Joseph J Buggy

Summary

Publications

  1. pmc HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination
    Shanthi Adimoolam
    Pharmacyclics, Inc, Sunnyvale, CA 94085 4521, USA
    Proc Natl Acad Sci U S A 104:19482-7. 2007
  2. ncbi request reprint CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo
    Joseph J Buggy
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Mol Cancer Ther 5:1309-17. 2006
  3. ncbi request reprint CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo
    Z Alexander Cao
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Mol Cancer Ther 5:1693-701. 2006
  4. ncbi request reprint Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases
    John R Somoza
    Celera, 180 Kimball Way, South San Francisco, CA 94080 USA
    Structure 12:1325-34. 2004

Collaborators

  • Z Alexander Cao
  • Liang Liu
  • Bradley A Katz
  • Shanthi Adimoolam
  • John R Somoza
  • Jun Chen
  • James M Ford
  • Patti Thiemann
  • Mint Sirisawad
  • Ellen Chi
  • Douglas R Dougan
  • Gyorgy Snell
  • Jie Tang
  • Ellen M Leahy
  • Marc Navre
  • Christine Luong
  • Erik Verner
  • Robert J Skene
  • Robert Wynands
  • Ronald V Swanson
  • Mark W Knuth
  • Bi Ching Sang
  • Andrew Arvai
  • Clifford Mol
  • Duncan E McRee
  • Joseph D Ho
  • Leslie W Tari
  • Andy J Jennings

Detail Information

Publications4

  1. pmc HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination
    Shanthi Adimoolam
    Pharmacyclics, Inc, Sunnyvale, CA 94085 4521, USA
    Proc Natl Acad Sci U S A 104:19482-7. 2007
    ..Together these results demonstrate that HDAC enzymes are critically important to enable functional HR by controlling the expression of HR-related genes and promoting the proper assembly of HR-directed subnuclear foci...
  2. ncbi request reprint CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo
    Joseph J Buggy
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Mol Cancer Ther 5:1309-17. 2006
    ..These results reveal CRA-024781 to be a novel HDAC inhibitor with potent antitumor activity...
  3. ncbi request reprint CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo
    Z Alexander Cao
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Mol Cancer Ther 5:1693-701. 2006
    ..These results reveal CRA-026440 to be a novel HDAC inhibitor with potent antitumor activity...
  4. ncbi request reprint Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases
    John R Somoza
    Celera, 180 Kimball Way, South San Francisco, CA 94080 USA
    Structure 12:1325-34. 2004
    ..This work sheds light on the catalytic mechanism of the HDACs, and on differences in substrate specificity across the HDAC family. The structure also suggests how phosphorylation of Ser39 affects HDAC8 activity...