Pharath Lim

Summary

Affiliation: Phnom Penh
Country: Cambodia

Publications

  1. pmc Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia
    William O Rogers
    Naval Medical Research Unit 2, Komp, P2P PLP LITBANGKES, Jl, Percetakan Negara No, 29, Jakarta 10560, Indonesia
    Malar J 8:10. 2009
  2. pmc Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia
    Pharath Lim
    Institut Pasteur in Cambodia, Phnom Penh, Cambodia
    Malar J 8:11. 2009
  3. ncbi request reprint Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia
    Mey Bouth Denis
    National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    Trop Med Int Health 11:1800-7. 2006
  4. pmc Decreased in vitro susceptibility of Plasmodium falciparum isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001 to 2007
    Pharath Lim
    Institut Pasteur in Cambodia, Molecular Epidemiology Unit, Phnom Penh, Cambodia
    Antimicrob Agents Chemother 54:2135-42. 2010
  5. ncbi request reprint In vitro monitoring of Plasmodium falciparum susceptibility to artesunate, mefloquine, quinine and chloroquine in Cambodia: 2001-2002
    Pharath Lim
    Laboratoire d Epidemiologie Moleculaire, Institut Pasteur du Cambodge, 5 Bd Monivong, P O Box 983, Phnom Penh, Cambodia
    Acta Trop 93:31-40. 2005
  6. ncbi request reprint Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in Cambodia
    Mey Bouth Denis
    National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    Trop Med Int Health 11:1360-6. 2006
  7. pmc Therapeutic efficacy of fixed dose artesunate-mefloquine for the treatment of acute, uncomplicated Plasmodium falciparum malaria in Kampong Speu, Cambodia
    Rithea Leang
    National Centre for Parasitology, Entomology and Malaria Control, 372, Monivong Blvd, Corner St, 322, Phnom Penh, Cambodia
    Malar J 12:343. 2013
  8. pmc FlexiChip package: an universal microarray with a dedicated analysis software for high-thoughput SNPs detection linked to anti-malarial drug resistance
    Nicolas Steenkeste
    Laboratoire d Epidemiologie Moleculaire, Institut Pasteur du Cambodge, 5 Bd Monivong, BP 983, Phnom Penh, Cambodia
    Malar J 8:229. 2009
  9. doi request reprint Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies
    Benoit Witkowski
    Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    Lancet Infect Dis 13:1043-9. 2013
  10. pmc Towards high-throughput molecular detection of Plasmodium: new approaches and molecular markers
    Nicolas Steenkeste
    Institut Pasteur du Cambodge, Laboratoire d Epidemiologie Moleculaire, Phnom Penh, Cambodia
    Malar J 8:86. 2009

Collaborators

Detail Information

Publications13

  1. pmc Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia
    William O Rogers
    Naval Medical Research Unit 2, Komp, P2P PLP LITBANGKES, Jl, Percetakan Negara No, 29, Jakarta 10560, Indonesia
    Malar J 8:10. 2009
    ..The efficacy of standard therapies for uncomplicated Plasmodium falciparum and Plasmodium vivax malaria was assessed in Chumkiri, Kampot Province, Cambodia...
  2. pmc Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia
    Pharath Lim
    Institut Pasteur in Cambodia, Phnom Penh, Cambodia
    Malar J 8:11. 2009
    ....
  3. ncbi request reprint Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia
    Mey Bouth Denis
    National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    Trop Med Int Health 11:1800-7. 2006
    ..To determine the efficacy of artemether-lumefantrine malaria treatment, as an alternative to artesunate + mefloquine, which is becoming ineffective in some areas of the Thai-Cambodian border...
  4. pmc Decreased in vitro susceptibility of Plasmodium falciparum isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001 to 2007
    Pharath Lim
    Institut Pasteur in Cambodia, Molecular Epidemiology Unit, Phnom Penh, Cambodia
    Antimicrob Agents Chemother 54:2135-42. 2010
    ..These results are worrisome, because they may signal deterioration of the efficacy of artesunate-mefloquine beyond the Cambodian-Thai border...
  5. ncbi request reprint In vitro monitoring of Plasmodium falciparum susceptibility to artesunate, mefloquine, quinine and chloroquine in Cambodia: 2001-2002
    Pharath Lim
    Laboratoire d Epidemiologie Moleculaire, Institut Pasteur du Cambodge, 5 Bd Monivong, P O Box 983, Phnom Penh, Cambodia
    Acta Trop 93:31-40. 2005
    ....
  6. ncbi request reprint Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in Cambodia
    Mey Bouth Denis
    National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    Trop Med Int Health 11:1360-6. 2006
    ..Side effects were common, especially dizziness, but were mild and transient and patients recovered without any medical intervention...
  7. pmc Therapeutic efficacy of fixed dose artesunate-mefloquine for the treatment of acute, uncomplicated Plasmodium falciparum malaria in Kampong Speu, Cambodia
    Rithea Leang
    National Centre for Parasitology, Entomology and Malaria Control, 372, Monivong Blvd, Corner St, 322, Phnom Penh, Cambodia
    Malar J 12:343. 2013
    ..Fixed dose combination (FDC) ASMQ is efficacious against acute uncomplicated, drug resistant Plasmodium falciparum malaria in Southeast Asia but has not been tested in Cambodia...
  8. pmc FlexiChip package: an universal microarray with a dedicated analysis software for high-thoughput SNPs detection linked to anti-malarial drug resistance
    Nicolas Steenkeste
    Laboratoire d Epidemiologie Moleculaire, Institut Pasteur du Cambodge, 5 Bd Monivong, BP 983, Phnom Penh, Cambodia
    Malar J 8:229. 2009
    ..Here a new Zip-code array is described, called FlexiChip, linked to a dedicated software program, which largely overcomes this problem...
  9. doi request reprint Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies
    Benoit Witkowski
    Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    Lancet Infect Dis 13:1043-9. 2013
    ....
  10. pmc Towards high-throughput molecular detection of Plasmodium: new approaches and molecular markers
    Nicolas Steenkeste
    Institut Pasteur du Cambodge, Laboratoire d Epidemiologie Moleculaire, Phnom Penh, Cambodia
    Malar J 8:86. 2009
    ..But sensitive diagnosis tools enabling to deal with a large number of samples are needed. The molecular detection approach offers a much higher sensitivity, and the flexibility to be automated and upgraded...
  11. pmc Large-scale malaria survey in Cambodia: novel insights on species distribution and risk factors
    Sandra Incardona
    Laboratory of Molecular Epidemiology, Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    Malar J 6:37. 2007
    ..A global estimate of the current malaria situation and associated risk factors is, therefore, still lacking...
  12. pmc pfcrt polymorphism and chloroquine resistance in Plasmodium falciparum strains isolated in Cambodia
    Pharath Lim
    Laboratoire d Epidemiologie Moleculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    Antimicrob Agents Chemother 47:87-94. 2003
    ..This indicates that in vitro resistance to chloroquine was associated with accumulation of point mutations in pfcrt...
  13. pmc Decreasing pfmdr1 Copy Number Suggests that Plasmodium falciparum in Western Cambodia Is Regaining In Vitro Susceptibility to Mefloquine
    Pharath Lim
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia
    Antimicrob Agents Chemother 59:2934-7. 2015
    ..falciparum clinical isolates collected in 2008 to 2013. The pfmdr1 copy number is decreasing in Western Cambodia, suggesting that P. falciparum is regaining in vitro susceptibility to MQ. ..