Luciane P Gaspar

Summary

Affiliation: Rio de Janeiro
Country: Brazil

Publications

  1. doi request reprint Pressure-inactivated yellow fever 17DD virus: implications for vaccine development
    Luciane P Gaspar
    Programa de Vacinas Virais, Instituto de Tecnologia em Imunobiologicos, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    J Virol Methods 150:57-62. 2008
  2. ncbi request reprint The fusogenic state of Mayaro virus induced by low pH and by hydrostatic pressure
    Monica Freitas
    Programa de Biologia Estrutural, Instituto de Bioquimica Medica, Centro Nacional de Ressonância Magnêtica Nuclear de Macromolêculas Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Cell Biochem Biophys 44:325-35. 2006
  3. doi request reprint Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation
    Evanilce Ferreira
    Programa de Vacinas Virais, Instituto de Tecnologia em Imunobiologicos, Fundacao Oswaldo Cruz, Rio de Janeiro 21045 900, Brazil
    Vaccine 27:5332-7. 2009
  4. ncbi request reprint Structure of the Ebola fusion peptide in a membrane-mimetic environment and the interaction with lipid rafts
    Monica S Freitas
    Programa de Biologia Estrutural, Instituto de Bioquimica Medica, Centro Nacional de Ressonancia Magnetica Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, 21941 590 Rio de Janeiro, RJ, Brazil
    J Biol Chem 282:27306-14. 2007
  5. doi request reprint An inactivated yellow fever 17DD vaccine cultivated in Vero cell cultures
    Renata C Pereira
    Oswaldo Cruz Foundation FIOCRUZ, Bio Manguinhos, Avenida Brasil 4365, 21045 900, Rio de Janeiro, RJ, Brazil
    Vaccine 33:4261-8. 2015
  6. doi request reprint Increasing Vero viable cell densities for yellow fever virus production in stirred-tank bioreactors using serum-free medium
    Diogo A Mattos
    Bio Manguinhos Fiocruz, Technological Development Vice directory, Rio de Janeiro, RJ, Brazil
    Vaccine 33:4288-91. 2015
  7. ncbi request reprint Hydrostatic pressure induces the fusion-active state of enveloped viruses
    Luciane P Gaspar
    Programa de Biologia Estrutural, Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Centro Nacional de Ressonância Magnética Nuclear de Macromoléculas, Universidade Federal do Rio de Janeiro, 21941 590 Rio de Janeiro, RJ, Brazil
    J Biol Chem 277:8433-9. 2002

Collaborators

  • Debora Foguel
  • Jerson L Silva
  • Marlon V Silva
  • Diogo A Mattos
  • Renata C Pereira
  • Marcos S Freire
  • Evanilce Ferreira
  • Monica S Freitas
  • Monica Freitas
  • Marta Cristina O Souza
  • Elena Caride
  • Anna M Y Yamamura
  • Andréa N M R Silva
  • Andrea A M V Silva
  • Patrícia P C C Neves
  • Miguel A O Herrera
  • Leda R Castilho
  • Denise D C S Matos
  • Ricardo Galler
  • Ygara S Mendes
  • Andréa C Oliveira
  • Luzineide W Tinoco
  • Marcius S Almeida
  • Léo Degrève
  • Fabio C L Almeida
  • Ana Paula Valente
  • Marcos Lorenzoni
  • Lenize F Maia
  • Moacyr A Rebello
  • Ortrud M Barth
  • Andrea T Da Poian

Detail Information

Publications7

  1. doi request reprint Pressure-inactivated yellow fever 17DD virus: implications for vaccine development
    Luciane P Gaspar
    Programa de Vacinas Virais, Instituto de Tecnologia em Imunobiologicos, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    J Virol Methods 150:57-62. 2008
    ..The data warrant further development of pressure-inactivated vaccine against YF...
  2. ncbi request reprint The fusogenic state of Mayaro virus induced by low pH and by hydrostatic pressure
    Monica Freitas
    Programa de Biologia Estrutural, Instituto de Bioquimica Medica, Centro Nacional de Ressonância Magnêtica Nuclear de Macromolêculas Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Cell Biochem Biophys 44:325-35. 2006
    ..In parallel, we used a neutralization assay to show that Mayaro virus in the fusogenic state retained most of the original immunogenic properties and could elicit high titers of neutralizing antibodies...
  3. doi request reprint Effects of hydrostatic pressure on the stability and thermostability of poliovirus: a new method for vaccine preservation
    Evanilce Ferreira
    Programa de Vacinas Virais, Instituto de Tecnologia em Imunobiologicos, Fundacao Oswaldo Cruz, Rio de Janeiro 21045 900, Brazil
    Vaccine 27:5332-7. 2009
    ....
  4. ncbi request reprint Structure of the Ebola fusion peptide in a membrane-mimetic environment and the interaction with lipid rafts
    Monica S Freitas
    Programa de Biologia Estrutural, Instituto de Bioquimica Medica, Centro Nacional de Ressonancia Magnetica Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, 21941 590 Rio de Janeiro, RJ, Brazil
    J Biol Chem 282:27306-14. 2007
    ..Our data shed light on the structural "domains" of fusion peptides and provide a clue for the development of a drug that might block the early steps of viral infection...
  5. doi request reprint An inactivated yellow fever 17DD vaccine cultivated in Vero cell cultures
    Renata C Pereira
    Oswaldo Cruz Foundation FIOCRUZ, Bio Manguinhos, Avenida Brasil 4365, 21045 900, Rio de Janeiro, RJ, Brazil
    Vaccine 33:4261-8. 2015
    ..In addition, animals immunized with inactivated vaccine showed survival rate of 100% after the challenge as well as animals immunized with commercial attenuated 17DD vaccine...
  6. doi request reprint Increasing Vero viable cell densities for yellow fever virus production in stirred-tank bioreactors using serum-free medium
    Diogo A Mattos
    Bio Manguinhos Fiocruz, Technological Development Vice directory, Rio de Janeiro, RJ, Brazil
    Vaccine 33:4288-91. 2015
    ..A modified cultivation process with four changes has resulted in higher cell densities and higher virus titers than previously observed for 17DD YFV. ..
  7. ncbi request reprint Hydrostatic pressure induces the fusion-active state of enveloped viruses
    Luciane P Gaspar
    Programa de Biologia Estrutural, Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Centro Nacional de Ressonância Magnética Nuclear de Macromoléculas, Universidade Federal do Rio de Janeiro, 21941 590 Rio de Janeiro, RJ, Brazil
    J Biol Chem 277:8433-9. 2002
    ..Our data strengthen the hypothesis that the native conformation of fusion proteins is metastable, and a cycle of pressure leads to a final state, the fusion-active state, of smaller volume...