000, St Hyacinthe, Quebec, Canada
    Can Vet J 50:1257-62. 2009
    ..6% (38/49) and 18% (9/50) in the treated and the control groups, respectively (P < 0.0001). A 5-day extended therapy with cephapirin is effective in treating cows chronically infected with S. aureus...
  51. doi In vitro ketamine CYP3A-mediated metabolism study using mammalian liver S9 fractions, cDNA expressed enzymes and liquid chromatography tandem mass spectrometry
    Raphaël Santamaria
    Groupe de Recherche en Pharmacologie Animal du Québec, Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Biomed Chromatogr 28:1660-9. 2014
    ..Experiments with cDNA expressed CYP3A enzymes showed that the formation of norketamine is mediated by CYP3A but results suggest an important contribution from other isoenzymes, most likely CYP2C particularly in rat...
  52. doi Evaluation of multiple reaction monitoring cubed for the analysis of tachykinin related peptides in rat spinal cord using a hybrid triple quadrupole-linear ion trap mass spectrometer
    Floriane Pailleux
    Groupe de recherche en pharmacologie animal du Québec GREPAQ, Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    J Chromatogr B Analyt Technol Biomed Life Sci 947:164-7. 2014
    ..HPLC-MS/MRM(3) may improve the assay sensitivity to detect difference between samples by reducing significantly the potential of interferences and therefore reduce instrumental errors. ..
  53. ncbi Cyclosporin A in blood and brain tissue following intra-carotid injections in normal and stroke-induced rats
    Pascal Vachon
    MDS Pharma Services, Ville St Laurent, Montreal, Quebec, Canada
    Brain Res 943:1-8. 2002
    ....
  54. ncbi Progesterone metabolism in bovine endometrial cells and the effect of metabolites on the responsiveness of the cells to OT-stimulation of PGF2alpha
    Ahmad A Jamshidi
    Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 rue Sicotte, St Hyacinthe, Quebec J2S 7C6, Canada
    Steroids 72:843-50. 2007
    ..These data suggest that 5-pregnanediones do not play a role in the regulation OT-stimulated PGF(2)alpha secretion during the bovine estrous cycle...
  55. ncbi Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma
    Liyu Yang
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033 1300, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 792:229-40. 2003
    ..This LC-MS-MS method for the determination of desloratadine and 3-OH desloratadine in human plasma met regulatory requirements for selectivity, sensitivity, goodness of fit, precision, accuracy and stability...