- Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A(2) inhibitors
Greenpharma S A, 1 rue de Chartres, B P 6759, 45067 Cedex 2, Orleans, France
Phytochemistry 58:865-74. 2001
..This suggestion was confirmed experimentally...
- Modulating testosterone pathway: a new strategy to tackle male skin aging?
Greenpharma SAS, Orleans, France
Clin Interv Aging 7:351-61. 2012
..Taken together, these data indicate that honokiol modulates testosterone levels, and its structure has the potential to serve as a lead for future designs of highly selective inhibitors of 5-alpha-reductase type 1...
- Application of drug repositioning strategy to TOFISOPAM
Greenpharma S A, 3 allée du Titane, 45 100 Orléans, France
Curr Med Chem 15:3196-203. 2008
..The identification of the biochemical mechanism of tofisopam isomers now allows to reposition this drug in new therapeutic indications where modulation of cAMP via PDE4 inhibitors are possible...
- Protein-based alignment in 3D QSAR of 26 indole inhibitors of human pancreatic phospholipase A2
Laboratory of Chemometrics and BioInformatics, Faculty of Sciences, , BP 6759, 45067 Cedex 2, , France
Eur J Med Chem 36:21-30. 2001
- A molecular modeling and 3D QSAR study of a large series of indole inhibitors of human non-pancreatic secretory phospholipase A2
Laboratory of Chemometrics and BioInformatics, , BP 6759, 45067 Cedex 2, , France
Eur J Med Chem 36:1-19. 2001
..A good correlation between predicted and experimental activity data allows to validate the 3D QSAR model. A second and global 3D QSAR including all the compounds was established, allowing the creation of the hnps-PLA2 pharmacophore...
- Preliminary screening of some tropical plants for anti-tyrosinase activity
Greenpharma S A, 3 allée du Titane, 45100 Orleans, France
J Ethnopharmacol 82:155-8. 2002
..These 5 plants will be studied in order to isolate and identify phytochemical compounds, involved in this biological activity...
- Reverse pharmacognosy: another way to harness the generosity of nature
Greenpharma SAS, 3 allée du titane 45100 Orléans, France
Curr Pharm Des 16:1682-96. 2010
..by exploiting existing data from pharmacognosy. This review will focus on recent advances in computer science applied to natural substance research that consolidate the new concept of reverse pharmacognosy...