Martin C Michel

Summary

Affiliation: Boehringer Ingelheim

Publications

  1. pmc A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor racecadotril
    Marion Eberlin
    Department of Medical Affairs Germany, Boehringer Ingelheim Pharma GmbH and Co KG Ingelheim, Germany
    Front Pharmacol 3:93. 2012
  2. pmc Observational study on safety and tolerability of duloxetine in the treatment of female stress urinary incontinence in German routine practice
    Martin C Michel
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    Br J Clin Pharmacol 75:1098-108. 2013
  3. doi request reprint A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists
    Martin C Michel
    Department of Clinical Development and Medical Affairs, Boehringer Ingelheim, 55216 Ingelheim, Germany
    Pharmacol Rev 65:809-48. 2013
  4. ncbi request reprint Polymorphisms in human muscarinic receptor subtype genes
    Martin C Michel
    Departments of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Handb Exp Pharmacol 208:49-59. 2012
  5. doi request reprint How can 1 + 1 = 3? β2-adrenergic and glucocorticoid receptor agonist synergism in obstructive airway diseases
    Martina Schmidt
    Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands
    Mol Pharmacol 80:955-8. 2011
  6. doi request reprint Are polymorphisms of the β(3)-adrenoceptor gene associated with an altered bladder function?
    Christine A Teitsma
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, The Netherlands
    Neurourol Urodyn 32:276-80. 2013
  7. doi request reprint Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder
    Henricus G Ruhe
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Pharmacogenet Genomics 19:67-76. 2009
  8. pmc Are "functionally related polymorphisms" of renin-angiotensin-aldosterone system gene polymorphisms associated with hypertension?
    Ines N Hahntow
    Dept of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, The Netherlands
    BMC Cardiovasc Disord 10:23. 2010
  9. doi request reprint The new radioligand [(3)H]-L 748,337 differentially labels human and rat β3-adrenoceptors
    Jan Peter van Wieringen
    Dept Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Pharmacol 720:124-30. 2013
  10. doi request reprint Synthesis and characterization of a novel series of agonist compounds as potential radiopharmaceuticals for imaging dopamine D₂/₃ receptors in their high-affinity state
    Jan Peter van Wieringen
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Med Chem 57:391-410. 2014

Collaborators

Detail Information

Publications45

  1. pmc A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor racecadotril
    Marion Eberlin
    Department of Medical Affairs Germany, Boehringer Ingelheim Pharma GmbH and Co KG Ingelheim, Germany
    Front Pharmacol 3:93. 2012
    ..Several guidelines recommend the use of racecadotril as addition to oral rehydration treatment in children with acute diarrhea...
  2. pmc Observational study on safety and tolerability of duloxetine in the treatment of female stress urinary incontinence in German routine practice
    Martin C Michel
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    Br J Clin Pharmacol 75:1098-108. 2013
    ....
  3. doi request reprint A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists
    Martin C Michel
    Department of Clinical Development and Medical Affairs, Boehringer Ingelheim, 55216 Ingelheim, Germany
    Pharmacol Rev 65:809-48. 2013
    ..Although there is general consensus that a continuous receptor blockade over a 24-hour period is desirable, the clinical relevance of other pharmacological differences between individual ARBs remains to be assessed...
  4. ncbi request reprint Polymorphisms in human muscarinic receptor subtype genes
    Martin C Michel
    Departments of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Handb Exp Pharmacol 208:49-59. 2012
    ....
  5. doi request reprint How can 1 + 1 = 3? β2-adrenergic and glucocorticoid receptor agonist synergism in obstructive airway diseases
    Martina Schmidt
    Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands
    Mol Pharmacol 80:955-8. 2011
    ..These molecular interactions may contribute to the observed clinical synergism between both drug classes in the treatment of obstructive airway diseases...
  6. doi request reprint Are polymorphisms of the β(3)-adrenoceptor gene associated with an altered bladder function?
    Christine A Teitsma
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, The Netherlands
    Neurourol Urodyn 32:276-80. 2013
    ....
  7. doi request reprint Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder
    Henricus G Ruhe
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Pharmacogenet Genomics 19:67-76. 2009
    ..In major depressive disorder, selective serotonin reuptake inhibitors target the serotonin transporter (SERT). Their response rates (30-50%) are modified by SERT promotor polymorphisms (5-HTTLPR)...
  8. pmc Are "functionally related polymorphisms" of renin-angiotensin-aldosterone system gene polymorphisms associated with hypertension?
    Ines N Hahntow
    Dept of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, The Netherlands
    BMC Cardiovasc Disord 10:23. 2010
    ..We have tested this hypothesis using genes encoding components of the renin-angiotensin-aldosterone system and the high blood pressure phenotype...
  9. doi request reprint The new radioligand [(3)H]-L 748,337 differentially labels human and rat β3-adrenoceptors
    Jan Peter van Wieringen
    Dept Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Pharmacol 720:124-30. 2013
    ..Nevertheless, [(3)H]-L 748,337 appears to be the most promising radioligand for the selective labelling of human β3-adrenoceptors reported to date...
  10. doi request reprint Synthesis and characterization of a novel series of agonist compounds as potential radiopharmaceuticals for imaging dopamine D₂/₃ receptors in their high-affinity state
    Jan Peter van Wieringen
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Med Chem 57:391-410. 2014
    ..Two fluorine-containing compounds were [(18)F]-labeled, and both displayed specific binding to striatal D2/3R in rat brain slices in vitro. These findings encourage further in vivo evaluations. ..
  11. doi request reprint Are RGS2 gene polymorphisms associated with high blood pressure in an ethnicity- and gender-specific manner?
    Ines N Hahntow
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Hypertens 22:80-6. 2009
    ..We have tested whether these proposed ethnicity- and gender-specific associations between RGS2 gene polymorphisms and HT can be confirmed in an independent population of male and female blacks, whites, and south Asians...
  12. doi request reprint Lack of evidence that nebivolol is a β₃-adrenoceptor agonist
    Elfaridah P Frazier
    Department of Pharmacology and Pharmacotherapy, University of Amsterdam, Meibergdreef 15, Amsterdam, The Netherlands
    Eur J Pharmacol 654:86-91. 2011
    ..However, they do not support the hypothesis that nebivolol is an agonist at cloned human β₃-adrenoceptors or in rat or human urinary bladder...
  13. doi request reprint Agonist-induced desensitization of human β3-adrenoceptors expressed in human embryonic kidney cells
    Martina B Michel-Reher
    Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Str 67, 55101, Mainz, Germany
    Naunyn Schmiedebergs Arch Pharmacol 386:843-51. 2013
    ....
  14. doi request reprint Specificity evaluation of antibodies against human β3-adrenoceptors
    Hana Cernecka
    Department of Urology, University of Amsterdam, Amsterdam, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 385:875-82. 2012
    ....
  15. doi request reprint Successful pharmacologic treatment of major depressive disorder attenuates amygdala activation to negative facial expressions: a functional magnetic resonance imaging study
    Henricus G Ruhe
    Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Psychiatry 73:451-9. 2012
    ..We quantified functional changes in the amygdala and the related limbic-subcortical-prefrontal structures after paroxetine treatment with functional magnetic resonance imaging relative to clinical responder status...
  16. doi request reprint Bradykinin modulates spontaneous nerve growth factor production and stretch-induced ATP release in human urothelium
    Peter Ochodnicky
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Pharmacol Res 70:147-54. 2013
    ..Bradykinin-induced changes in urothelial sensory function might contribute to the development of bladder dysfunction...
  17. doi request reprint Activation of sphingosine kinase by muscarinic receptors enhances NO-mediated and attenuates EDHF-mediated vasorelaxation
    Arthur C M Mulders
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, Meibergdreef 15, Amsterdam, The Netherlands
    Basic Res Cardiol 104:50-9. 2009
    ..Moreover, a disturbed regulation of sphingolipid metabolism in the vascular wall may therefore play a role in the aetiology/pathology of disease states characterized by endothelial dysfunction...
  18. pmc Signal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and beta-adrenoceptors
    Elfaridah P Frazier
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 377:449-62. 2008
    ..We conclude that apart from muscarinic receptor antagonists and beta-adrenoceptor agonists, inhibitors of Rho kinase and activators of BKCa channels may have potential to treat an overactive bladder...
  19. doi request reprint S1P receptor signalling and RGS proteins; expression and function in vascular smooth muscle cells and transfected CHO cells
    Mariëlle C Hendriks-Balk
    Dept Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Pharmacol 600:1-9. 2008
    ..However, major alterations in RGS protein expression have only limited effect on S1P receptor function...
  20. pmc Effects of strong CYP2D6 and 3A4 inhibitors, paroxetine and ketoconazole, on the pharmacokinetics and cardiovascular safety of tamsulosin
    Joachim Troost
    Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany
    Br J Clin Pharmacol 72:247-56. 2011
    ..However, data on potential drug-drug interactions between tamsulosin and inhibitors of CYP2D6 and 3A4 are limited and information on potential pharmacodynamic consequences of such pharmacokinetic interactions is missing...
  21. doi request reprint Bradykinin contracts rat urinary bladder largely independently of phospholipase C
    Carsten Sand
    Department of Pharmacology, University of Duisburg Essen, Essen, Germany C S and Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany M C M
    J Pharmacol Exp Ther 348:25-31. 2014
    ..Both responses strongly involve L-type Ca(2+) channels and rho kinase, whereas only the bradykinin response additionally involves the phospholipase A2/cyclooxygenase pathway. ..
  22. doi request reprint Muscarinic receptor subtype mRNA expression in the human prostate: association with age, pathological diagnosis, prostate size, or potentially interfering medications?
    Lambertus P W Witte
    Department of Urology, Academic Medical Center, Amsterdam, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 387:207-14. 2014
    ....
  23. pmc Do gene polymorphisms alone or in combination affect the function of human beta3-adrenoceptors?
    Wim Vrydag
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Br J Pharmacol 156:127-34. 2009
    ..While these clinical data suggest that the 64R variant is hypofunctional, previous in vitro studies in which this variant was generated by site-directed mutagenesis and subsequent transfection have not consistently confirmed this...
  24. doi request reprint Which single-item measures of overactive bladder symptom treatment correlate best with patient satisfaction?
    Martin C Michel
    Academic Medical Center, Department of Pharmacology and Pharmacotherapy, University of Amsterdam, Amsterdam, The Netherlands
    Neurourol Urodyn 30:510-4. 2011
    ..This study aimed to compare multiple single-item scales at baseline and after treatment with patient-reported overall rating of treatment efficacy...
  25. pmc Similarities and differences in the autonomic control of airway and urinary bladder smooth muscle
    Martin C Michel
    Department Pharmacology and Pharmacotherapy, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 378:217-24. 2008
    ..We conclude that the distinct functions of airways and urinary bladder are reflected in a differential regulation by the autonomic nervous system. Studying these differences may be informative for a better understanding of each tissue...
  26. pmc Muscarinic receptor subtypes and signalling involved in the attenuation of isoprenaline-induced rat urinary bladder relaxation
    Lambertus P W Witte
    Depts of Pharmacology and Pharmacotherapy and of Urology, Academic Medical Center, Amsterdam, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 384:555-63. 2011
    ....
  27. ncbi request reprint The role of nocturia in the quality of life of men with lower urinary tract symptoms
    Marleen M van Dijk
    Department of Urology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BJU Int 105:1141-6. 2010
    ....
  28. doi request reprint The odd sibling: features of β3-adrenoceptor pharmacology
    Hana Cernecka
    Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands H C Department of Pharmacology, University of Duisburg Essen, Essen, Germany C S and Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany M C M
    Mol Pharmacol 86:479-84. 2014
    ..All three of these factors have implications for future studies to better understand the β3-adrenoceptor as a novel pharmacological target. ..
  29. doi request reprint Agonist high- and low-affinity states of dopamine D₂ receptors: methods of detection and clinical implications
    Jan Peter van Wieringen
    Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 386:135-54. 2013
    ..The potential advantages of agonist ligands in studies of pathophysiology and as diagnostics are being discussed...
  30. ncbi request reprint The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: alpha-blockers in the treatment of male voiding dysfunction - how do they work and why do they differ in tolerability?
    Martin C Michel
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, The Netherlands
    J Pharmacol Sci 112:151-7. 2010
    ..Taken together, these data emphasize the idea that concepts about drug efficacy and tolerability despite being highly plausible may not necessarily be true and always require thorough experimental testing...
  31. doi request reprint Pharmacokinetics and pharmacodynamics of tamsulosin in its modified-release and oral controlled absorption system formulations
    Gabriela Franco-Salinas
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Pharmacokinet 49:177-88. 2010
    ..Clinical studies have indicated that despite its lower bioavailability, the OCAS formulation has the same treatment efficacy as the MR formulation but causes somewhat fewer cardiovascular adverse effects...
  32. doi request reprint Pharmacogenomics of G protein-coupled receptor ligands in cardiovascular medicine
    Dieter Rosskopf
    Department of Pharmacology, Ernst Moritz Arndt University, Greifswald, Germany
    Pharmacol Rev 60:513-35. 2008
    ..Moreover, we predict that even such additional research will result in only few cases where the promise of tailored treatment can be fulfilled; however, some of these few cases may be of major clinical relevance...
  33. pmc Are there functional β₃-adrenoceptors in the human heart?
    Martin C Michel
    Department of Pharmacology and Pharmacotherapy, University of Amsterdam, Amsterdam, The Netherlands
    Br J Pharmacol 162:817-22. 2011
    ..Whether the expected future use of β₃-adrenoceptor agonists in the treatment of urinary bladder dysfunction is associated with adverse events related to cardiac function remains to be determined from clinical studies...
  34. doi request reprint Therapeutic targets for overactive bladder other than smooth muscle
    Martin C Michel
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    Expert Opin Ther Targets 19:687-705. 2015
    ..However, other structures including urothelium, afferent nerves and bladder blood vessels may also be important in pathophysiology and its treatment...
  35. pmc More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease
    Nazha Hamdani
    Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Muscle Res Cell Motil 31:289-301. 2010
    ..Alterations in the βAR pathway are more pronounced in IDCM than in ISHD and may reflect sequential changes in cellular protein composition and function. Our data indicate that cellular dysfunction is more severe in IDCM than in ISHD...
  36. doi request reprint Prejunctional and peripheral effects of the cannabinoid CB(1) receptor inverse agonist rimonabant (SR 141716)
    Hester van Diepen
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 378:345-69. 2008
    ..Other peripheral effects, many of which occur prejunctionally, may also contribute to its overall clinical profile and lead to additional indications as well adverse events...
  37. ncbi request reprint Tolerability of amine uptake inhibitors in urologic diseases
    Martin C Michel
    Dept of Pharmacology and Pharmacotherapy, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Curr Drug Saf 1:73-85. 2006
    ..Their most common side effect is nausea. However, nausea tends to be mild and, importantly, transient. Patient counselling about side effects and up-titrating doses may be useful strategies for minimising discomfort and withdrawals...
  38. doi request reprint The effect of bladder outlet obstruction on alpha1- and beta-adrenoceptor expression and function
    Maurits M Barendrecht
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands
    Neurourol Urodyn 28:349-55. 2009
    ..To explore possible changes in expression and/or function of alpha(1)- and beta-adrenoceptor subtypes as a cause for bladder dysfunction in a rat model of bladder outlet obstruction (BOO)...
  39. doi request reprint Evidence why paroxetine dose escalation is not effective in major depressive disorder: a randomized controlled trial with assessment of serotonin transporter occupancy
    Henricus G Ruhe
    Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropsychopharmacology 34:999-1010. 2009
    ..This is explained by the absence of significant increases of SERT occupancy by paroxetine dose escalation, despite increased paroxetine serum concentrations (ISRCTN44111488)...
  40. doi request reprint β-adrenoceptor agonist effects in experimental models of bladder dysfunction
    Martin C Michel
    Dept Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, The Netherlands
    Pharmacol Ther 131:40-9. 2011
    ..Taken together these findings suggest that β₃-adrenoceptor agonists may become useful drugs for the treatment of bladder storage dysfunction, a view supported by recent phase III clinical studies for one such agent, mirabegron...
  41. ncbi request reprint Duloxetine in the treatment of stress urinary incontinence
    Martin C Michel
    Dept Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, Netherlands
    Womens Health (Lond Engl) 1:345-58. 2005
    ..Therefore, duloxetine appears suitable for the treatment of stress urinary incontinence...
  42. doi request reprint Expression profiling of G-protein-coupled receptors in human urothelium and related cell lines
    Peter Ochodnicky
    Department of Pharmacology and Pharmacotherapy, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    BJU Int 110:E293-300. 2012
    ..We characterize the mRNA expression of genes coding for GPCRs in human freshly isolated urothelium and compare the expression pattern with those in human urothelial cell lines...
  43. doi request reprint Nerve growth factor in bladder dysfunction: contributing factor, biomarker, and therapeutic target
    Peter Ochodnicky
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurourol Urodyn 30:1227-41. 2011
    ..Moreover, successful experimental therapeutic approaches, such as NGF sequestering proteins or modified NGF antibodies, await the translation to the clinical treatment of bladder disorders...
  44. doi request reprint Desirable properties of β3-adrenoceptor agonists: implications for the selection of drug development candidates
    Martin C Michel
    Dept of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Eur J Pharmacol 657:1-3. 2011
    ....
  45. pmc Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years
    Martin C Michel
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands
    Br J Clin Pharmacol 73:821-5. 2012
    ..To determine efficacy of the analgesic flupirtine in the treatment of overactive bladder syndrome in a proof-of-concept study...