Wagner F Gattaz

Summary

Country: Brazil

Publications

  1. doi request reprint Low platelet iPLA₂ activity predicts conversion from mild cognitive impairment to Alzheimer's disease: a 4-year follow-up study
    Wagner F Gattaz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Neural Transm (Vienna) 121:193-200. 2014
  2. pmc Stigma toward schizophrenia: do all psychiatrists behave the same? Latent profile analysis of a national sample of psychiatrists in Brazil
    Alexandre Andrade Loch
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, R Dr Ovidio Pires de Campos, 785, 3º andar, ala Norte, sala 1, São Paulo CEP 05403 000, Brazil
    BMC Psychiatry 13:92. 2013
  3. doi request reprint Increased PLA2 activity in the hippocampus of patients with temporal lobe epilepsy and psychosis
    Wagner F Gattaz
    Laboratory of Neuroscience LIM27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, Brazil
    J Psychiatr Res 45:1617-20. 2011
  4. pmc Loss of interest, depressed mood and impact on the quality of life: cross-sectional survey
    Valeri D Guajardo
    Department of Psychiatry, Institute of Psychiatry of Clinics Hospital, University of Sao Paulo, Brazil
    BMC Public Health 11:826. 2011
  5. ncbi request reprint Decreased S100-beta protein in schizophrenia: preliminary evidence
    W F Gattaz
    Laboratory of Neurosciences LIM 27, Department and Institute of Psychiatry, Faculty of Medicine of the University São Paulo, 01060 970, Sao Paulo, Brazil
    Schizophr Res 43:91-5. 2000
  6. ncbi request reprint Olanzapine versus flupenthixol in the treatment of inpatients with schizophrenia: a randomized double-blind trial
    W F Gattaz
    Department and Institute of Psychiatry, Laboratory of Neuroscience LIM 27, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos s n, PO Box 3671, 05403 010 Sao Paulo, Brazil
    Pharmacopsychiatry 37:279-85. 2004
  7. ncbi request reprint Childhood meningitis, brain maturation and the risk of psychosis
    Wagner F Gattaz
    Department of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Eur Arch Psychiatry Clin Neurosci 254:23-6. 2004
  8. ncbi request reprint [Münchhausen syndrome: diagnosis and management]
    Wagner F Gattaz
    Instituto Central de Saúde Mental, Mannheim, Brasil
    Rev Assoc Med Bras (1992) 49:220-4. 2003
  9. ncbi request reprint Platelet phospholipase A(2) activity in Alzheimer's disease and mild cognitive impairment
    W F Gattaz
    Laboratory of Neuroscience, University of Sao Paulo, Brazil
    J Neural Transm (Vienna) 111:591-601. 2004
  10. doi request reprint Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis
    Daniel Martins-de-Souza
    Laboratorio de Neurociencias, Faculdade de Medicina da USP, Instituto de Psiquiatria, Universidade de Sao Paulo, Rua Dr Ovidio Pires de Campos, no 785, s n Consolação, Sao Paulo, SP, CEP 05403 010, Brazil
    J Neural Transm (Vienna) 116:275-89. 2009

Detail Information

Publications111 found, 100 shown here

  1. doi request reprint Low platelet iPLA₂ activity predicts conversion from mild cognitive impairment to Alzheimer's disease: a 4-year follow-up study
    Wagner F Gattaz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Neural Transm (Vienna) 121:193-200. 2014
    ..Moreover, low sPLA₂ and cPLA₂ were related to cognitive decline in healthy controls, suggesting a relationship with the very early stages of the disease...
  2. pmc Stigma toward schizophrenia: do all psychiatrists behave the same? Latent profile analysis of a national sample of psychiatrists in Brazil
    Alexandre Andrade Loch
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, R Dr Ovidio Pires de Campos, 785, 3º andar, ala Norte, sala 1, São Paulo CEP 05403 000, Brazil
    BMC Psychiatry 13:92. 2013
    ..The aim of this investigation was to search for profiles of stigmatizing beliefs related to schizophrenia in a national sample of psychiatrists in Brazil...
  3. doi request reprint Increased PLA2 activity in the hippocampus of patients with temporal lobe epilepsy and psychosis
    Wagner F Gattaz
    Laboratory of Neuroscience LIM27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, Brazil
    J Psychiatr Res 45:1617-20. 2011
    ....
  4. pmc Loss of interest, depressed mood and impact on the quality of life: cross-sectional survey
    Valeri D Guajardo
    Department of Psychiatry, Institute of Psychiatry of Clinics Hospital, University of Sao Paulo, Brazil
    BMC Public Health 11:826. 2011
    ..The objective of this study is to investigate H-RQOL in the presence of loss of interest and depressed mood at a general medical outpatient unit...
  5. ncbi request reprint Decreased S100-beta protein in schizophrenia: preliminary evidence
    W F Gattaz
    Laboratory of Neurosciences LIM 27, Department and Institute of Psychiatry, Faculty of Medicine of the University São Paulo, 01060 970, Sao Paulo, Brazil
    Schizophr Res 43:91-5. 2000
    ..Decreased S100beta could be related to the findings of increased PLA2 activity and to brain maldevelopment in schizophrenia. These results are discussed further with respect to the role of adenosine in S100beta release...
  6. ncbi request reprint Olanzapine versus flupenthixol in the treatment of inpatients with schizophrenia: a randomized double-blind trial
    W F Gattaz
    Department and Institute of Psychiatry, Laboratory of Neuroscience LIM 27, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos s n, PO Box 3671, 05403 010 Sao Paulo, Brazil
    Pharmacopsychiatry 37:279-85. 2004
    ..This exploratory double-blind 4-week study was designed to compare the efficacy and the safety of olanzapine (OLA) and flupenthixol (FLU) which have recently been considered as a "partially atypical" antipsychotics...
  7. ncbi request reprint Childhood meningitis, brain maturation and the risk of psychosis
    Wagner F Gattaz
    Department of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Eur Arch Psychiatry Clin Neurosci 254:23-6. 2004
  8. ncbi request reprint [Münchhausen syndrome: diagnosis and management]
    Wagner F Gattaz
    Instituto Central de Saúde Mental, Mannheim, Brasil
    Rev Assoc Med Bras (1992) 49:220-4. 2003
    ....
  9. ncbi request reprint Platelet phospholipase A(2) activity in Alzheimer's disease and mild cognitive impairment
    W F Gattaz
    Laboratory of Neuroscience, University of Sao Paulo, Brazil
    J Neural Transm (Vienna) 111:591-601. 2004
    ..Further longitudinal studies should investigate whether those MCI individuals with the lowest PLA(2) values in platelets would be at a higher risk to develop AD during a longitudinal follow up...
  10. doi request reprint Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis
    Daniel Martins-de-Souza
    Laboratorio de Neurociencias, Faculdade de Medicina da USP, Instituto de Psiquiatria, Universidade de Sao Paulo, Rua Dr Ovidio Pires de Campos, no 785, s n Consolação, Sao Paulo, SP, CEP 05403 010, Brazil
    J Neural Transm (Vienna) 116:275-89. 2009
    ....
  11. pmc Early improvement of psychotic symptoms with lithium monotherapy as a predictor of later response in mania
    Rafael T de Sousa
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, School of Medicine, University of São Paulo HC FMUSP, Rua Dr Ovidio Pires de Campos 785, 3rd floor N, CEP 05403 010, Sao Paulo, Brazil
    J Psychiatr Res 46:1564-8. 2012
    ..Lithium showed a similar efficacy in both psychosis and non-psychosis mania. Early improvement of psychotic symptoms was associated with clinical response and remission at endpoint...
  12. doi request reprint Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia
    Daniel Martins-de-Souza
    Laboratorio de Neurociencias, Instituto de Psiquiatria, Universidade de Sao Paulo, Rua Dr Ovidio Pires de Campos, no 785, Consolação, Sao Paulo, SP 05403 010, Brazil
    Eur Arch Psychiatry Clin Neurosci 259:151-63. 2009
    ..In addition a number of new potential markers were found that may contribute to the understanding of the pathogenesis of this complex disease...
  13. doi request reprint Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence
    Sheila P Gregorio
    Laboratório de Neurociências LIM 27, Departmento e Instituto de Psiquiatria, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    Psychiatry Res 165:1-9. 2009
    ..Although our results are preliminary, due to the small number of individuals analyzed, such an approach could reveal new candidate genes implicated in anomalous neurodevelopment in schizophrenia...
  14. ncbi request reprint Clinical and biological predictors of Alzheimer's disease in patients with amnestic mild cognitive impairment
    Orestes V Forlenza
    Department and Institute of Psychiatry, Universidade de Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 32:216-22. 2010
    ..To identify predictors of the progression from pre-dementia stages of cognitive impairment in Alzheimer's disease is relevant to clinical management and to substantiate the decision of prescribing antidementia drugs...
  15. doi request reprint Inhibition of phospholipase A2 in rat brain decreases the levels of total Tau protein
    Evelin L Schaeffer
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos, 785, Sao Paulo, SP, CEP 05403 010, Brazil
    J Neural Transm (Vienna) 118:1273-9. 2011
    ..The results indicate that in vivo PLA(2) inhibition in rat brain decreases the levels of total (nonphosphorylated plus phosphorylated) Tau protein and corroborate our previous in vitro findings...
  16. doi request reprint Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27 Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    Br J Psychiatry 198:351-6. 2011
    ..Two recent clinical studies support the feasibility of trials to evaluate the disease-modifying properties of lithium in Alzheimer's disease, although no benefits were obtained from short-term treatment...
  17. doi request reprint Proteome analysis of human dorsolateral prefrontal cortex using shotgun mass spectrometry
    Daniel Martins-de-Souza
    Laboratorio de Neurociencias, Instituto de Psiquiatria, Facultdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    J Sep Sci 31:3122-6. 2008
    ..It will also aid comparative studies of different brain areas and medical conditions, with future applications in basic and clinical research...
  18. doi request reprint Inhibition of phospholipase A2 increases tau phosphorylation at Ser214 in embryonic rat hippocampal neurons
    Vanessa J De-Paula
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Prostaglandins Leukot Essent Fatty Acids 82:57-60. 2010
    ..Tau hyperphosphorylation affects its ability to stabilize microtubules...
  19. pmc Increased Brain Lactate During Depressive Episodes and Reversal Effects by Lithium Monotherapy in Drug-Naive Bipolar Disorder: A 3-T 1H-MRS Study
    Rodrigo Machado-Vieira
    From the Laboratory of Neuroscience LIM 27, Institute and Department of Psychiatry, University of São Paulo Center for Interdisciplinary Research on Applied Neurosciences NAPNA, University of Sao Paulo, Sao Paulo, Brazil Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, NIH, Bethesda, MD and Laboratory of Magnetic Resonance in Neuroradiology LIM 44, Institute and Department of Radiology, University of Sao Paulo, São Paulo Department of Clinical Medicine and Translational Psychiatry Research Group Faculty of Medicine, Federal University of Ceara, Fortaleza and Laboratory of Psychiatric Neuroimaging LIM 21, Institute and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    J Clin Psychopharmacol . 2016
    ..This study aimed to evaluate cingulate cortex (CC) lactate using 3-T H-MRS during acute depressive episodes in BD and the possible effects induced by lithium monotherapy...
  20. pmc Regulation of leukocyte tricarboxylic acid cycle in drug-naïve Bipolar Disorder
    Rafael T de Sousa
    Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil Experimental Therapeutics and Pathophysiology Branch ETPB, National Institute of Mental Health, NIH, Bethesda, MD, USA
    Neurosci Lett 605:65-8. 2015
    ..Overall, these data suggest that the activities of the TCA cycle enzymes are not altered in major depressive episodes of recent-onset BD, which may support the concept of illness staging and neuroprogression in BD. ..
  21. ncbi request reprint Reduced cortical folding in schizophrenia: an MRI morphometric study
    Paulo C Sallet
    Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos s n, 05403 010 Sāo Paulo SP, Brazil
    Am J Psychiatry 160:1606-13. 2003
    ..The aim of the present study was to investigate cortical folding as an index of the neuronal wiring in different subtypes of schizophrenia...
  22. doi request reprint Long-term sertraline treatment increases expression and decreases phosphorylation of glycogen synthase kinase-3B in platelets of patients with late-life major depression
    Helena P G Joaquim
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, Sao Paulo, SP, Brazil
    J Psychiatr Res 46:1053-8. 2012
    ..The aim of the present study was to investigate the effect of short-and long-term sertraline treatment on the expression and phosphorylation of GSK3B in platelets of patients with late-life major depression...
  23. doi request reprint Reduced platelet amyloid precursor protein ratio (APP ratio) predicts conversion from mild cognitive impairment to Alzheimer's disease
    Isis A Zainaghi
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Neural Transm (Vienna) 119:815-9. 2012
    ..However, diagnostic accuracy was relatively low. Therefore, studies in larger samples are needed to determine whether APPr may warrant its use as a biomarker to support the early diagnosis of AD...
  24. doi request reprint Inhibition of phospholipase A₂ in rat brain modifies different membrane fluidity parameters in opposite ways
    Evelin L Schaeffer
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Doutor Ovídio Pires de Campos 785, 05403 010, Sao Paulo, SP, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 35:1612-7. 2011
    ..The findings suggest that reduced cPLA(2) and iPLA(2) activities in AD brain might contribute to the cognitive impairment, in part, through alterations in membrane fluidity parameters...
  25. doi request reprint Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer's disease
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    J Psychiatr Res 45:220-4. 2011
    ....
  26. ncbi request reprint Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder
    Sheila P Gregorio
    Laboratory of Neurosciences LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Schizophr Res 75:5-9. 2005
    ..Genotyping of primate samples, suggest that this polymorphism is a recent event in human speciation...
  27. doi request reprint Lithium increases platelet serine-9 phosphorylated GSK-3β levels in drug-free bipolar disorder during depressive episodes
    Rafael T de Sousa
    Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil
    J Psychiatr Res 62:78-83. 2015
    ..Also, the effect of lithium monotherapy on GSK3β has never been studied in humans...
  28. doi request reprint Decreased AKT1/mTOR pathway mRNA expression in short-term bipolar disorder
    Rodrigo Machado-Vieira
    Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil Center for Interdisciplinary Research on Applied Neurosciences NAPNA, University of Sao Paulo, Brazil Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, NIH, Bethesda, MD, United States Electronic address
    Eur Neuropsychopharmacol 25:468-73. 2015
    ....
  29. pmc Assessment of non-BDNF neurotrophins and GDNF levels after depression treatment with sertraline and transcranial direct current stimulation in a factorial, randomized, sham-controlled trial (SELECT-TDCS): an exploratory analysis
    Andre R Brunoni
    Center for Clinical and Epidemiological Research and Interdisciplinary Center for Applied Neuromodulation CINA, University Hospital, University of Sao Paulo, Sao Paulo, Brazil Service of Interdisciplinary Neuromodulation SIN, Department and Institute of Psychiatry, Faculty of Medicine of University of Sao Paulo, Sao Paulo, Brazil Laboratory of Neuroscience LIM27, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 56:91-6. 2015
    ..These data suggest that these neurotrophic factors are not surrogate biomarkers of treatment response or involved in the antidepressant mechanisms of tDCS...
  30. doi request reprint Reduced serum levels of adiponectin in elderly patients with major depression
    Breno S Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Psychiatr Res 46:1081-5. 2012
    ..Additional studies are required to determine whether this abnormality pertains to the pathophysiology of geriatric depression per se, or is a consequence of the morbid state...
  31. doi request reprint Does lithium prevent Alzheimer's disease?
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    Drugs Aging 29:335-42. 2012
    ....
  32. ncbi request reprint Mild cognitive impairment: cognitive screening or neuropsychological assessment?
    Breno Satler Diniz
    Psychogeriatric Clinic and Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, School of Medicine, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 30:316-21. 2008
    ..We further address the diagnostic properties of the Mini-Mental State Examination and the Cambridge Cognitive Examination for the identification of the different mild cognitive impairment subtypes in clinical practice...
  33. ncbi request reprint Inhibition of phospholipase A2 reduces neurite outgrowth and neuronal viability
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos s n, 05403 010 Sao Paulo, Brazil
    Prostaglandins Leukot Essent Fatty Acids 76:47-55. 2007
    ..We conclude that the functional integrity of both calcium-dependent and calcium-independent cytosolic PLA2 is necessary for the in vitro development of cortical and hippocampal neurons...
  34. doi request reprint Plasma levels of soluble TNF receptors 1 and 2 after tDCS and sertraline treatment in major depression: Results from the SELECT-TDCS trial
    Andre R Brunoni
    Center for Clinical and Epidemiological Research and Interdisciplinary Center for Applied Neuromodulation CINA, University Hospital, University of Sao Paulo, Sao Paulo, Brazil Service of Interdisciplinary Neuromodulation SIN, Department and Institute of Psychiatry, Faculty of Medicine of University of Sao Paulo, Sao Paulo, Brazil Laboratory of Neuroscience LIM27, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil Electronic address
    J Affect Disord 185:209-13. 2015
    ....
  35. pmc Bcl-2 rs956572 polymorphism is associated with increased anterior cingulate cortical glutamate in euthymic bipolar I disorder
    Márcio Gerhardt Soeiro-de-Souza
    Mood Disorders Unit GRUDA, Institute and Department of Psychiatry, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Neuropsychopharmacology 38:468-75. 2013
    ..The present findings reinforce a key role for glutamatergic system dysfunction in the pathophysiology of BD, potentially involving modulatory effects by Bcl-2 in the ACC...
  36. ncbi request reprint Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects
    Sheila Passos Gregorio
    Laboratory of Neurosciences LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil, and University Department of Psychiatry, H S Frederiksberg Hospital, Denmark
    Schizophr Res 88:275-82. 2006
    ..002, x2=9.46, OR=1.46, 95% CI 1.15-1.87) to be associated with schizophrenia. The consistency of this finding in two independent and unrelated populations reinforces the veracity of this association...
  37. ncbi request reprint Association between BanI genotype and increased phospholipase A2 activity in schizophrenia
    Nadia R Barbosa
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Doutor Ovídio Pires de Campos, no 785, Sao Paulo, SP, CEP 05403 010, Brazil
    Eur Arch Psychiatry Clin Neurosci 257:340-3. 2007
    ..004 for both). Our data suggest an association between BanI genotype and PLA2G4A activity in platelets and that the presence of the allele A2 may increase risk for schizophrenia through an increment of PLA2 activity...
  38. pmc Thalamic nuclear abnormalities as a contributory factor in sudden cardiac deaths among patients with schizophrenia
    Fulvio A Scorza
    Disciplina de Neurologia Experimental, Universidade Federal de Sao Paulo, Sao Paulo, Brasil
    Clinics (Sao Paulo) 65:539-46. 2010
    ..Based on the results of these prior studies, it is clear that further research regarding the relationship between the thalamus and sudden cardiac death is of vital importance...
  39. pmc Antidepressant Efficacy of Adjunctive Aerobic Activity and Associated Biomarkers in Major Depression: A 4-Week, Randomized, Single-Blind, Controlled Clinical Trial
    Cristiana Carvalho Siqueira
    Laboratory of Neuroscience LIM 27, Institute and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 11:e0154195. 2016
    ....
  40. pmc Bimodal effect of lithium plasma levels on hippocampal glutamate concentrations in bipolar II depression: a pilot study
    Marcus V Zanetti
    Mood Disorders Program, Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, University of Sao Paulo, Brazil Drs Zanetti, de Sousa, Gattaz, and Machado Vieira Center for Interdisciplinary Research on Applied Neurosciences NAPNA, University of Sao Paulo, Brazil Drs Zanetti, Gattaz, Busatto, and Machado Vieira Laboratory of Psychiatric Neuroimaging, LIM 21, Department and Institute of Psychiatry, University of Sao Paulo, Brazil Drs Zanetti and Busatto Department of Radiology, University of Sao Paulo, Brazil Drs Otaduy and Leite Experimental Therapeutics and Pathophysiology Branch ETPB, National Institute of Mental Health, NIH, Bethesda, MD Dr Machado Vieira
    Int J Neuropsychopharmacol 18:. 2014
    ..The hippocampus has been highly implicated in the pathophysiology of bipolar disorder (BD). Nevertheless, no study has longitudinally evaluated hippocampal metabolite levels in bipolar depression under treatment with lithium...
  41. pmc Lithium efficacy in bipolar depression with flexible dosing: A six-week, open-label, proof-of-concept study
    Rodrigo Machado-Vieira
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, School of Medicine, University of São Paulo HC FMUSP, Sao Paulo, Brazil Center for Interdisciplinary Research on Applied Neurosciences NAPNA, University of Sao Paulo, Sao Paulo, Brazil
    Exp Ther Med 8:1205-1208. 2014
    ..In the context of personalized psychiatric treatments, it is necessary to evaluate the therapeutic action of lithium with individual regimens in order to develop more tolerable and effective treatment approaches...
  42. doi request reprint Epistasis between COMT Val158Met and DRD3 Ser9Gly polymorphisms and cognitive function in schizophrenia: genetic influence on dopamine transmission
    Alexandre A Loch
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, Universidade de Sao Paulo, Sao Paulo, SP, BR
    Rev Bras Psiquiatr 37:235-41. 2015
    ....
  43. doi request reprint Cognitive impairment in late-life bipolar disorder is not associated with Alzheimer's disease pathological signature in the cerebrospinal fluid
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo
    Bipolar Disord 18:63-70. 2016
    ..In this study, we sought to determine whether cognitive impairment in elderly patients with BD is associated with the AD CSF bio-signature...
  44. doi request reprint Lithium increases leukocyte mitochondrial complex I activity in bipolar disorder during depressive episodes
    Rafael T de Sousa
    Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    Psychopharmacology (Berl) 232:245-50. 2015
    ..Also, lithium has been shown to increase ETC gene expression/activity in preclinical models and in postmortem brains of BD subjects, but to date, no study has evaluated lithium's direct effects on ETC activity in vivo...
  45. doi request reprint Leukocyte telomerase activity and antidepressant efficacy in bipolar disorder
    Márcio Gerhardt Soeiro-de-Souza
    Mood Disorders Program GRUDA, Institute and Department of Psychiatry, University of Sao Paulo, Brazil
    Eur Neuropsychopharmacol 24:1139-43. 2014
    ..Lithium׳s antidepressant effects may involve regulation at telomerase activity. Further studies with larger samples and long-term illness are also warranted. ..
  46. pmc BDNF plasma levels after antidepressant treatment with sertraline and transcranial direct current stimulation: results from a factorial, randomized, sham-controlled trial
    Andre R Brunoni
    Center for Clinical and Epidemiological Research and Interdisciplinary Center for Applied Neuromodulation CINA, University Hospital, University of Sao Paulo, Sao Paulo, Brazil Service of Interdisciplinary Neuromodulation SIN, Department and Institute of Psychiatry, Faculty of Medicine of University of Sao Paulo, Sao Paulo, Brazil Laboratory of Neuroscience LIM27, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil Electronic address
    Eur Neuropsychopharmacol 24:1144-51. 2014
    ..Finally, our findings do not support a relationship between BDNF and improvement of depression. ..
  47. ncbi request reprint Mild cognitive impairment. Part 1: clinical characteristics and predictors of dementia
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, Universidade de Sao Paulo USP, Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 35:178-85. 2013
    ..To critically review and evaluate existing knowledge on the conceptual limits and clinical usefulness of the diagnosis of mild cognitive impairment (MCI) and the neuropsychological assessment and short- and long-term prognosis thereof...
  48. pmc Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation
    Daniel Martins-de-Souza
    Laboratorio de Neurociencias, Instituto de Psiquiatria, Faculdade de Medicina da USP, Rua Dr, Ovídio Pires de Campos, no 785, Sao Paulo, SP, CEP 05403 010, Brazil
    BMC Psychiatry 9:17. 2009
    ..The superior temporal gyrus is implicated in schizophrenia and executes functions such as the processing of speech, language skills and sound processing...
  49. ncbi request reprint Abnormal APP processing in platelets of patients with Alzheimer's disease: correlations with membrane fluidity and cognitive decline
    Isis A Zainaghi
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Psychopharmacology (Berl) 192:547-53. 2007
    ..Platelets contain more than 95% of the circulating APP and enclose the enzymatic machinery for the APP metabolism yielding both soluble APP and amyloid-beta peptides...
  50. ncbi request reprint Effects of repetitive transcranial magnetic stimulation on auditory hallucinations refractory to clozapine
    Marina O Rosa
    Institute of Psychiatry, University of Sao Paulo, Faculty of Medicine, Sao Paulo SP, Brazil
    J Clin Psychiatry 68:1528-32. 2007
    ..To study the therapeutic effects on auditory hallucinations refractory to clozapine with 1-Hz repetitive transcranial magnetic stimulation (rTMS) applied on the left temporoparietal cortex...
  51. doi request reprint A Longitudinal (6-week) 3T (1)H-MRS Study on the Effects of Lithium Treatment on Anterior Cingulate Cortex Metabolites in Bipolar Depression
    Rodrigo Machado-Vieira
    Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil Center for Interdisciplinary Research on Applied Neurosciences NAPNA, University of Sao Paulo, Brazil Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, NIH, Bethesda, MD, United States Electronic address
    Eur Neuropsychopharmacol 25:2311-7. 2015
    ..The present findings reinforce a role for ACC glutamate-glutamine cycling and myoinositol pathway as key targets for lithium׳s therapeutic effects in BD. ..
  52. doi request reprint Leukocyte mitochondrial DNA copy number in bipolar disorder
    Rafael T de Sousa
    Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 48:32-5. 2014
    ..Also, the effects of lithium treatment on mtDNA content have never been evaluated in humans...
  53. doi request reprint Correlation between platelet and brain PLA(2) activity
    Leda L Talib
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Prostaglandins Leukot Essent Fatty Acids 89:265-8. 2013
    ....
  54. pmc Lithium increases nitric oxide levels in subjects with bipolar disorder during depressive episodes
    Rafael T de Sousa
    Laboratory of Neuroscience, LIM 27, Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    J Psychiatr Res 55:96-100. 2014
    ..Lithium has shown to regulate NO levels in preclinical models. However, no study has addressed peripheral NO levels in unmedicated BD. Also, lithium's effects on NO levels have not been studied in humans...
  55. pmc Oxidative stress in early stage Bipolar Disorder and the association with response to lithium
    Rafael T de Sousa
    Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil
    J Psychiatr Res 50:36-41. 2014
    ..However, no study has evaluated OxS parameters in unmedicated early stage BD and their association with lithium treatment in bipolar depression...
  56. ncbi request reprint Reduced phospholipid breakdown in Alzheimer's brains: a 31P spectroscopy study
    Orestes V Forlenza
    Laboratory of Neuroscience LIM 27 Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Doutor Ovídio Pires de Campos 785, 05403 010, Sao Paulo, SP, Brazil
    Psychopharmacology (Berl) 180:359-65. 2005
    ..We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD...
  57. pmc Increased cell proliferation in the rat anterior cingulate cortex following neonatal hypoxia: relevance to schizophrenia
    Evelin L Schaeffer
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Neural Transm (Vienna) 120:187-95. 2013
    ..The results of the present study on the one hand support the assumption of chronic hypoxia influencing transient cell proliferation in the ACC, and on the other hand reveal normalization during ageing...
  58. doi request reprint Reduced serum nerve growth factor in patients with late-life depression
    Breno S Diniz
    Laboratory of Neuroscience LIM 27, Department of Mental Health, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Am J Geriatr Psychiatry 21:493-6. 2013
    ..Nerve growth factor (NGF) is one of the most abundant neurotrophic factors in the central nervous system and has been involved in several neuropsychiatric disorders...
  59. doi request reprint A radioenzymatic assay to identify three groups of phospholipase A(2) in platelets
    Leda L Talib
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    Prostaglandins Leukot Essent Fatty Acids 86:149-53. 2012
    ....
  60. pmc Diagnosis and biomarkers of predementia in Alzheimer's disease
    Orestes V Forlenza
    Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    BMC Med 8:89. 2010
    ..We further address recent developments in biomarker research to support the early diagnosis and prediction of dementia, and point out the challenges and perspectives for the translation of research data into clinical practice...
  61. ncbi request reprint Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder
    Paula V Nunes
    Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Br J Psychiatry 190:359-60. 2007
    ..This is in accordance with reports that lithium inhibits crucial processes in the pathogenesis of Alzheimer's disease...
  62. doi request reprint Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease
    Evelin L Schaeffer
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    Psychopharmacology (Berl) 202:37-51. 2009
    ..Evidence suggests that reduced activity of specific subtypes of intracellular phospholipases A2 (cPLA2 and iPLA2) is an early event in AD and may contribute to memory impairment and neuropathology in the disease...
  63. doi request reprint Cognitive training increases platelet PLA2 activity in healthy elderly subjects
    Leda L Talib
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Prostaglandins Leukot Essent Fatty Acids 78:265-9. 2008
    ..Our results suggest that memory training may have a modulating effect in PLA(2)-mediated biological systems associated with cognitive functions and neurodegenerative diseases...
  64. ncbi request reprint Complex slow potential generators in a simplified attention paradigm
    Luis F H Basile
    Department of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Int J Psychophysiol 61:149-57. 2006
    ..We discuss the fact that group averaging may de-emphasize weakly but consistently active areas, and emphasize strongly but inconsistently active ones...
  65. ncbi request reprint Modulation of phospholipase A2 activity in primary cultures of rat cortical neurons
    C T Mendes
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    J Neural Transm 112:1297-308. 2005
    ..We present a model of pharmacological challenge of PLA2 in vitro, which can be further used to address the involvement of the enzyme in neurodevelopment and neurodegeneration models...
  66. ncbi request reprint The role of phospholipase A2 in neuronal homeostasis and memory formation: implications for the pathogenesis of Alzheimer's disease
    O V Forlenza
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Neural Transm 114:231-8. 2007
    ....
  67. doi request reprint BDNF blood levels after non-invasive brain stimulation interventions in major depressive disorder: a systematic review and meta-analysis
    Andre R Brunoni
    Laboratory of Neuroscience LIM27, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    World J Biol Psychiatry 16:114-22. 2015
    ..To evaluate whether the antidepressant effects of novel non-invasive brain stimulation (NIBS) therapies are associated with neurotrophic effects, indexed by peripheral brain-derived neurotrophic factor (BDNF) levels...
  68. doi request reprint Elevated neurotrophin-3 and neurotrophin 4/5 levels in unmedicated bipolar depression and the effects of lithium
    Alexandre A Loch
    Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 56:243-6. 2015
    ..Thus, we aimed to assess NT-3 and NT-4/5 levels in medication-free BD type I or II individuals in a current depressive episode, before and after 6 weeks of lithium monotherapy and matched with healthy controls...
  69. doi request reprint Long-term, low-dose lithium treatment does not impair renal function in the elderly: a 2-year randomized, placebo-controlled trial followed by single-blind extension
    Ivan Aprahamian
    Department and Institute of Psychiatry, Laboratory of Neuroscience LIM 27, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    J Clin Psychiatry 75:e672-8. 2014
    ..Although potentially effective for these purposes, chronic lithium use in regard to safety in the elderly needs to be better explored...
  70. doi request reprint Effects of antipsychotics with different weight gain liabilities on human in vitro models of adipose tissue differentiation and metabolism
    Andrea L Sertie
    Centro de Pesquisa Experimental, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Sao Paulo, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 35:1884-90. 2011
    ..On the other hand, the haloperidol-mediated downregulation of the lipogenic capacity of human adipose tissue may be a possible mechanism contributing to its lower propensity to induce serious metabolic side effects...
  71. pmc Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype
    Giselle Izzo
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 68:277-80. 2013
    ..In this study, we investigated the associations between single-nucleotide polymorphisms in GAB2 (rs2373115), GSK3B (rs6438552) and SORL1 (rs641120) and Alzheimer's disease (AD), both alone and in combination with the APOE*4 allele...
  72. ncbi request reprint Childhood meningitis increases the risk for adult schizophrenia
    André L Abrahao
    Departament of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010 Sao Paulo, SP, Brazil
    World J Biol Psychiatry 6:44-8. 2005
    ..We investigated the hypothesis that a meningitic infection in childhood may increase the risk of a psychiatric disorder in adulthood...
  73. doi request reprint Does BDNF genotype influence creative output in bipolar I manic patients?
    Márcio Gerhardt Soeiro-de-Souza
    Mood Disorders Unit GRUDA, Department and Institute of Psychiatry, School of Medicine, University of Sao Paulo IPq HC FMUSP, Brazil
    J Affect Disord 139:181-6. 2012
    ..We hypothesized that the Val allele is associated with increased creativity in bipolar disorder...
  74. ncbi request reprint Conjugated estrogens as adjuvant therapy in the treatment of acute schizophrenia: a double-blind study
    Mario R Louzã
    Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos s n, P O Box 3671, 05403 010 Sao Paulo, SP, Brazil
    Schizophr Res 66:97-100. 2004
    ..Our negative findings regarding the antipsychotic effect of conjugated estrogens does not preclude, however, a possible efficacy of other estrogens, such as 17-beta-estradiol, in schizophrenia...
  75. doi request reprint Circulating Glial-derived neurotrophic factor is reduced in late-life depression
    Breno S Diniz
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 3rd Floor, 05403 010 Sao Paulo, SP, Brazil
    J Psychiatr Res 46:135-9. 2012
    ..The Glial cell-line derived neurotrophic factor (GDNF) is part of the TGF-β superfamily and is abundantly expressed in the central nervous system. Changes in GDNF homeostasis have been reported in affective disorders...
  76. ncbi request reprint The Short Cognitive Performance Test (SKT): a preliminary study of its psychometric properties in Brazil
    Mariana K Flaks
    Laboratory of Neuroscience, Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Int Psychogeriatr 18:121-33. 2006
    ....
  77. doi request reprint Lithium increases plasma brain-derived neurotrophic factor in acute bipolar mania: a preliminary 4-week study
    Rafael T de Sousa
    Laboratory of Neurosciences LIM27, Department and Institute of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Neurosci Lett 494:54-6. 2011
    ..Further studies with larger samples and longer period may confirm whether this biological effect is involved in the therapeutic efficacy of lithium in BPD...
  78. ncbi request reprint Inhibition of platelet phospholipase A2 activity by catuaba extract suggests antiinflammatory properties
    Nadia R Barbosa
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Phytother Res 18:942-4. 2004
    ....
  79. ncbi request reprint Multifocal slow potential generation revealed by high-resolution EEG and current density reconstruction
    Luis F H Basile
    Laboratory of Neurosciences LIM 27, Department of Psychiatry, School of Medicine, University of Sao Paulo, Av Dr Ovidio Pires de Campus s n, P O Box 3671, Sao Paulo, SP 05403 010 Brazil
    Int J Psychophysiol 45:227-40. 2002
    ..We discuss our results with respect to new possibilities in large-scale cortical physiology and with respect to their application in psychiatry...
  80. ncbi request reprint The generators of slow potentials obtained during verbal, pictorial and spatial tasks
    Luis F H Basile
    Laboratory of Neurosciences LIM 27, Department of Psychiatry, Faculty of Medicine, University of Sao Paulo, Av Dr Ovidio Pires de Campos s n, P O Box 3671, Brazil
    Int J Psychophysiol 48:55-65. 2003
    ..We discuss our results emphasizing intersubject variability in cortical activity patterns and the possibility of finding more universal patterns...
  81. doi request reprint DNA polymorphisms as tools for spinal cord injury research
    P E M Guimarães
    Laboratório de Neurociências LIM27, Instituto de Psiquiatria, Faculdade de Medicina, Universidade de Sao Paulo, Brazil
    Spinal Cord 47:171-5. 2009
    ..Data mining of single nucleotide polymorphisms (SNPs) in gene pathways related to spinal cord injury (SCI)...
  82. ncbi request reprint Phospholipase A2 activity in rat embryonic brain and in primary cultures of cortical neurons
    O V Forlenza
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    J Neural Transm (Vienna) 109:623-31. 2002
    ..We believe that we have produced a useful model for the tissue culture study of PLA(2) metabolism and biochemistry, which can be further addressed to the investigation of the biology of neurodegenerative and neuropsychiatric disorders...
  83. ncbi request reprint Topographic abnormality of slow cortical potentials in schizophrenia
    L F H Basile
    Laboratório de Neurosciências LIM 27, Departamento de Psiquiatria, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 37:97-109. 2004
    ..We conclude that the slow potential topographic abnormalities of schizophrenia indicate an abnormality in the configuration of large-scale electrical activity in association cortices...
  84. ncbi request reprint Requirement of hippocampal phospholipase A2 activity for long-term memory retrieval in rats
    E L Schaeffer
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Neural Transm (Vienna) 114:379-85. 2007
    ..Because reduced PLA(2) activity has been found in Alzheimer's disease brains, the present results may be relevant to clarify at least part of the biology of this disorder...
  85. doi request reprint Conditioning training and retrieval increase phospholipase A(2) activity in the cerebral cortex of rats
    E L Schaeffer
    Department and Institute of Psychiatry, University of Sao Paulo, Rua Doutor Ovídio Pires de Campos, Sao Paulo, SP, Brazil
    J Neural Transm (Vienna) 116:41-50. 2009
    ..Because reduced brain PLA(2) activity has been reported in Alzheimer disease, our results suggest that stimulation of PLA(2) activity may offer new treatment strategies for this disease...
  86. ncbi request reprint Inhibition of phospholipase A2 activity reduces membrane fluidity in rat hippocampus
    E L Schaeffer
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    J Neural Transm 112:641-7. 2005
    ..03). This finding is of interest because reduction of brain membrane fluidity impairs memory formation and both decreased PLA2 activity and reduced membrane fluidity have been reported in the brain from patients with Alzheimer's disease...
  87. doi request reprint BDNF blood levels after electroconvulsive therapy in patients with mood disorders: a systematic review and meta-analysis
    Andre R Brunoni
    Laboratory of Neuroscience LIM27, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    World J Biol Psychiatry 15:411-8. 2014
    ..To evaluate whether electroconvulsive therapy (ECT), a very effective non-pharmacological treatment for mood disorders, induces neurotrophic effects, indexed by the measurement of peripheral brain-derived neurotrophic factor (BDNF) levels...
  88. pmc Cytokines plasma levels during antidepressant treatment with sertraline and transcranial direct current stimulation (tDCS): results from a factorial, randomized, controlled trial
    Andre R Brunoni
    Center for Clinical and Epidemiological Research and Interdisciplinary Center for Applied Neuromodulation CINA, University Hospital, University of Sao Paulo, Av Prof Lineu Prestes 2565, 3o andar, CEP 05508 000, Sao Paulo, Sao Paulo, Brazil
    Psychopharmacology (Berl) 231:1315-23. 2014
    ..Transcranial direct current stimulation (tDCS) is a novel, promising, non-invasive somatic treatment for depression, although its antidepressant mechanisms are only partly understood...
  89. ncbi request reprint Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory
    Evelin L Schaeffer
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Psychopharmacology (Berl) 181:392-400. 2005
    ..In mice, intraperitoneal injections of a selective iPLA(2) inhibitor impaired spatial learning. Accordingly, reduced cPLA(2) and iPLA(2) activities were found in postmortem hippocampus of patients with Alzheimer's disease...
  90. ncbi request reprint Increased phospholipase A2 activity in schizophrenia with absent response to niacin
    Hildeberto Tavares
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos s n, P O Box 3671, Brazil
    Schizophr Res 61:1-6. 2003
    ..The relationship between absent response to niacin in schizophrenia and increased PLA2 activity suggests further that the skin test may be useful to easily identify a subgroup of patients with a disordered phospholipid metabolism...
  91. pmc Plasma cortisol in first episode drug-naïve mania: differential levels in euphoric versus irritable mood
    Leandro L Valiengo
    Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of Sao Paulo, SP, Brazil
    J Affect Disord 138:149-52. 2012
    ..Therefore, the present study aims to evaluate plasma cortisol levels in drug-naïve BD subjects during the first manic episode, as well as investigate the relationship between plasma cortisol levels and manic symptomatology...
  92. ncbi request reprint Inhibition of cPLA2 and sPLA2 activities in primary cultures of rat cortical neurons by Centella asiatica water extract
    Patrícia P Defillipo
    Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Nat Prod Commun 7:841-3. 2012
    ..asiatica. This extract may be a candidate for the treatment of neurodegenerative processes because of its pharmacological activity in the brain and its low toxicity, as attested by its long popular use as a natural product...
  93. ncbi request reprint Transcranial magnetic stimulation accelerates the antidepressant effect of amitriptyline in severe depression: a double-blind placebo-controlled study
    Demetrio Ortega Rumi
    Institute of Psychiatry, University of Sao Paulo, Faculty of Medicine, Sao Paulo SP, Brazil
    Biol Psychiatry 57:162-6. 2005
    ..Three recent meta analyses strongly suggest its benefits in the treatment of depression. The present study investigates whether repetitive TMS (rTMS) accelerates the onset of action and increases the therapeutic effects of amitriptyline...
  94. ncbi request reprint Widespread electrical cortical dysfunction in schizophrenia
    Luis F H Basile
    University of Sao Paulo, Department of Psychiatry, Laboratory of Neurosciences LIM 27, Faculty of Medicine, Av Dr Ovidio Pires de Campos s n, P O Box 3671, Sao Paulo, SP 05403 010, Brazil
    Schizophr Res 69:255-66. 2004
    ..Our results agree with the hypothesis of schizophrenia as a syndrome resulting from abnormalities in multiple encephalic foci...
  95. doi request reprint Differential roles of phospholipases A2 in neuronal death and neurogenesis: implications for Alzheimer disease
    Evelin L Schaeffer
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010, Sao Paulo, SP, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 34:1381-9. 2010
    ..The findings suggest that the inhibition of cPLA(2) and iPLA(2) isoforms (yet to be determined) might contribute to impaired neurogenesis, whereas stimulation of sPLA(2)-IIA and cPLA(2)-IVA might contribute to neurodegeneration in AD...
  96. doi request reprint Meeting report: the Schizophrenia International Research Society (SIRS) South America Conference (August 5-7, 2011)
    Raffael Massuda
    Department of Psychiatry, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    Schizophr Res 137:1-6. 2012
    ..For information on the poster presentations, readers are referred to the special issue of Revista de Psiquiatria Clínica (Brazil) dedicated to the conference (available at: http://www.hcnet.usp.br/ipq/revista/vol38/s1/)...
  97. pmc Insights into Alzheimer disease pathogenesis from studies in transgenic animal models
    Evelin L Schaeffer
    Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Clinics (Sao Paulo) 66:45-54. 2011
    ..In summary, the Alzheimer disease mouse models have been the key to understanding the roles of soluble b-amyloid oligomers in disease pathogenesis, as well as of the relationship between p-amyloid and Tau pathologies...
  98. doi request reprint Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme
    Evelin L Schaeffer
    Department and Institute of Psychiatry, Laboratory of Neuroscience LIM 27, Faculty of Medicine, University of Sao Paulo, Rua Dr Ovidio Pires de Campos 785, 05403 010, Sao Paulo, SP, Brazil
    Psychopharmacology (Berl) 198:1-27. 2008
    ..Evidence suggests the involvement of phospholipase A(2) (PLA(2)) enzyme in memory impairment and neurodegeneration in AD via actions on both cholinergic and glutamatergic systems...
  99. ncbi request reprint Altered thalamic membrane phospholipids in schizophrenia: a postmortem study
    Andrea Schmitt
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 56:41-5. 2004
    ..This region might play an important role in the pathophysiology of schizophrenia and has not been studied thus far with respect to its membrane lipid composition...
  100. doi request reprint The neuroprotective effect of dental pulp cells in models of Alzheimer's and Parkinson's disease
    C Apel
    Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    J Neural Transm (Vienna) 116:71-8. 2009
    ..DPCs protected primary neurons in in vitro models of Alzheimer's and Parkinson's disease and can be viewed as possible candidates for studies on cell-based therapy...
  101. doi request reprint Lower doses of sublingual Zolpidem are more effective than oral Zolpidem to anticipate sleep onset in healthy volunteers
    Kette D Valente
    Laboratory of Clinical Neurophysiology, Institute of Psychiatry, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Sleep Med 14:20-3. 2013
    ..To compare the efficacy of sublingual Zolpidem (5 and 10mg) to conventional oral Zolpidem (10mg)...