Dimas T Covas

Summary

Country: Brazil

Publications

  1. ncbi request reprint The profile of gene expression of human marrow mesenchymal stem cells
    Wilson A Silva
    Center for Cell Therapy and Regional Blood Center, Department of Clinical Medicine, Faculty of Medicine, Ribeirao Preto, Brazil
    Stem Cells 21:661-9. 2003
  2. ncbi request reprint Knops blood group haplotypes among distinct Brazilian populations
    Dimas Tadeu Covas
    Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, SP, Brazil
    Transfusion 47:147-53. 2007
  3. pmc Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis
    Raquel Tognon
    Department of Clinical, Toxicological and Bromatological Analysis, University of Sao Paulo, Ribeirao Preto, Brazil
    J Hematol Oncol 5:2. 2012
  4. pmc DC-SIGN (CD209) gene promoter polymorphisms in a Brazilian population and their association with human T-cell lymphotropic virus type 1 infection
    Simone Kashima
    Regional Blood Center of Ribeirão Preto, University of Sao Paulo, Brazil
    J Gen Virol 90:927-34. 2009
  5. ncbi request reprint Gene frequencies of the HPA-3 and HPA-5 platelet antigen alleles among the Amerindians
    D T Covas
    Department of Clinical Medicine, University of S Paulo, Brazil
    Eur J Haematol 65:128-31. 2000
  6. ncbi request reprint Isolation and culture of umbilical vein mesenchymal stem cells
    D T Covas
    Centro de Terapia Celular CEPID FAPESP, Fundação Hemocentro de Ribeirão Preto, Centro Regional de Hemoterapia, Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 36:1179-83. 2003
  7. ncbi request reprint Complete nucleotide sequences of the genomes of two Brazilian specimens of human T lymphotropic virus type 2 (HTLV-2)
    Dimas Tadeu Covas
    Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, 14051 140 Brazil
    AIDS Res Hum Retroviruses 19:689-97. 2003
  8. ncbi request reprint High frequency of the GWG (Pro Trp) envelope variant of HIV-1 in Southeast Brazil
    D T Covas
    Regional Blood Center of Ribeirão Preto, and Faculty of Medicine of Ribeirão Preto, University of Sao Paulo, Brazil
    J Acquir Immune Defic Syndr Hum Retrovirol 19:74-9. 1998
  9. ncbi request reprint Effects of hydroxyurea on the membrane of erythrocytes and platelets in sickle cell anemia
    Dimas Tadeu Covas
    Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Centro de Terapia Celular, CEPID, FAPESP, Ribeirao Preto, SP, Brazil
    Haematologica 89:273-80. 2004
  10. ncbi request reprint Variation in the FcgammaR3B gene among distinct Brazilian populations
    D T Covas
    University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Tissue Antigens 65:178-82. 2005

Collaborators

  • Simone Kashima
  • Kamilla Swiech
  • Daniel G Pinheiro
  • Felipe Saldanha-Araujo
  • Vanderson Rocha
  • M A Zago
  • Rodrigo T Calado
  • Edson Z Martinez
  • Raquel Tognon
  • Israel T Silva
  • Yuetsu Tanaka
  • Virgínia Picanço-Castro
  • Karen L Prata
  • Rodrigo Haddad
  • Yves Durocher
  • Elisa Ms Russo-Carbolante
  • Amine Kamen
  • A A Machado
  • Amanda Mizukami
  • Rodrigo A Panepucci
  • Maristela D Orellana
  • Gislane L V de Oliveira
  • Patrícia V B Palma
  • Belinda P Simões
  • Kelen C R Malmegrim
  • Mariana T Pinto
  • Sâmia R Caruso
  • Lucas C M Arruda
  • Kalil A de Lima
  • Lucas E B Souza
  • Júlia T C de Azevedo
  • Julio C Voltarelli
  • Juliana N U Yaochite
  • Doralina G Brum
  • Diego V Clé
  • Aparecida M Fontes
  • Lucila H Oliveira
  • Márcia Z Bellini
  • Eduardo A Donadi
  • Lilian M Figueiredo
  • Svetoslav N Slavov
  • Amélia G Araújo
  • Ana C Silva-Pinto
  • Tathiane M Malta
  • Idalete da Silva
  • Wilson A Silva
  • Antonio Adilton O Carneiro
  • Jorge L C Siufi
  • Maria Carolina Oliveira
  • Carlos E B Couri
  • Carlos T Guerreiro
  • Amilton A Barreira
  • Vanessa D Marques
  • Maria C Oliveira
  • Ana Fernandes-Platzgummer
  • Cláudia L da Silva
  • Gabriela T Scortegagna
  • Joana G Carmelo
  • Evandra S Rodrigues
  • Wilson Araujo Silva
  • Joaquim M S Cabral
  • Claudia O Rodrigues
  • Danilo C Almeida
  • Antonio R Lucena-Araujo
  • Carolina Caliari-Oliveira
  • Amanda M Colombini
  • Pedro Oliva-Neto
  • Eduardo M Rego
  • Everton B O Costa
  • Josiane L Schiavinato
  • Maria C de Oliveira
  • Maria Florencia Tellechea
  • Mariane S Fráguas
  • Angela M Moraes
  • Virginia M D Wagatsuma
  • Kalil W A de Lima
  • Leandro F Dalmazzo
  • Ana Cristina Silva-Pinto
  • Maria do Carmo Favarin
  • Barbara Santana-Lemos
  • Jacques Elion
  • Flávia I S Ferreira
  • Taisa R Fernandes
  • Viviane C Oliveira
  • Cláudio A T Suazo
  • Regina H C Queiroz
  • Carolina Dias-Carlos
  • Osvaldo M Takayanagui
  • Anemarie R D Santos
  • Glauce G Gomes

Detail Information

Publications35

  1. ncbi request reprint The profile of gene expression of human marrow mesenchymal stem cells
    Wilson A Silva
    Center for Cell Therapy and Regional Blood Center, Department of Clinical Medicine, Faculty of Medicine, Ribeirao Preto, Brazil
    Stem Cells 21:661-9. 2003
    ....
  2. ncbi request reprint Knops blood group haplotypes among distinct Brazilian populations
    Dimas Tadeu Covas
    Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, SP, Brazil
    Transfusion 47:147-53. 2007
    ..To better elucidate the complexity of Knops group system, the frequency of six single-nucleotide polymorphisms (SNPs) in three Brazilian populations is determined...
  3. pmc Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis
    Raquel Tognon
    Department of Clinical, Toxicological and Bromatological Analysis, University of Sao Paulo, Ribeirao Preto, Brazil
    J Hematol Oncol 5:2. 2012
    ..We also tested whether the gene expression results were correlated with JAK2 V617F allele burden percentage, PRV1 overexpression, and clinical and laboratory parameters...
  4. pmc DC-SIGN (CD209) gene promoter polymorphisms in a Brazilian population and their association with human T-cell lymphotropic virus type 1 infection
    Simone Kashima
    Regional Blood Center of Ribeirão Preto, University of Sao Paulo, Brazil
    J Gen Virol 90:927-34. 2009
    ..In conclusion, the variation observed in SNPs -336 and -139 indicates that this lectin may be of crucial importance in the susceptibility/transmission of HTLV-1 infections...
  5. ncbi request reprint Gene frequencies of the HPA-3 and HPA-5 platelet antigen alleles among the Amerindians
    D T Covas
    Department of Clinical Medicine, University of S Paulo, Brazil
    Eur J Haematol 65:128-31. 2000
    ..The determination of gene frequencies of the HPA systems in different populations allows inference of gene flows and genetic constitution of populations and the estimation of the risk of platelet-specific alloimmunization...
  6. ncbi request reprint Isolation and culture of umbilical vein mesenchymal stem cells
    D T Covas
    Centro de Terapia Celular CEPID FAPESP, Fundação Hemocentro de Ribeirão Preto, Centro Regional de Hemoterapia, Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 36:1179-83. 2003
    ..Taken together, these findings indicate that the umbilical cord obtained from term deliveries is an important source of mesenchymal stem cells that could be used in cell therapy protocols...
  7. ncbi request reprint Complete nucleotide sequences of the genomes of two Brazilian specimens of human T lymphotropic virus type 2 (HTLV-2)
    Dimas Tadeu Covas
    Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, 14051 140 Brazil
    AIDS Res Hum Retroviruses 19:689-97. 2003
    ....
  8. ncbi request reprint High frequency of the GWG (Pro Trp) envelope variant of HIV-1 in Southeast Brazil
    D T Covas
    Regional Blood Center of Ribeirão Preto, and Faculty of Medicine of Ribeirão Preto, University of Sao Paulo, Brazil
    J Acquir Immune Defic Syndr Hum Retrovirol 19:74-9. 1998
    ..Two GFG sequences and 1 GLG sequence were also detected. This finding is relevant for the planning of vaccines and for studies of the epidemiology of HIV-1 in Brazil...
  9. ncbi request reprint Effects of hydroxyurea on the membrane of erythrocytes and platelets in sickle cell anemia
    Dimas Tadeu Covas
    Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Centro de Terapia Celular, CEPID, FAPESP, Ribeirao Preto, SP, Brazil
    Haematologica 89:273-80. 2004
    ..In this study we examine the expression of PS on the surface of erythrocytes and platelets of sickle cell anemia patients before and during treatment with hydroxyurea...
  10. ncbi request reprint Variation in the FcgammaR3B gene among distinct Brazilian populations
    D T Covas
    University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Tissue Antigens 65:178-82. 2005
    ..In general, these data reveal variability in the frequency of alleles of the FCGR3B gene compared to other populations of the same genetic background in other regions of the world...
  11. doi request reprint Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts
    Dimas T Covas
    Department of Clinical Medicine, Center for Cell Therapy and Regional Blood Center, University of Sao Paulo, Ribeirao Preto, Brazil
    Exp Hematol 36:642-54. 2008
    ....
  12. ncbi request reprint Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells
    Rodrigo A Panepucci
    Center for Cell Therapy and Regional Blood Center, Department of Clinical Medicine, Faculty of Medicine, Ribeirao Preto, Brazil
    Stem Cells 22:1263-78. 2004
    ....
  13. ncbi request reprint Mesenchymal stem cells can be obtained from the human saphena vein
    Dimas T Covas
    Regional Blood Center of Ribeirão Preto, University of Sao Paulo, Brazil Faculty of Medicine of Ribeirão Preto, University of Sao Paulo, Brazil
    Exp Cell Res 309:340-4. 2005
    ....
  14. doi request reprint Stirred tank bioreactor culture combined with serum-/xenogeneic-free culture medium enables an efficient expansion of umbilical cord-derived mesenchymal stem/stromal cells
    Amanda Mizukami
    Hemotherapy Center of Ribeirão Preto, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto SP, Brazil
    Biotechnol J 11:1048-59. 2016
    ....
  15. pmc Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-κB signalling
    Felipe Saldanha-Araujo
    National Institute of Science and Technology in Stem Cell and Cell Therapy, Center for Cell Therapy, Regional Blood Center and Faculty of Medicine, University of Sao Paulo FMRP USP, Ribeirao Preto, Brazil
    J Cell Mol Med 16:1232-44. 2012
    ....
  16. pmc Transcriptional profiling reveals intrinsic mRNA alterations in multipotent mesenchymal stromal cells isolated from bone marrow of newly-diagnosed type 1 diabetes patients
    Kalil A de Lima
    Center for Cell Based Research, Regional Blood Center of Ribeirão Preto, Ribeirao Preto Medical, University of Sao Paulo, Ribeirao Preto, Brazil
    Stem Cell Res Ther 7:92. 2016
    ..Thus, studies that investigate biological characteristics of MSCs isolated from T1D patients are essential to guide future clinical applications...
  17. doi request reprint Efficient expansion of mesenchymal stromal cells in a disposable fixed bed culture system
    Amanda Mizukami
    Hemotherapy Center of Ribeirão Preto, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, CEP 14051 140, Ribeirao Preto SP, Brazil
    Biotechnol Prog 29:568-72. 2013
    ....
  18. doi request reprint Hydroxycarbamide modulates components involved in the regulation of adenosine levels in blood cells from sickle-cell anemia patients
    Ana C Silva-Pinto
    National Institute of Science and Technology in Stem Cell and Cell Therapy INCTC, Center for Cell Therapy CTC and Regional Blood Center, Faculty of Medicine FMRP, University of Sao Paulo USP, Rua Tenente Catao Roxo, 2 501, Bairro Monte Alegre, Campus Universitario, Ribeirao Preto, Sao Paulo, 14051 140, Brazil
    Ann Hematol 93:1457-65. 2014
    ..Our results indicate a novel mechanism of action of HU mediated by the reduction of adenosine levels and its effects on pathophysiological processes in SCA. ..
  19. doi request reprint Growth and functional harvesting of human mesenchymal stromal cells cultured on a microcarrier-based system
    Sâmia R Caruso
    Hemotherapy Center of Ribeirão Preto, School of Medicine of Ribeirao Preto, University of Sao Paulo, Tenente Catão Roxo Street, 2501, CEP 14051 140, Ribeirao Preto SP, Brazil
    Biotechnol Prog 30:889-95. 2014
    ..These results represent an important step toward the implementation of a GMP-compliant large-scale production system for hMSCs for cellular therapy...
  20. doi request reprint Mesenchymal stromal cells up-regulate CD39 and increase adenosine production to suppress activated T-lymphocytes
    Felipe Saldanha-Araujo
    National Institute of Science and Technology in Stem Cell and Cell Therapy, Center for Cell Therapy, Regional Blood Center and Faculty of Medicine of Ribeirão Preto University of São Paulo, Ribeirao Preto, Brazil
    Stem Cell Res 7:66-74. 2011
    ..These findings may open new avenues for the development of new treatments for GVHD and other inflammatory diseases...
  21. doi request reprint Altered expression of degranulation-related genes in CD8+ T cells in human T lymphotropic virus type I infection
    Tathiane M Malta
    National Institute of Science and Technology in Stem Cell and Cell Therapy, Center for Cell Therapy and Regional Blood Center, Blood Center of Ribeirão Preto, Ribeirao Preto, Sao Paulo, Brazil
    AIDS Res Hum Retroviruses 29:826-36. 2013
    ..These results should be further tested with biological functional assays to increase our understanding on the role of these molecules in the development of HTLV-1-related diseases...
  22. doi request reprint Immunological correlates of favorable long-term clinical outcome in multiple sclerosis patients after autologous hematopoietic stem cell transplantation
    Lucas C M Arruda
    Center for Cell Based Therapy, Regional Blood Center of Ribeirão Preto, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil
    Clin Immunol 169:47-57. 2016
    ..Here, we suggest that along with increased numbers of regulatory T-cell subsets, PD-1 inhibitory signaling is one possible immunoregulatory mechanism by which AHSCT restores immune tolerance in MS patients. ..
  23. pmc Potential roles of microRNA-29a in the molecular pathophysiology of T-cell acute lymphoblastic leukemia
    Lucila H Oliveira
    Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Cancer Sci 106:1264-77. 2015
    ..Overall, our results suggest that reduced miR-29a levels may contribute to the altered epigenetic status of T-ALL, highlighting its relevance in the physiopathology of this disease. ..
  24. doi request reprint Bone marrow mesenchymal stromal cells isolated from multiple sclerosis patients have distinct gene expression profile and decreased suppressive function compared with healthy counterparts
    Gislane L V de Oliveira
    Center for Cell Based Research, Regional Blood Center of Ribeirão Preto, Ribeirao Preto Medical School, University of Sao Paulo USP, Ribeirao Preto, Sao Paulo, Brazil
    Cell Transplant 24:151-65. 2015
    ..We also demonstrated that treatment of MS patients with AHSCT does not reverse the transcriptional and functional alterations observed in patient MSCs. ..
  25. pmc Endothelial Mesenchymal Transition: Comparative Analysis of Different Induction Methods
    Mariana T Pinto
    Interdisciplinary Stem Cell Institute, University of Miami Leonard M Miller School of Medicine, Biomedical Research Building, 1501 NW 10th Avenue, Room 826, Miami, FL 33136 USA Instituto Nacional de Ciência e Tecnologia em Células Tronco e Terapia Celular e Fundação Hemocentro de Ribeirão Preto, Ribeirao Preto, SP Brazil Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de Sao Paulo, Ribeirao Preto, SP Brazil
    Biol Proced Online 18:10. 2016
    ..The aim of this study was to compare the induction of EndMT by TGF-β isoforms in endothelial cells of different sources, and define a detailed protocol for EndMT assessment in vitro...
  26. doi request reprint Intravenous administration of bone marrow-derived multipotent mesenchymal stromal cells enhances the recruitment of CD11b(+) myeloid cells to the lungs and facilitates B16-F10 melanoma colonization
    Lucas E B Souza
    Department of Clinical Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil Hemotherapy Center of Ribeirão Preto, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil Electronic address
    Exp Cell Res 345:141-9. 2016
    ....
  27. doi request reprint OP9 Stromal Cells Proteins Involved in Hematoendothelial Differentiation from Human Embryonic Stem Cells
    Lilian M Figueiredo
    1 Department of Clinical Medicine Ribeirão Preto Medical School, University of Sao Paulo, Brazil, 14040 900
    Cell Reprogram 17:338-46. 2015
    ..Our proteomic profiles provide valuable insight about the proteins involved in in vitro hematoendothelial cell generation and in the future they might be used to optimize the differentiation process and produce both cell types in vitro. ..
  28. doi request reprint Combining xanthan and chitosan membranes to multipotent mesenchymal stromal cells as bioactive dressings for dermo-epidermal wounds
    Márcia Z Bellini
    School of Chemical Engineering, University of Campinas UNICAMP, Campinas, SP, Brazil Integrated Adamantinenses Colleges FAI, Adamantina, SP, Brazil
    J Biomater Appl 29:1155-66. 2015
    ....
  29. pmc Can pluripotent stem cells be used in cell-based therapy?
    Virgínia Picanço-Castro
    Blood Center of Ribeirão Preto, Ribeirao Preto, Brazil, 14022 000
    Cell Reprogram 16:98-107. 2014
    ..We also focus on the potential of these cells in clinical trials, and we describe the clinical trials that are underway...
  30. doi request reprint Maturation of human iDCs by IL-18 plus PGE2, but not by each stimulus alone, induced migration toward CCL21 and the secretion of IL-12 and IFN-γ
    Idalete da Silva
    Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos e Centro de Química de Proteínas, Brazil
    Immunobiology 218:238-44. 2013
    ..This system can be used to prepare mDCs with properties useful for cell therapy and also as a model to investigate the mechanisms of cytokine secretion and cell migration...
  31. doi request reprint Intravenous infusion of allogeneic mesenchymal stromal cells in refractory or relapsed aplastic anemia
    Diego V Clé
    Department of Internal Medicine, University of São Paulo at Ribeirão Preto School of Medicine, Ribeirao Preto, SP, Brazil Center for Cell based Therapy, São Paulo Research Foundation FAPESP, Ribeirao Preto, SP, Brazil Electronic address
    Cytotherapy 17:1696-705. 2015
    ..For patients with aplastic anemia (AA) who are refractory to anti-thymocyte globulin (ATG) and cyclosporine, a second course of immunosuppression is successful in only one-fourth to one-third of cases...
  32. pmc Glycoprotein B genotyping of human cytomegalovirus strains isolated from Brazilian patients with sickle cell disease and beta-thalassemia major
    Svetoslav N Slavov
    1 Regional Blood Center of Ribeirão Preto, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil
    Viral Immunol 28:123-9. 2015
    ..The extensive HCMV gB2 prevalence in patients with hemoglobinopathies is probably due to HCMV epidemiologic characteristics in the examined region, and can be important during the clinical management of these patients. ..
  33. pmc Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII
    Kamilla Swiech
    Regional Blood Center of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    BMC Biotechnol 11:114. 2011
    ..4, 0.6 and 0.8 μg/106 cells) and repeated transfections done at 34° and 37 °C...
  34. ncbi request reprint Liver iron concentration evaluated by two magnetic methods: magnetic resonance imaging and magnetic susceptometry
    Antonio Adilton O Carneiro
    Departamento de Fisica e Matematica, FFCLRP, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Magn Reson Med 54:122-8. 2005
    ..95) was found between the LIC by MRI and by BLS. These results show the feasibility of using two noninvasive methodologies to evaluate liver iron store in a large concentration range. Both methodologies represent an equivalent precision...