Affiliation: Boehringer Ingelheim
- BI-32169, a bicyclic 19-peptide with strong glucagon receptor antagonist activity from Streptomyces spOlivier Potterat
Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397 Biberach an der Riss, Germany
J Nat Prod 67:1528-31. 2004..BI-32169 and its methyl ester derivative showed potent inhibitory activity against the human glucagon receptor (IC(50) 440 and 320 nM, respectively) in a functional cell-based assay...
- Marine actinomycetes as a source of novel secondary metabolitesHans Peter Fiedler
Mikrobiologisches Institut, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
Antonie Van Leeuwenhoek 87:37-42. 2005..New marine members of the rare genus Verrucosispora seem to be a promising source for novel bioactive secondary metabolites as shown in the case of the abyssomicin producing strain AB-18-032...
- Terphenylquinone inhibitors of the src protein tyrosine kinase from Stilbella spCarsten Puder
Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397 Biberach Riss, Germany
J Nat Prod 68:323-6. 2005..strain 1586. The structures of these compounds were established by spectroscopic and chemical methods. The terphenylquinones 3-5 exhibited significant activity against human src protein tyrosine kinase...
- Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activationOlivier Potterat
Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397, Biberach an der Riss, Germany
J Nat Prod 70:1934-8. 2007..60 and 7.0 microM. Chlorocyclinone C ( 3) exhibited the most potent activity in all assays...