Gregory H Borschel

Summary

Publications

  1. doi request reprint The motor nerve to the masseter muscle: an anatomic and histomorphometric study to facilitate its use in facial reanimation
    Gregory H Borschel
    The Hospital for Sick Children, Division of Plastic and Reconstructive Surgery, University of Toronto, Department of Surgery, Toronto, Ontario, Canada
    J Plast Reconstr Aesthet Surg 65:363-6. 2012
  2. doi request reprint Functional recovery following peripheral nerve injury in the transgenic Thy1-GFP rat
    Stephen W P Kemp
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada The Hospital for Sick Children Research Institute Program in Neuroscience and Mental Health, Toronto, Ontario, Canada
    J Peripher Nerv Syst 18:220-31. 2013
  3. doi request reprint Fibrin gels containing GDNF microspheres increase axonal regeneration after delayed peripheral nerve repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, ON, Canada
    Regen Med 8:27-37. 2013
  4. doi request reprint Functional motor recovery is improved due to local placement of GDNF microspheres after delayed nerve repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Biotechnol Bioeng 110:1272-81. 2013
  5. doi request reprint GDNF released from microspheres enhances nerve regeneration after delayed repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8
    Muscle Nerve 46:122-4. 2012
  6. doi request reprint Outcome measures of peripheral nerve regeneration
    Matthew D Wood
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada
    Ann Anat 193:321-33. 2011
  7. doi request reprint Experimental and clinical evidence for use of decellularized nerve allografts in peripheral nerve gap reconstruction
    Mark Szynkaruk
    Division of Plastic and Reconstructive Surgery, Department of Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada
    Tissue Eng Part B Rev 19:83-96. 2013
  8. doi request reprint Daily Electrical Muscle Stimulation Enhances Functional Recovery Following Nerve Transection and Repair in Rats
    Michael P Willand
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Neurorehabil Neural Repair 29:690-700. 2015
  9. doi request reprint Retrograde labeling of regenerating motor and sensory neurons using silicone caps
    Joseph Catapano
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Canada Department of Surgery, Faculty of Medicine, University of Toronto, Canada Electronic address
    J Neurosci Methods 259:122-8. 2016
  10. doi request reprint Rat-derived processed nerve allografts support more axon regeneration in rat than human-derived processed nerve xenografts
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8 Program in Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Elizabeth McMaster Building, Toronto, ON, Canada M5G 1X8
    J Biomed Mater Res A 102:1085-91. 2014

Collaborators

  • Tessa Gordon
  • Susan E Mackinnon
  • Daniel A Hunter
  • Michael P Willand
  • Molly S Shoichet
  • Ehud Arad
  • Stephen W P Kemp
  • James G Wright
  • Saad Alqahtani
  • Michael J Brenner
  • Thomas H Tung
  • Philip J Johnson
  • Ralph T Manktelow
  • Adel Fattah
  • Manfred Frey
  • Matthew D Wood
  • Ronald M Zuker
  • Kasra Tajdaran
  • Edward H Liu
  • Mark Szynkaruk
  • Amy M Moore
  • Joseph Catapano
  • J Michael Hendry
  • Emily S Ho
  • Uri Elbaz
  • Howard Kim
  • Mathew D Wood
  • DAVID SCHOLL
  • Siba Haykal
  • Alison K Snyder-Warwick
  • Robert D Bains
  • Yumiko Hao
  • Pundrique R Sharma
  • M Cecilia Alvarez-Veronesi
  • Asim Ali
  • David C G Sainsbury
  • Eva Placheta
  • Narges Baluch
  • Blake D Murphy
  • Christine Lafontaine
  • James J Jung
  • Rahul Kasukurthi
  • Brendan M Lloyd
  • Jennifer J Zhang
  • Katie Bala
  • Leanne Zive
  • Carolyn Lai
  • Tessa Hadlock
  • Alison Snyder-Warwick
  • Matthew McRae
  • Marc Hohman
  • Emily Ho
  • Shaghayegh Bagher
  • Heather Carnahan
  • William Halliday
  • Sevan Hopyan
  • Robert Bains
  • Rasha N Alsaaran
  • Christine W Lafontaine
  • M Cecilia Alvarez Veronesi
  • Derek Stephens
  • Peter Phua
  • Alex Bilbily
  • Ying Yan
  • Piyaraj Newton
  • Eric R Flagg
  • Albert S Woo
  • Alice Y Tong
  • Katherine A Santosa
  • Christine Weber
  • Shelly E Sakiyama-Elbert
  • Kristopher Chenard
  • Christina K Magill
  • H Francis Farhadi
  • Brandon G Rocque
  • Terence M Myckatyn
  • Ryan D Luginbuhl

Detail Information

Publications36

  1. doi request reprint The motor nerve to the masseter muscle: an anatomic and histomorphometric study to facilitate its use in facial reanimation
    Gregory H Borschel
    The Hospital for Sick Children, Division of Plastic and Reconstructive Surgery, University of Toronto, Department of Surgery, Toronto, Ontario, Canada
    J Plast Reconstr Aesthet Surg 65:363-6. 2012
    ..In this study we conducted a detailed assessment of its gross and microscopic anatomy and develop a simple, reliable method for locating this nerve...
  2. doi request reprint Functional recovery following peripheral nerve injury in the transgenic Thy1-GFP rat
    Stephen W P Kemp
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada The Hospital for Sick Children Research Institute Program in Neuroscience and Mental Health, Toronto, Ontario, Canada
    J Peripher Nerv Syst 18:220-31. 2013
    ..Overall, these data support the use of the transgenic Thy1-GFP rat in experiments assessing functional and behavioral recovery following nerve injury and repair. ..
  3. doi request reprint Fibrin gels containing GDNF microspheres increase axonal regeneration after delayed peripheral nerve repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, ON, Canada
    Regen Med 8:27-37. 2013
    ..Recovery following nerve transection declines when target reconnection is delayed for prolonged periods. GDNF has previously been shown to promote motor axon regeneration following delayed nerve repair...
  4. doi request reprint Functional motor recovery is improved due to local placement of GDNF microspheres after delayed nerve repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Biotechnol Bioeng 110:1272-81. 2013
    ..GDNF microspheres partially reversed the deleterious effects of chronic nerve injury, and recovery was slightly favored with the 2 weeks formulation compared to the 4 weeks formulation...
  5. doi request reprint GDNF released from microspheres enhances nerve regeneration after delayed repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8
    Muscle Nerve 46:122-4. 2012
    ..Regeneration can be improved with delivery of exogenous growth factor. We developed a delivery system that could be applied at the nerve repair site to deliver growth factors locally to regenerating nerve...
  6. doi request reprint Outcome measures of peripheral nerve regeneration
    Matthew D Wood
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada
    Ann Anat 193:321-33. 2011
    ..Examples of erroneous conclusions are given to illustrate the need for researchers to ensure that the appropriate outcome measures are used in the evaluation of the success of peripheral nerve regeneration...
  7. doi request reprint Experimental and clinical evidence for use of decellularized nerve allografts in peripheral nerve gap reconstruction
    Mark Szynkaruk
    Division of Plastic and Reconstructive Surgery, Department of Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada
    Tissue Eng Part B Rev 19:83-96. 2013
    ..Finally, all clinical studies in which decellularized nerve allografts have been used to bridge nerve gaps in patients are reviewed...
  8. doi request reprint Daily Electrical Muscle Stimulation Enhances Functional Recovery Following Nerve Transection and Repair in Rats
    Michael P Willand
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Neurorehabil Neural Repair 29:690-700. 2015
    ..Incomplete recovery following surgical reconstruction of damaged peripheral nerves is common. Electrical muscle stimulation (EMS) to improve functional outcomes has not been effective in previous studies...
  9. doi request reprint Retrograde labeling of regenerating motor and sensory neurons using silicone caps
    Joseph Catapano
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada Institute of Medical Science, University of Toronto, Canada Department of Surgery, Faculty of Medicine, University of Toronto, Canada Electronic address
    J Neurosci Methods 259:122-8. 2016
    ..However, other techniques that inject tracers directly into the nerve or muscle may result in variable labeling depending on nerve preparation and location of injection...
  10. doi request reprint Rat-derived processed nerve allografts support more axon regeneration in rat than human-derived processed nerve xenografts
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8 Program in Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Elizabeth McMaster Building, Toronto, ON, Canada M5G 1X8
    J Biomed Mater Res A 102:1085-91. 2014
    ..Processed xenografts showed significantly reduced regeneration compared with autografts or processed allografts indicating that cross-species immunological reactions are important considerations in this rat model...
  11. doi request reprint An engineered biocompatible drug delivery system enhances nerve regeneration after delayed repair
    Kasra Tajdaran
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, M5G1X8, Canada
    J Biomed Mater Res A 104:367-76. 2016
    ..This biocompatible, nontoxic, fibrin gel-based DDS enhances outcomes following severe peripheral nerve injuries. ┬ę 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 367-376, 2016. ..
  12. doi request reprint Characterization of neuronal death and functional deficits following nerve injury during the early postnatal developmental period in rats
    Stephen W P Kemp
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Hospital for Sick Children, Toronto, Ont, Canada
    Dev Neurosci 37:66-77. 2015
    ..These findings have important implications concerning the timing of neonatal nerve injury in rats...
  13. doi request reprint A transgenic rat expressing green fluorescent protein (GFP) in peripheral nerves provides a new hindlimb model for the study of nerve injury and regeneration
    Amy M Moore
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurosci Methods 204:19-27. 2012
    ..In order to evaluate nerve regeneration in clinically relevant hindlimb surgical paradigms not feasible in fluorescent mice models, we developed a rat that expresses green fluorescent protein (GFP) in neural tissue...
  14. doi request reprint Controlled delivery of glial cell line-derived neurotrophic factor enhances motor nerve regeneration
    Amy M Moore
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Hand Surg Am 35:2008-17. 2010
    ..To determine the effect of a motor-specific neurotrophic factor, glial-derived neurotrophic factor (GDNF) on motor nerve regeneration...
  15. doi request reprint Facial palsy and reconstruction
    Adel Fattah
    Division of Plastic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada
    Plast Reconstr Surg 129:340e-352e. 2012
    ..This article outlines a thorough approach to facial nerve palsy and reconstruction...
  16. doi request reprint The use of Integra® bilaminar dermal regeneration template in apert syndactyly reconstruction: a novel alternative to simplify care and improve outcomes
    James J Jung
    Division of Plastic and Reconstructive Surgery, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    J Plast Reconstr Aesthet Surg 65:118-21. 2012
    ..We report that both left and right hands achieved similar outcomes, but the hand reconstructed with groin flaps required debulking, whilst the hand reconstructed with Integra was easier to care for...
  17. doi request reprint Side-To-Side Nerve Bridges Support Donor Axon Regeneration Into Chronically Denervated Nerves and Are Associated With Characteristic Changes in Schwann Cell Phenotype
    J Michael Hendry
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, ON, Canada Department of Surgery, Institute of Medical Science, and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada SickKids Research Institute Program in Neuroscience, Toronto, ON, Canada
    Neurosurgery 77:803-13. 2015
    ..Recent studies showed that multiple nerve grafts inserted between an intact donor nerve and a denervated distal recipient nerve stump (termed "side-to-side nerve bridges") enhanced regeneration after delayed nerve repair...
  18. doi request reprint A glial cell line-derived neurotrophic factor delivery system enhances nerve regeneration across acellular nerve allografts
    Kasra Tajdaran
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G1X8, Canada Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada Electronic address
    Acta Biomater 29:62-70. 2016
    ..The sustained delivery of GDNF to the implanted ANA achieved in this study demonstrates the promise of this DDS for the management of severe nerve injuries in which allografts are placed...
  19. doi request reprint Corneal neurotization from the supratrochlear nerve with sural nerve grafts: a minimally invasive approach
    Robert D Bains
    Toronto, Ontario, Canada From The Hospital for Sick Children
    Plast Reconstr Surg 135:397e-400e. 2015
    ..This article and accompanying video describes the relevant anatomy and demonstrates the technique in detail...
  20. doi request reprint The ErbB2 inhibitor Herceptin (Trastuzumab) promotes axonal outgrowth four weeks after acute nerve transection and repair
    Eva Placheta
    Division of Plastic and Reconstructive Surgery, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Neurosci Lett 582:81-6. 2014
    ..Enhanced axon outgrowth in the presence of this ErbB2 inhibitor indicates that ErbB2 signaling may limit the numbers of axons that are emitted from each regenerating neuron. ..
  21. doi request reprint Long-term outcomes following lower extremity sarcoma resection and reconstruction with vascularized fibula flaps in children
    David C G Sainsbury
    Toronto, Ontario, Canada From the Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, and the University of Toronto
    Plast Reconstr Surg 134:808-20. 2014
    ..This study aimed to evaluate functional outcomes, donor-site morbidity, and complications in lower limb bony oncologic defects reconstructed with vascularized fibula flaps in children...
  22. doi request reprint A novel polymeric drug delivery system for localized and sustained release of tacrolimus (FK506)
    Kasra Tajdaran
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada, M5G1X8
    Biotechnol Bioeng 112:1948-53. 2015
    ..This study suggests that local delivery of FK506 with fibrin hydrogel could be used to enhance peripheral nerve regeneration...
  23. doi request reprint A prospective study of pediatric hand fractures and review of the literature
    Edward H Liu
    From the Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, Ontario Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario College of Medicine, King Saud University, Riyadh, Saudi Arabia Department of Pediatrics, University of Manitoba, Winnipeg, MB Department of Occupational Science and Occupational Therapy and Institutes of Biomaterials and Biomedical Engineering and Medical Sciences, University of Toronto, Toronto, Ontario and Program in Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario
    Pediatr Emerg Care 30:299-304. 2014
    ..We examine the demographics, etiology, anatomic location, mechanism, and management of pediatric hand fractures in our center's hand unit...
  24. doi request reprint Reconstruction of facial nerve injuries in children
    Adel Fattah
    Department of Plastic and Reconstructive Surgery, Hospital for Sick Children, Toronto, Ontario, Canada
    J Craniofac Surg 22:782-8. 2011
    ..We review our strategies for addressing facial nerve injuries in children...
  25. pmc Limitations of conduits in peripheral nerve repairs
    Amy M Moore
    Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Washington University, Campus Box 8238, 660 South Euclid Avenue, St Louis, MO, 63110, USA
    Hand (N Y) 4:180-6. 2009
    ..The reported cases demonstrate the importance of evaluating the length, diameter, and function of nerves undergoing conduit repair. In large-diameter nerves, the use of conduits should be carefully considered...
  26. doi request reprint Establishing expert consensus on the evaluation of pediatric upper extremity function
    Yumiko Hao
    Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON, Canada Department of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, ON, Canada
    J Hand Ther 28:151-6; quiz 157. 2015
    ..Consensus statement...
  27. doi request reprint Perspectives in the reconstruction of paediatric facial paralysis
    Pundrique R Sharma
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children Toronto, Ontario, Canada
    Curr Opin Otolaryngol Head Neck Surg 23:470-9. 2015
    ..In this review article, aimed at those likely to encounter but relatively unfamiliar with paediatric facial paralysis, we summarize reconstructive options in its surgical management...
  28. doi request reprint The role of botulinum toxin a in the establishment of symmetry in pediatric paralysis of the lower lip
    Siba Haykal
    Division of Plastic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada2Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    JAMA Facial Plast Surg 17:174-8. 2015
    ..Botulinum toxin A has been described as an effective adjunct treatment for achieving symmetry in adults with facial paralysis. Few investigators have described the use of botulinum toxin A in pediatric patients with facial paralysis...
  29. pmc Nerve cross-bridging to enhance nerve regeneration in a rat model of delayed nerve repair
    Tessa Gordon
    Department of Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 10:e0127397. 2015
    ..Such autografts may be used in human repair surgery to improve outcomes after unavoidable delays. ..
  30. doi request reprint Restoration of Trigeminal Cutaneous Sensation with Cross-Face Sural Nerve Grafts: A Novel Approach to Facial Sensory Rehabilitation
    Joseph Catapano
    Toronto, Ontario, Canada From the Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children and the Department of Surgery, University of Toronto
    Plast Reconstr Surg 136:568-71. 2015
    ..Cross-face nerve grafts result in minimal donor-site morbidity and are promising as a surgical strategy to address sensory deficits of the face...
  31. doi request reprint Restoration of corneal sensation with regional nerve transfers and nerve grafts: a new approach to a difficult problem
    Uri Elbaz
    Department of Ophthalmology and Vision Sciences, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    JAMA Ophthalmol 132:1289-95. 2014
    ..Corneal anesthesia is recalcitrant to conventional treatment and can lead to permanent visual loss...
  32. doi request reprint The degree of facial movement following microvascular muscle transfer in pediatric facial reanimation depends on donor motor nerve axonal density
    Alison K Snyder-Warwick
    St Louis, Mo Liverpool, United Kingdom and Toronto, Ontario, Canada From the Facial Nerve Institute, Department of Surgery, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine the Facial Nerve Program, Regional Pediatric Burns and Plastic Surgery Service, Alder Hey Children s NHS Foundation Trust the Department of Surgery, Division of Plastic Surgery, and the Department of Pediatric Laboratory Medicine, Division of Pathology, The Hospital for Sick Children and the Division of Plastic and Reconstructive Surgery, University of Toronto
    Plast Reconstr Surg 135:370e-81e. 2015
    ..In this study, the authors compared donor nerve histomorphometry and clinical outcomes in a single patient population undergoing free muscle transfer to the face...
  33. doi request reprint Socioeconomic status and wait times for pediatric surgery in Canada
    Mark Szynkaruk
    Division of Plastic and Reconstructive Surgery, Department of Surgery, and
    Pediatrics 134:e504-11. 2014
    ..The purpose of this study was to determine whether SES was related to meeting surgical wait time access targets for children. We also assessed the effects of gender, age, and distance to hospital on meeting access targets...
  34. doi request reprint Vascularized composite allotransplantation: an update on medical and surgical progress and remaining challenges
    Blake D Murphy
    University of Toronto, Division of Plastic and Reconstructive Surgery, Toronto, Canada
    J Plast Reconstr Aesthet Surg 66:1449-55. 2013
    ..This technique has been performed for upper extremity, face, and abdominal wall transplants, among many others...
  35. doi request reprint Use of adjunctive palmaris longus abductorplasty (Camitz) tendon transfer in pediatric median nerve injury
    Narges Baluch
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, ON, Canada
    J Plast Reconstr Aesthet Surg 66:726-8. 2013
    ..Transfer of the palmaris longus tendon reliably restores palmar abduction, with minimal to no additional morbidity, in carefully selected pediatric patients with median nerve injury undergoing release of the carpal tunnel...
  36. ncbi request reprint Use of motor nerve material in peripheral nerve repair with conduits
    Brendan M Lloyd
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Microsurgery 27:138-45. 2007
    ..These findings suggest that intact nerve architecture, regardless of neurotrophic or biochemical factors, is a prerequisite for the beneficial effect of motor nerve grafting...