Tania Ueda-Nakamura

Summary

Affiliation: Universidade Estadual de Maring
Country: Brazil

Publications

  1. ncbi request reprint Comparative analysis of megasomes in members of the Leishmania mexicana complex
    Tania Ueda-Nakamura
    Laboratorio de Microbiologia, Departamento de Analises Clinicas, Universidade Estadual de Maringa, Av Colombo, 5790, Bloco I90, 87020 900, Maringa, PR, Brazil
    Res Microbiol 158:456-62. 2007
  2. ncbi request reprint Influence of tannins from Stryphnodendron adstringens on growth and virulence factors of Candida albicans
    Kelly Ishida
    Mestranda do Programa de Pós graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Avenida Colombo, 5790, 87020 900, Maringa, Parana, Brazil
    J Antimicrob Chemother 58:942-9. 2006
  3. pmc Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium
    Tatiana Shioji Tiuman
    Departamento de Analises Clinicas, Universidade Estadual de Maringa, Bloco I 90 Sala 123 CCS, Av Colombo 5790, BR 87020 900, Maringa, Parana, Brazil
    Antimicrob Agents Chemother 49:176-82. 2005
  4. doi request reprint Antimicrobial activity of plants used as medicinals on an indigenous reserve in Rio das Cobras, Paraná, Brazil
    Gislaine F Moura-Costa
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Av Colombo, 5790, 87020 900, Maringa, Parana, Brazil
    J Ethnopharmacol 143:631-8. 2012
  5. doi request reprint The natural compounds piperovatine and piperlonguminine induce autophagic cell death on Trypanosoma cruzi
    Phercyles Veiga-Santos
    Programa de Pós Graduação em Ciências Farmacêuticas, Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Universidade Estadual de Maringa, Parana, Brazil
    Acta Trop 125:349-56. 2013
  6. doi request reprint Trypanocidal activity of 1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone isolated from Kielmeyera coriacea
    Angelo de Oliveira Caleare
    Laboratório de Inovação Tecnológicas no Desenvolvimento de Fármacos e Cosméticos, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    Parasitol Int 62:405-11. 2013
  7. doi request reprint Trypanocidal action of eupomatenoid-5 is related to mitochondrion dysfunction and oxidative damage in Trypanosoma cruzi
    Karin Juliane Pelizzaro-Rocha
    Programa de Pós Graduação em Microbiologia, Universidade Estadual de Londrina, Londrina, PR, Brazil
    Microbes Infect 13:1018-24. 2011
  8. ncbi request reprint Ultrastructural alterations induced by the neolignan dihydrobenzofuranic eupomatenoid-5 on epimastigote and amastigote forms of Trypanosoma cruzi
    Patrícia Shima Luize
    Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Avenida Colombo, 5790, BR 87020 900, Maringa, PR, Brazil
    Parasitol Res 100:31-7. 2006
  9. doi request reprint Antileishmanial activity of 5-methyl-2,2' : 5',2″-terthiophene isolated from Porophyllum ruderale is related to mitochondrial dysfunction in Leishmania amazonensis
    Helena Teru Takahashi
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, PR, Brazil
    Planta Med 79:330-3. 2013
  10. ncbi request reprint In vitro activity of essential oil from Ocimum gratissimum L. against four Candida species
    Celso Vataru Nakamura
    Laboratorio de Microbiologia, Departamento de Analises Clinicas, Universidade Estadual de Maringa, 87020 900 Maringa, PR, Brazil
    Res Microbiol 155:579-86. 2004

Collaborators

  • Celso Vataru Nakamura
  • Diógenes Aparício Garcia Cortez
  • Wanderley de Souza
  • Jose Andres Morgado-Diaz
  • Kelly Ishida
  • Renato Crespo Pereira
  • Rachel Auzely-Velty
  • Carlos Alexandre Carollo
  • Marcello Iacomini
  • Celuta Sales Alviano
  • Marco Antonio Costa
  • Andrea Mayumi Koroishi
  • Edson R Silva
  • Benedito Prado Dias Filho
  • Vânia Cristina Desoti
  • Danielle Lazarin-Bidóia
  • Sueli de Oliveira Silva
  • João Carlos Palazzo de Mello
  • Tatiana Shioji Tiuman
  • Samara Requena Nocchi
  • Juliana Cogo
  • Francielle Pelegrin Garcia
  • Elizandra Aparecida Britta
  • Benedito P Dias Filho
  • Eliana Harue Endo
  • Jean Henrique da Silva Rodrigues
  • Arlene Gonçalves Côrrea
  • Mislaine Adriana Brenzan
  • Angelo de Oliveira Caleare
  • Helena Teru Takahashi
  • Karin Juliane Pelizzaro-Rocha
  • Renata Sespede Mazia
  • Vanessa Kaplum
  • Diego Pereira Sangi
  • Maria Helena Sarragiotto
  • Cláudio Roberto Novello
  • Benedito Prado Dias-Filho
  • Phercyles Veiga-Santos
  • Sueli Oliveira Silva
  • Izabel Cristina Piloto Ferreira
  • Adriana Oliveira dos Santos
  • Maria Claudia M Young
  • Valéria Aquilino Barbosa
  • Solange C Martins
  • Edson Rodrigues-Filho
  • Zia Ud Din
  • Hugo Falzirolli
  • Solange Cardoso Martins
  • Fabianne Martins Ribeiro
  • Hélito Volpato
  • Renata Longhini
  • Diógenes Aparício Garcia Cortez
  • Vera Lúcia Dias Siqueira
  • Gean Pier Panizzon
  • Simone R Foss
  • Willian Ferreira da Costa
  • Arildo José Braz de Oliveira
  • Valdecir Farias Ximenes
  • Jackeline T G Siraichi
  • Antonio Alonso
  • Daniela Bueno Sudatti
  • Fabio Bahls Machado
  • Gislaine F Moura-Costa
  • Milene Valéria Lopes
  • Ligia F Ceole
  • Mariele Caroline Marques Nogueira Puhl
  • Cleyton E M de Toledo
  • Tatiana S Tiuman
  • Mirian Ueda Yamaguchi
  • Flaviano João Basilio Marçal
  • Bruna Polacchine da Silva
  • Lilian T Düsman Tonin
  • Michele Cristina Vendrametto
  • Daniel Rodrigues Silva
  • Marta Regina Santin
  • Denise de Oliveira Scoaris
  • Patricia Costa Mincoff
  • Patrícia Shima Luize
  • Fabíola Barbieri Holetz
  • Celso Vatarunakamura
  • Marcos Luciano Bruschi
  • Ana Lucia T Goes Ruiz
  • Lizziane Maria Belloto de Francisco
  • Sueli de O Silva
  • Mary Ann Foglio
  • Juliana Rodrigues
  • Raphaela Regina de Araújo Pereira
  • Denise Brentan Silva
  • João Ernesto de Carvalho
  • Cleuza C da Silva

Detail Information

Publications60

  1. ncbi request reprint Comparative analysis of megasomes in members of the Leishmania mexicana complex
    Tania Ueda-Nakamura
    Laboratorio de Microbiologia, Departamento de Analises Clinicas, Universidade Estadual de Maringa, Av Colombo, 5790, Bloco I90, 87020 900, Maringa, PR, Brazil
    Res Microbiol 158:456-62. 2007
    ..These results suggest that these organelles and their constituents may be involved in the infectivity and virulence of Leishmania species...
  2. ncbi request reprint Influence of tannins from Stryphnodendron adstringens on growth and virulence factors of Candida albicans
    Kelly Ishida
    Mestranda do Programa de Pós graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Avenida Colombo, 5790, 87020 900, Maringa, Parana, Brazil
    J Antimicrob Chemother 58:942-9. 2006
    ..The main objective of this work was to investigate the antifungal activity of a crude extract, fractions and subfractions from Stryphnodendron adstringens (Mart.) Coville, known as 'barbatimão'...
  3. pmc Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium
    Tatiana Shioji Tiuman
    Departamento de Analises Clinicas, Universidade Estadual de Maringa, Bloco I 90 Sala 123 CCS, Av Colombo 5790, BR 87020 900, Maringa, Parana, Brazil
    Antimicrob Agents Chemother 49:176-82. 2005
    ..These results provide new perspectives on the development of novel drugs with leishmanicidal activities obtained from natural products...
  4. doi request reprint Antimicrobial activity of plants used as medicinals on an indigenous reserve in Rio das Cobras, Paraná, Brazil
    Gislaine F Moura-Costa
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Av Colombo, 5790, 87020 900, Maringa, Parana, Brazil
    J Ethnopharmacol 143:631-8. 2012
    ....
  5. doi request reprint The natural compounds piperovatine and piperlonguminine induce autophagic cell death on Trypanosoma cruzi
    Phercyles Veiga-Santos
    Programa de Pós Graduação em Ciências Farmacêuticas, Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Universidade Estadual de Maringa, Parana, Brazil
    Acta Trop 125:349-56. 2013
    ..These mitochondrial dysfunctions induced by the amides might trigger biochemical alterations that lead to cell death. Altogether, our data evidence a possible autophagic process...
  6. doi request reprint Trypanocidal activity of 1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone isolated from Kielmeyera coriacea
    Angelo de Oliveira Caleare
    Laboratório de Inovação Tecnológicas no Desenvolvimento de Fármacos e Cosméticos, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    Parasitol Int 62:405-11. 2013
    ..C23 might be a promising chemotherapeutic agent against T. cruzi because its trypanocidal action involves the disruption of mitochondrion, a specific target of Trypanosomatides. ..
  7. doi request reprint Trypanocidal action of eupomatenoid-5 is related to mitochondrion dysfunction and oxidative damage in Trypanosoma cruzi
    Karin Juliane Pelizzaro-Rocha
    Programa de Pós Graduação em Microbiologia, Universidade Estadual de Londrina, Londrina, PR, Brazil
    Microbes Infect 13:1018-24. 2011
    ..Thus, the trypanocidal action of eupomatenoid-5 may be associated with mitochondrial dysfunction and oxidative damage, which can trigger destructive effects on biological molecules of T. cruzi, leading to parasite death...
  8. ncbi request reprint Ultrastructural alterations induced by the neolignan dihydrobenzofuranic eupomatenoid-5 on epimastigote and amastigote forms of Trypanosoma cruzi
    Patrícia Shima Luize
    Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Avenida Colombo, 5790, BR 87020 900, Maringa, PR, Brazil
    Parasitol Res 100:31-7. 2006
    ..Furthermore, intense cytoplasmic vacuolization and autophagic vacuoles were observed in T. cruzi intracellular amastigotes after 72 h of incubation. Scanning electron microscopy confirmed the alterations in the shape of the parasites...
  9. doi request reprint Antileishmanial activity of 5-methyl-2,2' : 5',2″-terthiophene isolated from Porophyllum ruderale is related to mitochondrial dysfunction in Leishmania amazonensis
    Helena Teru Takahashi
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, PR, Brazil
    Planta Med 79:330-3. 2013
    ..Further studies should be performed employing compounds A and B for the development of new drugs for chemotherapy of leishmaniasis...
  10. ncbi request reprint In vitro activity of essential oil from Ocimum gratissimum L. against four Candida species
    Celso Vataru Nakamura
    Laboratorio de Microbiologia, Departamento de Analises Clinicas, Universidade Estadual de Maringa, 87020 900 Maringa, PR, Brazil
    Res Microbiol 155:579-86. 2004
    ..Bud formation in the yeasts was impaired in treated cells. The essential oil of O. gratissimum is a potential candidate as a phytotherapeutic agent in some fungal diseases and for the control of fungi in the environment...
  11. doi request reprint Activity of spray-dried microparticles containing pomegranate peel extract against Candida albicans
    Eliana Harue Endo
    Post graduate Program in Pharmaceutical Sciences, Universidade Estadual de Maringa, Av Colombo 5790, Maringa 87020 900, Parana, Brazil
    Molecules 17:10094-107. 2012
    ..The spray-drying process preserved the antifungal activity against Candida albicans. These results could be useful for developing dosage forms for treating candidiasis, and should be further investigated in in vivo models...
  12. ncbi request reprint Antileishmanial activity of Eugenol-rich essential oil from Ocimum gratissimum
    Tania Ueda-Nakamura
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Brazil
    Parasitol Int 55:99-105. 2006
    ..The essential oil showed no cytototoxic effects against mammalian cells. This set of results suggests that O. gratissimum essential oil and its compounds could be used as sources for new antileishmanial drugs...
  13. pmc Trypanocidal action of (-)-elatol involves an oxidative stress triggered by mitochondria dysfunction
    Vânia Cristina Desoti
    Postgraduate Program in Pharmaceutical Sciences, State University of Maringa, Colombo Avenue 5790, CEP 87020 900, Maringa, Parana, Brazil
    Mar Drugs 10:1631-46. 2012
    ..Our hypothesis is that the mitochondrial dysfunction leads to an increase of ROS production through the electron transport chain, which affects cell membrane and DNA integrity leading to different types of parasite death...
  14. doi request reprint Trypanocidal activity of guaianolide obtained from Tanacetum parthenium (L.) Schultz-Bip. and its combinational effect with benznidazole
    Juliana Cogo
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    Phytomedicine 20:59-66. 2012
    ..Flow cytometry revealed a cell volume reduction and decrease in mitochondrial membrane potential. However, no major changes in cell membrane integrity were found in the epimastigote form treated with guaianolide...
  15. doi request reprint Antimicrobial activity of Piper gaudichaudianum Kuntze and its synergism with different antibiotics
    Mariele Caroline Marques Nogueira Puhl
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, PR CEP 87020 900, Brazil
    Molecules 16:9925-38. 2011
    ..Morphological changes in form and structure were found by scanning electron microscopy in S. aureus treated with the combination of fraction F2 with vancomycin...
  16. doi request reprint Antifungal activity and nail permeation of nail lacquer containing Piper regnellii (Miq.) C. CD. var. pallescens (C. DC.) Yunck (Piperaceae) leave extracts and derivatives
    Andrea Mayumi Koroishi
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Brazil
    Molecules 15:3920-31. 2010
    ..The specie P. regnellii showed great antifungal activity against T. rubrum, and nail lacquer containing its chloroform fraction has great potential to treat onychomycosis caused by these microorganisms...
  17. doi request reprint Antimicrobial and cytotoxic activities of medicinal plants of the Brazilian cerrado, using Brazilian cachaça as extractor liquid
    Cleyton E M de Toledo
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Av Colombo 5790, Maringa, Brazil
    J Ethnopharmacol 133:420-5. 2011
    ..Many species of plants in the Brazilian cerrado (savanna) are widely used in ethnomedicine. However, the safety and effectiveness of medicinal plants used in communities with little or no access to manufactured drugs should be evaluated...
  18. doi request reprint Antifungal effects of Ellagitannin isolated from leaves of Ocotea odorifera (Lauraceae)
    Mirian Ueda Yamaguchi
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, PR, Brazil
    Antonie Van Leeuwenhoek 99:507-14. 2011
    ..05). The use of O. odorifera in traditional medicine seems to have a valid basis, in view of the antifungal activity of TEL demonstrated in this study, and may contribute to potential drug development...
  19. doi request reprint Intramuscular and topical treatment of cutaneous leishmaniasis lesions in mice infected with Leishmania amazonensis using coumarin (-) mammea A/BB
    Tatiana Shioji Tiuman
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    Phytomedicine 19:1196-9. 2012
    ..These results indicate that the coumarin obtained from C. brasiliense is the antileishmanially active compound and can be used to control the development of cutaneous leishmaniasis lesions caused by L. amazonensis...
  20. doi request reprint Antileishmanial activity of a guaianolide from Tanacetum parthenium (L.) Schultz Bip
    Bruna Polacchine da Silva
    Programa de Pós graduação em Ciências Farmacêuticas da Universidade Estadual de Maringá, PR, Brazil
    Parasitol Int 59:643-6. 2010
    ..Morphological alterations of protozoans treated with IC(50) included changes in size, shape, and structure (more than one nucleus and flagellum) under both light and scanning electron microscopies...
  21. doi request reprint Activity of the extracts and neolignans from Piper regnellii against methicillin-resistant Staphylococcus aureus (MRSA)
    Flaviano João Basilio Marçal
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Brazil
    Molecules 15:2060-9. 2010
    ..regnellii extract provides preliminary scientific validation for the traditional medicinal use of this plant. The active compound eupomatenoid-5 should be further studied in animal models to verify in vivo efficacy and toxicity...
  22. pmc In vitro Cytotoxicity and Anti-herpes Simplex Virus Type 1 Activity of Hydroethanolic Extract, Fractions, and Isolated Compounds from Stem Bark of Schinus terebinthifolius Raddi
    Samara Requena Nocchi
    Post graduate Program in Pharmaceutical Sciences, State University of Maringa, Maringa, Parana, Brazil
    Pharmacogn Mag 12:160-4. 2016
    ..Schinus terebinthifolius is used in several illnesses and among them, for the topical treatment of skin wounds, especially wounds of mucous membranes, whether infected or not...
  23. doi request reprint Structure and antiviral activity of arabinogalactan with (1→6)-β-D-galactan core from Stevia rebaudiana leaves
    Arildo José Braz de Oliveira
    Departamento de Farmacia, Universidade Estadual de Maringa, Avenida Colombo, 5790, CEP 87 020 900, Maringa, PR, Brazil
    Carbohydr Polym 94:179-84. 2013
    ..The crude aqueous and alkaline extracts and homogeneous SSFK-10RM showed antiviral activity against Herpes Simplex Virus type-1 (HSV-1) in vitro...
  24. ncbi request reprint Isolation and characterization of a 30 kD antifungal protein from seeds of Sorghum bicolor
    Patricia Costa Mincoff
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Av Colombo, 5790, 87020 900 Maringa, PR, Brazil
    Res Microbiol 157:326-32. 2006
    ..No toxicity of the 30 kD protein to the culture of Hep2 cells at concentrations equal to or less than 1,000 microg/ml was observed...
  25. pmc Benzaldehyde thiosemicarbazone derived from limonene complexed with copper induced mitochondrial dysfunction in Leishmania amazonensis
    Elizandra Aparecida Britta
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Parana, Brazil
    PLoS ONE 7:e41440. 2012
    ..Treatment presents several problems, including high toxicity and many adverse effects, leading to the discontinuation of treatment and emergence of resistant strains...
  26. doi request reprint Thiophene derivatives with antileishmanial activity isolated from aerial parts of Porophyllum ruderale (Jacq.) Cass
    Helena Teru Takahashi
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Av Colombo, 5790, 87020 900, Maringa, PR, Brazil
    Molecules 16:3469-78. 2011
    ..3 and 28.7 μg/mL, respectively. The activity of the isolated compounds against promastigote and axenic amastigote forms was better than that of the crude extract and more selective against protozoa than for macrophage cells...
  27. pmc In Vitro and In Vivo Activities of 2,3-Diarylsubstituted Quinoxaline Derivatives against Leishmania amazonensis
    Vanessa Kaplum
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, PR, Brazil
    Antimicrob Agents Chemother 60:3433-44. 2016
    ....
  28. doi request reprint Synthesis and biological evaluation of novel 2,3-disubstituted quinoxaline derivatives as antileishmanial and antitrypanosomal agents
    Juliana Cogo
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Avenida Colombo 5790, 87020 900 Maringa, PR, Brazil
    Eur J Med Chem 90:107-23. 2015
    ..The current results indicate that these quinoxaline derivatives are novel and promising agents for further development towards a treatment for Chagas' disease and leishmaniasis...
  29. pmc Additional evidence of the trypanocidal action of (-)-elatol on amastigote forms through the involvement of reactive oxygen species
    Vânia Cristina Desoti
    Postgraduate Program in Pharmaceutical Sciences, State University of Maringa, Colombo Avenue 5790, Maringa, Parana CEP 87020 900, Brazil
    Mar Drugs 12:4973-83. 2014
    ..The results suggest that the trypanocidal action of (-)-elatol might involve the induction of the autophagic and apoptotic death pathways triggered by an imbalance of the parasite's redox metabolism. ..
  30. ncbi request reprint Biological effects of extracts obtained from Stryphnodendron adstringens on Herpetomonas samuelpessoai
    Fabíola Barbieri Holetz
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, 87020 900 Maringa, PR, Brazil
    Mem Inst Oswaldo Cruz 100:397-401. 2005
    ..Cells exposed to 538 microg/ml of crude extract at 28 degrees C for 72 h, showed decreased activity of the enzyme succinate cytochrome c reductase, a typical mitochondrion marker, as compared to untreated cells...
  31. doi request reprint Recent advances in leishmaniasis treatment
    Tatiana S Tiuman
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Av Colombo 5790, 87020 900 Maringa, Parana, Brazil
    Int J Infect Dis 15:e525-32. 2011
    ..These observations serve as a basis to indicate novel routes for the development and design of effective anti-Leishmania drugs...
  32. doi request reprint Antitrypanosomal and antileishmanial activities of novel N-alkyl-(1-phenylsubstituted-beta-carboline)-3-carboxamides
    Lilian T Düsman Tonin
    Departamento de Quimica, Universidade Estadual de Maringa, Avenida Colombo, 5790, Zona 7, 87020 900, Maringa, PR, Brazil
    Biomed Pharmacother 64:386-9. 2010
    ..cruzi and L. amazonensis activity was also evaluated. Our results pointed the synthesized beta-carboline-3-carboxamide derivatives as potential compounds for new drugs for Chagas' disease and leishmaniasis' treatment...
  33. pmc Dibenzylideneacetones Are Potent Trypanocidal Compounds That Affect the Trypanosoma cruzi Redox System
    Danielle Lazarin-Bidóia
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    Antimicrob Agents Chemother 60:890-903. 2016
    ..cruzi, reflected by lipid peroxidation and DNA fragmentation. Consequently, A3K2A1 and A3K2A3 induced vital alterations in T. cruzi, leading to parasite death through the three pathways, apoptosis, autophagy, and necrosis. ..
  34. pmc Mitochondrial Dysfunction Induced by N-Butyl-1-(4-Dimethylamino)Phenyl-1,2,3,4-Tetrahydro-β-Carboline-3-Carboxamide Is Required for Cell Death of Trypanosoma cruzi
    Hélito Volpato
    Programa de Pós Graduação em Ciências Biológicas Biologia Celular e Molecular, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    PLoS ONE 10:e0130652. 2015
    ..Our group recently reported the trypanocidal activity of the synthetic compound N-butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide (C4), but the mechanism of action of this compound was unclear...
  35. pmc Eupomatenoid-5 Isolated from Leaves of Piper regnellii Induces Apoptosis in Leishmania amazonensis
    Francielle Pelegrin Garcia
    Programa de Pós Graduação em Ciências Biológicas, Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Bloco B 08, Universidade Estadual de Maringa, Avenida Colombo 5790, 87020 900 Maringa, PR, Brazil
    Evid Based Complement Alternat Med 2013:940531. 2013
    ....
  36. pmc Mitochondria Superoxide Anion Production Contributes to Geranylgeraniol-Induced Death in Leishmania amazonensis
    Milene Valéria Lopes
    Programa de Pós Graduação em Ciências Farmacêuticas, Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Bloco B 08, Universidade Estadual de Maringa, Avenida Colombo 5790, 87020 900 Maringa, PR, Brazil
    Evid Based Complement Alternat Med 2012:298320. 2012
    ..Additionally, geranylgeraniol induces an increase in superoxide anion production. Collectively, our in vitro studies indicate geranylgeraniol as a selective antileishmanial that appears to be mediated by apoptosis-like cell death...
  37. doi request reprint Evaluation of the antiproliferative activity of the leaves from Arctium lappa by a bioassay-guided fractionation
    Fabio Bahls Machado
    Post graduate Program in Pharmaceutical Sciences, State University of Maringa, Av Colombo, 5790, BR 87020 900, Maringa, PR, Brazil
    Molecules 17:1852-9. 2012
    ..The compounds tested in Caco-2 cells showed the following CC(50) (µg/mL) values: 1: 19.7 ± 3.4, 1 with 2: 24.6 ± 1.5, 2 with 3: 27 ± 11.7, 1 with 4: 42 ± 13.1, 6 30 ± 6.2; compound 5 showed no activity...
  38. doi request reprint Synergistic effects of parthenolide and benznidazole on Trypanosoma cruzi
    Karin Juliane Pelizzaro-Rocha
    Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    Phytomedicine 18:36-9. 2010
    ..Parthenolide induced morphological alterations in the body shape of trypomastigote forms, causing rounding and shortening of the parasite and loss of integrity of the plasma membrane, as previously described by other workers...
  39. doi request reprint Potent antifungal activity of extracts and pure compound isolated from pomegranate peels and synergism with fluconazole against Candida albicans
    Eliana Harue Endo
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Av Colombo, 5790, 87020 900 Maringa, PR, Brazil
    Res Microbiol 161:534-40. 2010
    ....
  40. ncbi request reprint Visualization of the cytostome in Trypanosoma cruzi by high resolution field emission scanning electron microscopy using secondary and backscattered electron imaging
    Celso Vatarunakamura
    Laboratorio de Microbiologia, Departamento de Analises Clinicas, Universidade Estadual de Maringa, 87020 900 PR, Brasil
    FEMS Microbiol Lett 242:227-30. 2005
    ..However, the extent of binding was much higher in the region of the cytostome. The results obtained show that high resolution scanning electron microscopy is a powerful technique for analyzing the surface of protozoa...
  41. ncbi request reprint A3K2A3-induced apoptotic cell death of Leishmania amazonensis occurs through caspase- and ATP-dependent mitochondrial dysfunction
    Francielle Pelegrin Garcia
    Programa de Pós Graduação em Ciências Biológicas, Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Universidade Estadual de Maringa, Bloco B 08, Av Colombo 5790, Maringa, PR, CEP 87020 900, Brazil
    Apoptosis . 2016
    ..Altogether, these findings indicate that apoptosis can indeed be triggered by chemotherapeutic agents...
  42. doi request reprint 1,3,4-Thiadiazole derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones cause death in Trypanosoma cruzi through oxidative stress
    Solange C Martins
    Programa de Pós Graduação em Ciências Biológicas, Universidade Estadual de Maringa, Av Colombo 5790, CEP 87020 900, Maringa, Parana, Brazil
    Microbes Infect . 2016
    ..The in vivo study found a reduction of parasitemia in animals treated with TDZ 2 alone or combined with benznidazole. Altogether, the alterations induced by TDZ 2 point to an oxidative stress condition that lead to T. cruzi cell death...
  43. ncbi request reprint Antiviral Activity of Crude Hydroethanolic Extract from Schinus terebinthifolia against Herpes simplex Virus Type 1
    Samara Requena Nocchi
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, PR, Brazil
    Planta Med . 2016
    ..Liquid chromatography-diode array detector-mass spectrometry and MS/MS identified 25 substances, which are condensed tannins mainly produced by a B-type linkage and prodelphinidin and procyanidin units...
  44. doi request reprint 4-Nitrobenzaldehyde thiosemicarbazone: a new compound derived from S-(-)-limonene that induces mitochondrial alterations in epimastigotes and trypomastigotes of Trypanosoma cruzi
    Elizandra Aparecida Britta
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, PR, Avenida Colombo, 5790, Jd Universitário, Maringa, Parana 87020 900, Brazil
    Parasitology 142:978-88. 2015
    ..Our results suggest that BZTS alters the ultrastructure and physiology of mitochondria, which could be closely related to parasite death. ..
  45. pmc Cell death in amastigote forms of Leishmania amazonensis induced by parthenolide
    Tatiana Shioji Tiuman
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Av, Colombo 5790, 87020 900 Maringa, Parana, Brazil
    BMC Microbiol 14:152. 2014
    ..Therefore, new, effective, and less toxic leishmaniasis treatments are still needed. We verified cell death in amastigote forms of Leishmania amazonensis induced by the sesquiterpene lactone parthenolide...
  46. doi request reprint Ultraviolet (UVB and UVA) photoprotector activity and percutaneous penetration of extracts obtained from Arrabidaea chica
    Jackeline T G Siraichi
    Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringa, Av Colombo, 5790, 87020 900 Maringa, PR, Brazil
    Appl Spectrosc 67:1179-84. 2013
    ..chica provides substantial protection against UVA + UVB radiation with a possible advantage of being natural and free of inorganic compounds compared with the majority of available commercial sunscreens. ..
  47. doi request reprint Safety evaluation of proanthocyanidin polymer-rich fraction obtained from stem bark of Stryphnodendron adstringens (BARBATIMAO) for use as a pharmacological agent
    Marco Antonio Costa
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    Regul Toxicol Pharmacol 58:330-5. 2010
    ..7±0.6, 7.7±0.6, and 5.7±1.2 survival, i.e., F2 did not inhibit 50% of the population when compared to the control (9.7±0.6). These results indicated that F2 obtained from stem bark of S. adstringens has no genotoxic activity...
  48. doi request reprint Evaluation of antileishmanial activity of eupomatenoid-5, a compound isolated from leaves of Piper regnellii var. pallescens
    Michele Cristina Vendrametto
    Programa de Pós Graduação em Ciências Farmacêuticas, Departamento de Analises Clinicas, Universidade Estadual de Maringa, Av Colombo 5790, Parana, Brazil
    Parasitol Int 59:154-8. 2010
    ..amazonensis...
  49. doi request reprint Synthesis and evaluation of novel hybrids β-carboline-4-thiazolidinones as potential antitumor and antiviral agents
    Valéria Aquilino Barbosa
    Departamento de Quimica, Universidade Estadual de Maringa, Av Colombo, 5790, 87020 900 Maringa, PR, Brazil
    Eur J Med Chem 124:1093-1104. 2016
    ..80, 2.15 and 2.02 μM, respectively. The assay results showed that the nature of 4-thiazolidinone moiety and of the substituent attached at the 3- and 1- position of β-carboline nucleus influenced the antitumor and antiviral activities...
  50. pmc Preparation of Spray-Dried Soy Isoflavone-Loaded Gelatin Microspheres for Enhancement of Dissolution: Formulation, Characterization and in Vitro Evaluation
    Gean Pier Panizzon
    Pharmaceutical Sciences Postgraduate Program, Department of Pharmacy, State University of Maringa, Av Colombo, 5790, Maringa, 87020 900, PR, Brazil
    Pharmaceutics 6:599-615. 2014
    ..The results indicated that SE microencapsulation might offer a good system to control SI release, as an alternative to improve bioavailability and industrial applications...
  51. doi request reprint Formulation and Evaluation of a Mucoadhesive Thermoresponsive System Containing Brazilian Green Propolis for the Treatment of Lesions Caused by Herpes Simplex Type I
    Renata Sespede Mazia
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    J Pharm Sci 105:113-21. 2016
    ....
  52. pmc The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process
    Vânia Cristina Desoti
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, PR, Brasil
    PLoS ONE 10:e0144033. 2015
    ..Our hypothesis is that the vitamin K3 + vitamin C combination induces oxidative imbalance in T. cruzi, probably started by a redox cycling process that leads to parasite cell death. ..
  53. pmc Antifungal activity of pomegranate peel extract and isolated compound punicalagin against dermatophytes
    Simone R Foss
    Post graduation in Microbiology, Universidade Estadual de Londrina, Londrina, PR, Brazil
    Ann Clin Microbiol Antimicrob 13:32. 2014
    ..The hydroalcoholic extract of pomegranate fruit peel showed activity against the dermatophyte fungi Trichophyton mentagrophytes, T. rubrum, Microsporum canis and M. gypseum...
  54. pmc Structural changes and differentially expressed genes in Pseudomonas aeruginosa exposed to meropenem-ciprofloxacin combination
    Vera Lúcia Dias Siqueira
    Postgraduate Program in Pharmaceutical Sciences, State University of Maringa, Maringa, Parana, Brazil Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringa, Parana, Brazil
    Antimicrob Agents Chemother 58:3957-67. 2014
    ..The effect of this antimicrobial combination may be not only the result of a summation of the effects of meropenem and ciprofloxacin but also a result of differential action that likely inhibits protective mechanisms in the bacteria. ..
  55. pmc A quinoxaline derivative as a potent chemotherapeutic agent, alone or in combination with benznidazole, against Trypanosoma cruzi
    Jean Henrique da Silva Rodrigues
    Programa de Pós Graduação em Ciências Biológicas Biologia Celular e Molecular, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    PLoS ONE 9:e85706. 2014
    ....
  56. doi request reprint In vitro activity of the essential oil of Cymbopogon citratus and its major component (citral) on Leishmania amazonensis
    Marta Regina Santin
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, PR, Brazil
    Parasitol Res 105:1489-96. 2009
    ..This study revealed that citral-rich essential oil from C. citratus has promising antileishmanial properties, and is a good candidate for further research to develop a new anti-protozoan drug...
  57. ncbi request reprint Antileishmanial activity of crude extract and coumarin from Calophyllum brasiliense leaves against Leishmania amazonensis
    Mislaine Adriana Brenzan
    Pós Graduação em Ciências Farmacêuticas, Maringa, PR, Brazil
    Parasitol Res 101:715-22. 2007
    ..amazonensis and caused important changes in the parasite's ultrastructure. This study provided new perspectives on the development of novel drugs with leishmanicidal activity obtained from natural products...
  58. ncbi request reprint Virulence and antibiotic susceptibility of Aeromonas spp. isolated from drinking water
    Denise de Oliveira Scoaris
    Programa de Pós Graduação em Microbiologia, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Pr 445 Km 380, Cx Postal 6001, 86051 990, Londrina, PR, Brazil
    Antonie Van Leeuwenhoek 93:111-22. 2008
    ..The majority of the isolates tested were not killed by chlorine at 1.2 mg/l. Whether the high tolerance to chlorine of Aeromonas isolates can be linked to greater virulence is not know...
  59. doi request reprint Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis
    Mislaine Adriana Brenzan
    Pós Graduação em Ciências Farmacêuticas, Departamento de Farmácia e Farmacologia, Universidade Estadual de Maringa, Av Colombo 5790, 87020 900 Maringa, PR, Brazil
    Biomed Pharmacother 62:651-8. 2008
    ..3, 0.6, 34.0 and 22.2 microM, respectively. Interestingly, compound (3) showed the most antileishmanial activity of all. This study demonstrated that several aspects of the structure were important for antileishmanial activity...
  60. doi request reprint Chemical Composition and Antimicrobial Properties of Piper ovatum Vahl
    Daniel Rodrigues Silva
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Maringa, Parana, Brazil
    Molecules 14:1171-82. 2009
    ..Amides were identified as piperovatine and piperlonguminine, and showed MIC values of 15.6 and 31.2 microg/mL to B. subtilis and 3.9 microg/mL to C. tropicalis, and low toxic effects to Vero cells and macrophages...