M E Bernardo

Summary

Publications

  1. pmc Survival after T cell-depleted haploidentical stem cell transplantation is improved using the mother as donor
    Martin Stern
    Department of Hematology, University Hospital Basel, Basel, Switzerland
    Blood 112:2990-5. 2008
  2. doi request reprint Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Cytotherapy 11:825-36. 2009
  3. doi request reprint Co-infusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation
    M E Bernardo
    Pediatric Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Bone Marrow Transplant 46:200-7. 2011
  4. doi request reprint Mesenchymal Stromal Cells in Hematopoietic Stem Cell Transplantation
    Maria Ester Bernardo
    Dipartimento di Emato Oncologia e Medicina Trasfusionale, IRCCS Ospedale Pediatrico Bambino Gesù, P le S Onofrio, 00165, Rome, Italy
    Methods Mol Biol 1416:3-20. 2016
  5. doi request reprint Treosulfan-based conditioning regimen for allogeneic haematopoietic stem cell transplantation in patients with thalassaemia major
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Br J Haematol 143:548-51. 2008
  6. ncbi request reprint Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute
    M E Bernardo
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    J Cell Physiol 211:121-30. 2007
  7. ncbi request reprint Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Cancer Res 67:9142-9. 2007
  8. ncbi request reprint Human mesenchymal stem cells derived from bone marrow display a better chondrogenic differentiation compared with other sources
    M E Bernardo
    Pediatric Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Connect Tissue Res 48:132-40. 2007
  9. doi request reprint Mesenchymal stromal cells: a novel and effective strategy for facilitating engraftment and accelerating hematopoietic recovery after transplantation?
    M E Bernardo
    Dipartimento di Ematologia ed Oncologia Pediatrica, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
    Bone Marrow Transplant 47:323-9. 2012
  10. pmc Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors
    Maria Antonietta Avanzini
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Haematologica 94:1649-60. 2009

Collaborators

Detail Information

Publications24

  1. pmc Survival after T cell-depleted haploidentical stem cell transplantation is improved using the mother as donor
    Martin Stern
    Department of Hematology, University Hospital Basel, Basel, Switzerland
    Blood 112:2990-5. 2008
    ..Although obtained in a retrospective analysis, these data suggest that the mother of the patient should be preferred as donor for haploidentical HSCT...
  2. doi request reprint Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Cytotherapy 11:825-36. 2009
    ..The aim of the study was in vitro characterization of MSC from active CD patients for future clinical application...
  3. doi request reprint Co-infusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation
    M E Bernardo
    Pediatric Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Bone Marrow Transplant 46:200-7. 2011
    ..Although these data do not support the use of MSCs in UCBT to support hematopoietic engraftment, they suggest that MSCs, possibly because of their immunosuppressive effect, may abrogate life-threatening acute GVHD and reduce early TRM...
  4. doi request reprint Mesenchymal Stromal Cells in Hematopoietic Stem Cell Transplantation
    Maria Ester Bernardo
    Dipartimento di Emato Oncologia e Medicina Trasfusionale, IRCCS Ospedale Pediatrico Bambino Gesù, P le S Onofrio, 00165, Rome, Italy
    Methods Mol Biol 1416:3-20. 2016
    ..This chapter focuses on recent advances in MSC therapy by reporting on the most important relevant studies in the field of HSCT. ..
  5. doi request reprint Treosulfan-based conditioning regimen for allogeneic haematopoietic stem cell transplantation in patients with thalassaemia major
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Br J Haematol 143:548-51. 2008
    ..This regimen might find elective application in patients at high risk of developing life-threatening complications...
  6. ncbi request reprint Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute
    M E Bernardo
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    J Cell Physiol 211:121-30. 2007
    ....
  7. ncbi request reprint Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Cancer Res 67:9142-9. 2007
    ..ALT was not evidenced in the MSCs tested. BM-derived MSCs can be safely expanded in vitro and are not susceptible to malignant transformation, thus rendering these cells suitable for cell therapy approaches...
  8. ncbi request reprint Human mesenchymal stem cells derived from bone marrow display a better chondrogenic differentiation compared with other sources
    M E Bernardo
    Pediatric Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Connect Tissue Res 48:132-40. 2007
    ..As MSCs represent an attractive tool for cartilage tissue repair strategies, our data suggest that bone marrow should be considered the preferred MSC source for these therapeutic approaches...
  9. doi request reprint Mesenchymal stromal cells: a novel and effective strategy for facilitating engraftment and accelerating hematopoietic recovery after transplantation?
    M E Bernardo
    Dipartimento di Ematologia ed Oncologia Pediatrica, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
    Bone Marrow Transplant 47:323-9. 2012
    ..Moreover, future researches should be oriented to gain more insights on MSC biological and functional mechanisms relevant for exploiting their use in the modulation of alloreactivity and in the promotion of hematopoietic reconstitution...
  10. pmc Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors
    Maria Antonietta Avanzini
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Haematologica 94:1649-60. 2009
    ..However, relatively little is known about the mechanisms responsible for their immunomodulatory effects, which could be influenced by both the cell source and culture conditions...
  11. doi request reprint Mesenchymal stromal cell therapy: a revolution in Regenerative Medicine?
    M E Bernardo
    Dipartimento di Ematologia ed Oncologia Pediatrica, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy
    Bone Marrow Transplant 47:164-71. 2012
    ..Nonetheless, MSCs promise to represent a revolution for many severe or presently untreatable disorders...
  12. ncbi request reprint Preemptive therapy of EBV-related lymphoproliferative disease after pediatric haploidentical stem cell transplantation
    P Comoli
    Laboratory of Transplant Immunology and Pediatric Hematology Oncology, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Am J Transplant 7:1648-55. 2007
    ..We conclude that preemptive therapy with rituximab is safe, but only partly effective in haplo-HSCT recipients. Patients who progress to PTLD under rituximab treatment can be rescued permanently by infusion of EBV-specific CTLs...
  13. ncbi request reprint The outcome of children with Fanconi anemia given hematopoietic stem cell transplantation and the influence of fludarabine in the conditioning regimen: a report from the Italian pediatric group
    Franco Locatelli
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Pavia, Italy
    Haematologica 92:1381-8. 2007
    ..While in the past HSCT from an HLA-identical sibling was proven to cure many patients, a higher incidence of treatment failure has been reported in recipients of an unrelated donor (UD) or HLA-partially matched related allograft...
  14. doi request reprint The role of reduced intensity preparative regimens in patients with thalassemia given hematopoietic transplantation
    Alice Bertaina
    Department of Paediatric Haematology Oncology, University of Pavia, Ospedale Bambino Gesu, Rome, Italy
    Ann N Y Acad Sci 1202:141-8. 2010
    ..This novel approach is a promising alternative for reducing the risk of life-threatening complications and increasing the number of TM patients successfully cured with an allograft...
  15. doi request reprint Mesenchymal stromal cells and chronic inflammatory bowel disease
    M Algeri
    Department of Pediatric Hematology Oncology, IRCCS, Bambino Gesu Children s Hospital, Rome, Italy
    Immunol Lett 168:191-200. 2015
    ....
  16. ncbi request reprint Low percentages of circulating CD8(+)/CD45RA(+) human T lymphocytes expressing beta7 integrin correlate with the occurrence of intestinal acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
    M Antonietta Avanzini
    Pediatric Hematology Oncology and Laboratory of Transplant Immunology, IRCCS Policlinico San Matteo Pavia, University of Pavia, Pavia, Italy
    Exp Hematol 34:1429-34. 2006
    ..Therefore, we evaluated the correlation existing between circulating beta7(+) T-lymphocyte subsets early after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and occurrence of a-GVHD...
  17. doi request reprint Mesenchymal stromal cells
    Maria Ester Bernardo
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Ann N Y Acad Sci 1176:101-17. 2009
    ....
  18. doi request reprint Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children with refractory/multiple relapsed acute lymphoblastic leukaemia
    Franco Locatelli
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Br J Haematol 147:371-8. 2009
    ..01). These data suggest that the clofarabine/cyclophosphamide/etoposide regimen is well tolerated and can induce clinical response in a relevant proportion of children with refractory/multiple relapsed ALL...
  19. doi request reprint T-cell lines specific for peptides of adenovirus hexon protein and devoid of alloreactivity against recipient cells can be obtained from HLA-haploidentical donors
    Patrizia Comoli
    Pediatric Hematology Oncology, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    J Immunother 31:529-36. 2008
    ..These T cells may be safely employed for adoptive treatment of HAdV complications...
  20. ncbi request reprint Use of a DNAemia cut-off for monitoring human cytomegalovirus infection reduces the number of preemptively treated children and young adults receiving hematopoietic stem-cell transplantation compared with qualitative pp65 antigenemia
    Daniele Lilleri
    Servizio di Virologia, Universita di Pavia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo, Pavia, Italy
    Blood 110:2757-60. 2007
    ..259), the number of patients treated was significantly lower in the DNAemia arm (18% vs 31%, P = .026). No patient developed HCMV disease. The use of a DNAemia cut-off avoids unnecessary antiviral treatment...
  21. ncbi request reprint Familial platelet disorder with propensity to acute myelogenous leukemia: genetic heterogeneity and progression to leukemia via acquisition of clonal chromosome anomalies
    Antonella Minelli
    Biologia Generale e Genetica Medica, Universita di Pavia, Pavia, Italy
    Genes Chromosomes Cancer 40:165-71. 2004
    ....
  22. ncbi request reprint Single-cell cloning of human, donor-derived antileukemia T-cell lines for in vitro separation of graft-versus-leukemia effect from graft-versus-host reaction
    Daniela Montagna
    Department of Pediatrics, Laboratory of Immunology, University of Pavia, Italy
    Cancer Res 66:7310-6. 2006
    ....
  23. ncbi request reprint Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation
    Lynne M Ball
    Department of Pediatric Stem Cell Transplantation, Leiden University Medical Centre, Leiden, The Netherlands
    Blood 110:2764-7. 2007
    ..These data suggest that MSCs, possibly thanks to their potent immunosuppressive effect on alloreactive host T lymphocytes escaping the preparative regimen, reduce the risk of graft failure in haploidentical HSC transplant recipients...
  24. ncbi request reprint Donor multipotent mesenchymal stromal cells may engraft in pediatric patients given either cord blood or bone marrow transplantation
    Sara Pozzi
    Centro Cellule Staminali e Terapia Cellulare, Ospedale San Martino, Genova, Italy
    Exp Hematol 34:934-42. 2006
    ..The aim of this study was to analyze the donor/recipient origin of MSCs in children receiving allogeneic either BM or cord blood (CB) transplantation...