David J Brooks

Summary

Publications

  1. doi request reprint Imaging biomarkers in Parkinson's disease
    David J Brooks
    Centre for Neuroscience, Department of Medicine, Imperial College London, UK
    Prog Neurobiol 95:614-28. 2011
  2. doi request reprint Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    Paul Edison
    MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 32:412-9. 2008
  3. doi request reprint Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    Mov Disord 26:1997-2003. 2011
  4. doi request reprint Serotonin neuron loss and nonmotor symptoms continue in Parkinson's patients treated with dopamine grafts
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Sci Transl Med 4:128ra41. 2012
  5. doi request reprint Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study
    Marios Politis
    Department of Clinical Neurosciences and MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Hum Brain Mapp 32:258-70. 2011
  6. doi request reprint Brain monoamine systems in multiple system atrophy: a positron emission tomography study
    Stephanie J Lewis
    Centre for Neuroscience, Dept of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Neurobiol Dis 46:130-6. 2012
  7. pmc Microglia, amyloid, and glucose metabolism in Parkinson's disease with and without dementia
    Paul Edison
    Centre of Neuroscience, Department of Medicine, Imperial College London, London, UK
    Neuropsychopharmacology 38:938-49. 2013
  8. pmc Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation
    Lucy J Garvey
    Department of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 7:e38980. 2012
  9. ncbi request reprint Microglial activation in presymptomatic Huntington's disease gene carriers
    Yen F Tai
    MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Brain 130:1759-66. 2007
  10. doi request reprint The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study
    Kit Wu
    Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK
    Brain 135:2449-57. 2012

Collaborators

Detail Information

Publications41

  1. doi request reprint Imaging biomarkers in Parkinson's disease
    David J Brooks
    Centre for Neuroscience, Department of Medicine, Imperial College London, UK
    Prog Neurobiol 95:614-28. 2011
    ..Additionally, widespread microglial activation can be detected in PD with PET. This review discusses the role of structural and functional imaging for understanding parkinsonian syndromes and aiding in their diagnosis and management...
  2. doi request reprint Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    Paul Edison
    MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 32:412-9. 2008
    ..MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage...
  3. doi request reprint Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    Mov Disord 26:1997-2003. 2011
    ..Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias...
  4. doi request reprint Serotonin neuron loss and nonmotor symptoms continue in Parkinson's patients treated with dopamine grafts
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Sci Transl Med 4:128ra41. 2012
    ....
  5. doi request reprint Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study
    Marios Politis
    Department of Clinical Neurosciences and MRC Clinical Sciences Centre, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Hum Brain Mapp 32:258-70. 2011
    ..These data suggest that pathologically activated microglia in AST and other areas related to cognitive function, maybe better predictors of clinical onset and stresses the importance of early cognitive assessment in HD...
  6. doi request reprint Brain monoamine systems in multiple system atrophy: a positron emission tomography study
    Stephanie J Lewis
    Centre for Neuroscience, Dept of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Neurobiol Dis 46:130-6. 2012
    ..In contrast to PD, there was no evidence of early compensatory increases in regional 18F-dopa uptake...
  7. pmc Microglia, amyloid, and glucose metabolism in Parkinson's disease with and without dementia
    Paul Edison
    Centre of Neuroscience, Department of Medicine, Imperial College London, London, UK
    Neuropsychopharmacology 38:938-49. 2013
    ..Significant microglial activation may be a factor in driving the disease process in PDD. Given this, agents that affect microglial activation could have an influence on disease progression...
  8. pmc Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation
    Lucy J Garvey
    Department of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 7:e38980. 2012
    ..The aim of this study was to investigate the effect of acute HCV infection upon cerebral function and microglial cell activation in HIV-infected individuals...
  9. ncbi request reprint Microglial activation in presymptomatic Huntington's disease gene carriers
    Yen F Tai
    MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Brain 130:1759-66. 2007
    ..PK PET may be a useful marker of active subclinical disease and a means of investigating the efficacy of neuroprotection strategies in PGCs...
  10. doi request reprint The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study
    Kit Wu
    Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK
    Brain 135:2449-57. 2012
    ....
  11. doi request reprint Serotonergic mediated body mass index changes in Parkinson's disease
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Neurobiol Dis 43:609-15. 2011
    ..The regions implicated are the rostral raphe nuclei and its connections to limbic and cognitive areas. It is conceivable that 5-HT agents could help alleviate abnormal changes in BMI in PD...
  12. doi request reprint Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Sci Transl Med 2:38ra46. 2010
    ..Our observations suggest strategies for avoiding and treating graft-induced dyskinesias that result from cell therapies for Parkinson's disease with fetal tissue or stem cells...
  13. pmc Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP
    Daniela A Riaño Barros
    Centre for Neuroscience, Department of Medicine, Imperial College London, London, UK MRC Clinical Sciences Centre Hammersmith Hospital, London, UK
    Neuroimage 97:151-62. 2014
    ..The objective of this study was to quantify the test-retest reproducibility of measures of the PET ligand [(11)C]MePPEP in order to assess the stability of CB1-receptor quantification in humans in vivo...
  14. doi request reprint Inflammation after trauma: microglial activation and traumatic brain injury
    Anil F Ramlackhansingh
    Centre for Neuroscience, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
    Ann Neurol 70:374-83. 2011
    ..In this study, we investigate whether an inflammatory response to TBI persists, and whether this response relates to structural brain abnormalities and cognitive function...
  15. doi request reprint Progression of monoaminergic dysfunction in Parkinson's disease: a longitudinal 18F-dopa PET study
    Nicola Pavese
    Centre for Neuroscience, Department of Medicine, Imperial College London, UK
    Neuroimage 56:1463-8. 2011
    ..When assessing the efficacy of novel neuroprotective agents on nigrostriatal dysfunction in PD, (18)F-dopa PET could provide supplementary information concerning function of extrastriatal monoaminergic structures...
  16. pmc Serotonergic loss in motor circuitries correlates with severity of action-postural tremor in PD
    Clare Loane
    Department of Medicine, Division of Brain Sciences, Hammersmith Hospital, Imperial College London, UK
    Neurology 80:1850-5. 2013
    ..It is suggested that serotonergic dysfunction could have a role in tremor development...
  17. doi request reprint Evidence of dopamine dysfunction in the hypothalamus of patients with Parkinson's disease: an in vivo 11C-raclopride PET study
    Marios Politis
    Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Cyclotron Building, Hammersmith Hospital, Imperial College London, DuCane Road W12 0NN, London, UK
    Exp Neurol 214:112-6. 2008
    ..Our results provide further evidence of dopaminergic dysfunction in the hypothalamus in PD, and this may contribute to the development of sleep, endocrine and autonomic disorders...
  18. doi request reprint Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility
    Paul Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Hammersmith Hospital, Imperial College London, UK
    Neuroimage 48:329-38. 2009
    ..Patlak analysis of [11C]PIB binding was the least reproducible...
  19. doi request reprint The role of pallidal serotonergic function in Parkinson's disease dyskinesias: a positron emission tomography study
    Ruben Smith
    Department of Clinical Sciences, Section for Neurology, Skane University Hospital, Lund University, Lund, Sweden Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
    Neurobiol Aging 36:1736-42. 2015
    ..Our findings indicate that LIDs in PD are associated with higher GP serotonergic function. This increased serotonin function may result in further dysregulation of thalamocortical signals and so promote the expression of dyskinesias. ..
  20. doi request reprint Initial evaluation of 18F-GE-179, a putative PET Tracer for activated N-methyl D-aspartate receptors
    Colm J McGinnity
    Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom
    J Nucl Med 55:423-30. 2014
    ..4 nM. No significant binding was observed with 10 nM GE-179 at 60 other neuroreceptors, channels, or transporters. We describe the kinetic behavior of the radioligand in vivo in humans...
  21. doi request reprint Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effect
    Colm J McGinnity
    Centre for Neuroscience, Department of Medicine, Imperial College London, London W12 0NN, UK
    Neuroimage 79:72-80. 2013
    ..Denoising, resolution recovery and precise anatomical segmentation can extract valuable information from PET studies that would be missed with conventional post-processing procedures...
  22. doi request reprint Increased microglia activation in neurologically asymptomatic HIV-infected patients receiving effective ART
    Lucy J Garvey
    aDepartment of Medicine, Faculty of Medicine, Imperial College London, St Mary s Hospital Campus, Norfolk Place bDepartment of HIV and GU Medicine, Imperial College Healthcare NHS Trust cDivision of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK
    AIDS 28:67-72. 2014
    ..We imaged microglial activation, the hallmark of neuroinflammation, in asymptomatic HIV-infected patients on effective combination ART...
  23. doi request reprint Glutamate NMDA receptor dysregulation in Parkinson's disease with dyskinesias
    Imtiaz Ahmed
    Centre for Neuroscience, Imperial College, London, UK
    Brain 134:979-86. 2011
    ..They support the hypothesis that blockade of glutamate transmission may have a place in the management of disabling dyskinesias in Parkinson's disease...
  24. doi request reprint Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study
    Marios Politis
    MRC Clinical Sciences Centre and Centre for Neuroscience, Faculty of Medicine, Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 40:216-21. 2010
    ..Our results suggest that progressive non-linear serotonergic dysfunction occurs in PD but it does not determine levels of disability. Additionally, chronic exposure to dopaminergic therapy does not appear to influence SERT binding...
  25. doi request reprint Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia
    Zhen Fan
    Neurology Imaging Unit, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Alzheimers Dement 11:608-21.e7. 2015
    ..Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common neurodegenerative diseases characterized by progressive neuronal dysfunction in the presence of pathological microglial activation...
  26. pmc Persistent nigrostriatal dopaminergic abnormalities in ex-users of MDMA ('Ecstasy'): an 18F-dopa PET study
    Yen F Tai
    Faculty of Medicine, Centre for Neuroscience, Hammersmith Campus, Imperial College London, London, UK
    Neuropsychopharmacology 36:735-43. 2011
    ..Further longitudinal studies are required to elucidate the significance of these findings as they may have important public health implications...
  27. doi request reprint Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction
    Nicola Pavese
    Department of Medicine, Centre for Neuroscience, Imperial College, London, UK
    Brain 133:3434-43. 2010
    ..These findings imply that strategies to increase brain level of serotonin would be a rational approach for relieving fatigue symptoms in Parkinson's disease and may also be relevant to alleviating fatigue in other clinical conditions...
  28. doi request reprint Parkinson's disease: diagnosis
    David J Brooks
    Centre for Neuroscience, Department of Medicine, Imperial College London, UK
    Parkinsonism Relat Disord 18:S31-3. 2012
    ..In this review the role of structural and functional imaging for supporting the differential diagnosis of the various degenerative parkinsonian syndromes will be discussed...
  29. doi request reprint Imaging neurodegeneration in Parkinson's disease
    Nicola Pavese
    MRC Clinical Sciences Centre and Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, UK
    Biochim Biophys Acta 1792:722-9. 2009
    ..In the future novel radiotracers may help us assess the involvement of non-dopaminergic brain pathways in the pathology of both motor and non-motor complications in PD...
  30. ncbi request reprint [11C]Flumazenil PET in temporal lobe epilepsy: do we need an arterial input function or kinetic modeling?
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 28:207-16. 2008
    ..Full quantification with an image-independent input should ideally be used in the evaluation of FMZ PET; at least in TLE, intrasubject correlations do not predict equivalent clinical usefulness...
  31. doi request reprint Imaging non-motor aspects of Parkinson's disease
    David J Brooks
    Division of Experimental Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Prog Brain Res 184:205-18. 2010
    ..Finally the discordance between the development of functional changes in PD and Braak staging is highlighted...
  32. doi request reprint Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's disease
    Zhen Fan
    1 Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Brain 138:3685-98. 2015
    ....
  33. doi request reprint An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers
    David J Brooks
    Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, London, UK
    Clin Neuropharmacol 33:55-60. 2010
    ....
  34. pmc Technical aspects of amyloid imaging for Alzheimer's disease
    Paul Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Imperial College London, Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Alzheimers Res Ther 3:25. 2011
    ..In the present short review we discuss the properties of amyloid imaging agent [11C]Pittsburgh Compound B, the different modalities of molecular imaging, image processing and data analysis, and newer amyloid imaging agents...
  35. doi request reprint Imaging dopamine transporters in Parkinson's disease
    David J Brooks
    Department of Medicine, Imperial College London, Cyclotron Building, Hammersmith Hospital, Du Cane Road, W12 0NN, UK
    Biomark Med 4:651-60. 2010
    ....
  36. doi request reprint Imaging neuroinflammation in Alzheimer's disease and other dementias: Recent advances and future directions
    James Varley
    Neurology Imaging Unit, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
    Alzheimers Dement 11:1110-20. 2015
    ..It is our view that a multimodal investigation into neuroinflammation in AD, Parkinson's disease dementia, FTD and HD will yield valuable pathological insights which will usefully inform development of therapeutic targets and biomarkers...
  37. doi request reprint Imaging biomarkers in tauopathies
    Melanie Dani
    Neurology Imaging Unit, Division of Neuroscience, Imperial College London, UK
    Parkinsonism Relat Disord 22:S26-8. 2016
    ..Here, we discuss the challenges posed in developing selective tau ligands as biomarkers, their state of development and the new clinical information that has been revealed...
  38. pmc Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage
    Gregory Scott
    Division of Brain Sciences, Department of Medicine, Hammersmith Hospital Campus, Imperial College London, London, UK
    J Neuroinflammation 12:224. 2015
    ..Animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury, but this relationship has never been shown in vivo...
  39. doi request reprint Progression of nonmotor symptoms in subgroups of patients with non-dopamine-deficient Parkinsonism
    Stuart Taylor
    Division of Brain Sciences, Imperial College London, UK
    Mov Disord 31:344-51. 2016
    ..Ten to fifteen percent of Parkinson's disease (PD) patients recruited to clinical trials have scans without evidence of dopaminergic deficit, whose presence represents a heterogeneous patient population...
  40. doi request reprint The role of neuroinflammation in dementias
    Giuseppe Pasqualetti
    Division of Brain Sciences, Department of Medicine, Imperial College London, 1st Floor B Block, Du Cane Road, London, W12 0NN, UK
    Curr Neurol Neurosci Rep 15:17. 2015
    ..Furthermore, we discuss the neuroimaging techniques that are currently used for the study of neuroinflammation in human brain. ..
  41. ncbi request reprint A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195
    Alexander N Anderson
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, UK
    Neuroimage 36:28-37. 2007
    ..The reference-to-target ratio and the Logan graphical approach were significantly less reliable and less sensitive...