Alberto Bianco

Summary

Publications

  1. doi Making carbon nanotubes biocompatible and biodegradable
    Alberto Bianco
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, Strasbourg, 67000, France
    Chem Commun (Camb) 47:10182-8. 2011
  2. doi Self-assembly of diphenylalanine backbone homologues and their combination with functionalized carbon nanotubes
    Bhimareddy Dinesh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France
    Nanoscale 7:15873-9. 2015
  3. doi Diameter-dependent release of a cisplatin pro-drug from small and large functionalized carbon nanotubes
    Laura Muzi
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, Strasbourg, France
    Nanoscale 7:5383-94. 2015
  4. pmc Impact of carbon nanotubes and graphene on immune cells
    Marco Orecchioni
    Dipartimento di Chimica e Farmacia, Universita degli Studi di Sassari, 07100 Sassari, Italy
    J Transl Med 12:138. 2014
  5. doi Evidencing the mask effect of graphene oxide: a comparative study on primary human and murine phagocytic cells
    Julie Russier
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Immunopathologie et Chimie Thérapeutique Laboratory of Excellence Medalis, Strasbourg, France
    Nanoscale 5:11234-47. 2013
  6. doi Graphene: safe or toxic? The two faces of the medal
    Alberto Bianco
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, 15 rue Rene Descartes, 67084 Strasbourg, France
    Angew Chem Int Ed Engl 52:4986-97. 2013
  7. ncbi The alluring potential of functionalized carbon nanotubes in drug discovery
    Cécilia Ménard-Moyon
    CNRS, Institut de Biologie Moleculaire et Cellulaire, UPR 9021 Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France
    Expert Opin Drug Discov 5:691-707. 2010
  8. ncbi Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells
    Hélène Dumortier
    CNRS UPR 9021, Institute of Molecular and Cellular Biology, Strasbourg, France
    Nano Lett 6:1522-8. 2006
  9. doi Synthesis and characterization of nucleobase-carbon nanotube hybrids
    Prabhpreet Singh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France
    J Am Chem Soc 131:13555-62. 2009
  10. doi Formation of efficient catalytic silver nanoparticles on carbon nanotubes by adenine functionalization
    Prabhpreet Singh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, Strasbourg, France
    Angew Chem Int Ed Engl 50:9893-7. 2011

Collaborators

Detail Information

Publications57

  1. doi Making carbon nanotubes biocompatible and biodegradable
    Alberto Bianco
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, Strasbourg, 67000, France
    Chem Commun (Camb) 47:10182-8. 2011
    ..This article highlights recent advances that can act as paradigm-shifts towards the design of biocompatible and biodegradable functionalised carbon nanotubes and allow their translation into the clinic...
  2. doi Self-assembly of diphenylalanine backbone homologues and their combination with functionalized carbon nanotubes
    Bhimareddy Dinesh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France
    Nanoscale 7:15873-9. 2015
    ..The dendritic organization obtained by mixing carbon nanotubes and peptides might find interesting applications in tissue engineering and neuronal interfacing. ..
  3. doi Diameter-dependent release of a cisplatin pro-drug from small and large functionalized carbon nanotubes
    Laura Muzi
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, Strasbourg, France
    Nanoscale 7:5383-94. 2015
    ..To conclude, our study shows that CNTs are promising nanocarriers to improve the accumulation of a chemotherapeutic drug and its slow release inside tumor cells, by tuning the CNT diameter, without inducing a high inflammatory response...
  4. pmc Impact of carbon nanotubes and graphene on immune cells
    Marco Orecchioni
    Dipartimento di Chimica e Farmacia, Universita degli Studi di Sassari, 07100 Sassari, Italy
    J Transl Med 12:138. 2014
    ..This comprehensive state of the art on biocompatible f-CNTs and graphene on immune cells provides a useful compass to guide future researches on immunological applications of carbon nanomaterials in medicine. ..
  5. doi Evidencing the mask effect of graphene oxide: a comparative study on primary human and murine phagocytic cells
    Julie Russier
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Immunopathologie et Chimie Thérapeutique Laboratory of Excellence Medalis, Strasbourg, France
    Nanoscale 5:11234-47. 2013
    ....
  6. doi Graphene: safe or toxic? The two faces of the medal
    Alberto Bianco
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, 15 rue Rene Descartes, 67084 Strasbourg, France
    Angew Chem Int Ed Engl 52:4986-97. 2013
    ..This Minireview critically discusses the recent studies on the toxicity of GFNs to provide some perspective on the possible risks to their future development in materials and biomedical sciences...
  7. ncbi The alluring potential of functionalized carbon nanotubes in drug discovery
    Cécilia Ménard-Moyon
    CNRS, Institut de Biologie Moleculaire et Cellulaire, UPR 9021 Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France
    Expert Opin Drug Discov 5:691-707. 2010
    ..They have the capacity to cross biological barriers and can be eliminated via renal and/or fecal excretion. They can transport small drug molecules while maintaining - and in some cases improving - their therapeutic efficacy...
  8. ncbi Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells
    Hélène Dumortier
    CNRS UPR 9021, Institute of Molecular and Cellular Biology, Strasbourg, France
    Nano Lett 6:1522-8. 2006
    ..f-CNT 3, which instead possesses reduced solubility and forms mainly stable water suspensions, preserved lymphocytes' functionality while provoking secretion of proinflammatory cytokines by macrophages...
  9. doi Synthesis and characterization of nucleobase-carbon nanotube hybrids
    Prabhpreet Singh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France
    J Am Chem Soc 131:13555-62. 2009
    ....
  10. doi Formation of efficient catalytic silver nanoparticles on carbon nanotubes by adenine functionalization
    Prabhpreet Singh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, Strasbourg, France
    Angew Chem Int Ed Engl 50:9893-7. 2011
    ..The catalytic efficiency of the resulting species was assessed in the oxidation of 2-methylhydroquinone to its corresponding benzoquinone, with complete recovery and without loss of activity of the catalyst...
  11. doi Antibody covalent immobilization on carbon nanotubes and assessment of antigen binding
    Enrica Venturelli
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, Strasbourg 67000, France
    Small 7:2179-87. 2011
    ..These results are very relevant for the design of future receptor-targeting strategies using chemically functionalized carbon nanotubes...
  12. doi Carbon nanotube-nucleobase hybrids: nanorings from uracil-modified single-walled carbon nanotubes
    Prabhpreet Singh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, Strasbourg, France
    Chemistry 17:6772-80. 2011
    ..These nanorings can be envisaged for the development of advanced electronic circuits...
  13. ncbi Solid-phase synthesis of CD40L mimetics
    Alberto Bianco
    Institut de Biologie Moleculaire et Cellulaire, UPR 9021 CNRS, Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67084 Strasbourg, France
    Org Biomol Chem 4:1461-3. 2006
    ..The present report describes a general solid-phase synthesis approach to and related trimeric architectures. In addition, their CD40 binding properties as well as their effector functions have been evaluated...
  14. doi G-quartet type self-assembly of guanine functionalized single-walled carbon nanotubes
    Prabhpreet Singh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67084 Strasbourg, France
    Nanoscale 4:1972-4. 2012
    ....
  15. doi Immunomodulatory consequences of ODN CpG-polycation complexes
    Charalambos D Partidos
    CNRS UPR 9021, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Methods 49:328-33. 2009
    ..Overall, our findings together with published data support the view that for harnessing the beneficial effects of ODN CpGs a careful consideration has to be given depending on the target intervention...
  16. doi Endowing carbon nanotubes with biological and biomedical properties by chemical modifications
    Alessia Battigelli
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France
    Adv Drug Deliv Rev 65:1899-920. 2013
    ..Biomolecules can be covalently grafted or non-covalently adsorbed on the nanotube surface. In addition, the inner core of CNTs can be exploited to encapsulate drugs, nanoparticles, or radioactive elements. ..
  17. ncbi Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties
    Alberto Bianco
    Institut de Biologie Moleculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France
    J Am Chem Soc 127:58-9. 2005
    ..Functionalized cationic carbon nanotubes are able to form a stable complex with CpG ODN based on charge interaction and to increase the immunostimulatory activity of CpG motifs...
  18. doi Double functionalization of carbon nanotubes with purine and pyrimidine derivatives
    Prabhpreet Singh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France
    Chem Asian J 8:1472-81. 2013
    ..The nucleobase/SWCNT conjugates can be envisaged for the modulation of the interactions with nucleic acids by means of base pairing, thereby opening new possibilities in the development of DNA/CNT nanobioconjugates. ..
  19. ncbi Carbon nanotubes: on the road to deliver
    Alberto Bianco
    UPR 9021, CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084, Strasbourg, France
    Curr Drug Deliv 2:253-9. 2005
    ..This opens new therapeutic and preventive opportunities to combat diseases. The scope of this review is to summarize our recent work in this rapidly growing field...
  20. ncbi Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics
    Cedric Klumpp
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 15 rue Rene Descartes, 67084 Strasbourg, France
    Biochim Biophys Acta 1758:404-12. 2006
    ..Once the cargos are carried into various cells, tissues and organs they are able to express their biological function. In this review, we will describe the potential of f-CNT to deliver different types of therapeutic molecules...
  21. ncbi Design and activity of cationic fullerene derivatives as inhibitors of acetylcholinesterase
    Giorgia Pastorin
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, Strasbourg, France
    Org Biomol Chem 4:2556-62. 2006
    ..The cationic C(60) derivatives used in this study represent a new class of molecules potentially able to modulate the enzymatic activity of acetylcholinesterase...
  22. doi Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers
    Cristian Samorì
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France
    Chem Commun (Camb) 46:1494-6. 2010
    ..The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker...
  23. ncbi Solid-phase synthesis and characterization of a novel fullerene-peptide derived from histone H3
    Alberto Bianco
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France
    Org Biomol Chem 1:4141-3. 2003
    ..By molecular modelling it was verified that this peptide derivative is able to retain a binding capacity to the MHC (major histocompatibility complex) molecule similar to that of the cognate epitope...
  24. ncbi Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses
    Davide Pantarotto
    Institut de Biologie Moleculaire et Cellulaire, UPR 9021 CNRS, Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67084 Strasbourg, France
    Chem Biol 10:961-6. 2003
  25. doi Dispersibility-Dependent Biodegradation of Graphene Oxide by Myeloperoxidase
    Rajendra Kurapati
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, 67000, Strasbourg, France
    Small 11:3985-94. 2015
    ..The spectroscopy and microscopy analyses provide unambiguous evidence for the key roles played by hydrophilicity, negative surface charge, and colloidal stability of the aqueous GO in their biodegradation by hMPO catalysis. ..
  26. ncbi Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes
    Wei Wu
    Institut de Biologie Moleculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France
    Angew Chem Int Ed Engl 44:6358-62. 2005
  27. doi Graphene-based nanomaterials for nanobiotechnology and biomedical applications
    K Vijaya Krishna
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France
    Nanomedicine (Lond) 8:1669-88. 2013
    ..In a tandem approach, this review presents the smooth inclusion of these nanomaterials into existing designs for creating efficient working models at the nanoscale level as well as discussing their broad future possibilities. ..
  28. doi Oxidative biodegradation of single- and multi-walled carbon nanotubes
    Julie Russier
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 67000, Strasbourg, France
    Nanoscale 3:893-6. 2011
    ..In particular, we demonstrate that oxidized multi-walled carbon nanotubes are highly degraded, although not to completeness when treated with horseradish peroxidase (HRP) in the presence of hydrogen peroxide...
  29. doi Multimerization of an apoptogenic TRAIL-mimicking peptide by using adamantane-based dendrons
    Giuseppe Lamanna
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67084 Strasbourg, France
    Chemistry 19:1762-8. 2013
    ..These results provide interesting insight into the multivalency effect on biological ligand/receptor interactions for future therapeutic applications...
  30. ncbi Applications of carbon nanotubes in drug delivery
    Alberto Bianco
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France
    Curr Opin Chem Biol 9:674-9. 2005
    ..Because functionalised CNT display low toxicity and are not immunogenic, such systems hold great potential in the field of nanobiotechnology and nanomedicine...
  31. doi Degradation-by-design: Surface modification with functional substrates that enhance the enzymatic degradation of carbon nanotubes
    Adukamparai Rajukrishnan Sureshbabu
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France
    Biomaterials 72:20-8. 2015
    ....
  32. doi Controlled Chemical Derivatisation of Carbon Nanotubes with Imaging, Targeting, and Therapeutic Capabilities
    Cécilia Ménard-Moyon
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, UPR 3572, 67000 Strasbourg France
    Chemistry 21:14886-92. 2015
    ....
  33. pmc Functionalized multiwalled carbon nanotubes as ultrasound contrast agents
    Lucia Gemma Delogu
    Dipartimento di Chimica e Farmacia, Sperimentale e Oncologica, Universita degli Studi di Sassari, 07100 Sassari, Italy
    Proc Natl Acad Sci U S A 109:16612-7. 2012
    ..Our results reveal the enormous potential of CNTs as ultrasound contrast agents, giving support for their future applications as theranostic nanoparticles, combining diagnostic and therapeutic modalities...
  34. doi Endowing carbon nanotubes with superparamagnetic properties: applications for cell labeling, MRI cell tracking and magnetic manipulations
    Giuseppe Lamanna
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, UPR 3572, 67000 Strasbourg, France
    Nanoscale 5:4412-21. 2013
    ..They are internalized into tumor cells without showing cytotoxicity. The labeled cells can be magnetically manipulated as they display magnetic mobility and are detected at a single cell level through high resolution MRI...
  35. doi Ammonium and guanidinium dendron-carbon nanotubes by amidation and click chemistry and their use for siRNA delivery
    Alessia Battigelli
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie, et Chimie Thérapeutique, 67000 Strasbourg, France Dipartimento di Scienze Chimiche e Farmaceutiche, Università di Trieste 34127, Trieste, Italy
    Small 9:3610-9. 2013
    ..The demonstration of the cell uptake capacity, the low cytotoxicity, and the ability of these cationic conjugates to silence cytotoxic genes suggests them to be promising carriers for genetic material. ..
  36. ncbi C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L
    Sylvie Fournel
    UPR 9021 CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084 Strasbourg, France
    Nat Chem Biol 1:377-82. 2005
    ..Architectures based on rigid C3-symmetric cores may thus represent a general approach to mimicking homotrimers of the TNF superfamily...
  37. doi Functionalized carbon nanotubes for probing and modulating molecular functions
    Cécilia Ménard-Moyon
    Centre National de la Recherche Scientifique, Institut de Biologie Moleculaire et Cellulaire, UPR 9021 Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France
    Chem Biol 17:107-15. 2010
    ....
  38. doi One-pot triple functionalization of carbon nanotubes
    Cécilia Ménard-Moyon
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, UPR 9021, 67000 Strasbourg, France
    Chemistry 17:3222-7. 2011
    ..The sequential removal of the protecting groups of the amine functions allows the grafting of the molecules of interest on the nanotube surface to be controlled...
  39. doi Enhancement of anti-inflammatory drug activity by multivalent adamantane-based dendrons
    Giuseppe Lamanna
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, Strasbourg, France
    Biomaterials 33:5610-7. 2012
    ..These results provide insights into the effect of HYDRAmer multivalency on biological interactions for therapeutic applications...
  40. doi Self-Assembly of Tyrosine into Controlled Supramolecular Nanostructures
    Cécilia Ménard-Moyon
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Immunopathologie et Chimie Thérapeutique, Strasbourg France
    Chemistry 21:11681-6. 2015
    ..Different supramolecular architectures, including nanoribbons, branched structures, and fern-like arrangements were also observed. ..
  41. doi The perception of nanotechnology and nanomedicine: a worldwide social media study
    Giovanni Sechi
    Dipartimento di Scienze Politiche, Scienze della Comunicazione and Ingegneria dell Informazione, Universita degli Studi di Sassari, 07100 Sassari, Italy
    Nanomedicine (Lond) 9:1475-86. 2014
    ..This study highlights the potential of online social media to influence scientific communities, grant committees and nanotechnology companies, spreading nanotechnology awareness in emerging countries and among new generations. ..
  42. doi Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions
    Claudia Crescio
    Dipartimento di Scienze Biomediche, Universita degli Studi di Sassari, 07100 Sassari, Italy
    Nanoscale 6:9599-603. 2014
    ..We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations. ..
  43. doi Adamantane-based dendrons for trimerization of the therapeutic P140 peptide
    Giuseppe Lamanna
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, Strasbourg, France
    Biomaterials 35:7553-61. 2014
    ..This work reveals that adamantane-based scaffolds with a well-defined spatial conformation are promising trivalent systems for molecular recognition and for biomedical applications. ..
  44. ncbi Opportunities and challenges of carbon-based nanomaterials for cancer therapy
    Alberto Bianco
    CNRS, Institut de Biologie Moleculaire et Cellulaire, UPR 9021 Immonulogie et Chimie Thérapeutiques, 67000 Strasbourg, France
    Expert Opin Drug Deliv 5:331-42. 2008
    ..A comparison between the characteristics, the advantages, the drawbacks, the benefits and the risks associated with these novel biocompatible forms of carbon is presented here...
  45. doi HYDRAmers: design, synthesis and characterization of different generation novel Hydra-like dendrons based on multifunctionalized adamantane
    Giuseppe Lamanna
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67084 Strasbourg, France
    Chem Commun (Camb) 47:8955-7. 2011
    ..The novel dendrons, which we termed HYDRAmers, possess at the periphery and at the central core orthogonal protections that can be exploited for conjugation of targeting ligands, drugs and/or imaging probes...
  46. doi Organic functionalisation and characterisation of single-walled carbon nanotubes
    Prabhpreet Singh
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67000, Strasbourg, France
    Chem Soc Rev 38:2214-30. 2009
    ..In this tutorial review, we survey the covalent modification of SWCNTs with organic moieties, and illustrate the major analytical techniques routinely used to characterise the functionalised materials...
  47. doi Exploring helical folding of oligoureas during chain elongation by high-resolution magic-angle-spinning (HRMAS) NMR spectroscopy
    Aude Violette
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Immunologie et Chimie Thérapeutiques, 15 rue Descartes, 67084 Strasbourg, France
    Chemistry 14:3874-82. 2008
    ..On-bead NOESY spectra of high quality and with resolution comparable to that of liquid samples were obtained for longer oligomers, thus allowing detailed structural characterization...
  48. doi Design and synthesis of intrinsically cell-penetrating nucleopeptides
    Piero Geotti-Bianchini
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67000, Strasbourg, France
    Org Biomol Chem 6:3661-3. 2008
    ..Nucleopeptides, which are constituted of alpha-amino acids bearing nucleobases at their side chains, are able to penetrate into cells and to reach the nucleus without cytotoxic effects...
  49. doi Multifunctional carbon nanomaterial hybrids for magnetic manipulation and targeting
    Ngoc Do Quyen Chau
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France
    Biochem Biophys Res Commun 468:454-62. 2015
    ....
  50. doi Elucidation of the Cellular Uptake Mechanisms of Polycationic HYDRAmers
    Julie Russier
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France
    Bioconjug Chem 26:1484-93. 2015
    ..These results suggest the possibility of addressing dendrimers toward specific subcellular compartments by tuning their structure properties and, in particular, the functional groups at their periphery. ..
  51. pmc Carbon nanomaterials combined with metal nanoparticles for theranostic applications
    Gloria Modugno
    Institut de Biologie Moleculaire et Cellulaire, Laboratoire d Immunopathologie et Chimie Thérapeutique, CNRS, Strasbourg, France
    Br J Pharmacol 172:975-91. 2015
    ..In this review, the preparation of CNMs conjugated to different types of metal NPs and their applications in diagnosis, imaging, therapy and theranostics are presented. ..
  52. ncbi Carbon nanotubes for the delivery of therapeutic molecules
    Alberto Bianco
    Institut de Biologie Moleculaire et Cellulaire, UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    Expert Opin Drug Deliv 1:57-65. 2004
    ..Research discussed in this review is focused on recent advances in the development of CNT technology for the delivery of drugs, antigens and genes...
  53. doi Carbon nanotube-coupled cell adhesion peptides are non-immunogenic: a promising step toward new biomedical devices
    Claire Gaillard
    CNRS, Institut de Biologie Moleculaire et Cellulaire, UPR 9021, Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France
    J Pept Sci 17:139-42. 2011
    ..Demonstration of the immune neutrality of peptide-carbon nanotubes reinforces their potential use as substrates for neuronal regeneration in vivo...
  54. doi Nanomaterials, Autophagy, and Lupus Disease
    Alberto Bianco
    CNRS, Immunopathologie et Chimie Thérapeutique, Institut de Biologie Moleculaire et Cellulaire, UPR3572 CNRS, 15 rue Rene Descartes, 67000, Strasbourg, France
    ChemMedChem 11:166-74. 2016
    ..The nanomaterial-autophagy interaction therefore must be treated with caution for therapeutic molecules and peptides that require vectorization for their administration. ..
  55. doi Multifunctional adamantane derivatives as new scaffolds for the multipresentation of bioactive peptides
    Maxime Grillaud
    CNRS, Institut de Biologie Moléculaire et, Cellulaire, Immunopathologie et Chimie Thérapeutique, Strasbourg, France
    J Pept Sci 21:330-45. 2015
    ..The results reported here will certainly encourage the development of novel adamantane-based structures for biological purposes...
  56. doi Polycationic adamantane-based dendrons of different generations display high cellular uptake without triggering cytotoxicity
    Maxime Grillaud
    CNRS, Institut de Biologie Moleculaire et Cellulaire, Immunopathologie et Chimie Thérapeutique, Strasbourg, France
    J Am Chem Soc 136:810-9. 2014
    ..These results suggest that the polycationic HYDRAmers are potentially interesting as new vectors in biomedical applications, including gene and drug delivery. ..
  57. ncbi Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides
    Davide Pantarotto
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France
    J Am Chem Soc 125:6160-4. 2003
    ..In addition, this peptide-NT conjugate is immunogenic, eliciting antibody responses of the right specificity. Such a system could be greatly advantageous for diagnostic purposes and could find future applications in vaccine delivery...