Nilton Lincopan

Summary

Country: Brazil

Publications

  1. pmc First isolation of metallo-beta-lactamase-producing multiresistant Klebsiella pneumoniae from a patient in Brazil
    Nilton Lincopan
    Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Avenida Professor Lineu Prestes 580, Butanta, CEP 05508 900, Sao Paulo SP, Brazil
    J Clin Microbiol 43:516-9. 2005
  2. doi Balanoposthitis caused by Pseudomonas aeruginosa co-producing metallo-beta-lactamase and 16S rRNA methylase in children with hematological malignancies
    Nilton Lincopan
    Department of Microbiology, Institute of Biomedical Sciences, Universidade de Sao Paulo, Sao Paulo, Brazil
    Int J Infect Dis 14:e344-7. 2010
  3. pmc Silica-based cationic bilayers as immunoadjuvants
    Nilton Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Caixa Postal 26077, Sao Paulo SP, Brazil
    BMC Biotechnol 9:5. 2009
  4. doi Draft genome sequence of a CTX-M-15-producing Klebsiella pneumoniae sequence type 340 (clonal complex 258) isolate from a food-producing animal
    Louise Cerdeira
    Department of Clinical Analysis, School of Pharmacy, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Glob Antimicrob Resist 7:67-68. 2016
  5. doi Novel immunoadjuvants based on cationic lipid: Preparation, characterization and activity in vivo
    Nilton Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Caixa Postal 26077, 05513 970 Sao Paulo, Brazil
    Vaccine 27:5760-71. 2009
  6. ncbi Low nephrotoxicity of an effective amphotericin B formulation with cationic bilayer fragments
    Nilton Lincopan
    Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, CP 66083, Avenida Lineu Prestes 580 Butantã, CEP 05315 970, Sao Paulo, Brazil
    J Antimicrob Chemother 55:727-34. 2005
  7. ncbi Toxicity of an effective amphotericin B formulation at high cationic lipid to drug molar ratio
    Nilton Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CP 26077, Avenida Lineu Prestes 748 Butantã, CEP 05513 970 Sao Paulo, Brazil
    Exp Toxicol Pathol 58:175-83. 2006
  8. ncbi Lipid-covered drug particles: combined action of dioctadecyldimethylammonium bromide and amphotericin B or miconazole
    Nilton Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de São Paulo CP 26077, Avenida Lineu Prestes 748 Butantã, CEP 05513 970, Sao Paulo SP, Brazil
    J Antimicrob Chemother 58:66-75. 2006
  9. doi Silent dissemination of colistin-resistant Escherichia coli in South America could contribute to the global spread of the mcr-1 gene
    Miriam R Fernandes
    Department of Clinical Analysis, School of Pharmacy, Universidade de Sao Paulo, Sao Paulo, Brazil
    Euro Surveill 21:. 2016
  10. pmc Draft Genome Sequence of a Hospital-Associated Clone of Klebsiella pneumoniae ST340/CC258 Coproducing RmtG and KPC-2 Isolated from a Pediatric Patient
    Louise Cerdeira
    Department of Clinical Analysis, School of Pharmacy, Universidade de Sao Paulo, Sao Paulo, Brazil
    Genome Announc 4:. 2016

Collaborators

  • Milena Dropa
  • Maria Helena B da Costa
  • Gabriel Gutkind
  • Primavera Borelli
  • Ana Maria Carmona-Ribeiro
  • Eliana Aparecida Varanda
  • Ana C Gales
  • Cristina Reinert
  • Beny Spira
  • Louise Cerdeira
  • Miriam R Fernandes
  • Susan Ienne
  • Ketrin C Silva
  • Maria Fernanda C Bueno
  • Tiago A Souza
  • Doroti de Oliveira Garcia
  • Nzi André Konan
  • Andrea M Moreno
  • Ketrin Cristina da Silva
  • Doroti de O Garcia
  • Terezinha Knobl
  • Luciana Sartori
  • Gabriela R Francisco
  • Fernanda Esposito
  • Quézia Moura
  • Helena Turano
  • Maria H Matte
  • Elfriede Marianne Bacchi
  • Mirela Caroline Vilela de Oliveira
  • Andrea Micke Moreno
  • Marcos Paulo Vieira Cunha
  • Cleise Ribeiro Gomes
  • Gabriela Rodrigues Francisco
  • Maria Gabriela Xavier de Oliveira
  • John A McCulloch
  • Marco A Vianello
  • Mariza Landgraf
  • Luciana K Otutumi
  • Carlos Cabrera
  • Micheli Medeiros
  • Tiago A de Souza
  • Maria Fc Bueno
  • Ralf Lopes
  • Daniel Fm Monte
  • Maria I Z Sato
  • Paula J Pérez-Chaparro
  • Daniela D Gonçalves
  • Fernando Gomes
  • Débora P A Lira
  • Marcos Pv Cunha
  • Silvane Oliveira
  • Marina Moreno
  • Lívia C Fontes
  • Elsa M Mamizuka
  • Ingrit Elida Collantes Diaz
  • João Gustavo Pessini Amarante Mendes
  • Jacqueline de Fátima Jacysyn
  • Mirtes Midori Tanae Tiba
  • Soraya Duarte Varela

Detail Information

Publications25

  1. pmc First isolation of metallo-beta-lactamase-producing multiresistant Klebsiella pneumoniae from a patient in Brazil
    Nilton Lincopan
    Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Avenida Professor Lineu Prestes 580, Butanta, CEP 05508 900, Sao Paulo SP, Brazil
    J Clin Microbiol 43:516-9. 2005
    ..We here report, for the first time, the detection of a metalloenzyme (IMP-1)-producing K. pneumoniae clinical strain in Latin America. The gene responsible for this phenotype was found to be bla(IMP-1), carried in a class 1 integron...
  2. doi Balanoposthitis caused by Pseudomonas aeruginosa co-producing metallo-beta-lactamase and 16S rRNA methylase in children with hematological malignancies
    Nilton Lincopan
    Department of Microbiology, Institute of Biomedical Sciences, Universidade de Sao Paulo, Sao Paulo, Brazil
    Int J Infect Dis 14:e344-7. 2010
    ..Furthermore, co-production of metallo-beta-lactamase and 16S rRNA methylase has a potential impact on the empirical management of complicated infections caused by P. aeruginosa...
  3. pmc Silica-based cationic bilayers as immunoadjuvants
    Nilton Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Caixa Postal 26077, Sao Paulo SP, Brazil
    BMC Biotechnol 9:5. 2009
    ....
  4. doi Draft genome sequence of a CTX-M-15-producing Klebsiella pneumoniae sequence type 340 (clonal complex 258) isolate from a food-producing animal
    Louise Cerdeira
    Department of Clinical Analysis, School of Pharmacy, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Glob Antimicrob Resist 7:67-68. 2016
    ..In this study, we present the draft genome sequence of a CTX-M-15-producing ST340 K. pneumoniae strain isolated from a food-producing animal in Brazil...
  5. doi Novel immunoadjuvants based on cationic lipid: Preparation, characterization and activity in vivo
    Nilton Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Caixa Postal 26077, 05513 970 Sao Paulo, Brazil
    Vaccine 27:5760-71. 2009
    ..The novel cationic adjuvant/protein complexes revealed good colloid stability and potential for vaccine design at a reduced DODAB concentration...
  6. ncbi Low nephrotoxicity of an effective amphotericin B formulation with cationic bilayer fragments
    Nilton Lincopan
    Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, CP 66083, Avenida Lineu Prestes 580 Butantã, CEP 05315 970, Sao Paulo, Brazil
    J Antimicrob Chemother 55:727-34. 2005
    ..Evaluation of nephrotoxicity of a novel amphotericin B (AMB) formulation with dioctadecyldimethylammonium bromide (DODAB) bilayer fragments (DOD/AMB)...
  7. ncbi Toxicity of an effective amphotericin B formulation at high cationic lipid to drug molar ratio
    Nilton Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CP 26077, Avenida Lineu Prestes 748 Butantã, CEP 05513 970 Sao Paulo, Brazil
    Exp Toxicol Pathol 58:175-83. 2006
    ..The majority of the toxic effects observed for the novel formulation were due to the DODAB carrier used at 10mg/mL, i.e., at a rather high concentration and further studies should minimize DODAB dose...
  8. ncbi Lipid-covered drug particles: combined action of dioctadecyldimethylammonium bromide and amphotericin B or miconazole
    Nilton Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de São Paulo CP 26077, Avenida Lineu Prestes 748 Butantã, CEP 05513 970, Sao Paulo SP, Brazil
    J Antimicrob Chemother 58:66-75. 2006
    ..Coverage of antifungal drug particles (miconazole and amphotericin B) with cationic lipid and evaluation of a synergistic action between lipid and drug...
  9. doi Silent dissemination of colistin-resistant Escherichia coli in South America could contribute to the global spread of the mcr-1 gene
    Miriam R Fernandes
    Department of Clinical Analysis, School of Pharmacy, Universidade de Sao Paulo, Sao Paulo, Brazil
    Euro Surveill 21:. 2016
    ..coli by European travellers visiting Latin American countries. ..
  10. pmc Draft Genome Sequence of a Hospital-Associated Clone of Klebsiella pneumoniae ST340/CC258 Coproducing RmtG and KPC-2 Isolated from a Pediatric Patient
    Louise Cerdeira
    Department of Clinical Analysis, School of Pharmacy, Universidade de Sao Paulo, Sao Paulo, Brazil
    Genome Announc 4:. 2016
    ..The multidrug-resistant strain coproduced the 16S rRNA methyltransferase rRNA RmtG and β-lactamases KPC-2 and CTX-M-15...
  11. ncbi Extended-spectrum beta-lactamases among Enterobacteriaceae isolated in a public hospital in Brazil
    Milena Dropa
    Public Health Laboratory, School of Public Health, University of Sao Paulo, Sao Paulo, SP, Brazil
    Rev Inst Med Trop Sao Paulo 51:203-9. 2009
    ..pneumoniae in some hospital wards, and also that some strongly related strains were identified in different hospital wards, suggesting clonal spread in the institutional environment...
  12. doi Draft genome sequence of an aminoglycoside-resistant RmtG-producing Pseudomonas aeruginosa ST235 isolated from a cystic fibrosis patient
    Maria Fernanda C Bueno
    Center of Bacteriology, Instituto Adolfo Lutz, Sao Paulo, Brazil
    J Glob Antimicrob Resist . 2017
    ..Whole-genome sequencing analysis revealed a 6.7 Mb genome size and the presence of 12 antibiotic resistance genes, including the rmtG gene conferring high-level aminoglycoside resistance, located on the chromosome...
  13. doi Complex class 1 integrons harboring CTX-M-2-encoding genes in clinical Enterobacteriaceae from a hospital in Brazil
    Milena Dropa
    School of Public Health, University of Sao Paulo, Sao Paulo, Brazil
    J Infect Dev Ctries 9:890-7. 2015
    ..The spread of CTX-M lies in their ability to be mobilized by insertion sequences and integrons. This study aimed to identify the mobile genetic structures associated with bla(CTX-M) genes from clinical Enterobacteriaceae strains...
  14. doi Cytotoxicity of cashew flavonoids towards malignant cell lines
    Nzi André Konan
    Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Exp Toxicol Pathol 64:435-40. 2012
    ..The two latter ones were only mildly affected by agathisflavone. It is also shown that agathisflavone induces apoptosis in Jurkat cells and it this proposed that this is the likely mechanism of agathisflavone specific cytotoxicity...
  15. ncbi Protein assembly onto cationic supported bilayers
    Nilton Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Caixa Postal 26077, São Paulo SF, Brazil
    J Nanosci Nanotechnol 9:3578-86. 2009
    ....
  16. pmc First Report of the Globally Disseminated IncX4 Plasmid Carrying the mcr-1 Gene in a Colistin-Resistant Escherichia coli Sequence Type 101 Isolate from a Human Infection in Brazil
    Miriam R Fernandes
    Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Antimicrob Agents Chemother 60:6415-7. 2016
    ..These results suggest that self-transmissible IncX4-type plasmids may represent promiscuous plasmids contributing to the intercontinental spread of the mcr-1 gene. ..
  17. doi Genetic background of novel sequence types of CTX-M-8- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae from public wastewater treatment plants in São Paulo, Brazil
    Milena Dropa
    Public Health Laboratory, School of Public Health, University of Sao Paulo, Avenida Dr Arnaldo 715, Cerqueira Cesar, 01146 904, Sao Paulo, SP, Brazil
    Environ Sci Pollut Res Int 23:4953-8. 2016
    ....
  18. doi Presence of high-risk clones of OXA-23-producing Acinetobacter baumannii (ST79) and SPM-1-producing Pseudomonas aeruginosa (ST277) in environmental water samples in Brazil
    Helena Turano
    Department of Microbiology, Institute of Biomedical Sciences, Universidade de Sao Paulo, Sao Paulo, Brazil
    Diagn Microbiol Infect Dis 86:80-2. 2016
    ..These findings indicate that urban rivers can act as reservoirs of clinically important multidrug-resistant bacteria, which constitute a potential risk to human and animal health. ..
  19. doi Draft genome sequence of an environmental multidrug-resistant Klebsiella pneumoniae ST340/CC258 harbouring blaCTX-M-15 and blaKPC-2 genes
    Louise Cerdeira
    Department of Clinical Analysis, School of Pharmacy, Universidade de Sao Paulo, Sao Paulo, Brazil Electronic address
    J Glob Antimicrob Resist . 2017
    ....
  20. doi High-virulence CMY-2- and CTX-M-2-producing avian pathogenic Escherichia coli strains isolated from commercial turkeys
    Ketrin Cristina da Silva
    Department of Preventive Veterinary Medicine and Animal Health, University of Sao Paulo, College of Veterinary Medicine and Zootechny, Sao Paulo, Brazil
    Diagn Microbiol Infect Dis 87:64-67. 2017
    ..coli. Furthermore, to the best of our knowledge, this is the first complete sequence of a CMY-2-encoding plasmid derived from an Escherichia coli isolated from food-producing animals in Latin America...
  21. pmc First Characterization of CTX-M-15-Producing Escherichia coli Strains Belonging to Sequence Type (ST) 410, ST224, and ST1284 from Commercial Swine in South America
    Ketrin C Silva
    Department of Preventive Medicine and Animal Health, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Antimicrob Agents Chemother 60:2505-8. 2016
    ....
  22. pmc Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil
    Milena Dropa
    School of Public Health, University of Sao Paulo, Sao Paulo, Brazil
    Antimicrob Agents Chemother 59:1815-7. 2015
    ..Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime. ..
  23. ncbi In vivo activity of a novel amphotericin B formulation with synthetic cationic bilayer fragments
    Nilton Lincopan
    Departamento de Analises Clinicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Brazil
    J Antimicrob Chemother 52:412-8. 2003
    ..From spleen and kidneys tissue burden experiments, similar efficacy of both preparations in reducing tissue cfu counts was obtained. In summary, DODAB/AMB was as effective as DOC/AMB for treating systemic candidiasis in a mouse model...
  24. ncbi Acute, subacute toxicity and genotoxic effect of a hydroethanolic extract of the cashew (Anacardium occidentale L.)
    Nzi André Konan
    Departamento de Farmacia, Universidade de Sao Paulo, CP 66083, Av Prof Lineu, Prestes 580, B 15 São Paulo 05508 900, SP, Brazil
    J Ethnopharmacol 110:30-8. 2007
    ..The extract was shown to induce frameshift, base pair substitution and damage to the chromosomes. However, this effect was less deleterious than the clastogenic effect of ciclophosphamide...
  25. ncbi Enterobacteria producing extended-spectrum beta-lactamases and IMP-1 metallo-beta-lactamases isolated from Brazilian hospitals
    Nilton Lincopan
    J Med Microbiol 55:1611-3. 2006