Petronela Ancuta

Summary

Country: Canada

Publications

  1. doi Th17 lineage commitment and HIV-1 pathogenesis
    Petronela Ancuta
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Saint Luc Hospital, Pavillon Edouard Asselin, 264 Blvd René Lévesque East, Montreal, Quebec, Canada
    Curr Opin HIV AIDS 5:158-65. 2010
  2. pmc Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication
    Annie Bernier
    Department of Microbiology, Infectiology, and Immunology, Universite de Montreal, Faculty of Medicine, Montreal Quebec, Canada
    Retrovirology 10:160. 2013
  3. pmc Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets
    Petronela Ancuta
    CRCHUM, Universite de Montreal, INSERM Unit 743, Montreal, Quebec, Canada
    BMC Genomics 10:403. 2009
  4. doi Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7
    Patricia Monteiro
    Department of Microbiology and Immunology, University of Montreal, Montreal, H3C 3J7 Quebec, Canada
    J Immunol 186:4618-30. 2011
  5. pmc Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection
    Annie Gosselin
    Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada
    J Immunol 184:1604-16. 2010
  6. pmc The colocalization potential of HIV-specific CD8+ and CD4+ T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid
    Vanessa Sue Wacleche
    Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 7:e32964. 2012
  7. pmc Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
    Elias A Said
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Hôpital St Luc, Montreal, Quebec, Canada
    Nat Med 16:452-9. 2010
  8. pmc Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation
    Mohamed El-Far
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada Department of Microbiology, Infectiology and Immunology, Universite de Montreal, Quebec, Canada
    J Gen Virol 96:1463-77. 2015
  9. pmc Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART
    Sandrina DaFonseca
    Faculty of Medicine, Department of Microbiology, Infectiology and Immunology, Universite de Montreal, Montreal, QC, Canada
    Retrovirology 12:38. 2015
  10. pmc Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach
    Aurélie Cleret-Buhot
    Department of Microbiology, Infectiology and Immunology, Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada
    Retrovirology 12:102. 2015

Collaborators

Detail Information

Publications21

  1. doi Th17 lineage commitment and HIV-1 pathogenesis
    Petronela Ancuta
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Saint Luc Hospital, Pavillon Edouard Asselin, 264 Blvd René Lévesque East, Montreal, Quebec, Canada
    Curr Opin HIV AIDS 5:158-65. 2010
    ....
  2. pmc Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication
    Annie Bernier
    Department of Microbiology, Infectiology, and Immunology, Universite de Montreal, Faculty of Medicine, Montreal Quebec, Canada
    Retrovirology 10:160. 2013
    ..We previously demonstrated that primary Th1Th17 cells are highly permissive to HIV-1, whereas Th1 cells are relatively resistant. Molecular mechanisms underlying these differences remain unknown...
  3. pmc Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets
    Petronela Ancuta
    CRCHUM, Universite de Montreal, INSERM Unit 743, Montreal, Quebec, Canada
    BMC Genomics 10:403. 2009
    ..CD16+ Mo produce pro-inflammatory cytokines and are expanded in certain inflammatory conditions including sepsis and HIV infection...
  4. doi Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7
    Patricia Monteiro
    Department of Microbiology and Immunology, University of Montreal, Montreal, H3C 3J7 Quebec, Canada
    J Immunol 186:4618-30. 2011
    ....
  5. pmc Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection
    Annie Gosselin
    Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada
    J Immunol 184:1604-16. 2010
    ..It is necessary that new therapeutic strategies against HIV interfere with viral replication/persistence in discrete CCR6(+) T cell subsets...
  6. pmc The colocalization potential of HIV-specific CD8+ and CD4+ T-cells is mediated by integrin β7 but not CCR6 and regulated by retinoic acid
    Vanessa Sue Wacleche
    Department of Microbiology and Immunology, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 7:e32964. 2012
    ....
  7. pmc Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
    Elias A Said
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Hôpital St Luc, Montreal, Quebec, Canada
    Nat Med 16:452-9. 2010
    ..We describe a new function for PD-1 whereby microbial products inhibit T cell expansion and function by upregulating PD-1 levels and IL-10 production by monocytes after binding of PD-1 by PD-L1...
  8. pmc Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation
    Mohamed El-Far
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada Department of Microbiology, Infectiology and Immunology, Universite de Montreal, Quebec, Canada
    J Gen Virol 96:1463-77. 2015
    ..This also highlights the propensity of HIV-1 to evade restriction of the key negative immune regulator CTLA-4 on cell activation and viral replication, and therefore contributes to the overall HIV-1 pathogenesis. ..
  9. pmc Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART
    Sandrina DaFonseca
    Faculty of Medicine, Department of Microbiology, Infectiology and Immunology, Universite de Montreal, Montreal, QC, Canada
    Retrovirology 12:38. 2015
    ..Here we investigated alterations in the Th17 polarization potential of naive-like CD4(+) T-cells, depletion of Th17-commited subsets during HIV pathogenesis, and Th17 restoration in response to antiretroviral therapy (ART)...
  10. pmc Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach
    Aurélie Cleret-Buhot
    Department of Microbiology, Infectiology and Immunology, Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada
    Retrovirology 12:102. 2015
    ..Although several key HIV dependency factors (HDF) were identified in the past years via genome-wide siRNA screens in cell lines, molecular determinants of HIV permissiveness in primary Th17 cells remain to be elucidated...
  11. pmc HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses
    Yuwei Zhang
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Hopital Saint Luc, Quebec H2X 0A9, Canada
    Sci Rep 6:29447. 2016
    ..Novel anti-HCV vaccination strategies should target the induction of TLR7/8 stimulation in APCs in order to establish potent immune responses against HCV. ..
  12. pmc New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy
    Vanessa Sue Wacleche
    Département of Microbiologie, Infectiologie et Immunologie, Faculte de Medecine, Universite de Montreal, Montreal, QC, Canada
    Retrovirology 13:59. 2016
    ..Most recent evidence supports the contribution of long-lived Th17 cells to HIV persistence during antiretroviral therapy (ART). However, the identity of long-lived Th17 cells remains unknown...
  13. pmc Down-regulation of CTLA-4 by HIV-1 Nef protein
    Mohamed El-Far
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Hôpital St Luc, Montreal, Quebec, Canada
    PLoS ONE 8:e54295. 2013
    ..Down-regulation of CTLA-4 may contribute to the mechanisms by which HIV-1 sustains T cell activation, a critical step in viral replication and dissemination...
  14. doi Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection
    Julien van Grevenynghe
    Laboratoire d Immunologie, Centre de Recherche, Hopital Saint Luc, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Semin Immunol 20:196-203. 2008
    ....
  15. pmc Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers
    Mohammad Ali Jenabian
    Chronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada Research Institute, McGill University Health Centre, Montreal, Quebec, Canada
    PLoS ONE 8:e78146. 2013
    ..These results suggest a distinctive Trp catabolism and Th17/Treg balance in HIV progressors and EC. Thus, IDO-induced immune-metabolism may be considered as a new inflammation-related marker for HIV-1 disease progression. ..
  16. ncbi Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults
    Mohammad Ali Jenabian
    aDepartment of Biological Sciences and BioMed Research Centre, Université du Québec à Montréal UQAM bChronic Viral Illness Service and Research Institute, McGill University Health Centre cFaculty of Medicine, McGill University dDepartment of Microbiology, Infectiology and Immunology, Faculty of Medicine, Universite de Montreal, and Centre de recherche du CHUM eMetropolitan Centre for Plastic Surgery, Montreal, Québec fDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario gDivision of Hematology, McGill University Health Centre, Montreal, Quebec, Canada
    AIDS 30:2777-2786. 2016
    ..We assessed immunotolerance properties of the testicular tissue in individuals receiving suppressive antiretroviral therapy (ART)...
  17. pmc HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapy
    Annie Gosselin
    aCHUM Research Centre bDepartment of Microbiology, Infectiology and Immunology, Faculty of Medicine, Université de Montréal cInstitut de Recherche Clinique de Montréal, Montreal, Quebec, Canada dUniversity of California Davis, Davis, California, USA eChronic Viral Illness Service and Research Institute fDivision of Gastroenterology and Hepatology gDivision of Hematology, McGill University Health Centre, Montreal, Quebec, Canada
    AIDS 31:35-48. 2017
    ..The objective of this article is to investigate the contribution of colon and blood CD4 T-cell subsets expressing the chemokine receptor CCR6 to HIV persistence during antiretroviral therapy...
  18. pmc Proinflammatory isoforms of IL-32 as novel and robust biomarkers for control failure in HIV-infected slow progressors
    Mohamed El-Far
    CHUM Research Centre, Montreal, QC, Canada
    Sci Rep 6:22902. 2016
    ..We present here a proof-of-concept for the use of IL-32 as a predictive biomarker for disease progression in SP subjects and identify IL-32 as a potential therapeutic target. ..
  19. pmc HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    Nicolas Chomont
    Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal Saint Luc, Montreal, Quebec, Canada
    Nat Med 15:893-900. 2009
    ....
  20. pmc Sustained hyperresponsiveness of dendritic cells is associated with spontaneous resolution of acute hepatitis C
    Sandy Pelletier
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hôpital St Luc, Montreal, Quebec, Canada
    J Virol 87:6769-81. 2013
    ..Altogether, our results suggest that the immature pDC phenotype and sustained pDC and mDC hyperresponsiveness are associated with spontaneous resolution of acute HCV infection...
  21. pmc Regulatory T cells in HIV infection: can immunotherapy regulate the regulator?
    Mohammad Ali Jenabian
    Chronic Viral Illnesses Service, McGill University Health Centre, 3650 St Urbain Street, Montreal, QC, Canada H2X 2P4
    Clin Dev Immunol 2012:908314. 2012
    ..However, such approaches require a better understanding of the time upon infection when interfering with Treg function may not cause a deleterious state of hyperimmune activation...