Janete M Cerutti

Summary

Country: Brazil

Publications

  1. pmc Gene expression profiling of papillary thyroid carcinoma identifies transcripts correlated with BRAF mutational status and lymph node metastasis
    Gisele Oler
    Division of Genetics, Federal University of Sao Paulo, Sãp Paulo, Brazil
    Clin Cancer Res 14:4735-42. 2008
  2. pmc A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression
    Janete M Cerutti
    Laboratory of Molecular Endocrinology, Division of Endocrinology, Department of Medicine, Federal University of Sao Paulo, Brazil
    J Clin Invest 113:1234-42. 2004
  3. ncbi request reprint Diagnosis of suspicious thyroid nodules using four protein biomarkers
    Janete M Cerutti
    Department of Neurosurgery, Johns Hopkins University Medical School, Baltimore, Maryland 21231, USA
    Clin Cancer Res 12:3311-8. 2006
  4. ncbi request reprint [Nodule diagnosed as follicular patterned lesion: are biomarkers the promise?]
    Janete M Cerutti
    Departamento de Morfologia, Universidade Federal de Sao Paulo, SP, Brazil
    Arq Bras Endocrinol Metabol 51:832-42. 2007
  5. doi request reprint Extended RET gene analysis in patients with apparently sporadic medullary thyroid cancer: clinical benefits and cost
    Susan C Lindsey
    Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo 04039 032, Brazil
    Horm Cancer 3:181-6. 2012
  6. pmc ABI3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescence
    Flavia R M Latini
    Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics and Division of Endocrinology, Universidade Federal de Sao Paulo, SP, Brazil
    BMC Cancer 11:11. 2011
  7. pmc PVALB, a new Hürthle adenoma diagnostic marker identified through gene expression
    Janete M Cerutti
    Genetic Bases of Thyroid Tumor Laboratory, Federal University of Sao Paulo, Sao Paulo, SP, Brazil
    J Clin Endocrinol Metab 96:E151-60. 2011
  8. doi request reprint Genome-wide copy number analysis in a family with p.G533C RET mutation and medullary thyroid carcinoma identified regions potentially associated with a higher predisposition to lymph node metastasis
    Aline N Araujo
    Genetic Bases of Thyroid Tumors Laboratory A N A, L M, J M C, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de Sao Paulo, and Laboratory of Molecular and Translational Endocrinology M I C F, R M B M, Division of Endocrinology, Department of Medicine, Universidade Federal de Sao Paulo, São Paulo SP 04039 032, Brazil Center for Applied Genomics H H, J L, R P, The Children s Hospital of Philadelphia, Research Institute and Department of Pediatrics H H, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Clin Endocrinol Metab 99:E1104-12. 2014
  9. doi request reprint A ten-year clinical update of a large RET p.Gly533Cys kindred with medullary thyroid carcinoma emphasizes the need for an individualized assessment of affected relatives
    Priscila S Signorini
    Department of Medicine, Laboratory of Molecular and Translational Endocrinology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Clin Endocrinol (Oxf) 80:235-45. 2014
  10. ncbi request reprint Molecular profiling of matched samples identifies biomarkers of papillary thyroid carcinoma lymph node metastasis
    Janete M Cerutti
    Department of Neurosurgery, Johns Hopkins University Medical School, Baltimore, Maryland, USA
    Cancer Res 67:7885-92. 2007

Collaborators

  • Rui M B Maciel
  • Rosa Paula M Biscolla
  • Osmar Monte
  • Jin Li
  • Peng Huang
  • Sandro J de Souza
  • E T Kimura
  • L P Kowalski
  • Laura Sterian Ward
  • Sergio Verjovski-Almeida
  • Hugo P Monteiro
  • Maria Aparecida Nagai
  • Cleber P Camacho
  • Laís Moraes
  • Gisele Oler
  • Susan C Lindsey
  • Priscila S Signorini
  • Flavia R M Latini
  • Rosana Delcelo
  • Magnus R Dias-da-Silva
  • Flávia O F Valente
  • Ilda S Kunii
  • Beatriz C G Freitas
  • Gustavo S Guimaraes
  • Maria Isabel C V Cordioli
  • Maria Isabel C Vieira Cordioli
  • Daniela Rodrigues de Oliveira
  • Aline N Araujo
  • Maria Inez C França
  • Teresa S Kasamatsu
  • Marina M L Kizys
  • Suzete M Cerutti
  • Ana O Hoff
  • Maria Sharmila A Sousa
  • Jefferson Pessoa Hemerly
  • Gregory J Riggins
  • Daniela R Oliveira
  • Rosana Tamanaha
  • Pedro Michaluart
  • Emmanuel Dias-Neto
  • Eduardo M Reis
  • Claudia C D Nakabashi
  • Adriano N Cury
  • Luiza Sisdelli
  • Maria Teresa S Alves
  • Gianna Carvalheira
  • Adriana M Alvares Da Silva
  • Ileana Rubio
  • Ana Luiza R Galrão
  • Carlos A Longui
  • Adriano Namo Cury
  • Alberto L Machado
  • Renan Barreta Gaiardo
  • Camila P Salim
  • Hakon Hakonarson
  • Renata Pellegrino
  • Gizelda Maia Rêgo
  • Alberto J Cavalheiro
  • Cláudia R Zamberlam
  • Gisele Giannocco
  • Fausto Germano-Neto
  • Ji H Yang
  • Maria Clara C Melo
  • Michelle Y Harada
  • Marlyn Z Montoya
  • Joao Roberto M Martins
  • Mirian G Cardoso
  • Fernando A Soares
  • Misaki Y Sittoni
  • Jefferson P Hemerly
  • André Uchimura Bastos
  • Priscila F Sanada
  • L R Innocenti
  • A C Saragossa Filho
  • Flavio C Hojaij
  • Claudia D Nakabashi
  • Mariana N L Oliveira
  • Elza S Ikejiri
  • Andre L Carvalho
  • Francisco G Nobrega
  • Gloria M A Thompson
  • Mar Cleide Sogayar
  • Silvia E Matsuo
  • Fatima Solange Pasini
  • Gonçalo G Pereira
  • Maria Cristina R Costa
  • Tarcisio Peres
  • Maria Ines M C Pardini
  • Fabio Nunes
  • Paula Rahal

Detail Information

Publications27

  1. pmc Gene expression profiling of papillary thyroid carcinoma identifies transcripts correlated with BRAF mutational status and lymph node metastasis
    Gisele Oler
    Division of Genetics, Federal University of Sao Paulo, Sãp Paulo, Brazil
    Clin Cancer Res 14:4735-42. 2008
    ..To identify papillary thyroid carcinoma (PTC)-associated transcripts, we compared the gene expression profiles of three Serial Analysis of Gene Expression libraries generated from thyroid tumors and a normal thyroid tissue...
  2. pmc A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression
    Janete M Cerutti
    Laboratory of Molecular Endocrinology, Division of Endocrinology, Department of Medicine, Federal University of Sao Paulo, Brazil
    J Clin Invest 113:1234-42. 2004
    ..76; 95% confidence interval, [0.59, 0.93]). A simple test based on a combination of these markers might improve preoperative diagnosis of thyroid nodules, allowing better treatment decisions and reducing long-term health costs...
  3. ncbi request reprint Diagnosis of suspicious thyroid nodules using four protein biomarkers
    Janete M Cerutti
    Department of Neurosurgery, Johns Hopkins University Medical School, Baltimore, Maryland 21231, USA
    Clin Cancer Res 12:3311-8. 2006
    ..The goal of this study was to determine if antibody markers used alone or in combination could accurately distinguish between a wider variety of benign and malignant thyroid lesions in fixed sections and FNA samples...
  4. ncbi request reprint [Nodule diagnosed as follicular patterned lesion: are biomarkers the promise?]
    Janete M Cerutti
    Departamento de Morfologia, Universidade Federal de Sao Paulo, SP, Brazil
    Arq Bras Endocrinol Metabol 51:832-42. 2007
    ....
  5. doi request reprint Extended RET gene analysis in patients with apparently sporadic medullary thyroid cancer: clinical benefits and cost
    Susan C Lindsey
    Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo 04039 032, Brazil
    Horm Cancer 3:181-6. 2012
    ..The cost evaluation in apparent sMTC using a tiered approach may help clinicians make more suitable decisions regarding the benefits of investigating only the hot spots against the entire coding region of RET...
  6. pmc ABI3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescence
    Flavia R M Latini
    Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics and Division of Endocrinology, Universidade Federal de Sao Paulo, SP, Brazil
    BMC Cancer 11:11. 2011
    ..Mounting evidence has indicated that ABI3 (ABI family member 3) function as a tumor suppressor gene, although the molecular mechanism by which ABI3 acts remains largely unknown...
  7. pmc PVALB, a new Hürthle adenoma diagnostic marker identified through gene expression
    Janete M Cerutti
    Genetic Bases of Thyroid Tumor Laboratory, Federal University of Sao Paulo, Sao Paulo, SP, Brazil
    J Clin Endocrinol Metab 96:E151-60. 2011
    ..One lingering problem with these markers was that false positives occurred with Hürthle cell adenomas (HCA) which lowered test specificity...
  8. doi request reprint Genome-wide copy number analysis in a family with p.G533C RET mutation and medullary thyroid carcinoma identified regions potentially associated with a higher predisposition to lymph node metastasis
    Aline N Araujo
    Genetic Bases of Thyroid Tumors Laboratory A N A, L M, J M C, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de Sao Paulo, and Laboratory of Molecular and Translational Endocrinology M I C F, R M B M, Division of Endocrinology, Department of Medicine, Universidade Federal de Sao Paulo, São Paulo SP 04039 032, Brazil Center for Applied Genomics H H, J L, R P, The Children s Hospital of Philadelphia, Research Institute and Department of Pediatrics H H, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Clin Endocrinol Metab 99:E1104-12. 2014
    ..G533C RET gene mutation in a large family with multiple endocrine neoplasia type 2 syndrome. Clinical heterogeneity, primarily associated with the presence of lymph node metastases, was observed among the p.G533C carriers...
  9. doi request reprint A ten-year clinical update of a large RET p.Gly533Cys kindred with medullary thyroid carcinoma emphasizes the need for an individualized assessment of affected relatives
    Priscila S Signorini
    Department of Medicine, Laboratory of Molecular and Translational Endocrinology, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Clin Endocrinol (Oxf) 80:235-45. 2014
    ..Reviewing the clinical outcomes of a large kindred with a RET p.Gly533Cys mutation, 10 years after the first description of this kindred, has provided an important set of clinical data for healthcare decision-making...
  10. ncbi request reprint Molecular profiling of matched samples identifies biomarkers of papillary thyroid carcinoma lymph node metastasis
    Janete M Cerutti
    Department of Neurosurgery, Johns Hopkins University Medical School, Baltimore, Maryland, USA
    Cancer Res 67:7885-92. 2007
    ..The functional role of these genes may also provide insight into mechanisms of thyroid cancer metastasis...
  11. ncbi request reprint Seven-year follow-up of a juvenile female with papillary thyroid carcinoma with poor outcome, BRAF mutation and loss of expression of iodine-metabolizing genes
    Gisele Oler
    Federal University of Sao Paulo, SP, Brazil
    Arq Bras Endocrinol Metabol 52:1313-6. 2008
    ..In the present study we report an unusual clinical behavior of PTC and correlate with BRAF mutational status and level of expression of TSHR and NIS...
  12. doi request reprint Genetic markers differentiating follicular thyroid carcinoma from benign lesions
    Beatriz C G Freitas
    Genetic Bases of Thyroid Tumor Laboratory, Division of Genetics, Department of Morphology and Genetics, Federal University of Sao Paulo, SP, Brazil
    Mol Cell Endocrinol 321:77-85. 2010
    ..This review will focus on those biomarkers that are potentially useful in the diagnosis of thyroid lesions commonly classified as indeterminate...
  13. ncbi request reprint [Pathogenesis of differentiated thyroid cancer (papillary and follicular)]
    Rui M B Maciel
    Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP
    Arq Bras Endocrinol Metabol 49:691-700. 2005
    ..Several genes, as TRgamma, PTEN, PKAR1A, DDIT3, ARG2, ITM1 and C1orf24--some discovered by techniques of differential gene expression--, have been recently implicated in the pathogenesis of FTC...
  14. doi request reprint Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas
    Jefferson Pessoa Hemerly
    Laboratório Bases Genéticas dos Tumores da Tiroide, Disciplinas de Genética e Endocrinologia, Universidade Federal de Sao Paulo, Rua Pedro de Toledo 669, Sao Paulo, SP, Brazil
    Eur J Endocrinol 163:747-55. 2010
    ..Somatic mutations at residue R132 of isocitrate dehydrogenase 1 (IDH1) were recently discovered in gliomas and leukaemia at a high frequency. IDH1 is a metabolic gene, and the R132 mutations create a new enzymatic activity...
  15. ncbi request reprint Optimizing nucleic acid extraction from thyroid fine-needle aspiration cells in stained slides, formalin-fixed/paraffin-embedded tissues, and long-term stored blood samples
    Marina M L Kizys
    Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Arq Bras Endocrinol Metabol 56:618-26. 2012
    ..Here, we evaluate several procedures to improve current methodologies for DNA (salting-out) and RNA isolation...
  16. doi request reprint Arginase 2 and nitric oxide synthase: Pathways associated with the pathogenesis of thyroid tumors
    Maria Sharmila A Sousa
    Genetic Basis of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Federal University of Sao Paulo, 04039 032 Sao Paulo, SP, Brazil
    Free Radic Biol Med 49:997-1007. 2010
    ..Fine modulation of ARG2, eNOS, and related genes may represent a potential source for targeted therapy of several cancer types...
  17. ncbi request reprint Early diagnosis of multiple endocrine neoplasia type 2B: a challenge for physicians
    Cleber P Camacho
    Department of Medicine, Federal University of Sao Paulo, SP, Brazil
    Arq Bras Endocrinol Metabol 52:1393-8. 2008
    ..Here we report four cases of MEN2B in which the late diagnosis had a significant impact in clinical evolution and, potentially, in overall survival...
  18. pmc AGK-BRAF gene fusion is a recurrent event in sporadic pediatric thyroid carcinoma
    Maria Isabel C V Cordioli
    Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Cancer Med 5:1535-41. 2016
    ..Understanding the molecular events underlying pediatric PTC may improve preoperative diagnosis, allow molecular prognostication and define a therapeutic approach toward sporadic PTC patients. ..
  19. pmc Transcriptional regulation of the potential tumor suppressor ABI3 gene in thyroid carcinomas: interplay between methylation and NKX2-1 availability
    Laís Moraes
    Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, SP, Brazil
    Oncotarget 7:25960-70. 2016
    ..Our study shows that the transcriptional silencing of ABI3 in cancer cells occurs via methylation and uncovered a previously unrecognized role for NKX2-1 in the regulation of ABI3. ..
  20. doi request reprint Are we really at the dawn of understanding sporadic pediatric thyroid carcinoma?
    Maria Isabel C Vieira Cordioli
    Genetic Bases of Thyroid Tumors LaboratoryDivision of Genetics, Department of Morphology and Genetics and Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Pedro de Toledo 669, 11 andar, 04039 032, Sao Paulo, SP, BrazilDivision of EndocrinologyDepartment of Medicine, Faculdade de Ciencias Medicas, Irmandade da Santa Casa de Misericordia de Sao Paulo, Dr Cesário Mota Jr, 112, 01221 020, Sao Paulo, SP, Brazil
    Endocr Relat Cancer 22:R311-24. 2015
    ..The aim of this review is to present an extensive literature review with emphasis on the molecular differences between pediatric sporadic and radiation-exposed differentiated thyroid carcinomas and adult population. ..
  21. pmc Flavones from Erythrina falcata are modulators of fear memory
    Daniela Rodrigues de Oliveira
    Department of Biological Science, Behavior Pharmacology and Ethnopharmacology Laboratory, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    BMC Complement Altern Med 14:288. 2014
    ..The aim of this study was to identify the flavonoids present in the stem bark crude extract of Erythrina falcata (CE) and to perform a bioactivity-guided study on conditioned fear memory...
  22. doi request reprint Neuromodulatory property of standardized extract Ginkgo biloba L. (EGb 761) on memory: behavioral and molecular evidence
    Daniela R Oliveira
    Department of Biological Science, Federal University of Sao Paulo, SP, Brazil
    Brain Res 1269:68-89. 2009
    ..All together, our findings not only provide new evidence for a role of EGb 761 on memory but also identify molecular changes that underlie the fear memory consolidation...
  23. ncbi request reprint The expression of PAX8-PPARgamma rearrangements is not specific to follicular thyroid carcinoma
    Claudia C D Nakabashi
    Clin Endocrinol (Oxf) 61:280-2. 2004
  24. ncbi request reprint Large-scale transcriptome analyses reveal new genetic marker candidates of head, neck, and thyroid cancer
    Eduardo M Reis
    Departamento de Bioquimica, Faculdade de Medicina, Universidade de Sao Paulo, Brazil
    Cancer Res 65:1693-9. 2005
    ..Similar analysis is warranted for a number of other tumors for which large EST data sets are available...
  25. ncbi request reprint Identification of candidates for tumor-specific alternative splicing in the thyroid
    Gustavo S Guimaraes
    Laboratory of Molecular Endocrinology, Department of Medicine, Federal University of Sao Paulo, Brazil
    Genes Chromosomes Cancer 45:540-53. 2006
    ..In addition, real-time PCR analysis revealed that expression of an alternative PFDN5 variant was higher in malignant lesions than in benign lesions or normal tissues...
  26. ncbi request reprint Y791F RET mutation and early onset of medullary thyroid carcinoma in a Brazilian kindred: evaluation of phenotype-modifying effect of germline variants
    Rosana Tamanaha
    Clin Endocrinol (Oxf) 67:806-8. 2007
  27. ncbi request reprint A novel germ-line point mutation in RET exon 8 (Gly(533)Cys) in a large kindred with familial medullary thyroid carcinoma
    Adriana M Alvares Da Silva
    Laboratory of Molecular Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulist de Medicina, Federal University of Sao Paulo, Brazil
    J Clin Endocrinol Metab 88:5438-43. 2003
    ..To improve the diagnosis of FMTC, analysis of exon 8 of RET should be considered in families with no identified classical RET mutations...