Clark A Briggs

Summary

Publications

  1. pmc Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors
    Clark A Briggs
    Neuroscience Research, Abbott Laboratories, Abbott Park, IL, USA
    Br J Pharmacol 158:1486-94. 2009
  2. doi request reprint In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107
    John Malysz
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, Abbott Park, Illinois 60064 6125, USA
    J Pharmacol Exp Ther 334:863-74. 2010
  3. doi request reprint In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile
    John Malysz
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064 6125, USA
    J Pharmacol Exp Ther 330:257-67. 2009
  4. doi request reprint Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination
    David J Anderson
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Biochem Pharmacol 78:844-51. 2009
  5. doi request reprint Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station
    John Malysz
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, Abbott Park, Illinois 60064 6125, USA
    Assay Drug Dev Technol 7:374-90. 2009
  6. doi request reprint Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor
    Ramin Faghih
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Med Chem 52:3377-84. 2009
  7. ncbi request reprint High- and low-sensitivity subforms of alpha4beta2 and alpha3beta2 nAChRs
    Clark A Briggs
    Neuroscience Research, R47W AP9A 3, Abbott Laboratories, Abbott Park, IL 60064, USA
    J Mol Neurosci 30:11-2. 2006
  8. ncbi request reprint Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors
    Clark A Briggs
    Neuroscience Research, R47W Bldg AP9A 3, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Mol Pharmacol 70:227-40. 2006
  9. ncbi request reprint A-85380: a pharmacological probe for the preclinical and clinical investigation of the alphabeta neuronal nicotinic acetylcholine receptor
    Lynne E Rueter
    Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL, USA
    CNS Drug Rev 12:100-12. 2006
  10. doi request reprint SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore
    Michael R Schrimpf
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6117, USA
    Bioorg Med Chem Lett 22:1633-8. 2012

Collaborators

Detail Information

Publications19

  1. pmc Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors
    Clark A Briggs
    Neuroscience Research, Abbott Laboratories, Abbott Park, IL, USA
    Br J Pharmacol 158:1486-94. 2009
    ..The possibility that agonists of this receptor actually function in vivo as inhibitors via desensitization has not been finally resolved...
  2. doi request reprint In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107
    John Malysz
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, Abbott Park, Illinois 60064 6125, USA
    J Pharmacol Exp Ther 334:863-74. 2010
    ..In summary, ABT-107 is a selective high affinity alpha7 nAChR agonist suitable for characterizing the roles of this subtype in pharmacological studies...
  3. doi request reprint In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile
    John Malysz
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064 6125, USA
    J Pharmacol Exp Ther 330:257-67. 2009
    ..In summary, this study identifies a novel and selective alpha7 PAM showing activity at recombinant and native alpha7 nAChRs exhibiting a unique pharmacological interaction with the receptor...
  4. doi request reprint Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination
    David J Anderson
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Biochem Pharmacol 78:844-51. 2009
    ..In summary, this study provides support for HS alpha4beta2* nAChR involvement in neurotransmitter release...
  5. doi request reprint Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station
    John Malysz
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, Abbott Park, Illinois 60064 6125, USA
    Assay Drug Dev Technol 7:374-90. 2009
    ....
  6. doi request reprint Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor
    Ramin Faghih
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Med Chem 52:3377-84. 2009
    ..In a rodent model of sensory gating, 19 normalized gating deficits. These results suggest that 19 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs...
  7. ncbi request reprint High- and low-sensitivity subforms of alpha4beta2 and alpha3beta2 nAChRs
    Clark A Briggs
    Neuroscience Research, R47W AP9A 3, Abbott Laboratories, Abbott Park, IL 60064, USA
    J Mol Neurosci 30:11-2. 2006
    ..In contrast, injection of messages with UTRs (1:1 ratio) led to expression of a monophasic concentration response to ACh and a high-sensitivity EC50 value of 2.3 microM, as shown in Fig. 1...
  8. ncbi request reprint Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors
    Clark A Briggs
    Neuroscience Research, R47W Bldg AP9A 3, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Mol Pharmacol 70:227-40. 2006
    ....
  9. ncbi request reprint A-85380: a pharmacological probe for the preclinical and clinical investigation of the alphabeta neuronal nicotinic acetylcholine receptor
    Lynne E Rueter
    Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL, USA
    CNS Drug Rev 12:100-12. 2006
    ..Although not developed as a therapeutic agent, A-85380 has proven to be an important component in the development of novel nAChR ligands for the treatment of pain and other disorders...
  10. doi request reprint SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore
    Michael R Schrimpf
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6117, USA
    Bioorg Med Chem Lett 22:1633-8. 2012
    ..Analogs in which the fluorenone core is replaced with either dibenzothiophene-5,5-dioxide or xanthenone also retain potent activity...
  11. doi request reprint Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
    Karin R Tietje
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    CNS Neurosci Ther 14:65-82. 2008
    ....
  12. ncbi request reprint Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways
    Robert S Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurosci 27:10578-87. 2007
    ....
  13. ncbi request reprint High throughput electrophysiology using a fully automated, multiplexed recording system
    Jonathan D Trumbull
    Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Receptors Channels 9:19-28. 2003
    ..The design of the system is detailed along with examples of data generated in support of lead optimization and discovery...
  14. doi request reprint Allosteric modulators of the alpha7 nicotinic acetylcholine receptor
    Ramin Faghih
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Med Chem 51:701-12. 2008
  15. ncbi request reprint Loss of functional neuronal nicotinic receptors in dorsal root ganglion neurons in a rat model of neuropathic pain
    Gilles R Dubé
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9 1125, 100 Abbott Park Rd, Abbott Park, IL 60064 6118, USA
    Neurosci Lett 376:29-34. 2005
    ....
  16. ncbi request reprint ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders
    Lynne E Rueter
    Abbott Laboratories, Neuroscience Research, R4N5, AP9A, 100 Abbott Park Rd, Abbott Park, IL 60064 6115, USA
    CNS Drug Rev 10:167-82. 2004
    ..Together these data suggest that ABT-089 is a NNR modulator with the potential for treating cognitive disorders with markedly limited adverse cardiovascular and gastrointestinal side effects...
  17. pmc Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides
    Anthony J Hinrich
    Department of Cell Biology and Anatomy, Chicago Medical School Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    EMBO Mol Med 8:328-45. 2016
    ....
  18. pmc β amyloid peptide plaques fail to alter evoked neuronal calcium signals in APP/PS1 Alzheimer's disease mice
    Clark A Briggs
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    Neurobiol Aging 34:1632-43. 2013
    ....
  19. ncbi request reprint Potent desensitization of human P2X3 receptors by diadenosine polyphosphates
    Heath A McDonald
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R04PM, AP9A 218, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Eur J Pharmacol 435:135-42. 2002
    ..Thus, P2X3 receptor desensitization by diadenosine polyphosphates may provide an important modulatory mechanism of P2X3 receptor activation in vivo...