M Bickel

Summary

Publications

  1. ncbi request reprint A randomized, open-label study to compare the effects of two different doses of recombinant human growth hormone on fat reduction and fasting metabolic parameters in HIV-1-infected patients with lipodystrophy
    M Bickel
    HIV Treatment and Research Unit, JW Goethe University, Frankfurt, Germany
    HIV Med 7:397-403. 2006
  2. ncbi request reprint The Protease Inhibitor Transfer Study (PROTRA 1): abacavir and efavirenz in combination as a substitute for a protease inhibitor in heavily pretreated HIV-1-infected patients with undetectable plasma viral load
    M Bickel
    Department of Infectious Disease, HIV Treatment and Research Unit, JW Goethe University, Frankfurt, Germany
    HIV Med 6:179-84. 2005
  3. ncbi request reprint Severe rhabdomyolysis, acute renal failure and posterior encephalopathy after 'magic mushroom' abuse
    Markus Bickel
    Department of Internal Medicine ICU, J W Goethe University, Frankfurt, Germany
    Eur J Emerg Med 12:306-8. 2005
  4. doi request reprint Once-daily treatment with saquinavir mesylate (2000 mg) and ritonavir (100 mg) together with a fixed-dose combination of abacavir/lamivudine (600/300 mg) or tenofovir/emtricitabine (245/200 mg) in HIV-1-infected patients
    M Bickel
    HIVCENTER, JW Goethe University Hospital, Theodor Stern Kai 7, Frankfurt, Germany
    J Antimicrob Chemother 64:1260-4. 2009
  5. ncbi request reprint Severe CNS side-effect and persistent high efavirenz plasma levels in a patient with HIV/HCV coinfection and liver cirrhosis
    Markus Bickel
    HIV Treatment and Research Unit, JW Goethe University, Frankfurt, Germany
    Scand J Infect Dis 37:520-2. 2005
  6. pmc Daily dosing of tacrolimus in patients treated with HIV-1 therapy containing a ritonavir-boosted protease inhibitor or raltegravir
    Markus Bickel
    HIVCENTER, Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Antimicrob Chemother 65:999-1004. 2010
  7. ncbi request reprint A standardized, comprehensive magnetic resonance imaging protocol for rapid and precise quantification of HIV-1-associated lipodystrophy
    M Bickel
    HIV Medical Treatment and Research Unit, JW Goethe University, Frankfurt, Germany
    HIV Med 8:413-9. 2007
  8. doi request reprint Acute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administration
    M Bickel
    Department of Infectious Disease, Goethe University, Frankfurt Main, Germany
    HIV Med 14:633-8. 2013
  9. doi request reprint End-stage renal disease and dialysis in HIV-positive patients: observations from a long-term cohort study with a follow-up of 22 years
    M Bickel
    Department of Infectious Disease, Goethe University, Frankfurt Main, Germany
    HIV Med 14:127-35. 2013
  10. pmc Improved virological and immunological efficacy of resistance-guided switch in antiretroviral therapy: a Frankfurt HIV cohort analysis
    T Wolf
    Infectious Diseases Unit at Medical Department No 2, HIVCENTER, Hospital of the Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Med Microbiol Immunol 203:409-14. 2014

Detail Information

Publications23

  1. ncbi request reprint A randomized, open-label study to compare the effects of two different doses of recombinant human growth hormone on fat reduction and fasting metabolic parameters in HIV-1-infected patients with lipodystrophy
    M Bickel
    HIV Treatment and Research Unit, JW Goethe University, Frankfurt, Germany
    HIV Med 7:397-403. 2006
    ..Several studies have shown beneficial effects of recombinant human growth hormone (r-hGH) in reducing visceral adipose tissue (VAT) in HIV-1-infected patients with lipodystrophy...
  2. ncbi request reprint The Protease Inhibitor Transfer Study (PROTRA 1): abacavir and efavirenz in combination as a substitute for a protease inhibitor in heavily pretreated HIV-1-infected patients with undetectable plasma viral load
    M Bickel
    Department of Infectious Disease, HIV Treatment and Research Unit, JW Goethe University, Frankfurt, Germany
    HIV Med 6:179-84. 2005
    ....
  3. ncbi request reprint Severe rhabdomyolysis, acute renal failure and posterior encephalopathy after 'magic mushroom' abuse
    Markus Bickel
    Department of Internal Medicine ICU, J W Goethe University, Frankfurt, Germany
    Eur J Emerg Med 12:306-8. 2005
    ..Magic mushrooms are becoming increasingly fashionable among drug users, as they are believed to be more harmless than other hallucinogenic designer drugs. So far, little is known about their possible severe side effects...
  4. doi request reprint Once-daily treatment with saquinavir mesylate (2000 mg) and ritonavir (100 mg) together with a fixed-dose combination of abacavir/lamivudine (600/300 mg) or tenofovir/emtricitabine (245/200 mg) in HIV-1-infected patients
    M Bickel
    HIVCENTER, JW Goethe University Hospital, Theodor Stern Kai 7, Frankfurt, Germany
    J Antimicrob Chemother 64:1260-4. 2009
    ..To investigate the feasibility and pharmacokinetics of a once-daily regimen of 2000 mg saquinavir mesylate boosted with 100 mg ritonavir...
  5. ncbi request reprint Severe CNS side-effect and persistent high efavirenz plasma levels in a patient with HIV/HCV coinfection and liver cirrhosis
    Markus Bickel
    HIV Treatment and Research Unit, JW Goethe University, Frankfurt, Germany
    Scand J Infect Dis 37:520-2. 2005
    ..Plasma levels of efavirenz were 10 times the upper limit and remained elevated (at twice the upper limit) 4 weeks after cessation of therapy. Efavirenz resistance (K103N) developed and was probably due to 'functional' monotherapy...
  6. pmc Daily dosing of tacrolimus in patients treated with HIV-1 therapy containing a ritonavir-boosted protease inhibitor or raltegravir
    Markus Bickel
    HIVCENTER, Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Antimicrob Chemother 65:999-1004. 2010
    ..The introduction of raltegravir, which is not metabolized by the cytochrome system, may allow concomitant treatment without dose adaptation...
  7. ncbi request reprint A standardized, comprehensive magnetic resonance imaging protocol for rapid and precise quantification of HIV-1-associated lipodystrophy
    M Bickel
    HIV Medical Treatment and Research Unit, JW Goethe University, Frankfurt, Germany
    HIV Med 8:413-9. 2007
    ..Although multiple methods have been proposed, there is no current gold standard for assessing HIV-1-associated lipodystrophy...
  8. doi request reprint Acute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administration
    M Bickel
    Department of Infectious Disease, Goethe University, Frankfurt Main, Germany
    HIV Med 14:633-8. 2013
    ..Case reports indicated that diclofenac might increase TFV-associated nephrotoxicity via a drug-drug interaction, leading to an increased intracellular TFV concentration in proximal tubular cells...
  9. doi request reprint End-stage renal disease and dialysis in HIV-positive patients: observations from a long-term cohort study with a follow-up of 22 years
    M Bickel
    Department of Infectious Disease, Goethe University, Frankfurt Main, Germany
    HIV Med 14:127-35. 2013
    ..Renal disease is a common and serious complication in HIV-infected patients...
  10. pmc Improved virological and immunological efficacy of resistance-guided switch in antiretroviral therapy: a Frankfurt HIV cohort analysis
    T Wolf
    Infectious Diseases Unit at Medical Department No 2, HIVCENTER, Hospital of the Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Med Microbiol Immunol 203:409-14. 2014
    ..A significant virological and immunological benefit could be demonstrated for patients of a cohort with resistance-guided antiretroviral therapy adjustments. ..
  11. doi request reprint Tuberculosis skin test, but not interferon-γ-releasing assays is affected by BCG vaccination in HIV patients
    T Wolf
    Department of Medicine II, Infectious Diseases Unit, Johann Wolfgang Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Infect 66:376-80. 2013
    ..Of this study was to compare the results of tuberculin skin test (TST) with two interferon-γ releasing-assays (IGRA) in a cohort of HIV positive patients, to analyze impact of prior Bacille-Calmette-Guérin (BCG)-vaccination...
  12. doi request reprint Intensification of a failing regimen with zidovudine may cause sustained virologic suppression in the presence of resensitising mutations including K65R
    C Stephan
    HIVCENTER, Johann Wolfgang Goethe University Hospital, Department of Internal Medicine II, Theodor Stern Kai 7, Frankfurt, Germany
    J Infect 61:346-50. 2010
    ..The reverse transcriptase (RT)-mutation K65R limits further therapeutic options and has been selected by unfavorable RT-combinations, e.g. tenofovir in combination with abacavir and/or didanosine...
  13. ncbi request reprint First case of successful allogeneic stem cell transplantation in an HIV-patient who acquired severe aplastic anemia
    T Wolf
    Department of Infectious Diseases, Hospital of the Johann Wolfgang Goethe University, Frankfurt, Germany
    Haematologica 92:e56-8. 2007
    ..The patient is in good condition with an ECOG score of 0 twelve months after transplantation. This report demonstrates the feasibility of allogeneic stem cell transplantation in the HIV setting...
  14. ncbi request reprint Long-term effect on body composition and metabolic parameters after treatment with recombinant human growth hormone (r-hGH) in HIV-1 infected patients with lipodystrophy
    Markus Bickel
    HIV Medical Treatment and Research Unit, Frankfurt, Germany
    Scand J Infect Dis 40:36-9. 2008
    ..006). These results suggest that the achieved reduction of VAT using r-hGH in lipodystrophic HIV+ patients is in part maintained after a median follow-up of 9 months...
  15. doi request reprint Atazanavir plasma concentrations are impaired in HIV-1-infected adults simultaneously taking a methadone oral solution in a once-daily observed therapy setting
    Annette Haberl
    HIVCENTER, Medical Clinics II, J W Goethe University Hospital, Frankfurt am Main, Germany
    Eur J Clin Pharmacol 66:375-81. 2010
    ..We performed a matched-pairs analysis on 24 patients (12 men/women) taking atazanavir/ritonavir 300/100 mg daily plus reverse transcriptase inhibitors, with (n = 12) or without (n = 12) methadone co-administration...
  16. ncbi request reprint A case of severe CMV-colitis in an HIV positive patient despite moderate immunodeficiency
    Timo Wolf
    Department of Infectious Diseases, JWG University, Frankfurt, Germany
    Scand J Infect Dis 35:904-6. 2003
    ..The diagnosis was confirmed by repeated biopsies. The patient experienced an unusually long recovery which was only achieved after initiation of HAART...
  17. doi request reprint Low rate of seroconversion after vaccination with a split virion, adjuvanted pandemic H1N1 influenza vaccine in HIV-1-infected patients
    Markus Bickel
    HIVCENTER, Frankfurt, Germany
    AIDS 24:F31-5. 2010
    ..To determine rates of seroconversion after single vaccination with a novel split virion, inactivated, adjuvanted pandemic H1N1 influenza vaccine (A/California/7/2009) in HIV-1-infected patients (ClinicalTrials.gov Identifier: NCT01017172)...
  18. ncbi request reprint Impact of tenofovir-containing antiretroviral therapy on chronic hepatitis B in a cohort co-infected with human immunodeficiency virus
    Christoph Stephan
    HIV Research and Treatment Unit at Center for Internal Medicine, Johann Wolfgang Goethe University Hospital Frankfurt, Germany
    J Antimicrob Chemother 56:1087-93. 2005
    ..We studied the impact of tenofovir disoproxil fumarate, given as an antiretroviral medication, on patients with chronic hepatitis B virus (HBV) co-infection...
  19. ncbi request reprint Human immunodeficiency virus rebound after suppression to <400 copies/mL during initial highly active antiretroviral therapy regimens, according to prior nucleoside experience and duration of suppression
    Andrew N Phillips
    Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom
    J Infect Dis 186:1086-91. 2002
    ..95; P=.009). It appears that only a small period of pre-HAART nucleoside therapy is sufficient to confer a disadvantage, in terms of risk of virus rebound, that persists for several years...
  20. ncbi request reprint Evidence of nucleoside analogue reverse transcriptase inhibitor--associated genetic and structural defects of mitochondria in adipose tissue of HIV-infected patients
    Ulrich A Walker
    Department of Rheumatology and Clinical Immunology, Medizinische Universitatsklinik, Freiburg, Germany
    J Acquir Immune Defic Syndr 29:117-21. 2002
    ..mtDNA depletion and ultrastructural abnormalities of adipocytes suggest a link between mitochondrial damage, the use of NRTIs, and lipoatrophy in HIV-infected patients...
  21. ncbi request reprint Hypertension in HIV-1-infected patients and its impact on renal and cardiovascular integrity
    Oliver Jung
    Klinikum der Johann Wolfgang Goethe Universitat, Medizinische Klinik IV, Funktionsbereich Nephrologie, D 60590 Frankfurt Main, Germany
    Nephrol Dial Transplant 19:2250-8. 2004
    ..Data on prevalence and consequences of hypertension are limited, but recent studies suggest that HIV-infected individuals are at a higher risk of developing hypertension...
  22. ncbi request reprint HIV-related neuropathology, 1985 to 1999: rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy
    Jutta K Neuenburg
    Department of Neurology, University of California, San Francisco, USA
    J Acquir Immune Defic Syndr 31:171-7. 2002
    ..Although combination therapies decrease overall mortality and prevalence of CNS opportunistic infections, these therapies may be less active in preventing direct HIV-1 effects on the brain...
  23. ncbi request reprint Safe interruption of maintenance therapy against previous infection with four common HIV-associated opportunistic pathogens during potent antiretroviral therapy
    Ole Kirk
    Coordinating Centre of EuroSIDA, Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Kettegaard Alle, 2650 Hvidovre, Denmark
    Ann Intern Med 137:239-50. 2002
    ..The safety of interrupting maintenance therapy for previous opportunistic infections other than Pneumocystis carinii pneumonia among patients with HIV infection who respond to potent antiretroviral therapy has not been well documented...