Harry Heimberg

Summary

Affiliation: Vrije Universiteit Brussel
Country: Belgium

Publications

  1. pmc Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas
    M Van de Casteele
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    Cell Death Dis 4:e523. 2013
  2. pmc Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming
    Nathalie Swales
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    PLoS ONE 7:e37055. 2012
  3. doi request reprint Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
    Xiaobo Xu
    Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B1090 Brussels, Belgium
    Cell 132:197-207. 2008
  4. ncbi request reprint Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis
    Benjamin A Kefas
    Diabetes Research Center, Partner of the Juvenile Diabetes Research Center for Beta Cell Therapy in Europe, Brussels Free University VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Biochem Pharmacol 68:409-16. 2004
  5. pmc Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
    Yves Heremans
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    J Cell Biol 159:303-12. 2002
  6. ncbi request reprint Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas
    Isabelle Houbracken
    Cell Differentiation Laboratory, Diabetes Research Center, Free University of Brussels, Brussels, Belgium
    Gastroenterology 141:731-41, 741.e1-4. 2011
  7. ncbi request reprint Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling
    Zhidong Ling
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Diabetes 52:2497-502. 2003
  8. pmc Gene delivery to pancreatic exocrine cells in vivo and in vitro
    Isabelle Houbracken
    Cell Differentiation Lab, Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, B 1090, Belgium
    BMC Biotechnol 12:74. 2012
  9. ncbi request reprint Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells
    Peter Huypens
    Diabetes Research Center, Brussels Free University VUB, Brussels, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Life Sci 77:1273-82. 2005
  10. pmc Ectopic expression of E2F1 stimulates beta-cell proliferation and function
    Gael Grouwels
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    Diabetes 59:1435-44. 2010

Collaborators

Detail Information

Publications23

  1. pmc Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas
    M Van de Casteele
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    Cell Death Dis 4:e523. 2013
    ..We conclude that Ngn3(+) cell-dependent proliferation of pre-existing and newly-formed β cells as well as reprogramming of non-β cells contribute to in vivo β cell expansion in the injured pancreas of adult mice...
  2. pmc Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming
    Nathalie Swales
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    PLoS ONE 7:e37055. 2012
    ..In this study we aimed to fully characterize the extent of this reprogramming and intended to improve it...
  3. doi request reprint Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
    Xiaobo Xu
    Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B1090 Brussels, Belgium
    Cell 132:197-207. 2008
    ....
  4. ncbi request reprint Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis
    Benjamin A Kefas
    Diabetes Research Center, Partner of the Juvenile Diabetes Research Center for Beta Cell Therapy in Europe, Brussels Free University VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Biochem Pharmacol 68:409-16. 2004
    ..It is concluded that metformin-induced AMPK-activation in beta-cells reduces their glucose responsiveness and may, following sustained exposure, result in apoptosis...
  5. pmc Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
    Yves Heremans
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    J Cell Biol 159:303-12. 2002
    ....
  6. ncbi request reprint Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas
    Isabelle Houbracken
    Cell Differentiation Laboratory, Diabetes Research Center, Free University of Brussels, Brussels, Belgium
    Gastroenterology 141:731-41, 741.e1-4. 2011
    ..However, little is known about human acinar cell plasticity. We developed nongenetic and genetic lineage tracing methods to study the fate of human acinar cells in culture...
  7. ncbi request reprint Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling
    Zhidong Ling
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Diabetes 52:2497-502. 2003
    ..We conclude that the IB1/JIP-1 level in beta-cells can control their susceptibility to apoptosis independent of JNK signaling...
  8. pmc Gene delivery to pancreatic exocrine cells in vivo and in vitro
    Isabelle Houbracken
    Cell Differentiation Lab, Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, B 1090, Belgium
    BMC Biotechnol 12:74. 2012
    ..Different transduction methods and viral vectors were tested in vitro and in vivo, in rat and mouse pancreas...
  9. ncbi request reprint Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells
    Peter Huypens
    Diabetes Research Center, Brussels Free University VUB, Brussels, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Life Sci 77:1273-82. 2005
    ..We conclude that adiponectin induces an activation of AMPK in beta cells, which inhibits their cataplerosis of glucose-carbon to lipids...
  10. pmc Ectopic expression of E2F1 stimulates beta-cell proliferation and function
    Gael Grouwels
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    Diabetes 59:1435-44. 2010
    ..However, the consequences of overexpression of E2F1 in beta-cells are unknown...
  11. pmc Conditional hypovascularization and hypoxia in islets do not overtly influence adult β-cell mass or function
    Joke D'Hoker
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    Diabetes 62:4165-73. 2013
    ..Our data thus argue against a major role of blood vessels to preserve adult β-cell generation and function, restricting their importance to facilitating rapid and adequate insulin delivery. ..
  12. doi request reprint Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR
    Ying Cai
    Diabetes Research Center, Brussels Free University, VUB, Partner of the Juvenile Diabetes Research Center for Beta Cell Therapy in Europe, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Biochem Pharmacol 75:1981-93. 2008
    ....
  13. pmc Prospectively Isolated NGN3-Expressing Progenitors From Human Embryonic Stem Cells Give Rise to Pancreatic Endocrine Cells
    Qing Cai
    Stamcelinstituut Leuven, Laboratory for Experimental Medicine and Endocrinology, Department of Human Genetics, and University Hospitals Leuven, KU Leuven, Leuven, Belgium Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    Stem Cells Transl Med 3:489-99. 2014
    ..In addition, this hESC reporter line constitutes a unique tool that may aid in gaining insight into the developmental mechanisms underlying fate choices in human pancreas and in developing cell-based therapies. ..
  14. ncbi request reprint Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development
    Josué K Mfopou
    Cell Differentiation Unit, Diabetes Research Centre, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Stem Cells 25:1156-65. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  15. pmc Clusters of conserved beta cell marker genes for assessment of beta cell phenotype
    Geert A Martens
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    PLoS ONE 6:e24134. 2011
    ..This panel was then used to compare isolated versus laser capture microdissected beta cells, monitor adaptations of the beta cell phenotype to fasting, and retrieve possible conserved transcriptional regulators...
  16. pmc Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas
    Ilse Rooman
    Cell Differentiation Unit Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Am J Pathol 169:1206-14. 2006
    ..In addition, we show that Notch signaling is implicated in the suppression of proliferation of these metaplastic exocrine cells. The latter may be important in protection from neoplastic transformation...
  17. ncbi request reprint Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc
    Mark Van De Casteele
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Biochem Biophys Res Commun 312:937-44. 2003
    ..These effects may be due to sustained restriction in nutrient-derived metabolic signals...
  18. doi request reprint Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro
    Luc Baeyens
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    Gastroenterology 136:1750-60.e13. 2009
    ..The mechanisms regulating this phenotypic conversion are largely unknown...
  19. ncbi request reprint IL-6-dependent proliferation of alpha cells in mice with partial pancreatic-duct ligation
    Ying Cai
    Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B1090, Brussels, Belgium
    Diabetologia 57:1420-7. 2014
    ..As alpha cells can reprogramme to beta cells in a number of beta cell (re)generation models, we examined whether this phenomenon also exists in PDL pancreas...
  20. ncbi request reprint Purification of rat pancreatic B-cells by fluorescence-activated cell sorting
    Geert Stangé
    Diabetes Research Center, Vrije Universiteit Brussel, Belgium
    Methods Mol Med 83:15-22. 2003
  21. doi request reprint Mouse beta cell proliferation is inhibited by thymidine analogue labelling
    Mark Van De Casteele
    Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B1090, Brussels, Belgium
    Diabetologia 56:2647-50. 2013
    ..Multiple thymidine analogue labelling is applied for evaluating the duration of postmitotic quiescence in beta cells. We hypothesise, however, that long-term labelling by thymidine analogues hampers beta cell proliferation...
  22. ncbi request reprint Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
    Luc Baeyens
    1 Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium 2 Diabetes Center, California Institute for Regenerative Medicine CIRM, University of California San Francisco, San Francisco, California, USA
    Nat Biotechnol 32:76-83. 2014
    ....
  23. ncbi request reprint Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis
    Mark Van De Casteele
    Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Endocrinology 143:320-6. 2002
    ..The beta-cell-specific expression of Bax-omega makes this protein a possible effector in the protection of this cell type against apoptosis...