- Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCRPedram Argani
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Surg Pathol 29:230-40. 2005..Finally, the special molecular features of the Alpha-TFEB gene fusion allow its molecular detection by DNA PCR as a robust alternative to RT-PCR in clinical tumor samples...
- The evolving story of renal translocation carcinomasPedram Argani
Am J Clin Pathol 126:332-4. 2006
- Xp11 translocation carcinoma of the kidney presenting with multilocular cystic renal cell carcinoma-like featuresSueli Suzigan
Laborclin Lab, School of Medicine, Sao Jose do Rio Preto, SP, Brazil
Int J Surg Pathol 15:199-203. 2007..A similar case has not been found in the literature. The example emphasizes the high index of suspicion needed for an accurate diagnosis of renal carcinomas...
- PRCC-TFE3 renal cell carcinoma in a boy with a history of contralateral mesoblastic nephromaAli Mirza Onder
Department of Pediatrics, Division of Pediatric Nephrology, Miller School of Medicine, University of Miami, Miami, FL, USA
Pediatr Nephrol 21:1471-5. 2006..He has been on hemodialysis, is tumor free, and has not been receiving chemotherapy for 24 months. This is the first report of a RCC as a second malignant neoplasm in a child treated for a congenital mesoblastic nephroma...
- Translocation carcinomas of the kidneyPedram Argani
Department of Surgical Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231 2410, USA
Clin Lab Med 25:363-78. 2005..The clinical behavior of these neoplasms relative to conventional, adult-type renal carcinomas remains to be determined, and will be an important area of future investigation...
- Translocation carcinomas of the kidney after chemotherapy in childhoodPedram Argani
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
J Clin Oncol 24:1529-34. 2006..Renal cell carcinoma (RCC) occurring as a secondary malignancy is uncommon. Translocation RCC, bearing TFE3 or TFEB gene fusions, are recently recognized entities for which risk factors have not been identified...
- Xp11 translocation renal cell carcinoma: delayed but massive and lethal metastases of a chemotherapy-associated secondary malignancySoroush Rais-Bahrami
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Urology 70:178.e3-6. 2007....
- Distinctive neoplasms characterised by specific chromosomal translocations comprise a significant proportion of paediatric renal cell carcinomasPedram Argani
Department of Pathology, Surgical Pathology, The Johns Hopkins Hospital, Weinberg Building Room 2242, 401 N Broadway, Baltimore, MD 21231 2410, USA
Pathology 35:492-8. 2003
- Xp11 translocation renal cell carcinoma in adults: expanded clinical, pathologic, and genetic spectrumPedram Argani
Department of Pathology, The Johns Hopkins University, Baltimore, MD 21231 2140, USA
Am J Surg Pathol 31:1149-60. 2007..Although they may be uncommon on a percentage basis, given the vast predominance of RCC in adults compared with children, adult Xp11 translocation RCC may well outnumber their pediatric counterparts...
- Recent advances in pediatric renal neoplasiaPedram Argani
The Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Adv Anat Pathol 10:243-60. 2003..Together, these last two translocation-associated tumors represent a significant proportion of pediatric renal cell carcinomas. This review highlights each of these recent advances...
- Translocation renal cell carcinoma: lack of negative impact due to lymph node spreadJames I Geller
Department of Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
Cancer 112:1607-16. 2008..Pediatric renal cell carcinoma (RCC) is clinically distinct from adult RCC. Characterization of the unique biological and clinical features of pediatric RCC are required...
- Pediatric renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusionNi Wayan Winarti
Department of Pathology, Medical Faculty of Udayana University, Denpasar, Bali, Indonesia
Int J Surg Pathol 16:66-72. 2008..Immunohistochemically, the cells showed strong nuclear immunoreactivity for TFE3. We concluded that this case was an RCC associated with Xp11.2 translocation/TFE3 fusion, Fuhrman grade 3, stage IV...
- Fat-predominant mixed epithelial stromal tumor (MEST): report of a unique case mimicking angiomyolipomaAnthony N Sireci
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Int J Surg Pathol 16:73-7. 2008..Melanocytic markers HMB45 and Melan A, typically positive in angiomyolipoma, were nonreactive. This case expands the morphologic spectrum of MEST to include mimics of angiomyolipoma...
- Unusual renal pathology associated with a Wilms tumor in a 15-month-old infantSoroush Rais-Bahrami
Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
Int J Surg Pathol 14:218-20. 2006..Proper screening of these children can allow for early detection of cancers and treatment while these cancers are curable...
- Anaplastic nephrogenic restPedram Argani
Am J Surg Pathol 30:1339-41. 2006
- Bilateral Wilms' tumor with anaplasia: lessons from the National Wilms' Tumor StudyThomas E Hamilton
Division of Pediatric Surgery, Maine Medical Center, Portland, ME 04102, USA
J Pediatr Surg 41:1641-4. 2006..We hypothesized that delay in diagnosis of anaplasia could affect time to appropriate surgery and intensive multimodality therapy...
- Wnt signaling pathway analysis in renal cell carcinoma in young patientsElisabeth Bruder
Institute of Pathology, University Hospital Basel, Schoenbeinstrasse 40, Basel, Switzerland
Mod Pathol 20:1217-29. 2007..2 translocation carcinomas. WT1 mutation in the nephroblastoma component of a mixed-type renal cell carcinoma provides direct evidence for clonal independence of nephroblastoma and carcinoma components in this exceptional tumor...
- Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidneySamson W Fine
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Am J Surg Pathol 30:1554-60. 2006..Pathologists must be aware of the spectrum of histologic findings within MTSCs to ensure their accurate diagnosis...
- Mucinous tubular and spindle cell carcinoma of the kidney: cytopathologic findingsChristopher L Owens
Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Diagn Cytopathol 35:593-6. 2007..Subsequent nephrectomy was performed and the surgical pathology specimen showed a mucinous tubular and spindle cell carcinoma of the kidney. The patient has done well post-operatively with 10 months of benign follow-up...
- Malignant solitary fibrous tumor of the kidney: report of a case and comprehensive review of the literatureSamson W Fine
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231 2410, USA
Arch Pathol Lab Med 130:857-61. 2006..To our knowledge, this is the first reported case of malignant renal SFT, likely representing transformation from a histologically documented benign SFT component...
- Angiomyolipoma with epithelial cysts (AMLEC): a distinct cystic variant of angiomyolipomaSamson W Fine
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 30:593-9. 2006....
- PRCC-TFE3 renal carcinomas: morphologic, immunohistochemical, ultrastructural, and molecular analysis of an entity associated with the t(X;1)(p11.2;q21)Pedram Argani
Department of Pathology, Surgical Pathology, Johns Hopkins Hospital, Weinberg Building, Room 2242, 401 N Broadway, Baltimore, MD 21231 2410, USA
Am J Surg Pathol 26:1553-66. 2002..Aside from their distinctive clinicopathologic features described here, there is experimental evidence suggesting that these tumors may show differential sensitivity to certain chemotherapeutic agents...
- Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocationIan J Davis
Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:6051-6. 2003..Alpha-TFEB is thus identified as a fusion gene in a subset of pediatric renal neoplasms...
- Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions: a sensitive and specific immunohistochemical assayPedram Argani
Department of Pathology, John Hopkins Medical Institutions, Baltimore, MD, USA
Am J Surg Pathol 27:750-61. 2003..Carcinomas associated with TFE3 gene fusions may account for a significant proportion of pediatric renal carcinomas, and this immunohistochemistry assay may help to clarify their true prevalence...
- Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable malignanciesElizabeth Montgomery
Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
Cancer Biol Ther 2:248-52. 2003....
- A novel CLTC-TFE3 gene fusion in pediatric renal adenocarcinoma with t(X;17)(p11.2;q23)Pedram Argani
The Johns Hopkins Hospital, Baltimore, MD 21287, USA
Oncogene 22:5374-8. 2003..Further analysis of the shared features of CLTC and other TFE3 fusion partners may shed light on the essential biology of TFE3 fusion proteins...
- Nephrogenic rests mimicking Wilms' tumor on CTNaveen Subhas
Russell H Morgan Department of Radiology, The Johns Hopkins Hospital and School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
Pediatr Radiol 34:152-5. 2004..One of the NR grew on serial imaging studies mimicking a WT, but after resection was confirmed to be a benign hyperplastic NR on pathologic examination...
- Pathologic quiz case: a 77-year-old woman with bilateral breast masses. Amyloidosis involving the breastAisling M Fleury
School of Medicine, University College, Cork, Ireland
Arch Pathol Lab Med 128:e67-9. 2004
- Telomere lengths of translocation-associated and nontranslocation-associated sarcomas differ dramaticallyElizabeth Montgomery
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 1000, USA
Am J Pathol 164:1523-9. 2004....
- Morphologic and molecular characterization of renal cell carcinoma in children and young adultsElisabeth Bruder
Institute of Pathology, University of Basel, Switzerland
Am J Surg Pathol 28:1117-32. 2004..The far lower frequency of clear cell carcinomas and VHL alterations compared with adults suggests that renal cell carcinomas in young patients have a unique genetic background...
- Metanephric neoplasms: the hyperdifferentiated, benign end of the Wilms tumor spectrum?Pedram Argani
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231 2410, USA
Clin Lab Med 25:379-92. 2005..Although this concept implies that the more active lesions (Wilms tumor) mature with time into inactive ones (usual MAFs or MA), the converse (that an active Wilms tumor can arise within an inactive usual MAF or MA) remains possible...
- Incidental stromal-predominant mixed epithelial-stromal tumors of the kidney: a mimic of intraparenchymal renal leiomyomaParin Parikh
Division of Surgical Pathology, Johns Hopkins University, Baltimore, MD, USA
Arch Pathol Lab Med 129:910-4. 2005..The recognized morphologic spectrum of this recently described entity is evolving...
- Fate of bilateral renal lesions missed on preoperative imaging: a report from the National Wilms Tumor Study GroupMichael L Ritchey
Division of Urology, University of Texas Houston Medical School, Houston, Texas, USA
J Urol 174:1519-21; discussion 1521. 2005..In this review of the National Wilms Tumor Study (NWTS) 4 cases of bilateral Wilms tumors (BWT) we evaluate incidence and outcome of missed bilateral lesions...
- Bilateral Wilms' tumors with progressive or nonresponsive diseaseRobert C Shamberger
Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 41:652-7; discussion 652-7. 2006..To provide guidelines for future cooperative group trials, we reviewed the outcomes of children with bilateral Wilms' tumors (BWTs) treated on National Wilms Tumor Study-4 (NWTS-4) who had progressive or nonresponsive disease (PNRD)...
- Performance characteristics of a reverse transcriptase-polymerase chain reaction assay for the detection of tumor-specific fusion transcripts from archival tissueMichael K Fritsch
Department of Pathology, The Johns Hopkins Medical Institutions, 401 N Broadway, Baltimore, MD 22131 2410, USA
Pediatr Dev Pathol 6:43-53. 2003..Additional studies such as FISH may be useful in clarifying the nature of equivocal or unexpected results...
- Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinomaPedram Argani
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
Am J Surg Pathol 32:1353-9. 2008..Fluorescence in situ hybridization analysis effectively separates these morphologically very similar yet genetically distinctive entities...