Albert Adam

Summary

Country: Canada

Publications

  1. ncbi Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors
    Albert Adam
    Faculte de Pharmacie, Universite de Montreal, Montreal, Canada
    Lancet 359:2088-9. 2002
  2. ncbi Angiotensin-converting enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine(9)-bradykinin
    Giuseppe Molinaro
    Faculte de Pharmacie, Departement de Mathematiques et de Statistique, Universite de Montreal, Canada
    J Pharmacol Exp Ther 303:232-7. 2002
  3. ncbi [Physiopathology of the acute adverse effects of angiotensin-converting-enzyme inhibitors]
    Albert Adam
    Universite de Montreal, Faculté de pharmarcie, 2900 Boulevard Edouard Montpetit, Montreal, Quebec, Canada H3C 3J7
    Bull Acad Natl Med 191:1433-43; discussion 1443-4. 2007
  4. pmc Bradykinin forming capacity of oversulfated chondroitin sulfate contaminated heparin in vitro
    Albert Adam
    Faculty of Pharmacy, Universite de Montreal, 2900, Boulevard E Montpetit, Montreal, QC H3T 1J4, Canada
    Biomaterials 31:5741-8. 2010
  5. doi Altered cardiac bradykinin metabolism in experimental diabetes caused by the variations of angiotensin-converting enzyme and other peptidases
    Albert Adam
    Faculty of Pharmacy, Universite de Montreal, Montreal, QC, Canada H3C 3J7
    Neuropeptides 44:69-75. 2010
  6. ncbi Expression of metallopeptidases and kinin receptors in swine oropharyngeal tissues: effects of angiotensin I-converting enzyme inhibition and inflammation
    Marie Eve Moreau
    Universite de Montreal, Faculte de Pharmacie, Room 3190, 2900 Blvd Edouard Montpetit, C P 6128, Succ Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Pharmacol Exp Ther 315:1065-74. 2005
  7. ncbi The cardioprotective effect of dual metallopeptidase inhibition: respective roles of endogenous kinins and natriuretic peptides
    Marie Josée Dumoulin
    Faculty of Pharmacy, Universite de Montreal, Canada
    Can J Physiol Pharmacol 83:166-73. 2005
  8. ncbi Hypotensive reaction during staphylococcal protein A column therapy in a patient with anomalous degradation of bradykinin and Des-Arg9-bradykinin after contact activation
    Giuseppe Molinaro
    Faculty of Pharmacy, Department of Mathematics and Statistics, University of Montreal, Montreal, Canada
    Transfusion 42:1458-65. 2002
  9. pmc The effect of electronegativity and angiotensin-converting enzyme inhibition on the kinin-forming capacity of polyacrylonitrile dialysis membranes
    Anik Desormeaux
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Biomaterials 29:1139-46. 2008
  10. ncbi A study of the mediators involved in the protection induced by exogenous kinins in the isolated rat heart
    Caroline Lagneux
    Faculte de Pharmacie, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, QC, Canada H3C3J7
    Int Immunopharmacol 3:1511-8. 2003

Collaborators

  • Francois Marceau
  • Angelo Agostoni
  • Louis Thibault
  • Caroline Lagneux
  • Guy A Rouleau
  • M Cugno
  • NANCY JOAN BROWN
  • Jean Lucien Rouleau
  • Saba Sile
  • Pierre Robillard
  • France Gauvin
  • C Doria
  • Pierre Simon
  • Christian Drouet
  • Giuseppe Molinaro
  • Marie Eve Moreau
  • Nathalie Lapointe
  • Yves Lepage
  • Anik Desormeaux
  • James Brian Byrd
  • Marie Josée Dumoulin
  • Guillaume Morissette
  • Charles Blais
  • Miguel Chagnon
  • Robert Clement
  • Jacques Chanard
  • James V Gainer
  • Josée Robillard
  • Qing Ling Duan
  • Thomas G Parker
  • Daniel Lamontagne
  • Donald M Arnold
  • Jean Philippe Fortin
  • Hugues Gosselin
  • Nicole Gervais
  • Tej Sheth
  • Jean Philippe Couture
  • John Nadeau
  • Karine Touzin
  • Chang Yu
  • Robert W Colman
  • Georges Etienne Rivard
  • Réal Lemieux
  • Marie Thérèse Bawolak
  • Tatiana Foroud
  • Patrick Dion
  • Elena Malitskaya
  • Jacky Potier
  • Jean Francois Desjardins
  • Maria A Juliano
  • Luiz Juliano
  • Gordon Moe
  • Nancy Garbacki
  • Denise Heublein
  • Line Leduc
  • Guy Boileau
  • William H Simmons
  • Inge A Meijer
  • Borzoo Nikpoor
  • Bassem Wehbe
  • Pierre Clavel
  • Quang Trinh Nguyen
  • Marie Pierre Dube
  • John Burnett
  • Pascal Dubreuil
  • Judith Saint-Onge
  • Ali Pourdjabbar
  • Adriana K Carmona
  • Georges E Rivard
  • Leah Flury
  • Daniel Rochefort
  • Seddik Benarbia
  • Marie Andrée Yessine
  • Jim Tsoporis
  • Werner Muller-Esterl
  • Nobuharu Yamaguchi
  • Julien Marc-Aurele
  • Francois Marcotte
  • Kathryn E Webert
  • Geoffrey Dunn
  • Theodore E Warkentin
  • Lawrence Lesiuk
  • Nancy M Heddle
  • Julie DiTomasso
  • Morris A Blajchman
  • Ian Davis
  • Dominique Rouleau
  • Graham Slaughter
  • Christian E Deschepper
  • Domenico Regoli

Detail Information

Publications32

  1. ncbi Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors
    Albert Adam
    Faculte de Pharmacie, Universite de Montreal, Montreal, Canada
    Lancet 359:2088-9. 2002
    ..Our data suggest that low plasma concentrations of aminopeptidase P could be a predisposing factor for development of angio-oedema in patients treated with ACE inhibitors...
  2. ncbi Angiotensin-converting enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine(9)-bradykinin
    Giuseppe Molinaro
    Faculte de Pharmacie, Departement de Mathematiques et de Statistique, Universite de Montreal, Canada
    J Pharmacol Exp Ther 303:232-7. 2002
    ....
  3. ncbi [Physiopathology of the acute adverse effects of angiotensin-converting-enzyme inhibitors]
    Albert Adam
    Universite de Montreal, Faculté de pharmarcie, 2900 Boulevard Edouard Montpetit, Montreal, Quebec, Canada H3C 3J7
    Bull Acad Natl Med 191:1433-43; discussion 1443-4. 2007
    ..Experimental evidence obtained in our laboratory suggests that acquired, genetic and pharmacological factors can influence the risk of these rare but potentially life-threatening effects...
  4. pmc Bradykinin forming capacity of oversulfated chondroitin sulfate contaminated heparin in vitro
    Albert Adam
    Faculty of Pharmacy, Universite de Montreal, 2900, Boulevard E Montpetit, Montreal, QC H3T 1J4, Canada
    Biomaterials 31:5741-8. 2010
    ....
  5. doi Altered cardiac bradykinin metabolism in experimental diabetes caused by the variations of angiotensin-converting enzyme and other peptidases
    Albert Adam
    Faculty of Pharmacy, Universite de Montreal, Montreal, QC, Canada H3C 3J7
    Neuropeptides 44:69-75. 2010
    ..A number of tissue or molecular factors may determine these variations, such as remodeling of cardiac tissue, ectoenzyme shedding to the extracellular fluid and the pathologic regulation of peptidase gene expression...
  6. ncbi Expression of metallopeptidases and kinin receptors in swine oropharyngeal tissues: effects of angiotensin I-converting enzyme inhibition and inflammation
    Marie Eve Moreau
    Universite de Montreal, Faculte de Pharmacie, Room 3190, 2900 Blvd Edouard Montpetit, C P 6128, Succ Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Pharmacol Exp Ther 315:1065-74. 2005
    ..The expression of critical components of the kallikrein-kinin system in the oropharyngeal tissues supports the role of kinins in ACEi-induced AE...
  7. ncbi The cardioprotective effect of dual metallopeptidase inhibition: respective roles of endogenous kinins and natriuretic peptides
    Marie Josée Dumoulin
    Faculty of Pharmacy, Universite de Montreal, Canada
    Can J Physiol Pharmacol 83:166-73. 2005
    ....
  8. ncbi Hypotensive reaction during staphylococcal protein A column therapy in a patient with anomalous degradation of bradykinin and Des-Arg9-bradykinin after contact activation
    Giuseppe Molinaro
    Faculty of Pharmacy, Department of Mathematics and Statistics, University of Montreal, Montreal, Canada
    Transfusion 42:1458-65. 2002
    ..A patient with anomalous bradykinin (BK) metabolism who experienced hypotension during extracorporeal staphylococcal protein A (SPA) therapy while on an ACE inhibitor was studied...
  9. pmc The effect of electronegativity and angiotensin-converting enzyme inhibition on the kinin-forming capacity of polyacrylonitrile dialysis membranes
    Anik Desormeaux
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Biomaterials 29:1139-46. 2008
    ....
  10. ncbi A study of the mediators involved in the protection induced by exogenous kinins in the isolated rat heart
    Caroline Lagneux
    Faculte de Pharmacie, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, QC, Canada H3C3J7
    Int Immunopharmacol 3:1511-8. 2003
    ..Endothelium-derived mediators such as nitric oxide, prostanoids, and endothelium-derived hyperpolarizing factor, as well as an SR141716A-sensitive mediator, appear to be involved in this beneficial effect...
  11. ncbi Generation of kinins during preparation and storage of whole blood-derived platelet concentrates
    Marie Eve Moreau
    Faculty of Pharmacy, Faculty of Arts and Sciences, Department of Mathematics and Statistics, University of Montreal, Montreal, Quebec, Canada
    Transfusion 47:410-20. 2007
    ..Leukoreduction of platelet (PLT) concentrates (PCs) may be associated with hypotension in recipients, and a role for bradykinin (BK)-related peptides has been proposed for this side effect...
  12. ncbi Biochemical basis of angioedema associated with recombinant tissue plasminogen activator treatment: an in vitro experimental approach
    Giuseppe Molinaro
    Faculte de Pharmacie, Universite de Montreal, Montreal, Quebec, Canada
    Stroke 33:1712-6. 2002
    ..Second, we sought to define the mechanism by which rtPA liberates BK from purified human single-chain high-molecular-weight kininogen, a key constituent of the contact system of plasma and the precursor of BK...
  13. ncbi Bradykinin metabolism in rat hearts with left-ventricular hypertrophy following myocardial infarction
    Marie Josée Dumoulin
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centreville, Montreal QC H3C 3J7, Canada
    Can J Physiol Pharmacol 81:740-6. 2003
    ..In conclusion, experimental MI in rats induces complex changes in the metabolism of exogenous BK. The changes resulted in an increased relative contribution of NEP 36 days after infarction...
  14. pmc Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates
    Giuseppe Molinaro
    Faculte de Pharmacie, Universite de Montreal, 2900, boul Edouard Montpetit bureau S338, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Biochem J 385:389-97. 2005
    ....
  15. ncbi Role of nuclear factor-kappaB and protein kinase C signaling in the expression of the kinin B1 receptor in human vascular smooth muscle cells
    Marie Eve Moreau
    Faculte de Pharmacie, Universite de Montreal, Canada
    Mol Pharmacol 71:949-56. 2007
    ..Both NF-kappaB and protein kinase C signaling are required for the effective expression of the kinin B1 receptor in human umbilical artery smooth muscle cells...
  16. pmc A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors
    Qing Ling Duan
    Centre de Recherche du CHUM, Hopital Notre Dame, Montreal, Quebec, Canada
    Am J Hum Genet 77:617-26. 2005
    ..0364). In conclusion, our findings provide supporting evidence that the C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi...
  17. ncbi Biocompatibility of thermosensitive chitosan-based hydrogels: an in vivo experimental approach to injectable biomaterials
    Giuseppe Molinaro
    Faculte de Pharmacie, Universite de Montreal, Que, Canada
    Biomaterials 23:2717-22. 2002
    ..In conclusion, it appears that a higher degree of deacetylation of the chitin chain is desirable for superior biocompatibility...
  18. ncbi The syndrome of amniotic fluid embolism: a potential contribution of bradykinin
    Josée Robillard
    Faculte de Pharmacie, Universite de Montreal, Montreal, Quebec, Canada
    Am J Obstet Gynecol 193:1508-12. 2005
    ..The objective of this study was to assess whether bradykinin is involved in amniotic fluid embolism...
  19. ncbi Vasopeptidase inhibitors: a new class of dual zinc metallopeptidase inhibitors for cardiorenal therapeutics
    Giuseppe Molinaro
    Faculte de Pharmacie, Universite de Montreal, Montreal, Quebec, H3C 3J7, Canada
    Curr Opin Pharmacol 2:131-41. 2002
    ..However, like angiotensin-I-converting-enzyme inhibitors, vasopeptidase inhibitors are characterized by acute and chronic side-effects that need to be clarified...
  20. pmc Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema
    James Brian Byrd
    Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Hypertension 51:141-7. 2008
    ..Environmental or genetic factors that reduce dipeptidyl peptidase IV activity may predispose individuals to angioedema...
  21. doi Lack of direct interaction between enalaprilat and the kinin B1 receptors
    Guillaume Morissette
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, Quebec, QC, Canada G1V 4G2
    Peptides 29:606-12. 2008
    ..A typical ACE inhibitor did not bind to nor stimulate the human B1Rs; nevertheless, several other indirect mechanisms could connect ACE inhibition to B1R stimulation in vivo...
  22. pmc Metallopeptidase activities in hereditary angioedema: effect of androgen prophylaxis on plasma aminopeptidase P
    Christian Drouet
    GREPI CNRS UMR 5525 and Université Joseph Fourier, Grenoble, France
    J Allergy Clin Immunol 121:429-33. 2008
    ..The pathophysiology of hereditary angioedema is presently attributed only to a quantitative/qualitative C1 inhibitor (CI-INH) defect with increased bradykinin release...
  23. doi Acute hypotensive transfusion reaction during liver transplantation in a patient on angiotensin converting enzyme inhibitors from low aminopeptidase P activity
    Cataldo Doria
    Division of Transplantation, Department of Surgery, Jefferson Medical College Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Liver Transpl 14:684-7. 2008
    ....
  24. ncbi Comparison of the effects of an angiotensin-converting enzyme inhibitor and a vasopeptidase inhibitor after myocardial infarction in the rat
    Nathalie Lapointe
    Division of Cardiology, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
    J Am Coll Cardiol 39:1692-8. 2002
    ..Vasopeptidase inhibitors inhibit both ACE and neutral endopeptidase (NEP), further reduce BK metabolism and increase natriuretic peptides, which may result in better cardioprotective effects than with ACEIs after MI...
  25. ncbi Comparison of the effects of omapatrilat and lisinopril on circulating neurohormones and cytokines in patients with chronic heart failure
    Tej Sheth
    Division of Cardiology, University of Toronto and University Health Network, Toronto, Ontario, Canada
    Am J Cardiol 90:496-500. 2002
    ..Potentially important effects of omapatrilat on endothelin-1 and anti-inflammatory cytokines were identified, providing potential explanations for differences in clinical outcome...
  26. ncbi Angiotensin-converting enzyme inhibitor-associated angioedema
    James Brian Byrd
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, 560 Robinson Research Building, Nashville, TN 37232 6602, USA
    Immunol Allergy Clin North Am 26:725-37. 2006
    ..Defective degradation of vasoactive peptide substrates of ACE, such as bradykinin or substance P, may contribute via non-ACE pathways to the pathogenesis of ACE inhibitor-associated angioedema...
  27. ncbi Vasopeptidase inhibition peri- and post-MI in Zucker insulin resistant rats: effect on MI size, arrhythmias, remodeling, function and fetal gene expression
    Nathalie Lapointe
    Division of Cardiology, Toronto General Hospital, University Health Network, Canada
    Cardiovasc Drugs Ther 19:323-32. 2005
    ..Ventricular dilatation, dysfunction, and fetal gene expression are variably attenuated but not prevented...
  28. ncbi The kallikrein-kinin system: current and future pharmacological targets
    Marie Eve Moreau
    Faculty of Pharmacy, University of Montreal, Canada
    J Pharmacol Sci 99:6-38. 2005
    ....
  29. ncbi Hypotensive transfusion reactions can occur with blood products that are leukoreduced before storage
    Donald M Arnold
    Canadian Blood Services, Ontario, Canada
    Transfusion 44:1361-6. 2004
    ..Leukoreduction before storage, rather than bedside white blood cell filtration, is recommended to prevent hypotensive transfusion reactions...
  30. ncbi Comparative effects of a vasopeptidase inhibitor vs. an angiotensin converting enzyme inhibitor on cardiomyocyte apoptosis in rats with heart failure
    Nathalie Lapointe
    Division of Cardiology, University Health Network Mount Sinai Hospital, Toronto General Hospital, Toronto, ON, Canada
    Mol Cell Biochem 254:235-45. 2003
    ....
  31. ncbi Do angiotensin-converting enzyme inhibitors directly stimulate the kinin B1 receptor?
    Jean Philippe Fortin
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Centre de recherche du Pavillon l Hôtel Dieu de Québec, Canada G1R 2J6
    Am J Physiol Heart Circ Physiol 285:H277-82. 2003
    ..The phospho-ERK1/2 content of arterial smooth muscle cells of human or rabbit origin was increased by treatment with Lys-des-Arg9-BK but not with enalaprilat. ACE inhibitors do not act as bona fide agonists of the kinin B1 receptors...
  32. ncbi Effects of captopril and omapatrilat on early post-myocardial infarction survival and cardiac hemodynamics in rats: interaction with cardiac cytokine expression
    Charles Blais
    Faculte de Pharmacie, Universite de Montreal, Centre Ville, QC, Canada
    Can J Physiol Pharmacol 80:48-58. 2002
    ....