Matt T Bianchi

Summary

Publications

  1. pmc Power law versus exponential state transition dynamics: application to sleep-wake architecture
    Jesse Chu-Shore
    Institute for Quantitative Social Science, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 5:e14204. 2010
  2. pmc Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity?
    Matt T Bianchi
    Neurology Department, Sleep Division, Massachusetts General Hospital, Boston, MA, USA
    BMC Pharmacol 10:3. 2010
  3. doi request reprint Promiscuous modulation of ion channels by anti-psychotic and anti-dementia medications
    Matt T Bianchi
    Department of Neurology, Sleep Division, Massachusetts General Hospital, Wang Ambulatory Center 7th Floor, Boston, MA 02114, USA
    Med Hypotheses 74:297-300. 2010
  4. doi request reprint From ion channels to complex networks: magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy
    Matt T Bianchi
    Beth Israel Deaconess Medical Center, Sleep Medicine, 300 Brookline Ave, KS 4, Boston, MA 02115, United States
    Med Hypotheses 72:297-305. 2009
  5. doi request reprint Incorporating uncertainty into medical decision making: an approach to unexpected test results
    Matt T Bianchi
    Partners Neurology, Massachusetts General Hospital and Brigham and Women s Hospital, Wang Ambulatory Center, Boston, MA, USA
    Med Decis Making 29:116-24. 2009
  6. pmc Emergence of stable functional networks in long-term human electroencephalography
    Catherine J Chu
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neurosci 32:2703-13. 2012
  7. pmc Probabilistic sleep architecture models in patients with and without sleep apnea
    Matt T Bianchi
    Neurology Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Sleep Res 21:330-41. 2012
  8. pmc Benzodiazepine modulation of GABA(A) receptor opening frequency depends on activation context: a patch clamp and simulation study
    Matt T Bianchi
    Sleep Disorders Center, Beth Israel Deaconess Medical Center, Boston, MA, United States
    Epilepsy Res 85:212-20. 2009
  9. doi request reprint The information theoretic perspective on medical diagnostic inference
    Nathaniel A Eiseman
    Massachusetts General Hospital, Boston, MA
    Hosp Pract (1995) 42:125-38. 2014
  10. doi request reprint The subjective-objective mismatch in sleep perception among those with insomnia and sleep apnea
    Matt T Bianchi
    Sleep Division, Neurology Department, Massachusetts General Hospital, Boston, MA, USA Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
    J Sleep Res 22:557-68. 2013

Collaborators

Detail Information

Publications47

  1. pmc Power law versus exponential state transition dynamics: application to sleep-wake architecture
    Jesse Chu-Shore
    Institute for Quantitative Social Science, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 5:e14204. 2010
    ..Although mono-exponential distributions are distinct from power law distributions, multi-exponential distributions may in fact resemble power laws by appearing linear on a log-log plot...
  2. pmc Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity?
    Matt T Bianchi
    Neurology Department, Sleep Division, Massachusetts General Hospital, Boston, MA, USA
    BMC Pharmacol 10:3. 2010
    ..For this approach to be successful, however, a framework for understanding pharmacological "promiscuity"--the ability of individual agents to modulate multiple molecular targets--is needed...
  3. doi request reprint Promiscuous modulation of ion channels by anti-psychotic and anti-dementia medications
    Matt T Bianchi
    Department of Neurology, Sleep Division, Massachusetts General Hospital, Wang Ambulatory Center 7th Floor, Boston, MA 02114, USA
    Med Hypotheses 74:297-300. 2010
    ..We hypothesize that promiscuous ion channel modulation may contribute to the efficacy of drugs used to treat psychosis and dementia...
  4. doi request reprint From ion channels to complex networks: magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy
    Matt T Bianchi
    Beth Israel Deaconess Medical Center, Sleep Medicine, 300 Brookline Ave, KS 4, Boston, MA 02115, United States
    Med Hypotheses 72:297-305. 2009
    ..Although the relevance of this promiscuity remains untested, it may contribute to anticonvulsant efficacy and should therefore be considered in drug development strategies and in therapeutic decision making...
  5. doi request reprint Incorporating uncertainty into medical decision making: an approach to unexpected test results
    Matt T Bianchi
    Partners Neurology, Massachusetts General Hospital and Brigham and Women s Hospital, Wang Ambulatory Center, Boston, MA, USA
    Med Decis Making 29:116-24. 2009
    ..This graphical framework overcomes the limitation of pretest probability uncertainty in Bayesian analysis and guides decision making when it is most challenging: interpretation of unexpected test results...
  6. pmc Emergence of stable functional networks in long-term human electroencephalography
    Catherine J Chu
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neurosci 32:2703-13. 2012
    ....
  7. pmc Probabilistic sleep architecture models in patients with and without sleep apnea
    Matt T Bianchi
    Neurology Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Sleep Res 21:330-41. 2012
    ..Markov sleep models may prove important for quantifying sleep disruption to provide objective metrics to correlate with endpoints ranging from sleepiness to cardiovascular morbidity...
  8. pmc Benzodiazepine modulation of GABA(A) receptor opening frequency depends on activation context: a patch clamp and simulation study
    Matt T Bianchi
    Sleep Disorders Center, Beth Israel Deaconess Medical Center, Boston, MA, United States
    Epilepsy Res 85:212-20. 2009
    ..The functional impact of BDZs on GABA(A) receptors therefore depends upon the physiological context of receptor activation...
  9. doi request reprint The information theoretic perspective on medical diagnostic inference
    Nathaniel A Eiseman
    Massachusetts General Hospital, Boston, MA
    Hosp Pract (1995) 42:125-38. 2014
    ..We show that information theory provides a quantitative framework for understanding uncertainty that readily extends to medical diagnostic contexts. ..
  10. doi request reprint The subjective-objective mismatch in sleep perception among those with insomnia and sleep apnea
    Matt T Bianchi
    Sleep Division, Neurology Department, Massachusetts General Hospital, Boston, MA, USA Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
    J Sleep Res 22:557-68. 2013
    ..Further insight is needed into the complex relationships between subjective perception of sleep and conventional, objective measurements. ..
  11. pmc Calculating the risk benefit equation for aggressive treatment of non-convulsive status epilepticus
    Matthew Ferguson
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurocrit Care 18:216-27. 2013
    ..To address the question: does non-convulsive status epilepticus warrant the same aggressive treatment as convulsive status epilepticus?..
  12. pmc Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation
    Matt T Bianchi
    Partners Neurology, Massachusetts General Hospital and Brigham and Women s Hospital, Boston, MA 02114, USA
    J Physiol 584:769-87. 2007
    ..Finally, these findings permitted development of an algorithmic framework for kinetic interpretation of experimental manipulations that alter macroscopic current properties...
  13. ncbi request reprint Pentobarbital differentially modulates alpha1beta3delta and alpha1beta3gamma2L GABAA receptor currents
    Hua Jun Feng
    Department of Neurology, Vanderbilt University, Nashville, TN, USA
    Mol Pharmacol 66:988-1003. 2004
    ..The remarkable increase in gating efficacy of alpha1beta3delta receptors suggests that alphabetadelta isoforms, and by inference tonic forms of inhibition, may be important targets for barbiturates...
  14. pmc Inferring seizure frequency from brief EEG recordings
    M Brandon Westover
    MGH Epilepsy Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    J Clin Neurophysiol 30:174-7. 2013
    ..This framework should aid the clinician in applying a more principled approach toward decision making in the setting of a single seizure on a routine EEG...
  15. ncbi request reprint Mutations linked to generalized epilepsy in humans reduce GABA(A) receptor current
    Robert L Macdonald
    Department of Neurology, Vanderbilt University, Nashville, TN 37212, USA
    Exp Neurol 184:S58-67. 2003
    ..These two gamma mutations likely produce disinhibition and familial epilepsy by distinct mechanisms, suggesting that maintenance of normal neuronal inhibition depends on both the peak amplitude of IPSCs and their time course...
  16. pmc The impact of body posture and sleep stages on sleep apnea severity in adults
    Nathaniel A Eiseman
    Neurology Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Sleep Med 8:655-66A. 2012
    ..Making this determination presents a diagnostic challenge, given that summary metrics do not consider certain factors that influence severity, such as body position and the composition of sleep stages...
  17. doi request reprint Propagation of uncertainty in Bayesian diagnostic test interpretation
    Preethi Srinivasan
    Bioinformatics Department, Northeastern University, Boston, Massachusetts, USA
    South Med J 105:452-9. 2012
    ..We thus sought to demonstrate how uncertainty in sensitivity, specificity, and disease pretest probability can be accommodated in Bayesian interpretation of diagnostic testing...
  18. doi request reprint Should risky treatments be reserved for secondary prevention? Theoretical considerations regarding risk-benefit tradeoffs
    M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Epidemiol 65:877-86. 2012
    ..However, under certain conditions treatment benefits may be greater in primary prevention, even when the treatment carries harmful adverse effect potential...
  19. pmc The probability of seizures during EEG monitoring in critically ill adults
    M Brandon Westover
    Department of Neurology, Epilepsy Service, Massachusetts General Hospital, Wang 720, Boston, MA 02114, USA Electronic address
    Clin Neurophysiol 126:463-71. 2015
    ..To characterize the risk for seizures over time in relation to EEG findings in hospitalized adults undergoing continuous EEG monitoring (cEEG)...
  20. pmc Sleep misperception in healthy adults: implications for insomnia diagnosis
    Matt T Bianchi
    Sleep Division, Neurology Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Sleep Med 8:547-54. 2012
    ....
  21. pmc Estimating cerebral microinfarct burden from autopsy samples
    M Brandon Westover
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    Neurology 80:1365-9. 2013
    ..To estimate whole-brain microinfarct burden from microinfarct counts in routine postmortem examination...
  22. doi request reprint Mammalian sleep genetics
    Jessica M Kelly
    Neurology Department, Sleep Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurogenetics 13:287-326. 2012
    ....
  23. pmc Revising the "Rule of Three" for inferring seizure freedom
    M Brandon Westover
    Neurology Department, Epilepsy Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 53:368-76. 2012
    ..Therefore, we set out to determine whether an alternative approach to the Rule of Three might be possible, and under what conditions the rule may be expected to hold or would need to be extended...
  24. pmc Emergence of persistent networks in long-term intracranial EEG recordings
    Mark A Kramer
    Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 31:15757-67. 2011
    ..These results suggest that a metastable, frequency-band-dependent scaffold of brain connectivity exists from which transient activity emerges and recedes...
  25. pmc Aspirin for acute stroke of unknown etiology in resource-limited settings: a decision analysis
    Aaron L Berkowitz
    From the Department of Neurology, Brigham and Women s Hospital A L B, S H Y C, and the Department of Neurology, Massachusetts General Hospital M B W, M T B, Harvard Medical School, Boston, MA
    Neurology 83:787-93. 2014
    ..To analyze the potential impact of aspirin on outcome at hospital discharge after acute stroke in resource-limited settings without access to neuroimaging to distinguish ischemic stroke from intracerebral hemorrhage (ICH)...
  26. pmc Information theoretic quantification of diagnostic uncertainty
    M Brandon Westover
    Neurology Department, Massachusetts General Hospital, Wang 720, Boston, MA 02114, USA
    Open Med Inform J 6:36-50. 2012
    ..Finally, we illustrate how, in information theoretic terms, one can understand the effect on diagnostic uncertainty of considering ranges instead of simple point estimates of pre-test probability...
  27. pmc Evidence based diagnosis: does the language reflect the theory?
    Matt T Bianchi
    Partners Neurology, Massachusetts General Hospital and Brigham and Women s Hospital, Boston, MA 02114, USA
    BMJ 333:442-5. 2006
  28. ncbi request reprint Statistics for Sleep and Biological Rhythms Research: From Distributions and Displays to Correlation and Causation
    Matt T Bianchi
    Neurology Department, Massachusetts General Hospital, Boston, Massachusetts
    J Biol Rhythms . 2016
    ..These ideas are then applied to sample size, power calculations, correlation testing, differences between description and prediction, and the narrative fallacy...
  29. doi request reprint The challenge of undiagnosed sleep apnea in low-risk populations: a decision analysis
    Matt T Bianchi
    Neurology Department, 55 Fruit Street, Wang 720, MGH Neurology, Boston, MA 02114
    Mil Med 179:47-54. 2014
    ..We used decision analysis to evaluate three approaches to identifying and treating OSA in low-risk populations, which may differ from current standard practice for high-risk populations...
  30. pmc The wake-promoting transmitter histamine preferentially enhances α-4 subunit-containing GABAA receptors
    Matt T Bianchi
    Sleep Division, Neurology Department, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuropharmacology 61:747-52. 2011
    ....
  31. pmc Technical advances in the characterization of the complexity of sleep and sleep disorders
    Matt T Bianchi
    Department of Neurology, Sleep Division, Massachusetts General Hospital, 55 Fruit Street, Wang 720 Neurology, Boston, MA 02114, United States
    Prog Neuropsychopharmacol Biol Psychiatry 45:277-86. 2013
    ..These methods are complemented by autonomic measurements that provide additional important insights. We review here the spectrum of approaches that have been leveraged towards improved understanding of the complexity of sleep. ..
  32. pmc Instantaneous monitoring of sleep fragmentation by point process heart rate variability and respiratory dynamics
    Luca Citi
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:7735-8. 2011
    ..An automatic threshold-based procedure is further able to detect brief arousals, with the instantaneous indices characterizing specific arousal dynamic signatures...
  33. pmc Classification algorithms for predicting sleepiness and sleep apnea severity
    Nathaniel A Eiseman
    Neurology Department, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Sleep Res 21:101-12. 2012
    ....
  34. ncbi request reprint Non-serotonin anti-depressant actions: direct ion channel modulation by SSRIs and the concept of single agent poly-pharmacy
    Matt T Bianchi
    Partners Neurology, Massachusetts General Hospital and Brigham and Women s Hospital, Fruit Street, Neurology Clinic, Wang Ambulatory Center 8th Floor, Boston, MA 02114, United States
    Med Hypotheses 70:951-6. 2008
    ..Is it possible that certain brain dysfunction (such as depression) may be more amenable to a poly-pharmacy approach? The promiscuity of SSRIs suggests that such poly-pharmacy can emerge from a single agent...
  35. pmc Network analysis: applications for the developing brain
    Catherine J Chu-Shore
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Child Neurol 26:488-500. 2011
    ....
  36. doi request reprint Auditory auras in patients with postencephalitic epilepsy: case series
    Matt T Bianchi
    Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Epilepsy Behav 14:250-2. 2009
    ....
  37. pmc Periodic limb movements of sleep: empirical and theoretical evidence supporting objective at-home monitoring
    Marilyn Moro
    Neurology Department, Massachusetts General Hospital
    Nat Sci Sleep 8:277-89. 2016
    ..However, most people with PLMS are either asymptomatic or have nonspecific symptoms. Therefore, predicting elevated PLMS in the absence of restless legs syndrome remains an important clinical challenge...
  38. pmc Decision Modeling in Sleep Apnea: The Critical Roles of Pretest Probability, Cost of Untreated Obstructive Sleep Apnea, and Time Horizon
    Marilyn Moro
    Neurology Department, Massachusetts General Hospital, Boston, MA
    J Clin Sleep Med 12:409-18. 2016
    ..However, the optimal diagnostic strategy remains a subject of debate. Prior modeling studies have not consistently supported the widely held assumption that home sleep testing (HST) is cost-effective...
  39. pmc Estimating Total Cerebral Microinfarct Burden From Diffusion-Weighted Imaging
    Eitan Auriel
    From the Department of Neurology, J Philip Kistler Stroke Research Center E A, M B W, M T B, Y R, S M R, J N, E V E, P F, K S, A Vashkevich, G B, M E G, A Viswanathan, S M G and Department of Pathology, Neuropathology Service, C S Kubik Laboratory for Neuropathology M P F, Massachusetts General Hospital, Harvard Medical School, Boston Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown A P Y, K A J, R A S, T H and Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA R A S
    Stroke 46:2129-35. 2015
    ..We aim to describe a mathematical method for estimating total number of CMI based on the presence of incidental DWI lesions...
  40. pmc Aspirin for secondary prevention after stroke of unknown etiology in resource-limited settings
    Aaron L Berkowitz
    From the Department of Neurology A L B, S H C, Brigham and Women s Hospital, Harvard Medical School and Department of Neurology M B W, M T B, Massachusetts General Hospital, Harvard Medical School, Boston
    Neurology 83:1004-11. 2014
    ....
  41. pmc Obstructive sleep apnea alters sleep stage transition dynamics
    Matt T Bianchi
    Neurology Department, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11356. 2010
    ..One approach involves using stage transition analysis to characterize sleep continuity...
  42. pmc Statin use following intracerebral hemorrhage: a decision analysis
    M Brandon Westover
    Massachusetts General Hospital Stroke Research Center, 175 Cambridge Street, Boston, MA 02114, USA
    Arch Neurol 68:573-9. 2011
    ..For patients with baseline elevated risk of ICH, it is not known whether this potential adverse effect offsets the cardiovascular and cerebrovascular benefits...
  43. pmc Significance testing as perverse probabilistic reasoning
    M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med 9:20. 2011
    ..This essay provides a technically sound review of these concepts that is accessible to a medical audience. We also briefly review the debate in the cognitive sciences regarding physicians' aptitude for probabilistic inference...
  44. pmc Interactions of time of day and sleep with between-session habituation and extinction memory in young adult males
    Edward F Pace-Schott
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    Exp Brain Res 232:1443-58. 2014
    ..We conclude that: (1) sleep augments between-session habituation, as does morning testing; (2) extinction recall is predicted by concurrent between-session habituation; and (3) both phenomena may be influenced by sleep...
  45. pmc Recent developments in home sleep-monitoring devices
    Jessica M Kelly
    Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Wang 720, Boston, MA 02114, USA
    ISRN Neurol 2012:768794. 2012
    ..From a wellness standpoint, commercially available devices may allow individuals to track their own sleep with the goal of finding patterns and correlations with modifiable behaviors such as exercise, diet, and sleep aids...
  46. ncbi request reprint Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit
    Kai M Wohlfarth
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48104 1687, USA
    J Neurosci 22:1541-9. 2002
    ..Our results suggest that the GABA(A) receptor delta subunit confers increased sensitivity to neurosteroid modulation and that the intrinsic gating and desensitization kinetics of alpha1beta3delta GABA(A) receptors are altered by THDOC...
  47. pmc Desiderata or dogma: what the evidence reveals about physician attire
    Matt T Bianchi
    Partners Neurology, Massachusetts General Hospital and Brigham and Women s Hospital, Neurology Clinic, Wang Ambulatory Center 8th Floor, Boston, MA, USA
    J Gen Intern Med 23:641-3. 2008
    ..The once purely philosophical debate over what constitutes appropriate physician attire can benefit from a growing evidence base in the literature...