Chantal Mathieu

Summary

Affiliation: University Hospitals Leuven
Country: Belgium

Publications

  1. pmc Patient-reported outcomes among patients using exenatide twice daily or insulin in clinical practice in six European countries: the CHOICE prospective observational study
    Matthew Reaney
    Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece
    Health Qual Life Outcomes 11:217. 2013
  2. pmc Using Exenatide Twice Daily or Insulin in Clinical Practice: Results from CHOICE
    Chantal Mathieu
    Department of Endocrinology, UZ Gasthuisberg, 3000, Leuven, Belgium
    Diabetes Ther 4:285-308. 2013
  3. pmc Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long)
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:2464-71. 2012
  4. doi request reprint How long should a long acting insulin analogue be?
    Chantal Mathieu
    Endocrinology, UZ Gasthuisberg, Herestraat 49, 3000 KU Leuven, Belgium
    Diabetes Res Clin Pract 100:170-2. 2013
  5. pmc Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): a 26-week randomized, treat-to-target trial with a 26-week extension
    Chantal Mathieu
    Clinical and Experimental Endocrinology, UZ Herestraat 49, BOX 902, Room 08 43, 3000 Leuven, Belgium
    J Clin Endocrinol Metab 98:1154-62. 2013
  6. doi request reprint Vitamin D and diabetes
    Tatiana Takiishi
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, UZ Gasthuisberg, O and N I Herestraat, Leuven, Belgium
    Endocrinol Metab Clin North Am 39:419-46, table of contents. 2010
  7. doi request reprint Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells
    Gabriela Bomfim Ferreira
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    J Proteome Res 11:941-71. 2012
  8. doi request reprint Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction
    Michael Maris
    Laboratory of Clinical and Experimental Endocrinology, Herestraat 49, KU Leuven, Leuven, Belgium
    J Proteome Res 12:347-62. 2013
  9. doi request reprint Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system
    Femke Baeke
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven KUL, Herestraat 49, O and N1, bus 902, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 121:221-7. 2010
  10. doi request reprint Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010

Detail Information

Publications97

  1. pmc Patient-reported outcomes among patients using exenatide twice daily or insulin in clinical practice in six European countries: the CHOICE prospective observational study
    Matthew Reaney
    Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece
    Health Qual Life Outcomes 11:217. 2013
    ..We examined PROs in patients initiating injectable treatment in the CHOICE (CHanges to treatment and Outcomes in patients with type 2 diabetes initiating InjeCtablE therapy) study...
  2. pmc Using Exenatide Twice Daily or Insulin in Clinical Practice: Results from CHOICE
    Chantal Mathieu
    Department of Endocrinology, UZ Gasthuisberg, 3000, Leuven, Belgium
    Diabetes Ther 4:285-308. 2013
    ....
  3. pmc Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long)
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:2464-71. 2012
    ..To compare ultra-long-acting insulin degludec with glargine for efficacy and safety in insulin-naive patients with type 2 diabetes inadequately controlled with oral antidiabetic drugs (OADs)...
  4. doi request reprint How long should a long acting insulin analogue be?
    Chantal Mathieu
    Endocrinology, UZ Gasthuisberg, Herestraat 49, 3000 KU Leuven, Belgium
    Diabetes Res Clin Pract 100:170-2. 2013
    ....
  5. pmc Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): a 26-week randomized, treat-to-target trial with a 26-week extension
    Chantal Mathieu
    Clinical and Experimental Endocrinology, UZ Herestraat 49, BOX 902, Room 08 43, 3000 Leuven, Belgium
    J Clin Endocrinol Metab 98:1154-62. 2013
    ..This study investigated the efficacy and safety of insulin degludec (IDeg) once daily (OD), varying injection timing day to day in subjects with type 1 diabetes...
  6. doi request reprint Vitamin D and diabetes
    Tatiana Takiishi
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, UZ Gasthuisberg, O and N I Herestraat, Leuven, Belgium
    Endocrinol Metab Clin North Am 39:419-46, table of contents. 2010
    ..This article reviews the role of vitamin D in the pathogenesis of T1D and T2D, focusing on the therapeutic potential for vitamin D in the prevention/intervention of T1D and T2D as well as its complications...
  7. doi request reprint Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells
    Gabriela Bomfim Ferreira
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    J Proteome Res 11:941-71. 2012
    ..These findings provide new insights on the molecular basis of DC tolerogenicity induced by 1,25(OH)(2)D(3) and/or DEX, which may lead to the discovery of new pathways involved in DC immunomodulation...
  8. doi request reprint Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction
    Michael Maris
    Laboratory of Clinical and Experimental Endocrinology, Herestraat 49, KU Leuven, Leuven, Belgium
    J Proteome Res 12:347-62. 2013
    ..This study contributes to a better understanding and revealed novel mechanisms of palmitate-induced beta cell dysfunction and death and may provide new targets for drug discovery...
  9. doi request reprint Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system
    Femke Baeke
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven KUL, Herestraat 49, O and N1, bus 902, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 121:221-7. 2010
    ..In conclusion, we validate T cells as direct targets for 1,25(OH)2D3 and provide this optimized in vitro model to improve our understanding of the role of vitamin D as a direct regulator of T cell responses...
  10. doi request reprint Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
    ..Vitamin D deficiency has been associated with many chronic illnesses, but little is known about its relationship with chronic obstructive pulmonary disease (COPD)...
  11. doi request reprint Pdx1- and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads to endocrine hormone imbalances that affect glucose metabolism
    Jeroen Declercq
    Stem Cell Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    Cell Transplant 20:1285-97. 2011
    ..These results suggest that once stem cell-derived islet transplantations become possible, the appropriate balance between different hormone-producing cells will need to be preserved to prevent deregulated glucose metabolism...
  12. ncbi request reprint Unaltered diabetes presentation in NOD mice lacking the vitamin D receptor
    Conny Gysemans
    Laboratory of Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Diabetes 57:269-75. 2008
    ..Vitamin D deficiency increases risk for type 1 diabetes in genetically predisposed individuals, while high doses of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] prevent insulitis and diabetes in NOD mice...
  13. ncbi request reprint Effect of recombinant human TNF-binding protein-1 and GnRH antagonist on mRNA expression of inflammatory cytokines and adhesion and growth factors in endometrium and endometriosis tissues in baboons
    Cleophas M Kyama
    Leuven University Fertility Centre, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Fertil Steril 89:1306-13. 2008
    ....
  14. doi request reprint 1,25-Dihydroxyvitamin D3 alters murine dendritic cell behaviour in vitro and in vivo
    Gabriela Bomfim Ferreira
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven KUL, 3000 Leuven, Belgium
    Diabetes Metab Res Rev 27:933-41. 2011
    ..1,25(OH)2D3, the active form of vitamin D3, fosters the development of tolerogenic dendritic cells. This study aimed to evaluate the effects of 1,25(OH)2D3 on murine dendritic cell behaviour in vitro and in vivo...
  15. ncbi request reprint Endometrial and peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis
    Cleophas M Kyama
    Leuven University Fertility Center, Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Leuven, Belgium
    Fertil Steril 89:301-10. 2008
    ..To examine messenger (m) RNA expression of aromatase, cytokines, and adhesion factors in women with and without endometriosis...
  16. doi request reprint Two-dimensional gel proteome reference map of INS-1E cells
    Wannes D'Hertog
    Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Leuven, Belgium
    Proteomics 11:1365-9. 2011
    ..We believe that the availability of this reference map will enhance our knowledge of β-cell physiology...
  17. doi request reprint High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach
    Michael Maris
    Laboratory for Experimental Medicine and Endocrinology, Herestraat 49, Catholic University of Leuven, Leuven, Belgium
    J Proteome Res 9:6274-87. 2010
    ..The present findings provide new insights in glucotoxicity and identify key target proteins for the prevention and treatment of beta cell dysfunction in type 2 diabetes...
  18. pmc Vitamin D and human health: lessons from vitamin D receptor null mice
    Roger Bouillon
    Katholieke Universiteit Leuven, Laboratory of Experimental Medicine and Endocrinology, Herestraat 49, O and N 1 bus 902, 3000 Leuven, Belgium
    Endocr Rev 29:726-76. 2008
    ..Prospective vitamin D supplementation studies with multiple noncalcemic endpoints are needed to define the benefits of an optimal vitamin D status...
  19. doi request reprint Oleate-induced beta cell dysfunction and apoptosis: a proteomic approach to glucolipotoxicity by an unsaturated fatty acid
    Michael Maris
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Herestraat 49, Catholic University of Leuven, Leuven, Belgium
    J Proteome Res 10:3372-85. 2011
    ..The present findings provide new insights in oleate-induced beta cell dysfunction and identify target proteins for preservation of functional beta cell mass in type 2 diabetes...
  20. doi request reprint 1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice
    Gabriela B Ferreira
    Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    J Immunol 192:4210-20. 2014
    ..Altogether, these results argue for the potential of 1,25D3-mDCs to restore Ag-specific immune tolerance and arrest autoimmune disease progression in vivo. ..
  21. ncbi request reprint Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory
    Annapaula Giulietti
    Laboratory of Experimental Medicine and Endocrinology, Catholic University of Leuven, Herestraat 49, Leuven, Belgium
    Diabetes Res Clin Pract 77:47-57. 2007
    ..From these data we concluded that monocytes from type 2 diabetic patients have a pro-inflammatory profile. In addition, 1,25-dihydroxyvitamin D(3) was able to modulate inflammation in these monocytes...
  22. doi request reprint Vitamin D: a pleiotropic hormone
    Annemieke Verstuyf
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Kidney Int 78:140-5. 2010
    ....
  23. doi request reprint Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine
    Roger Bouillon
    Clinical and Experimental Endocrinology, KU Leuven, Department of Endocrinology, Herestraat 49 ON1, BOX 902, 3000 Leuven, Belgium
    J Clin Endocrinol Metab 98:E1283-304. 2013
    ..Public health authorities around the world recommend widely variable supplementation strategies for adults, whereas several professional organizations, including The Endocrine Society, recommend higher supplementation...
  24. ncbi request reprint IL-12 contributes to allergen-induced airway inflammation in experimental asthma
    Isabelle Meyts
    Laboratory of Experimental Immunology, University Hospitals, Faculty of Medicine, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Immunol 177:6460-70. 2006
    ..IFN-gamma-producing cells or cells dependent on IFN-gamma activity, play a major role in this unexpected proinflammatory effect of IL-12 in allergic airway disease...
  25. doi request reprint The vitamin D analog TX527 ameliorates disease symptoms in a chemically induced model of inflammatory bowel disease
    Lieve Verlinden
    Laboratorium voor Klinische en Experimentele Endocrinologie, KU Leuven, Herestraat 49, bus 902, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 136:107-11. 2013
    ..These results indicate that TX527 may have a therapeutic value in the setting of inflammatory bowel disease. This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  26. ncbi request reprint The vitamin D receptor gene FokI polymorphism: functional impact on the immune system
    Evelyne van Etten
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Immunol 37:395-405. 2007
    ..Together, these data provide the first evidence that the VDR FokI polymorphism affects immune cell behavior, with a more active immune system for the short F-VDR, thus possibly playing a role in immune-mediated diseases...
  27. doi request reprint How can macroscopically normal peritoneum contribute to the pathogenesis of endometriosis?
    Amelie Fassbender
    Leuven University Fertility Centre, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Fertil Steril 96:697-9. 2011
    ..Peritoneal interleukin 6, interleukin 12, and ferritin were differentially expressed in women with and without endometriosis...
  28. ncbi request reprint Antiproliferative and calcemic actions of trans-decalin CD-ring analogs of 1,25-dihydroxyvitamin D3
    Guy Eelen
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Leuven, Belgium
    Anticancer Res 29:3579-84. 2009
    ..Therefore, analogs of 1,25-(OH)2D3 are designed with a clear dissociation between both effects. Here the biological activity of the trans-decalin CD-ring analog CY10012 is discussed...
  29. doi request reprint Monitoring modifiable cardiovascular risk in type 2 diabetes care in general practice: the use of an aggregated z-score
    Geert Goderis
    Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium double daggerDepartment of Endocrinology, University Hospitals Leuven, Leuven, Belgium
    Med Care 48:589-95. 2010
    ..We therefore developed a tool based on a composite end point considering blood pressure, lipids, and glycaemia...
  30. doi request reprint Glucagon-like peptide-1 protects human islets against cytokine-mediated β-cell dysfunction and death: a proteomic study of the pathways involved
    Dieter Rondas
    Laboratory for Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Proteome Res 12:4193-206. 2013
    ..These data illustrate the beneficial effects of GLP-1 on human islets under immune attack, leading to a better understanding of the underlying mechanisms involved, a prerequisite for improving therapies for diabetic patients. ..
  31. pmc Traffic air pollution and oxidized LDL
    Lotte Jacobs
    Occupational and Environmental Medicine, Unit of Lung Toxicology, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS ONE 6:e16200. 2011
    ..We tested this hypothesis in patients with diabetes, who are at high risk for atherosclerosis...
  32. doi request reprint 1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism
    Hannelie Korf
    Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O and N1, Katholieke Universiteit Leuven KU Leuven, Leuven, Belgium
    Immunobiology 217:1292-300. 2012
    ..Combined, these results highlight the possible therapeutic applicability of this natural immunomodulator, due to its ability to counteract macrophage inflammatory and T cell-activating pathways...
  33. doi request reprint 1α,25-Dihydroxyvitamin D3 and its analogs as modulators of human dendritic cells: a comparison dose-titration study
    Gabriela Bomfim Ferreira
    Laboratory for Clinical and Experimental Endocrinology LEGENDO, University Hospital Gasthuisberg, KU Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 136:160-5. 2013
    ..This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  34. ncbi request reprint Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction
    Lut Overbergh
    LEGENDO, UZ Gasthuisberg, Onderwijs en Navorsing, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 91:3566-74. 2006
    ..In pathological situations, such as sarcoidosis, this can lead to systemic excess of 1,25(OH)(2)D(3) and hypercalcemia...
  35. doi request reprint Vitamin D in thyroid tumorigenesis and development
    Isabelle Clinckspoor
    Laboratory of Clinical and Experimental Endocrinology, KU Leuven, bus 902, Herestraat 49, 3000 Leuven, Belgium
    Prog Histochem Cytochem 48:65-98. 2013
    ..Altered 1,25(OH)2D3-VDR signalling does not influence normal thyroid development nor thyrocyte function, but does affect C-cell function, at least in rodents. If these findings also apply to humans deserves further study. ..
  36. pmc Reversal of hyperglycemia by insulin-secreting rat bone marrow- and blastocyst-derived hypoblast stem cell-like cells
    Anujith Kumar
    Stamcel Instituut Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS ONE 8:e63491. 2013
    ....
  37. doi request reprint Novel insights into the global proteome responses of insulin-producing INS-1E cells to different degrees of endoplasmic reticulum stress
    Wannes D'Hertog
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, Leuven, Belgium
    J Proteome Res 9:5142-52. 2010
    ..In conclusion, INS-1E cells are highly sensitive to ER stress, leading to important post-transcriptional and post-translational modifications that may contribute to β-cell dysfunction and death...
  38. doi request reprint Decreased miR-181a expression in monocytes of obese patients is associated with the occurrence of metabolic syndrome and coronary artery disease
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Katholieke Universiteit Leuven, Herestraat 49, PB 705, 3000 Leuven, Belgium
    J Clin Endocrinol Metab 97:E1213-8. 2012
    ..Weight loss after bariatric surgery leads to significant improvement of obesity-related comorbidities. MicroRNA (miR), a class of small noncoding RNA, have been implicated as negative regulators of inflammatory processes...
  39. ncbi request reprint Novel insights in the immune function of the vitamin D system: synergism with interferon-beta
    Evelyne van Etten
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Herestraat 49, O and N1 bus 902, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 103:546-51. 2007
    ....
  40. ncbi request reprint Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection
    Hanne I Callewaert
    Laboratory of Experimental Medicine and Endocrinology, Campus Gasthuisberg O and N 1, Catholic University of Leuven, Leuven, Belgium
    Diabetes 56:2169-73. 2007
    ..We previously demonstrated that beta-cells lacking STAT-1 are resistant to cytokine-induced cell death in vitro. The aim of this study was to investigate the effect of STAT-1 elimination on immune-mediated beta-cell destruction in vivo...
  41. doi request reprint Vitamin D insufficiency: implications for the immune system
    Femke Baeke
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Herestraat 49 ON1 bus 902, 3000 Leuven, Belgium
    Pediatr Nephrol 25:1597-606. 2010
    ..In this review, specific attention is given to the effects of 1,25(OH)(2)D(3) on the immune system and the implications of vitamin D deficiency, a feature of many patients with CKD, on immune function...
  42. pmc A cluster randomized trial to improve adherence to evidence-based guidelines on diabetes and reduce clinical inertia in primary care physicians in Belgium: study protocol [NTR 1369]
    Liesbeth Borgermans
    Catholic University Leuven, Department of General Practice, Kapucijnenvoer 33 J Box 7001, 3000 Leuven, Belgium
    Implement Sci 3:42. 2008
    ..Few studies have applied all of these dimensions to address clinical inertia...
  43. doi request reprint Regulation of vitamin D homeostasis: implications for the immune system
    Evelyne van Etten
    The Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Leuven, Belgium
    Nutr Rev 66:S125-34. 2008
    ..Moreover, the strict regulation of these enzymes by immune signals is highly suggestive for an autocrine/paracrine role in the immune system, and opens new treatment possibilities...
  44. doi request reprint Protein-induced changes during the maturation process of human dendritic cells: A 2-D DIGE approach
    Gabriela Bomfim Ferreira
    Laboratory for Experimental Medicine and Endocrinology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Proteomics Clin Appl 2:1349-60. 2008
    ..This will open new avenues for investigating treatment regimens for immune-associated disorders...
  45. ncbi request reprint Vitamin D resistance
    Roger Bouillon
    Laboratory for Experimental Medicine and Endocrinology, Campus Gasthuisberg, Onderwijs and Navorsing 1, Herestraat 49, bus 902, B 3000 Leuven, Belgium
    Best Pract Res Clin Endocrinol Metab 20:627-45. 2006
    ..Taken together, the vitamin D endocrine system not only regulates calcium homeostasis but affects several systems mainly by altering gene expression but also by ligand-independent actions...
  46. ncbi request reprint 1alpha,25-Dihydroxyvitamin D3-induced down-regulation of the checkpoint proteins, Chk1 and Claspin, is mediated by the pocket proteins p107 and p130
    Lieve Verlinden
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 103:411-5. 2007
    ....
  47. pmc Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
    PLoS ONE 7:e32794. 2012
    ..Because it was low we determined the involvement of this miR in the anti-inflammatory, antioxidative and insulin signaling action of globular adiponectin...
  48. doi request reprint Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice
    Sofie Robert
    Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Diabetes 63:2876-87. 2014
    ..These preclinical data indicate a great therapeutic potential of orally administered autoantigen-secreting LL for tolerance induction in T1D. ..
  49. pmc Interdisciplinary diabetes care teams operating on the interface between primary and specialty care are associated with improved outcomes of care: findings from the Leuven Diabetes Project
    Liesbeth Borgermans
    Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
    BMC Health Serv Res 9:179. 2009
    ..A third hypothesis was that patients who used the IDCT in an Advanced quality Improvement Program (AQIP) would have significantly better outcomes compared to users of a Usual Quality Improvement Program (UQIP)...
  50. pmc Increased beta-cell mass by islet transplantation and PLAG1 overexpression causes hyperinsulinemic normoglycemia and hepatic insulin resistance in mice
    Jeroen Declercq
    Stamcel Instituut, Katholieke Universiteit Leuven, Leuven, Belgium
    Diabetes 59:1957-65. 2010
    ..However, some transgenic mouse models with beta-cell hyperplasia suggest that insulin production remains excessive and that normoglycemia is maintained by insulin resistance...
  51. doi request reprint 1,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer
    Isabelle Clinckspoor
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie LEGENDO, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium
    J Steroid Biochem Mol Biol 124:1-9. 2011
    ..Our in vitro findings demonstrate that the superagonistic vitamin D analog CD578 holds promise as adjuvant antiproliferative therapy of anaplastic thyroid cancer, especially in combination with other drugs such as paclitaxel or SAHA...
  52. pmc Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors
    Isabelle Clinckspoor
    Laboratory for Experimental Medicine and Endocrinology, KU Leuven, Leuven, Belgium
    J Histochem Cytochem 60:502-11. 2012
    ..These findings advocate further studies with 1,25(OH)(2)D(3) and analogs in persistent and recurrent iodine-refractory DTC...
  53. pmc Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS ONE 7:e30414. 2012
    ..Visceral obesity is associated with the rising incidence of type 2 diabetes and metabolic syndrome. Low-grade chronic inflammation and oxidative stress synergize in obesity and obesity-induced disorders...
  54. doi request reprint Late CD8+ T cell-dependent xenoantibody production in innate tolerant nude rats after hamster islet grafting but not after hamster heart grafting
    Timothy Devos
    Department of Experimental Medicine, Laboratory for Experimental Transplantation, University of Leuven, Leuven, Belgium
    Transplantation 85:1489-95. 2008
    ..We investigated the interdependent roles of T and B lymphocytes in vascularized (heart) and cellular (islet) xenograft rejection in a model with established xeno-nonreactivity of the innate immune system...
  55. pmc Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice
    Tatiana Takiishi
    Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium
    J Clin Invest 122:1717-25. 2012
    ..Therefore, we believe this method could be an effective treatment strategy for type 1 diabetes in humans...
  56. pmc The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity
    James Dooley
    VIB, Leuven, Belgium Department of Microbiology and Immunology, KUL University of Leuven, Leuven, Belgium
    Diabetes 65:53-61. 2016
    ..These results demonstrate strong regulatory functions for the miR-29 family in obesity and diabetes, culminating in a hierarchical and dose-dependent effect on premature lethality...
  57. doi request reprint The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation
    Femke Baeke
    Laboratory of Experimental Medicine and Endocrinology, Catholic University of Leuven, Leuven, Belgium
    J Immunol 186:132-42. 2011
    ....
  58. pmc Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial
    Miek Hornikx
    Respiratory Division and Rehabilitation, Laboratory of Pneumology, University Hospital Gasthuisberg, KULeuven, Herestraat 49, Leuven, 3000, Belgium
    Respir Res 13:84. 2012
    ..As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease...
  59. doi request reprint Effect of a transcriptional inactive or absent vitamin D receptor on beta-cell function and glucose homeostasis in mice
    Roman Vangoitsenhoven
    Clinical and Experimental Medicine and Endocrinology, KU Leuven, Herestraat 49, BOX 902, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol . 2016
    ..001). We conclude that in the presence of normocalcemia, absence of VDR or its ligand-activated transcription of genes has no direct regulatory effect on murine glucose homeostasis or gene expression in islets of Langerhans...
  60. pmc A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
    Abhishek D Garg
    Cell Death Research and Therapy Unit, Department of Cellular and Molecular Medicine KU Leuven, KU Leuven, Leuven, Belgium
    EMBO J 31:1062-79. 2012
    ..These results unravel a novel PERK-dependent subroutine for the early and simultaneous emission of two critical DAMPs following ROS-mediated ER stress...
  61. doi request reprint Screening for gestational diabetes in Europe: where do we stand and how to move forward?: A scientific paper commissioned by the European Board & College of Obstetrics and Gynaecology (EBCOG)
    Katrien Benhalima
    Department of Endocrinology, UZ Gasthuisberg, KU Leuven, Belgium Electronic address
    Eur J Obstet Gynecol Reprod Biol 201:192-6. 2016
    ..Here we describe the ongoing controversy on GDM screening and diagnosis, and provide an overview of important topics for future research concerning GDM screening in Europe. ..
  62. doi request reprint Maternal obesity in Europe: where do we stand and how to move forward?: A scientific paper commissioned by the European Board and College of Obstetrics and Gynaecology (EBCOG)
    Roland Devlieger
    Department of Development and Regeneration, KU Leuven, University of Leuven, Leuven, Belgium Department of Obstetrics and Gynecology, University Hospitals KU Leuven, Leuven, Belgium Department of Obstetrics, Gynecology and Fertility, GZA Sint Augustinus, Wilrijk, Belgium Electronic address
    Eur J Obstet Gynecol Reprod Biol 201:203-8. 2016
    ..An agenda for research is proposed with the hope that it will catch the attention of policy-makers and funders and ultimately lead to the development of European-wide evidence-based guidelines for clinicians. ..
  63. doi request reprint Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis
    Inne Crèvecoeur
    Laboratory for Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49 bus 902, 3000, Leuven, Belgium
    Diabetologia . 2017
    ..The aim of this study was to investigate intrinsic differences present in the islets from diabetes-prone NOD mice before the onset of insulitis...
  64. pmc Vitamin D deficiency impairs skeletal muscle function in a smoking mouse model
    Nele Cielen
    Laboratory of Respiratory DiseasesDepartment of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium
    J Endocrinol 229:97-108. 2016
    ..We conclude that the synergy of smoking and vitamin D deficiency in contrast to its effect on lung disease, had different, independent but important noxious effects on skeletal muscles in a mouse model of mild COPD. ..
  65. doi request reprint The phenotype and function of murine bone marrow-derived dendritic cells is not affected by the absence of VDR or its ability to bind 1α,25-dihydroxyvitamin D3
    An Sofie Vanherwegen
    Laboratory for Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium
    J Steroid Biochem Mol Biol 164:239-245. 2016
    ....
  66. doi request reprint Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes
    Dieter Rondas
    Laboratory for Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium
    Diabetes 64:573-86. 2015
    ....
  67. doi request reprint Clinical Immunosuppressants Inhibit Inflammatory, Proliferative, and Reprogramming Potential, But Not Angiogenesis of Human Pancreatic Duct Cells
    Lei Ding
    Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O and N1, Faculty of Medicine, Katholieke Universiteit Leuven KU Leuven, Leuven, Belgium
    Cell Transplant 24:1585-98. 2015
    ....
  68. doi request reprint Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term
    Tatiana Takiishi
    Clinical and Experimental Endocrinology CEE, Department of Clinical and Experimental Medicine, Katholieke Universiteit Leuven, Campus Gasthuisberg, Leuven, Belgium
    Diabetes 63:2026-36. 2014
    ....
  69. doi request reprint Vitamin D and diabetes: the odd couple
    Tom L Van Belle
    Clinical and Experimental Endocrinology, Katholieke Universiteit KU Leuven, Campus Gasthuisberg, O and N 1 Herestraat 49, BOX 902, 3000 Leuven, Belgium
    Trends Endocrinol Metab 24:561-8. 2013
    ..This should be possible by implementing global guidelines and by focusing on daily dietary supplementation with small doses of vitamin D. ..
  70. ncbi request reprint Vitamin D action: lessons from VDR and Cyp27b1 null mice
    Roger Bouillon
    Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49 ON1 bus 902, 300 Leuven, Belgium
    Pediatr Endocrinol Rev 10:354-66. 2013
    ..We will compare the findings in VDR- and Cyp27bi-null mice with findings in man to elucidate what is presently understood of the vitamin D endocrine system and to identify the still outstanding questions...
  71. pmc Vitamin D deficiency exacerbates COPD-like characteristics in the lungs of cigarette smoke-exposed mice
    Nele Heulens
    Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, 3000, Leuven, Belgium
    Respir Res 16:110. 2015
    ..Many in vitro studies demonstrate important anti-inflammatory and antibacterial effects of vitamin D, but a direct contribution of vitamin D deficiency to COPD onset and disease progression has not been explored...
  72. doi request reprint Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, ON, Canada
    Lancet 377:924-31. 2011
    ....
  73. pmc Antigen-based vs. systemic immunomodulation in type 1 diabetes: the pros and cons
    Sofie Robert
    Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Leuven, Belgium
    Islets 5:53-66. 2013
    ..In order for future strategies to be effective, new well-defined biomarkers need to be developed and the extrapolation process of dose, timing and frequency from in vivo models to patients needs to be carefully reconsidered...
  74. doi request reprint Effects of vitamin D on antigen-specific and non-antigen-specific immune modulation: relevance for type 1 diabetes
    Tatiana Takiishi
    Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven, Belgium
    Pediatr Diabetes 14:81-9. 2013
    ..In this review, we will mainly focus on vitamin D as a component of immune regulation and on the role of vitamin D in antigen-specific and non-specific therapies with potential relevance for type 1 diabetes (T1D)...
  75. doi request reprint Immune and cell therapy in type 1 diabetes: too little too late?
    Pieter Gillard
    University Hospital Leuven, Department of Experimental Medicine and Endocrinology, KULeuven, Herestraat 49, B 3000 Leuven, Belgium
    Expert Opin Biol Ther 11:609-21. 2011
    ..Therapies that aim at protecting or restoring endogenous insulin secretion might help in decreasing the risk of severe hypoglycemia and long-term complications...
  76. pmc Differences in pregnancy outcomes and characteristics between insulin- and diet-treated women with gestational diabetes
    Katrien Benhalima
    Department of Endocrinology, UZ Gasthuisberg, KU Leuven, Herestraat 49, 3000, Leuven, Belgium
    BMC Pregnancy Childbirth 15:271. 2015
    ..Our aim was to evaluate the difference in pregnancy outcomes and characteristics between insulin- and diet-treated women with gestational diabetes (GDM)...
  77. doi request reprint Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act
    Wim Janssens
    Division of Respiratory Medicine, University Hospital Gasthuisberg KUL Herestraat 49, 3000 Leuven, Belgium
    Am J Respir Crit Care Med 179:630-6. 2009
    ..A further challenge of such studies is to define optimal serum 25-OHD levels for such noncalcemic endpoints...
  78. doi request reprint Vitamin D in autoimmune, infectious and allergic diseases: a vital player?
    Tom L Van Belle
    Laboratory for Experimental Medicine and Endocrinology, Catholic University Leuven, Herestraat 49, Leuven, Belgium
    Best Pract Res Clin Endocrinol Metab 25:617-32. 2011
    ..We also discuss how vitamin D influences the immune responses in each of those conditions based on the data generated using patient samples or preclinical models of each of these diseases...
  79. ncbi request reprint Economic aspects of diabetic foot care in a multidisciplinary setting: a review
    Giovanni A Matricali
    Multidisciplinary Diabetic Foot Clinic, U Z Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Diabetes Metab Res Rev 23:339-47. 2007
    ..To evaluate the economic aspects of diabetic foot care in a multidisciplinary setting...
  80. doi request reprint Glucose intolerance in early postpartum in women with gestational diabetes: Who is at increased risk?
    Liesbeth Leuridan
    Department of Endocrinology, UZ Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    Prim Care Diabetes 9:244-52. 2015
    ..We also discuss the current recommendations for screening in early postpartum and the many challenges to organize postpartum follow up in primary care. ..
  81. doi request reprint Cereulide food toxin, beta cell function and diabetes: Facts and hypotheses
    Roman Vangoitsenhoven
    Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium
    Diabetes Res Clin Pract 109:1-5. 2015
    ....
  82. doi request reprint Gestational diabetes: update of screening strategy and diagnostic criteria
    Katrien Benhalima
    Department of Endocrinology, UZ Gasthuisberg, KU Leuven, Leuven, Belgium
    Curr Opin Obstet Gynecol 25:462-7. 2013
    ..To review recently published studies examining new data on screening strategies and diagnostic criteria for gestational diabetes (GDM)...
  83. pmc Vildagliptin: a new oral treatment for type 2 diabetes mellitus
    Chantal Mathieu
    Department of Endocrinology, Katholieke Universiteit Leuven, UZ Gasthuisberg, Herestraat 49, Leuven, Belgium
    Vasc Health Risk Manag 4:1349-60. 2008
    ....
  84. doi request reprint Uremia suppresses immune signal-induced CYP27B1 expression in human monocytes
    Liesbeth Viaene
    Department of Nephrology, KU Leuven, UZ Gasthuisberg, Leuven, Belgium
    Am J Nephrol 36:497-508. 2012
    ..The present study aimed to elucidate this issue and to define the pathogenic role of p-cresyl sulfate (PCS), indoxyl sulfate (IndS), and fibroblast growth factor 23 (FGF23)...
  85. ncbi request reprint Vitamin d and diabetes
    Tatiana Takiishi
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, UZ Gasthuisberg, O and N I Herestraat 49 bus 902, 3000, Leuven, Belgium
    Rheum Dis Clin North Am 38:179-206. 2012
    ..This article reviews the role of vitamin D in the pathogenesis of T1D and T2D, focusing on the therapeutic potential for vitamin D in the prevention/intervention of T1D and T2D as well as its complications...
  86. doi request reprint A proposal for the use of uniform diagnostic criteria for gestational diabetes in Europe: an opinion paper by the European Board & College of Obstetrics and Gynaecology (EBCOG)
    Katrien Benhalima
    Department of Endocrinology, UZ Gasthuisberg, KU Leuven, Herestraat 49, 3000, Leuven, Belgium
    Diabetologia 58:1422-9. 2015
    ..The use of the same WHO diagnostic GDM criteria across Europe will be an important step towards uniformity...
  87. doi request reprint Vitamin D for infections
    Hannelie Korf
    Clinical and Experimental Endocrinology, Department of Experimental and Clinical Medicine, KU Leuven, Leuven, Belgium
    Curr Opin Endocrinol Diabetes Obes 21:431-6. 2014
    ....
  88. ncbi request reprint Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved
    Lut Overbergh
    Laboratory for Experimental Medicine and Endocrinology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    Mol Cell Proteomics 6:2180-99. 2007
    ..The present findings may open new avenues for the understanding and prevention of beta-cell loss in type 1 diabetes...
  89. doi request reprint The role of blood glucose monitoring in non-insulin treated type 2 diabetes: what is the evidence?
    Katrien Benhalima
    Department of Diabetes and Endocrinology, UZ Gasthuisberg, Catholic University of Leuven, Belgium
    Prim Care Diabetes 6:179-85. 2012
    ..We review the conflicting evidence on the use of SMBG in insulin-naïve T2DM patients...
  90. pmc Analysis of Pregnancy Outcomes Using the New IADPSG Recommendation Compared with the Carpenter and Coustan Criteria in an Area with a Low Prevalence of Gestational Diabetes
    Katrien Benhalima
    Department of Endocrinology, UZ Leuven and KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    Int J Endocrinol 2013:248121. 2013
    ..736), and in 1.4% of NGT women (P = 0.007). Conclusion. Using the IADPSG criteria, more women are identified as having GDM, and these women carry an increased risk for adverse gestational outcome compared to women without GDM...
  91. pmc The Belgian Diabetes in Pregnancy Study (BEDIP-N), a multi-centric prospective cohort study on screening for diabetes in pregnancy and gestational diabetes: methodology and design
    Katrien Benhalima
    Department of Endocrinology and Department of Obstetrics and Gynecology, UZ Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    BMC Pregnancy Childbirth 14:226. 2014
    ....
  92. ncbi request reprint Vitamin D and cancer
    Roger Bouillon
    Laboratory for Experimental Medicine and Endocrinology, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 102:156-62. 2006
    ....
  93. ncbi request reprint Inhaled human insulin ((insulin human [rDNA origin]) Inhalation Powder) in diabetes mellitus
    Chantal Mathieu
    UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Expert Opin Drug Metab Toxicol 2:779-91. 2006
    ..Availability of inhaled insulin may increase insulin acceptance and thus improve glycaemic control in patients with diabetes...
  94. doi request reprint Cytokine signalling in the beta-cell: a dual role for IFNgamma
    Conny Gysemans
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, UZ Gasthuisberg O and N, Katholieke Universiteit Leuven, Herestraat 49, bus 902, B 3000 Leuven, Belgium
    Biochem Soc Trans 36:328-33. 2008
    ..Transcription factors drive this dual role, with STAT-1 driving beta-cell destruction and IRF-1 possibly playing a role in up-regulation of protective pathways induced by IFNgamma...
  95. ncbi request reprint Vitamin D3 and the immune system: maintaining the balance in health and disease
    Femke Baeke
    LEGENDO, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Nutr Res Rev 20:106-18. 2007
    ....
  96. doi request reprint Glycated hemoglobin in pregnancies at increased risk for gestational diabetes mellitus
    Johan Verhaeghe
    Department of Obstetrics and Gynecology, Health Sciences Campus Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Eur J Obstet Gynecol Reprod Biol 161:157-62. 2012
    ..We sought to identify clinical and metabolic correlates of HbA(1c) in pregnancies at increased risk for gestational diabetes mellitus (GDM)...